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1Dense ceramics with complex shape fabricated by 3D printing:A review显示文摘Three-dimensional(3D)printing technology is becoming a promising method for fabricating highly complex ceramics owing to the arbitrary design and the infinite combination of materials.Insufficient density is one of the main problems with 3D printed ceramics,but concentrated descriptions of making dense ceramics are scarce.This review specifically introduces the principles of the four 3D printing technologies and focuses on the parameters of each technology that affect the densification of 3D printed ceramics,such as the performance of raw materials and the interaction between energy and materials.The technical challenges and suggestions about how to achieve higher ceramic density are presented subsequently.The goal of the presented work is to comprehend the roles of critical parameters in the subsequent 3D printing process to prepare dense ceramics that can meet the practical applications.Zhe Chen Xiaohong Sun Yunpeng Shang Kunzhou Xiong Zhongkai Xu Ruisong Guo Shu Cai Chunming Zheng 2021Journal of Advanced Ceramics2021,10,2:10
2Purification and Characterization of a New Ribosome Inactivating Protein from Cinchonaglycoside C-treated Tobacco Leaves显示文摘A new ribosome-inactivating protein(RIP)with a molecular weight of 31 kDa induced by Cinchonaglycoside C(1)designatedCLP31,was isolated from tobacco leaves.Analysis of this protein sequence indicated that it belongs to the RIP family and itwas distinct from the other plant RIPs reported previously at its N-terminal amino acid sequence.CIP31 can directly impairsynthesis of coat protein(CP)of tobacco mosaic virus(TMV),which resulted in inhibition of TMV long distance movementand multiplication in tobacco plants at concentrations of ng/mL.Furthermore,no toxicity was shown to the growth andfertility of the plants.CIP31 was synthesized only in the presence of Cinchonaglycoside C(1)and was independent of thesalicylic acid(SA)signal pathway.We provided evidence for the SA-independent biological induction of resistance.Yanmei Li Yantao Jia Zhongkai Zhang Xiaoying Chen Hongping He Rongxiang Fang Xiaojiang Hao 2007Journal of Integrative Plant Biology2007,49,9:8
3Isorhapontigenin protects against doxorubicin-induced cardiotoxicity via increasing YAP1 expression显示文摘As an effective anticancer drug, the clinical limitation of doxorubicin(Dox) is the time-and dose-dependent cardiotoxicity. Yes-associated protein 1(YAP1) interacts with transcription factor TEA domain 1(TEAD1) and plays an important role in cell proliferation and survival. However, the role of YAP1 in Dox-induced cardiomyopathy has not been reported. In this study, the expression of YAP1 was reduced in clinical human failing hearts with dilated cardiomyopathy and Dox-induced in vivo and in vitro cardiotoxic model. Ectopic expression of Yap1 significantly blocked Dox-induced cardiomyocytes apoptosis in TEAD1 dependent manner. Isorhapontigenin(Isor) is a new derivative of stilbene and responsible for a wide range of biological processes. Here, we found that Isor effectively relieved Doxinduced cardiomyocytes apoptosis in a dose-dependent manner in vitro. Administration with Isor(30 mg/kg/day, intraperitoneally, 3 weeks) significantly protected against Dox-induced cardiotoxicity in mice. Interestingly, Isor increased Dox-caused repression in YAP1 and the expression of its target genes in vivo and in vitro. Knockout or inhibition of Yap1 blocked the protective effects of Isor on Dox-induced cardiotoxicity. In conclusion, YAP1 may be a novel target for Dox-induced cardiotoxicity and Isor might be a new compound to fight against Dox-induced cardiotoxicity by increasing YAP1 expression.Panxia Wang Minghui Wang Yuehuai Hu Jianxing Chen Yanjun Cao Cui Liu Zhongkai Wu Juan Shen Jing Lu Peiqing Liu 2021Acta Pharmaceutica Sinica B2021,11,3:7
4Antiskid Control of Railway Train Braking Based on Adhesion Creep Behavior显示文摘In modern trains wheelset skidding leads to the deterioration of braking behavior,the degradation of comfort,as well as a boost in system hazards.Because of the nonlinearity and unknown characteristics of wheelset adhesion,simplifications are widely adopted in the modeling process of conventional antiskid controllers.Therefore,conventional antiskid controllers usually cannot perform satisfactorily.In this paper,systematic computer simulation and field tests for railway antiskid control system are introduced.The operating principal of antiskid control system is explained,which is fundamental to the simulation of antiskid brakes,and the simulation model is introduced,which incorporates both the adhesion creep curve and a pneumatic submodel of antiskid control system.In addition,the characteristics of adhesion curves and the simulation target are also provided.Using DHSplus,the pneumatic submodel is created to analyze the performance of the different control strategies of antiskid valves.Then the system simulation is realized by combining the kinematical characteristics of railway trains and the pneumatic submodel.The simulation is performed iteratively to obtain the optimized design of the antiskid control system.The design result is incorporated in the hardware design of the antiskid control system and is evaluated in the field tests in Shanghai Subway Line 1.Judging by the antiskid efficiency,the antiskid braking performance observed in the field tests shows the superiority of the optimized design.Therefore,the proposed simulation method,especially in view of its ease of application,appears to be a useful one for designing railway antiskid control systems.ZUO Jianyong CHEN Zhongkai 2012Chinese Journal of Mechanical Engineering2012,25,3:6
5METHOD FOR PRECISE CALCULATION OF ROOT STRESS OF SPIRAL BEVEL GEARS显示文摘METHODFORPRECISECALCULATIONOFROOTSTRESSOFSPIRALBEVELGEARSMETHODFORPRECISECALCULATIONOFROOTSTRESSOFSPIRALBEVELGEARSChenLiangyu...Chen Liangyu Wang Yanzhong Zheng Xijian E Zhongkai Cai Chunyuan(Northeastern University) 1994Chinese Journal of Mechanical Engineering1994,7,4:5
6Sensor Configuration and Test for Fault Diagnoses of Subway Braking System Based on Signed Digraph Method显示文摘Fault diagnosis of various systems on rolling stock has drawn the attention of many researchers.However,obtaining an optimized sensor set of these systems,which is a prerequisite for fault diagnosis,remains a major challenge.Available literature suggests that the configuration of sensors in these systems is presently dependent on the knowledge and engineering experiences of designers,which may lead to insufficient or redundant development of various sensors.In this paper,the optimization of sensor sets is addressed by using the signed digraph(SDG)method.The method is modified for use in braking systems by the introduction of an effect-function method to replace the traditional quantitative methods.Two criteria are adopted to evaluate the capability of the sensor sets,namely,observability and resolution.The sensors configuration method of braking system is proposed.It consists of generating bipartite graphs from SDG models and then solving the set cover problem using a greedy algorithm.To demonstrate the improvement,the sensor configuration of the HP2008 braking system is investigated and fault diagnosis on a test bench is performed.The test results show that SDG algorithm can improve single-fault resolution from 6 faults to 10 faults,and with additional four brake cylinder pressure(BCP)sensors it can cover up to 67 double faults which were not considered by traditional fault diagnosis system.SDG methods are suitable for reducing redundant sensors and that the sensor sets thereby obtained are capable of detecting typical faults,such as the failure of a release valve.This study investigates the formal extension of the SDG method to the sensor configuration of braking system,as well as the adaptation supported by the effect-function method.ZUO Jianyong CHEN Zhongkai 2014Chinese Journal of Mechanical Engineering2014,27,3:4
7Distribution Features of the Nanhua-Sinian Rifts and their Significance to Hydrocarbon Accumulation in the Tarim Basin显示文摘On the basis of reprocessing 34 new two-dimensional spliced long sections(20,191 km) in the Tarim Basin, the deep structure features of the Tarim Basin were analyzed through interpreting 30,451 km of two-dimensional seismic data and compiling basic maps. Seismic interpretation and geological analysis conclude that the Nanhua-Sinian strata are a set of rift-depression depositional systems according to their tectonic and depositional features. The rift valley formed in the Nanhua Period, and the transformation became weaker during the late Sinian Period, which eventually turned into depression. From bottom to top, the deposited strata include mafic igneous, tillite, mudstone, and dolomite. Three major depocenters developed inside this basin during the rift stage and are distributed in the eastern Tarim Basin, the Awati area, and the southwestern Tarim Basin. Among them, the rift in the eastern Tarim Basin strikes in the near east-west direction on the plane and coincides with the aeromagnetic anomaly belt. This represents a strong magnetic zone formed by upwelling basic volcanic rock along high, steep normal faults of the Nanhua Period. Controlled by the tectonic background, two types of sedimentary systems were developed in the rift stage and depression stage, showing two types of sequence features in the Sinian depositional stage. The Nanhua System appears as a wedge-shaped formation, with its bottom in unconformable contact with the base. The rifting event has a strong influence on the current tectonic units in the Tarim Basin, and affects the distribution of source rock in the Yuertus Formation and reservoir beds in the Xiaoerbulake Formation in Lower Cambrian, as well as the gypseous cap rock in Middle Cambrian. The distribution features of the rifts have important and realistic significance for determining the direction of oil and gas exploration in the deep strata of the Tarim Basin. Comprehensive analysis suggests that the Tazhong region is the most favorable zone, and the Kalpin-Bachu region is the optimal potential zone for exploring sub-salt oil and gas in deep Cambrian strata.BAI Zhongkai CHENG Minghua CHEN Cheng HUO Junzhou ZHANG Junfeng ZHOU Xingui GAO Yongjin ZHAO Bo QIU Haijun HAN Miao YANG Youxing SUN Zhichao MIAO Miaoqing ZHANG Jinhu LI Qingyao 2020Acta Geologica Sinica(English Edition)2020,94,2:3
8An Iterative Learning Approach to Identify Fractional Order KiBaM Model显示文摘This paper discusses the parameter and differentiation order identification of continuous fractional order Ki Ba M models in ARX(autoregressive model with exogenous inputs)and OE(output error model) forms. The least squares method is applied to the identification of nonlinear and linear parameters,in which the Grunwald-Letnikov definition and short memory principle are applied to compute the fractional order derivatives.An adaptive P-type order learning law is proposed to estimate the differentiation order iteratively and accurately. Particularly,a unique estimation result and a fast convergence speed can be arrived by using the small gain strategy, which is unidirectional and has certain advantages than some state-of-art methods. The proposed strategy can be successfully applied to the nonlinear systems with quasi-linear characteristics. The numerical simulations are shown to validate the concepts.Yang Zhao Yan Li Fengyu Zhou Zhongkai Zhou YangQuan Chen 2017IEEE/CAA Journal of Automatica Sinica2017,4,2:2
9Functional analysis of the promoter of the dmrt1 gene in Chinese tongue sole,Cynoglossus semilaevis显示文摘The dmrt1 (doublesex and mab-3 related transcription factor 1) gene is considered to play an essential role in testis differentiation and development among metazoan species. As an economically important marine fish in China, Chinese tongue sole (Cynoglossus semilaevis) possess a ZW/ZZ sex-determining system, and the females usually grow two to four times bigger than males. Previous studies have confirmed that Z-linked dmrt1 gene is the male determining gene in C. semilaevis and TALENs-mediated knocking-out individuals showed increased growth phenotype. In order to investigate the function of dmrt1 regulatory regions and its potential application, we have cloned the promoter of C. semilaevis dmrt1. The acquired sequence consisted of a 5'-upstream sequence and a partial exon1;functional analysis showed that there were two positive regulatory regions in the promoter, as well as one negative region and one neutral region. These positive regions were then combined to obtain several newly constructed promoters. Both in vitro and in vivo analysis confirmed one of them (dmrt1-Δ3+Δ4) showed elevated promoting activity compared to the full-length promoter and could drive exogenous gene expression in tongue sole gonads. Our results will provide useful information for understanding the regulatory mechanism of dmrt1 gene during C. semilaevis sex determination, and the endogenous promoter will facilitate the transgenic research for analyzing sex- and growth-related genes.WANG Qian CUI Zhongkai GUO Hua ZHANG Nianwei XU Wenteng YANG Yingming CHEN Songlin 2019Journal of Oceanology and Limnology2019,37,4:1
10Greenhouse gas emissions from swine manure stored at different stack heights显示文摘Hongmin Dong Zhiping Zhu Zhongkai Zhou Hongwei Xin Yongxing Chen 2011Animal Feed Science and Technology2011,,:1
11Enabling ultrafast lithium-ion conductivity of Li_(2)ZrCl_(6) by indium doping显示文摘Solid-state batteries with high energy density and safety are promising next-generation battery systems.However,lithium oxide and lithium sulfide electrolytes suffer low ionic conductivity and poor electrochemical stability,respectively.Lithium halide solid electrolyte shows high conductivity and good compatibility with the pristine high-voltage cathode but limited applications due to the high price of rare metal.Zr-based lithium halides with low cost and high stability possess great potential.Herein,a small amount of In^(3+)is introduced in Li_(2)ZrCl_(6) to synthesize Li_(2.25)Zr_(0.75)In_(0.25)Cl_(6) electrolytes with a high room temperature Li-ion conductivity of 1.08 mS/cm.Solid-state batteries using Li_(2.25)Zr_(0.75)In_(0.25)Cl_(6)/Li_(5.5)PS_(4.5)Cl_(1.5) bilayer solid electrolytes combined with Li-In anode and pristine LiNi_(0.7)Mn_(0.2)Co_(0.1)O_(2) cathode deliver high initial discharge capacities under different cut-off voltages.This work provides an effective strategy for enhancing the conductivity of Li2ZrCl6 electrolytes,promoting their applications in solid-state batteries.Shuai Chena Chuang Yu Shaoqing Chen Linfeng Peng Cong Liao Chaochao Wei Zhongkai Wu Shijie Cheng Jia Xie 2022Chinese Chemical Letters2022,33,10:1
12Position Control Optimization of Aerodynamic Brake Device for High-speed Trains显示文摘The aerodynamic braking is a clean and non-adhesion braking, and can be used to provide extra braking force during high-speed emergency braking. The research of aerodynamic braking has attracted more and more attentions in recent years. However, most researchers in this field focus on aerodynamic effects and seldom on issues of position control of the aerodynamic braking board. The purpose of this paper is to explore position control optimization of the braking board in an aerodynamic braking prototype. The mathematical models of the hydraulic drive unit in the aerodynamic braking system are analyzed in detail, and the simulation models are established. Three control functions—constant, linear, and quadratic—are explored. Two kinds of criteria, including the position steady-state error and the acceleration of the piston rod, are used to evaluate system performance. Simulation results show that the position steady state-error is reduced from around 12–2 mm by applying a linear instead of a constant function, while the acceleration is reduced from 25.71–3.70 m/s2 with a quadratic control function. Use of the quadratic control function is shown to improve system performance. Experimental results obtained by measuring the position response of the piston rod on a test-bench also suggest a reduced position error and smooth movement of the piston rod. This implies that the acceleration is smaller when using the quadratic function, thus verifying the effectiveness of control schemes to improve to system performance. This paper proposes an effective and easily implemented control scheme that improves the position response of hydraulic cylinders during position control.ZUO Jianyong LUO Zhuojun CHEN Zhongkai 2014Chinese Journal of Mechanical Engineering2014,27,2:1
13Visualization of the electronic phase separation in superconducting K_(x)Fe_(2−y)Se_(2)显示文摘Type-II iron-based superconductors(Fe-SCs),the alkali-metal-intercalated iron selenide A_(x)Fe_(2−y)Se_(2)(A=K,Tl,Rb,etc.)with a superconducting transition temperature of 32 K,exhibit unique properties such as high Néel temperature,Fe-vacancies ordering,antiferromagnetically ordered insulating state in the phase diagram,and mesoscopic phase separation in the superconducting materials.In particular,the electronic and structural phase separation in these systems has attracted intensive attention since it provides a platform to unveil the insulating parent phase of type-II Fe-SCs that mimics the Mott parent phase in cuprates.In this work,we use spatial-and angle-resolved photoemission spectroscopy to study the electronic structure of superconducting K_(x)Fe_(2−y)Se_(2).We observe clear electronic phase separation of K_(x)Fe_(2−y)Se_(2) into metallic islands and insulating matrix,showing different K and Fe concentrations.While the metallic islands show strongly dispersive bands near the Fermi level,the insulating phase shows an energy gap up to 700 meV and a nearly flat band around 700 meV below the Fermi energy,consistent with previous experimental and theoretical results on the superconducting K_(1−x)Fe_(2)Se_(2)(122 phase)and Fe-vacancy ordered K_(0.8)Fe_(1.6)Se_(2)(245 phase),respectively.Our results not only provide important insights into the mysterious composition of phase-separated superconducting and insulating phases of K_(x)Fe_(2−y)Se_(2),but also present their intrinsic electronic structures,which will shed light on the comprehension of the unique physics in type-II Fe-SCs.Yujie Chen Juan Jiang Haifeng Yang Pavel Dudin Alexey Barinov Zhongkai Liu Haihu Wen Lexian Yang Yulin Chen 2021Nano Research2021,14,3:1
14Application with theory of vibration equivalence on reliability test bed of train brake system 显示文摘Wang Xiaoyan Wu Mengling Chen Zhongkai 2010Applied Mechanics and Materials2010,34,:1
15Prepara tion o{ PS/TiOz Core-shell Microspheres and TiOz Hol- low shells显示文摘Yin jiliang Chen Hongjin Li Zhongkai 2003Journal O{ Materials Science2003,38,24:1
16ARPES investigation of the electronic structure and its evolution in magnetic topological insulator MnBi_(2+2n)Te_(4+3n)family显示文摘In the past 5 years,there has been significant research interest in the intrinsic magnetic topological insulator family compounds MnBi_(2+2n)Te_(4+3n)n(where n=0,1,2…).In particular,exfoliated thin films of MnBi_(2)Te_(4)have led to numerous experimental breakthroughs,such as the quantum anomalous Hall effect,axion insulator phase and high-Chern number quantum Hall effect without Landau levels.However,despite extensive efforts,the energy gap of the topological surface states due to exchange magnetic coupling,which is a key feature of the characteristic band structure of the system,remains experimentally elusive.The electronic structure measured by using angle-resolved photoemission(ARPES)shows significant deviation from ab initio prediction and scanning tunneling spectroscopy measurements,making it challenging to understand the transport results based on the electronic structure.This paper reviews the measurements of the band structure of MnBi_(2+2n)Te_(4+3n)n magnetic topological insulators using ARPES,focusing on the evolution of their electronic structures with temperature,surface and bulk doping and film thickness.The aim of the review is to construct a unified picture of the electronic structure of MnBi_(2+2n)Te_(4+3n)n compounds and explore possible control of their topological properties.Runzhe Xu Lixuan Xu Zhongkai Liu Lexian Yang Yulin Chen 2024National Science Review2024,11,2:0
17Novel fast lithium-ion conductor LiTa_(2)PO_(8)enhances the performance of poly(ethylene oxide)-based polymer electrolytes in all-solid-state lithium metal batteries显示文摘At present,replacing the liquid electrolyte in a lithium metal battery with a solid electrolyte is considered to be one of the most powerful strategies to avoid potential safety hazards.Composite solid electrolytes(CPEs)have excellent ionic conductivity and flexibility owing to the combination of functional inorganic materials and polymer solid electrolytes(SPEs).Nevertheless,the ionic conductivity of CPEs is still lower than those of commercial liquid electrolytes,so the development of high-performance CPEs has important practical significance.Herein,a novel fast lithium-ion conductor material LiTa_(2)PO_(8) was first filled into poly(ethylene oxide)(PEO)-based SPE,and the optimal ionic conductivity was achieved by filling different concentrations(the ionic conductivity is 4.61×10^(-4)S/cm with a filling content of 15 wt%at 60℃).The enhancement in ionic conductivity is due to the improvement of PEO chain movement and the promotion of LiTFSI dissociation by LiTa_(2)PO_(8).In addition,LiTa_(2)PO_(8) also takes the key in enhancing the mechanical strength and thermal stability of CPEs.The assembled LiFePO_(4) solid-state lithium metal battery displays better rate performance(the specific capacities are as high as 157.3,152,142.6,105 and 53.1 mAh/g under0.1,0.2,0.5,1 and 2 C at 60℃,respectively)and higher cycle performance(the capacity retention rate is86.5%after 200 cycles at 0.5 C and 60℃).This research demonstrates the feasibility of LiTa_(2)PO_(8) as a filler to improve the performance of CPEs,which may provide a fresh platform for developing more advanced solid-state electrolytes.Ying Na Zhe Chen Zhongkai Xu Qi An Xi Zhang Xiaohong Sun Shu Cai Chunming Zheng 2022Chinese Chemical Letters2022,33,8:0
18Transcriptome Analysis of Pacific White Shrimp (Litopenaeus vannamei) Under Prolonged High-Salinity Stress显示文摘The Pacific white shrimp(Litopenaeus vannamei)is a marine species commonly farmed worldwide.In northern China,it has been increasingly cultured in high-salinity waters(>40),but exhibits poor growth performance.In this study,postlarval shrimps were acclimated to salinity 55,cultivated for 3 months at this salinity,and compared with a control group reared at general salinity 25.Subsequently,high-throughput RNA sequencing was applied to compare the transcriptomic responses in the gills and hepatopancreas of the shrimps in the control group and the treatment group,while the weights of the shrimps in these two groups were significantly different.The results revealed that 11834 and 2115 genes were significantly differentially expressed in the gills and hepatopancreas,respectively.Additionally,enrichment analysis of the differentially expressed genes indicated that osmoregula-tion-associated Gene Ontology terms and KEGG pathways were similar between the two subgroups of the shrimp maintained at high salinity,suggesting that the growth rate of shrimp at high salinity is independent of osmoregulation.Furthermore,examination of the shrimp with different growth rates(i.e.,weights)at high salinity revealed molt-associated processes,namely,increased expression of ecdysone response genes and downstream effector genes in the gills and hepatopancreas of slow-growing shrimp,suggesting a role of the molt-associated processes in the regulation of shrimp growth at high salinity.Thus,we not only report adaptive transcriptomic responses of L.vannamei to prolonged high-salinity stress,but also provide new insights into the shrimp growth regulation at high salinity.LI Yuquan CHEN Yigeng CUI Yanting SHEN Min WANG Renjie WANG Zhongkai 2022Journal of Ocean University of China2022,21,2:0
19A steady composite molecular anode Ru1/MWCNTsCOOH/GC for robust catalytic water oxidation显示文摘Development of efficient molecular devices for overall water splitting has always been a hotspot of research to realize clean and sustainable energy conversion. In the case, long-term durability of molecular devices is a crucial factor to determine their practical application. Here, an efficient composite molecular anode was assembled by immobilization of charge-neutral mononuclear Ru1 complex on COOHfunctionalized multiwalled carbon nanotubes(MWCNTs COOH) sticking on a glassy carbon(GC) electrode(Ru1/MWCNTsCOOH/GC). The prepared hybrid anode showed a low onset overpotential of only 380 mV for electrocatalytic water oxidation. Moreover, the anode displayed a steady catalytic current density of1.25 mA/cm^2 for more than 5 h at the overpotential of 580 m V, a high TON of 186000(5 h), a TOF of10.3 s-1 and a faradic efficiency of 96%, indicating the significant efficiency and extremely durability.The excellent durability of the molecular anode should be attributed to the key charge-neutral catalytic intermediates(Ru1 ad) of the catalytic step and the two long flexible carbon chains of the catalyst.Yan Gao Yu Wei Zhongkai Lu Xuyang Chen Dongping Wang 2019Journal of Energy Chemistry2019,28,8:0
20Endocarditis caused by Arcanobacteriumpyogenes显示文摘A21-year-old male farmer was admitted to our hospital on December 28,2011 with intermittent fever and chills of three months duration.Two weeks previously he had developed chest congestion and shortness of breath.His medical history was unremarkable.On physical examination,his temperature was 37.5℃,pulse 115/ min,and respiratory rate 20/min.His blood pressure was 118/49 mmHg.Cardiac auscultation revealed the presence of a systolic ejection murmur at the left sternal border and diastolic murmur at the right sternal border.A transthoracic echocardiogram performed on December 28 revealed left ventricular hypertrophy,an 8 mm ventricular septum,mild aortic valve stenosis,moderate to severe aortic insufficiency,moderate mitral valve insufficiency,vegetation on the aortic valve (measuring 5 mm×5 mm),and trace pericardial effusion.The remaining physical examination was unremarkable.The laboratory test results for this patient are shown in the Table 1.Zhang Hui Shi Zhongkai Yang Qiwen Chen Yu Xu Yingchun 2014Chinese Medical Journal2014,,19:0
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