6篇
您的检索式：作者名="CHEN Yilang"
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| 1 | The effect of the tightness of abdominal beats on the determination of maximal acceptable weight of lift显示文摘 | Chen Yilang | 2003 | International Journal of Industrial Ergonomics2003，311，： | 1 |
| 2 | The effect of the tightness of abdominal belts on the determination of maximal acceptable weight of lift 显示文摘 | CHEN Yilang | 2003 | International journal of Industrial Ergonomics2003，31，： | 1 |
| 3 | The effect of the tightness of abdominal belts on the determination of maximal acceptable weight of lift 显示文摘 | CHEN Yilang | 2003 | International Journal of Industrial Ergonomics2003，31，： | 1 |
| 4 | High‐Efficiency Fluorescent Organic Light‐Emitting Devices Using Sensitizing Hosts with a Small Singlet–Triplet Exchange Energy显示文摘 | Dongdong Zhang Lian Duan Chen Li Yilang Li Haoyuan Li Deqiang Zhang Yong Qiu | 2014 | Adv Mater2014，，29： | 1 |
| 5 | CX3C-chemokine receptor 1 modulates cognitive dysfunction induced by sleep deprivation显示文摘Background:Microglia plays an indispensable role in the pathological process of sleep deprivation(SD).Here,the potential role of microglial CX3C-chemokine receptor 1(CX3CR1)in modulating the cognition decline during SD was evaluated in terms of microglial neuroinflammation and synaptic pruning.In this study,we aimed to investigat whether the interference in the microglial function by the CX3CR1 knockout affects the CNS's response to SD.Methods:Middle-aged wild-type(WT)C57BL/6 and CX3CR1^(−/−)mice were either subjected to SD or allowed normal sleep(S)for 8 h to mimic the pathophysiological changes of middle-aged people after staying up all night.After which,behavioral and histological tests were used to explore their different changes.Results:CX3CR1 deficiency prevented SD-induced cognitive impairments,unlike WT groups.Compared with the CX3CR1^(−/−)S group,the CX3CR1^(−/−)SD mice reported a markedly decreased microglia and cellular oncogene fos density in the dentate gyrus(DG),decreased expression of pro-inflammatory cytokines,and decreased microglial phagocytosis-related factors,whereas increased levels of anti-inflammatory cytokines in the hippocampus and a significant increase in the density of spines of the DG were also noted.Conclusions:These findings suggest that CX3CR1 deficiency leads to different cerebral behaviors and responses to SD.The inflammation-attenuating activity and the related modification of synaptic pruning are possible mechanism candidates,which indicate CX3CR1 as a candidate therapeutic target for the prevention of the sleep loss-induced cognitive impairments. | Jiawei Xin Chao Wang Xiaojuan Cheng Changfu Xie Qiuyang Zhang Yilang Ke Xuanyu Huang Xiaochun Chen Xiaodong Pan | 2022 | Chinese Medical Journal2022，，2： | 0 |
| 6 | Integrating multi-modal information to detect spatial domains of spatial transcriptomics by graph attention network显示文摘Recent advances in spatially resolved transcriptomic technologies have enabled unprecedented opportunities to elucidate tissue architecture and function in situ.Spatial transcriptomics can provide multimodal and complementary information simultaneously,including gene expression profiles,spatial locations,and histology images.However,most existing methods have limitations in efficiently utilizing spatial information and matched high-resolution histology images.To fully leverage the multi-modal information,we propose a SPAtially embedded Deep Attentional graph Clustering(SpaDAC)method to identify spatial domains while reconstructing denoised gene expression profiles.This method can efficiently learn the low-dimensional embeddings for spatial transcriptomics data by constructing multi-view graph modules to capture both spatial location connectives and morphological connectives.Benchmark results demonstrate that SpaDAC outperforms other algorithms on several recent spatial transcriptomics datasets.SpaDAC is a valuable tool for spatial domain detection,facilitating the comprehension of tissue architecture and cellular microenvironment.The source code of SpaDAC is freely available at Github(http://gffzz188fe103f8f1460asb95obvuuvcvp69un.ffgz.tsg.suse.edu.cn/huoyuying/SpaDAC.git). | Yuying Huo Yilang Guo Jiakang Wang Huijie Xue Yujuan Feng Weizheng Chen Xiangyu Li | 2023 | Journal of Genetics and Genomics2023，50，9： | 0 |
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