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| 1 | Automatic Navigation for Rat-Robots with Modeling of the Human Guidance显示文摘 | Chao Sun Nenggan Zheng Xinlu Zhang Weidong Chen Xiaoxiang Zheng | 2013 | Journal of Bionic Engineering2013，10，1： | 5 |
| 2 | A first-principles investigation into the hydrogen bond interaction in β-HMX显示文摘A theoretical study of structural and electronic properties of β-HMX crystal is performed using density-functional theory(DFT). The total density of states(TDOS) is presented. The atomic orbit projected density of state(PDOS) from the p-type orbit of C,N,O and the s-type orbit of H is discussed. The study by analyzing the PDOS shows that the structure of β-HMX crystal possesses C-H···O intra- and inter-molecular hydrogen-bonding. There exists a hydrogen bonding between H5 -1s and O12 -2p orbits,between H19 -1s and O28 -2p orbits of intra molecules,and between H19 -1s and O24 -2p orbits of inter molecules. The Mulliken population analysis is also made. | CHEN Fang 1 ,ZHANG Hong 1,2,ZHAO Feng 3 ,MENG ChuanMin 3 & CHENG XinLu 1 1 Institute of Atomic and Molecular Physics,Sichuan University,Chengdu 610065,China 2 School of Physical Science and Technology,Sichuan University,Chengdu 610065,China 3 Laboratory for Shock Wave and Detonation Physics Research,Southwest Institute of Fluid Physics,China Academy of Engineering Physics,Mianyang 621900,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，6： | 4 |
| 3 | Geochemistry, U-Pb Geochronology and Sr-Nd-Hf Isotopes of the Early Cretaceous Volcanic Rocks in the Northern Da Hinggan Mountains显示文摘Whole-rock geochemical, zircon U-Pb geochronological and Sr-Nd-Hf isotopic data are presented for the Early Cretaceous volcanic rocks from the northern Da Hinggan Mountains. The volcanic rocks generally display high SiO2(73.19–77.68 wt%) and Na2O+K2O(6.53–8.98 wt%) contents, with enrichment in Rb, Th, U, Pb and LREE, and depletion in Nb, Ta, P and Ti. Three rhyolite samples, one rhyolite porphyry sample, and one volcanic breccia sample yield weighted mean 206Pb/238 U ages of 135.1±1.2 Ma, 116.5±1.1 Ma, 121.9±1.0 Ma, 118.1±0.9 Ma and 116.9±1.4 Ma, respectively. All these rocks have moderate(87Sr/86Sr)i values of 0.704912 to 0.705896, slightly negative εNd(t) values of –1.4 to –0.1, and positive εHf(t) values of 3.7 to 8. Their zircon Hf and whole-rock Nd isotopic model ages range from 594 to 1024 Ma. These results suggest that the Early Cretaceous volcanic rocks were originated from melting of subducted oceanic crust and associated sediments during the closure of the Mongol-Okhotsk Ocean. | HU Xinlu YAO Shuzhen HE Mouchun DING Zhenju CHEN Bin | 2015 | Acta Geologica Sinica(English Edition)2015，89，1： | 2 |
| 4 | Punicalagin Inhibits Inflammation in LPS-Induced RAW264.7 Macrophages via the Suppression of TLR4-Mediated MAPKs and NF-κB Activation显示文摘 | Xiaolong Xu Peng Yin Changrong Wan Xinlu Chong Mingjiang Liu Peng Cheng Jiajia Chen Fenghua Liu Jianqin Xu | 2014 | Inflammation2014，，3： | 2 |
| 5 | The role of transporters in cancer redox homeostasis and cross-talk with nanomedicines显示文摘Tumor cell usually exhibits high levels of reactive oxygen species and adaptive antioxidant system due to the metabolic,genetic,and microenvironment-associated alterations.The altered redox homeostasis can promote tumor progression,development,and treatment resistance.Several membrane transporters are involved in the resetting redox homeostasis and play important roles in tumor progression.Therefore,targeting the involved transporters to disrupt the altered redox balance emerges as a viable strategy for cancer therapy.In addition,nanomedicines have drawn much attention in the past decades.Using nanomedicines to target or reset the redox homeostasis alone or combined with other therapies has brought convincing data in cancer treatment.In this review,we will introduce the altered redox balance in cancer metabolism and involved transporters,and highlight the recent advancements of redox-modulating nanomedicines for cancer treatment. | Longfa Kou Xinyu Jiang Huirong Huang Xinlu Lin Youting Zhang Qing Yao Ruijie Chen | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 2 |
| 6 | Elucidation and biological activities of a new polysaccharide from cultured Cordyceps militaris显示文摘 | Yongshuai Jing Xinlu Cui Zhiyan Chen Lijiao Huang Liyan Song Ting Liu Wenjie Lv Rongmin Yu | 2014 | Carbohydrate Polymers2014，，： | 1 |
| 7 | The influence of the X atoms and Al 3p occupied states in AlTiX2 (X=Fe; Cu; Co; Ni) intermetallics 显示文摘 | Fu Hongzhi Chen Dong Cheng Xinlu | 2007 | Physica B2007，388，12： | 1 |
| 8 | Agrobacterium–mediated Transformation of Kalanchoe laxiflora显示文摘Plants with crassulacean acid metabolism(CAM) generally utilize water 20%–80% more efficiently than non-CAM plants. The whole genomes of several CAM plants have been sequenced or are being sequenced. For effective genome characterization and genome editing of CAM plants,an efficient transformation system is essential. In this study, we developed an Agrobacterium-mediated transformation protocol for Kalanchoe laxiflora, an obligate CAM plant,by optimizing several factors affecting the transformation efficiency. Agrobacterium strains AGL1, C58, EHA105,and GV3101 were all suitable for K. laxiflora transformation. Fifty-nine percent of the leaf explants yielded kanamycin-resistant and GUS-positive shoots. Polymerase chain reaction and quantitative real-time PCR(qRT-PCR) using gus A-, gus Plus-, npt II-and hpt-specific primers confirmed that the transgenes were integrated into K. laxiflora genome and expressed. This efficient transformation system will allow effective functional characterization of genes through over-or down-expression, knockout, or genome editing. | Xiling Wang Xinlu Chen Qunkang Cheng Kaikai Zhu Xiaohan Yang Zongming Cheng | 2019 | Horticultural Plant Journal2019，5，5： | 1 |
| 9 | Efficient de novo assembly and modification of large DNA fragments显示文摘Synthetic genomics has provided new bottom-up platforms for the functional study of viral and microbial genomes.The construction of the large,gigabase(Gb)-sized genomes of higher organisms will deepen our understanding of genetic blueprints significantly.But for the synthesis and assembly of such large-scale genomes,the development of new or expanded methods is required.In this study,we develop an efficient pipeline for the construction of large DNA fragments sized 100 kilobases(kb)or above from scratches and describe an efficient method for“scar-free”engineering of the assembled sequences.Our method,therefore,should provide a standard framework for producing long DNA molecules,which are critical materials for synthetic genomics and metabolic engineering. | Shuangying Jiang Yuanwei Tang Liang Xiang Xinlu Zhu Zelin Cai Ling Li Yingxi Chen Peishuang Chen Yuge Feng Xin Lin Guoqiang Li Jafar Sharif Junbiao Dai | 2022 | Science China(Life Sciences)2022，65，7： | 1 |
| 10 | Improvement of Agrobacterium-mediated transformation in Hi-II maize (Zea mays) using standard binary vectors显示文摘 | Juan M. Vega Weichang Yu Angela R. Kennon Xinlu Chen Zhanyuan J. Zhang | 2008 | Plant Cell Reports2008，，2： | 1 |
| 11 | Increasing Anthropogenic Mercury Pollution over the Last 200 Years Revealed by Lagoonal Sediments from Hainan Island,South China显示文摘The toxic heavy metal mercury(Hg)has significantly enhanced the global Hg cycle influenced by human activities over the last century.In this study,we presented a high-resolution Hg deposition history between∼1780 and 2015 AD in a sediment core from Xincun Lagoon,located in the southeastern Hainan Island,South China,and analyzed it in conjunction with geochemical elements,grain-size distribution,organic matter,and HYSPLIT backward trajectory simulation.The objective was to investigate the influencing factors affecting historical Hg deposition in relatively remote regions and assess the extent of the effects of natural background and human activities.The results showed that the Hg in the sediment was deposited primarily through atmospheric deposition,which was closely related to regional and even global human activities.Anthropogenic Hg contamination increased gradually from the 1830s to 1850s,possibly due to Hg emissions from Opium Wars I and II occurring in southeastern China.High broad peaks of anthropogenic Hg were observed during the 1910s to 1950s and in the 1980s,likely associated with the two world wars and modern Chinese wars.In addition,a further sharp increase in anthropogenic Hg from the mid-1970s to the present occurred,likely originating from the intense industrial activities in China triggered by the reform and opening-up policy of China in 1978 and some countries in Southeast Asia. | LI Yanting XUE Jibin CHEN Jingqiang LU Yi MA Xinlu | 2023 | Chinese Geographical Science2023，33，6： | 0 |
| 12 | Interleukin 35 protects cardiomyocytes following ischemia/reperfusion-induced apoptosis via activation of mitochondrial STAT3显示文摘Mitochondrial reactive oxygen species(mtROS)-induced apoptosis has been suggested to contribute to myocardial ischemia/reperfusion injury.Interleukin 35(IL-35),a novel anti-inflammatory cytokine,has been shown to protect the myocardium and inhibit mtROS production.However,its effect on cardiomyocytes upon exposure to hypoxia/reoxygenation(H/R)damage has not yet been elucidated.The present study aimed to investigate the potential protective role and underlying mechanisms of IL-35 in H/R-induced mouse neonatal cardiomyocyte injury.Mouse neonatal cardiomyocytes were challenged to H/R in the presence of IL-35,and we found that IL-35 dose dependently promotes cell viability,diminishes mtROS,maintains mitochondrial membrane potential,and decreases the number of apoptotic cardiomyocytes.Meanwhile,IL-35 remarkably activates mitochondrial STAT3(mitoSTAT3)signaling,inhibits cytochrome c release,and reduces apoptosis signaling.Furthermore,co-treatment of the cardiomyocytes with the STAT3 inhibitor AG490 abrogates the IL-35-induced cardioprotective effects.Our study identified the protective role of IL-35 in cardiomyocytes following H/R damage and revealed that IL-35 protects cardiomyocytes against mtROS-induced apoptosis through the mitoSTAT3 signaling pathway during H/R. | Fengyun Zhou Ting Feng Xiangqi Lu Huicheng Wang Yangping Chen Qiuxia Zhang Xinlu Zhang Jiancheng Xiu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 0 |
| 13 | Innovative design and optimization of a two-dimensional deployable nine-grid planar antenna mechanism with a flat reflection surface显示文摘With the development of the aerospace industry,space missions are becoming more complicated and diversified,and there is a demand for antenna mechanisms with a larger physical aperture.In this paper,a planar deployable mechanism is proposed,which can form a flat reflection surface with a small gap between plates.To this end,a novel large-scale two-dimensional deployable nine-grid planar antenna mechanism is designed.First,two antenna folding schemes and four supporting mechanism schemes are proposed.Through comparison analysis,the antenna configuration scheme with the best comprehensive performance is selected.A kinematic model of the deployable mechanism is established,and its kinematic characteristics are analyzed.Then,the correctness of the kinematic model is verified by comparing the analytical and simulation results of the kinematic model.Subsequently,a finite element model of the antenna is developed.Based on the response surface method,the structural parameters of the support rods of the antenna are optimized,and a set of optimized solutions with lightweight and high fundamental frequency characteristics are obtained.Finally,a prototype of the proposed nine-grid planar antenna is fabricated.The feasibility of the deployment principle and the rationality of the designed mechanism are verified by deployment experiments. | Bo CHEN Ze JIANG Xinlu WEI Luyao GUO Xin ZHOU Yundou XU Junjie QIAN Yongsheng ZHAO | 2023 | Chinese Journal of Aeronautics2023，36，11： | 0 |
| 14 | PREPARATION OF Co50Ni50 ULTRAFINES BY CO-REDUCTION OF SOLUTION IN PRESENCE OF POLYMER显示文摘INTRODUCTIONThemetalCo,asoneofferomagnetictransitionelements,anditsaloysandcompounds,especialyitsultrafineparticlesandpowder... | Chen, Zuyao Zhang, Guochun Zhu, Yurui Jiang, Wanquan Tang, Xinlu | 1999 | 中国有色金属学会会刊:英文版1999，9，1： | 0 |
| 15 | Sinistral strike slip of the Zhangjiakou-Penglai Fault and its control on hydrocarbon accumulation in the northeast of Shaleitian Bulge,Bohai Bay Basin,East China显示文摘The structural style, fault activity, strike-slip displacement, and the formation mechanism and hydrocarbon migration and accumulation in the center tectonic zone in the northeast Shaleitian Bulge of Zhangjiakou-Penglai Fault Zone were studied by seismic attribute analysis, structural geometric analysis, fault activity analysis, structure evolution history and simulation of hydrocarbon migration, based on 3-D seismic and drilling data. The main results are as follows:(1) The study area is a superimposed tectonic zone, which experienced early(Paleocene and Eocene) extension and late(Oligocene and Pliocene-Quaternary) strike-slip and pull-apart.(2) The sinistral strike slip of the northeast Shaleitian Bulge of Zhangjiakou-Penglai Fault Zone went through two periods, Oligocene and Pliocene-Quaternary, and the Bohai section was active earlier than the inland section.(3) The sinistral strike slip displacement of Zhangjiakou-Penglai Fault is 4 km since Cenozoic, including 1 km in the Oligocene, and 3 km in the Pliocene-Quaternary.(4) The strike-slip movements have resulted in the increase of fault activity and basin-mountain restructure in the fault zone, also contributed to the formation of the central tectonic belt and the conjugate evolution in north-east structural belt.(5) The conjugate strike slip of the Zhangjiakou-Penglai Fault Zone dominated the migration and accumulation of hydrocarbon in shallow formations by controlling the injection points and segments of hydrocarbon from the deep layers to shallow layers. | PENG Jingsong WEI Ajuan SUN Zhe CHEN Xinlu ZHAO Dijiang | 2018 | Petroleum Exploration and Development2018，45，2： | 0 |
| 16 | LncRNA ZFAS1 regulates cardiomyocyte differentiation of human embryonic stem cells显示文摘Background:Cardiomyocytes derived from human embryonic stem cells(hESCs)are regulated by complex and stringent gene networks during differentiation.Long non-coding RNAs(lncRNAs)exert critical epigenetic regulatory functions in multiple differentiation processes.However,the involvement of lncRNAs in the differentiation of hESCs into cardiomyocytes has not yet been fully elucidated.Here,we identified the key roles of ZFAS1(lncRNA zinc finger antisense 1)in the differentiation of cardiomyocytes from hESCs.Methods:A model of cardiomyocyte differentiation from stem cells was established using the monolayer differentiation method,and the number of beating hESCs-derived cardiomyocytes was calculated.Gene expression was analyzed by quantitative real-time PCR(qRTPCR).Immunofluorescence assays were performed to assess the expression of cardiac troponin T(cTnT)andα-actinin protein in cardiomyocytes.Results:qRT-PCR showed that ZFAS1 expression in the mesoderm was significantly higher than that in embryonic stem cells,cardiac progenitor cells,and cardiomyocytes.Knockdown of ZFAS1 inhibited cardiomyocyte differentiation from hESCs,which was characterized by reduced expression of the cardiac-specific markers cTnT,α-actinin,myosin heavy chain 6(MYH6),and myosin heavy chain 7(MYH7).In contrast,ZFAS1 overexpression remarkably increased the percentage of spontaneously beating cardiomyocytes.In terms of the mechanism,we found that ZFAS1 is an antisense lncRNA at the 5′end of the protein-coding gene ZNFX1.Knockdown of ZFAS1 could increase the mRNA expression level of ZNFX1.Furthermore,qRT-PCR demonstrated that the silencing of ZNFX1 led to an increase in cardiac-specific markers that predicted the promotion of cardiomyocyte differentiation.Conclusion:Altogether,these data suggest that lncRNA-ZFAS1 is required for cardiac differentiation by functionally inhibiting the expression of ZNFX1,which may provide a reference for the treatment of heart disease to a certain extent. | YANG CAO YINING LIU YANG YU XIAOFEI GUO XIUXIU WANG WENYA MA HANJING LI ZHONGYU REN XINLU GAO SIJIA LI HAOYU JI HONGYANG CHEN HONG YAN YANAN TIAN XIN WANG BENZHI CAI | 2023 | BIOCELL2023，47，6： | 0 |
| 17 | Highly Uniform Alkali Doped Cobalt Oxide Derived from Anionic Metal-Organic Framework:Improving Activity and Water Tolerance for CO Oxidation显示文摘A sequence of alkali metal cation-exchanged Co metal-organic frameworks(Co-MOFs),therein after denoted as M@Co-MOF,M=Na+,K+,Rb\and Cs+,was prepared and used as the precursors to obtain the corresponding alkali doped cobalt oxide(defined as M/C03O4,M=Na+,K\Rb\and Cs+)through calcination under air atmosphere.The cobalt oxide modified by unifbnn alkali metals exhibited a significant promotion of catalytic activity for CO oxidation.The activity of M/Co3O4 decreased in the order of Cs+>Na+>K+>Rb+.Experimental and theoretical results revealed that the anionic skeleton of Co-MOF could tacilely adsorb alkali metal cations and play a cnicial role in the formation of higlily unilonn alkali doped cobalt oxide.The further characterizations,such as temperature-programmed reduction of H2(H2-TPR),oxygen temperature-programmed desorption(O2-TPD),X-ray photoelectron spectroscopy(XPS),and in situ diffuse reflectance infrared Fourier transiorm(DRIFT)spectra demonstrated that the enlianced catalytic activity is originated from the interfacial electron transfer as well as weakened the Co-O bond strength,which promoted oxygen desorption from CO3O4 and fomiation of cobalt species with the lower valence state.The Cs/Co3O4 catalyst was maintained for 60 h without deactivation and still showed a high activity in the presence of water. | LEI Huijin ZHANG Xinlu JIN Jiongke WANG Shuhua DING Shunmin ZHANG Ning CHEN Chao | 2020 | Chemical Research in Chinese Universities2020，36，5： | 0 |
| 18 | NITROGEN USE AND MANAGEMENT IN ORCHARDS AND VEGETABLE FIELDS IN CHINA: CHALLENGES AND SOLUTIONS显示文摘China is the largest producer and consumer of fruits and vegetables in the world.Although the annual planting areas of orchards and vegetable fields(OVF)account for 20%of total croplands,they consume more than 30%of the mineral nitrogen fertilizers in China and have become hotspots of reactive N emissions.Excess N fertilization has not only reduced the N use efficiency(NUE)and quality of grown fruits and vegetables but has also led to soil acidification,biodiversity loss and climate change.Studies using 15N labeling analysis showed that the recovery rate of N fertilizer in OVFs was only 16.6%,and a high proportion of fertilizer N resided in soils(48.3%)or was lost to the environment(35.1%).Nitrate accumulation in the soil of OVFs is the main fate of N fertilizer in northern China,which threatens groundwater quality,while leaching and denitrification are the important N fates of N fertilizer in southern China.Therefore,taking different measures to reduce N loss and increase NUE based on the main pathways of N loss in the various regions is urgent,including rational N fertilization,substituting mineral N fertilizers with organic fertilizers,fertigation,and adding mineral N fertilizers with urease inhibitors and nitrification inhibitors. | Xueqiang ZHU Peng ZHOU Peng MIAO Haoying WANG Xinlu BAI Zhujun CHEN Jianbin ZHOU | 2022 | Frontiers of Agricultural Science and Engineering2022，9，3： | 0 |
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