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| 1 | T cell–associated immunoregulation and antiviral effect of oxymatrine in hydrodynamic injection HBV mouse model显示文摘Although oxymatrine(OMT) has been shown to directly inhibit the replication of hepatitis B virus(HBV) in vitro, limited research has been done with this drug in vivo. In the present study, the antiviral effect of OMT was investigated in an immunocompetent mouse model of chronic HBV infection.The infection was achieved by tail vein injection of a large volume of DNA solution. OMT(2.2, 6.7 and20 mg/kg) was administered by daily intraperitoneal injection for 6 weeks. The efficacy of OMT was evaluated by the levels of HBV DNA, hepatitis B surface antigen(HBs Ag), hepatitis B e antigen(HBe Ag)and hepatitis B core antigen(HBc Ag). The immunoregulatory activity of OMT was evaluated by serum ELISA and flow cytometry. Results shows that OMT at 20 mg/kg inhibited HBV replication, and it was more efficient than entecavir(ETV) in the elimination of serum HBs Ag and intrahepatic HBc Ag. Inaddition, OMT accelerated the production of interferon-γ(IFN-γ) in a dose-dependent manner in CD4^+T cells. Our findings demonstrate the beneficial effects of OMT on the enhancement of immunological function and in the control of HBV antigens. The findings suggest this drug to be a good antiviral therapeutic candidate for the treatment of HBV infection. | Xiuxiu Sang Ruilin Wang Yanzhong Han Cong’en Zhang Honghui Shen Zhirui Yang Yin Xiong Huimin Liu Shijing Liu Ruisheng Li Ruichuang Yang Jiabo Wang Xuejun Wang Zhaofang Bai Xiaohe Xiao | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 20 |
| 2 | Reply to the Comment by Tan Mingxuan et al.(2017), on “A new Discovery of the Early Cretaceous Supercritical Hyperpycnal Flow Deposits on the Lingshan Island, East China”显示文摘We thank Tan Mingxuan et al.(2017)for their comments stimulated by our short paper in the recent Acta Geologica Sinica(English edition).We are grateful for the opportunity to expand on the model of the supercritical hyperpycnal flow deposits in the Beilaishi section on the Lingshan Island,and to explain why the model proposed by Tan Mingxuan et al.(2017)cannot explain the bulk | YANG Tian CAO Yingchang WANG Yanzhong | 2017 | Acta Geologica Sinica(English Edition)2017，91，6： | 19 |
| 3 | Status and Trends in Research on Deep-Water Gravity Flow Deposits显示文摘Deep-water gravity flows are one of the most important sediment transport mechanisms on Earth. After 60 years of study,significant achievements have been made in terms of classification schemes,genetic mechanisms,and depositional models of deep-water gravity flows. The research history of deep-water gravity flows can be divided into five stages: incipience of turbidity current theory; formation of turbidity current theory; development of deep-water gravity flow theory; improvement and perfection of deep-water gravity flow theory; and comprehensive development of deep-water gravity flow theory. Currently,three primary classification schemes based on the sediment support mechanism,the rheology and transportation process,and the integration of sediment support mechanisms,rheology,sedimentary characteristics,and flow state are commonly used.Different types of deep-water gravity flow events form different types of gravity flow deposits. Sediment slump retransportation mainly forms muddy debris flows,sandy debris flows,and surge-like turbidity currents. Resuspension of deposits by storms leads to quasi-steady hyperpycnal turbidity currents(hyperpycnal flows). Sustainable sediment supplies mainly generate muddy debris flows,sandy debris flows,and hyperpycnal flows. Deep-water fans,which are commonly controlled by debris flows and hyperpycnal flows,are triggered by sustainable sediment supply; in contrast,deep-water slope sedimentary deposits consist mainly of debris flows that are triggered by the retransportation of sediment slumps and deep-water fine-grained sedimentary deposits are derived primarily from finegrained hyperpycnal flows that are triggered by the resuspension of storm deposits. Harmonization of classification schemes,transformation between different types of gravity flow deposit,and monitoring and reproduction of the sedimentary processes of deep-water gravity flows as well as a source-to-sink approach to document the evolution and deposition of deep-water gravity flows are the most important research aspects for future studies of deep-water gravity flows study in the future. | YANG Tian CAO Yingchang WANG Yanzhong LI Ya ZHANG Shao Min | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 18 |
| 4 | Characteristics and origin of abnormally high porosity zones in buried Paleogene clastic reservoirs in the Shengtuo area, Dongying Sag, East China显示文摘There are three abnormally high porosity zones developed in buried Paleogene nearshore subaqueous fan and sublacustrine fan clastic reservoirs at 2,800-3,200 m, 3,250-3,700 m and 3,900-4,400 m, respectively, within the Shengtuo area of the Dongying Sag. Here the porosity of reservoirs buried deeper than 4,000 m can still be greater than 20%. Investigation of these three abnormally high porosity(AHP) zones in the 3rd to 4th member of the Paleogene Shahejie Formation in the Shengtuo area was carried out with utilization of core observation, thin section identification, SEM observation, image analysis, core physical property testing and other technical methods. The results show that, the AHP zones in 2,800-3,200 m and 3,250-3,700 m are visible pores primary AHP zones dominated by significant primary intergranular pores(more than 50% of the total porosity), while secondary pores and micropores in authigenic clays may develop in some reservoirs. AHP reservoirs in the AHP zone of 3,900-4,400 m are dominated by micropores in matrix, visible pores are mainly grain dissolution pores but with low absolute content(< 1%), so this zone belongs to the micropores primary AHP zone. The genesis of the three AHP zones was studied to distinguish between porosity enhancement and porosity preservation. Our research shows that, in deeply buried clastic reservoirs in the Shengtuo area, mineral dissolution occurred in a relatively closed diagenetic system with high temperature and high salinity. Reservoir rocks underwent extensive feldspar dissolution, while detrital carbonate grains and carbonate cements show no evidence of extensive dissolution. Although significant feldspar dissolution pores developed, feldspar dissolution enhanced porosity only a little due to the precipitation of almost isovolumetric dissolution products in the nearby primary intergranular pores in forms of authigenic clays and quartz cements. Net enhanced porosity originating from feldspar dissolution is generally less than 0.25%. Thus, the subsurface dissolution has little impact on the mid-deep buried high porosity reservoirs. Reservoirs in braided channels of middle fans in sublacustrine fans and reservoirs in the middle-front of fan bodies of nearshore subaqueous fans provide the basis for the development of AHP zones. The shallow development of fluid overpressure and early hydrocarbon emplacement have effectively retarded compaction and carbonate cementation, so that the high porosity in the superficial layers is preserved in the mid-deep layers. These are the main controlling factors in the development of AHP zones. | Cao Yingchang Yuan Guanghui Li Xiaoyan Wang Yanzhong Xi Kelai Wang Xiaoming Jia Zhenzhen Yang Tian | 2014 | Petroleum Science2014，11，3： | 18 |
| 5 | Boron neutron capture therapy for malignant melanoma: first clinical case report in China显示文摘A phase Ⅰ/Ⅱ clinical trial for treating malignant melanoma by boron neutron capture therapy(BNCT) was designed to evaluate whether the world's first in-hospital neutron irradiator(IHNI) was qualified for BNCT. In this clinical trial planning to enroll 30 patients, the first case was treated on August 19, 2014. We present the protocol of this clinical trial, the treating procedure, and the clinical outcome of this first case. Only grade 2 acute radiation injury was observed during the first four weeks after BNCT and the injury healed after treatment. No late radiation injury was found during the 24-month follow-up. Based on positron emission tomography-computed tomography(PET/CT) scan, pathological analysis and gross examination, the patient showed a complete response to BNCT,indicating that BNCT is a potent therapy against malignant melanoma and IHNI has the potential to enable the delivery of BNCT in hospitals. | Zhong Yong Zewen Song Yongmao Zhou Tong Liu Zizhu Zhang Yanzhong Zhao Yang Chen Congjun Jin Xiang Chen Jianyun Lu Rui Han Pengzhou Li Xulong Sun Guohui Wang Guangqing Shi Shaihong Zhu | 2016 | Chinese Journal of Cancer Research2016，28，6： | 13 |
| 6 | Landscape of DILI-related adverse drug reaction in China Mainland显示文摘Drug-induced liver injury(DILI)is a type of bizarre adverse drug reaction(ADR)damaging liver(L-ADR)which may lead to substantial hospitalizations and mortality.Due to the general low incidence,detection of L-ADR remains an unsolved public health challenge.Therefore,we used the data of 6.673 million of ADR reports from January 1st,2012 to December 31st,2016 in China National ADR Monitoring System to establish a new database of L-ADR reports for future investigation.Results showed that totally 114,357 ADR reports were retrieved by keywords searching of liver-related injuries from the original heterogeneous system.By cleaning and standardizing the data fields by the dictionary of synonyms and English translation,we resulted 94,593 ADR records reported to liver injury and then created a new database ready for computer mining.The reporting status of L-ADR showed a persistent 1.62-fold change over the past five years.The national population-adjusted reporting numbers of L-ADR manifested an upward trend with age increasing and more evident in men.The annual reporting rate of L-ADR in age group over 80 years old strikingly exceeded the annual DILI incidence rate in general population,despite known underreporting situation in spontaneous ADR reporting system.The percentage of herbal and traditional medicines(H/TM)L-ADR reports in the whole number was 4.5%,while 80.60%of the H/TM reports were new findings.There was great geographical disparity of reported agents,i.e.more cardiovascular and antineoplastic agents were reported in higher socio-demographic index(SDI)regions and more antimicrobials,especially antitubercular agents,were reported in lower SDI regions.In conclusion,this study presented a large-scale,unbiased,unified,and computer-minable L-ADR database for further investigation.Age-,sex-and SDI-related risks of L-ADR incidence warrant to emphasize the precise pharmacovigilance policies within China or other regions in the world. | Jiabo Wang Haibo Song Feilin Ge Peng Xiong Jing Jing Tingting He Yuming Guo Zhuo Shi Chao Zhou Zixin Han Yanzhong Han Ming Niu Zhaofang Bai Guangbin Luo Chuanyong Shen Xiaohe Xiao | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 12 |
| 7 | Mechanism of diagenetic trap formation in nearshore subaqueous fans on steep rift lacustrine basin slopes—A case study from the Shahejie Formation on the north slope of the Minfeng Subsag, Bohai Basin, China显示文摘Diagenetic traps in conglomerate in nearshore subaqueous fans in the steep slope zones of rift basins have been important exploration targets for subtle reservoirs in eastern China. However, the mechanism of how those traps were formed is not clear, which inhibits further exploration for this type of reservoir. In order to solve the problem, we take as an example nearshore subaqueous fans in the upper part of the fourth member of the Shahejie Formation(Es4s) on the north slope of the Minfeng Subsag in the Dongying Sag. Combining different research methods, such as core observation, thin section examination, scanning electron microscope(SEM) observation, fluid-inclusion analysis, carbon and oxygen isotope analysis of carbonate cements, and analysis of core properties, we studied the genetic mechanisms of diagenetic traps on the basis of diagenetic environment evolution and diagenetic evolution sequence in different sub/micro-facies. Conglomerate in Es4 s in the north Minfeng Subsag experienced several periods of transition between alkaline and acidic environments as 'alkaline–acidic–alkaline–acidic–weak alkaline'. As a result, dissolution and cementation are also very complex, and the sequence is 'early pyrite cementation / siderite cementation / gypsum cementation / calcite and dolomite cementation——feldspar dissolution / quartz overgrowth——quartz dissolution / ferroan calcite cementation / ankerite cementation / lime-mud matrix recrystallization / feldspar overgrowth——carbonate dissolution / feldspar dissolution / quartz overgrowth / pyrite cementation'. The difference in sedimentary characteristics between different sub/micro-facies of nearshore subaqueous fans controls diagenetic characteristics. Inner fan conglomerates mainly experienced compaction and lime-mud matrix recrystallization, with weak dissolution, which led to a reduction in the porosity and permeability crucial to reservoir formation. Lime-mud matrix recrystallization results in a rapid decrease in porosity and permeability in inner fan conglomerates in middle-to-deep layers. Because acid dissolution reworks reservoirs and hydrocarbon filling inhibits cementation, reservoirs far from mudstone layers in middle fan braided channels develop a great number of primary pores and secondary pores, and are good enough to be effective reservoirs of hydrocarbon. With the increase of burial depth, both the decrease of porosity and permeability of inner fan conglomerates and the increase of the physical property difference between inner fans and middle fans enhance the quality of seals in middle-to-deep layers. As a result, inner fan conglomerates can be sealing layers in middle-to-deep buried layers. Reservoirs adjacent to mudstones in middle fan braided channels and reservoirs in middle fan interdistributaries experienced extensive cementation, and tight cemented crusts formed at both the top and bottom of conglomerates, which can then act as cap rocks. In conclusion, diagenetic traps in conglomerates of nearshore subaqueous fans could be developed with inner fan conglomerates as lateral or vertical sealing layers, tight carbonate crusts near mudstone layers in middle fan braided channels as well as lacustrine mudstones as cap rocks, and conglomerates far from mudstone layers in middle fan braided channels as reservoirs. Lime-mud matrix recrystallization of inner fan conglomerates and carbonate cementation of conglomerates adjacent to mudstone layers in middle fan braided channels took place from 32 Ma B.P. to 24.6 Ma B.P., thus the formation of diagenetic traps was from 32 Ma B.P. to 24.6 Ma B.P. and diagenetic traps have a better hydrocarbon sealing ability from 24 Ma B.P.. The sealing ability of inner fans gradually increases with the increase of burial depth and diagenetic traps buried more than 3,200 m have better seals. | Wang Yanzhong Cao Yingchang Ma Benben Liu Huimin Gao Yongjin Chen Lin | 2014 | Petroleum Science2014，11，4： | 9 |
| 8 | Isolation and Characterization of a C-repeat Binding Transcription Factor from Maize显示文摘C-repeat binding proteins (CBFs) are a group of transcription factors that have been proven to be important for stress tolerance in plants. Many of these transcription factors transactivate the promoters of cold-regulated genes via binding to low temperature-or dehydration-responsive cis-elements, thus conferring plants cold acclimation. In the present study, we isolated a C-repeat binding transcription factor from maize using the yeast one-hybrid system with the C-repeat motif from the promoter of the Arabidopsis COR15a gene as bait. The isolated transcription factor is highly similar to the Arabidopsis CBF3 in their predicted amino acid sequences, and is therefore designated ZmCBF3. Point mutation analyses of the ZmCBF3-binding cis-element revealed (A/G)(C/T)CGAC as the core binding sequence. Expression analyses showed that ZmCBF3 was upregulated by both abscisic acid and low temperature, and was actively expressed during embryogenesis, suggesting that ZmCBF3 plays a role in stress response in maize. | Lei Wang Yanzhong Luo Lan Zhang Jun Zhao Zhiqiu Hu Yunliu Fan Chunyi Zhang | 2008 | Journal of Integrative Plant Biology2008，50，8： | 6 |
| 9 | METHOD FOR PRECISE CALCULATION OF ROOT STRESS OF SPIRAL BEVEL GEARS显示文摘METHODFORPRECISECALCULATIONOFROOTSTRESSOFSPIRALBEVELGEARSMETHODFORPRECISECALCULATIONOFROOTSTRESSOFSPIRALBEVELGEARSChenLiangyu... | Chen Liangyu Wang Yanzhong Zheng Xijian E Zhongkai Cai Chunyuan(Northeastern University) | 1994 | Chinese Journal of Mechanical Engineering1994，7，4： | 5 |
| 10 | Ductile and ultrahigh-strength eutectic high-entropy alloys by large-volume 3D printing显示文摘1.Introduction Additive manufacturing or 3D printing outweighs conventional casting methods in the aspect of complex parts fabrication,which can realize one-step formation without the need of complicated cast dies.3D printing significantly promotes industrial production for making near-net shaped components.However,this promising technique is not always ideally applicable for metals and alloys.For example,titanium alloys prepared by 3D printing often suf-fer from poor plasticity,and usually require further complex heat treatment or hot isostatic pressing treatment,in order to remove internal stress and regulate plasticity and strength[1,2],which de-feats the original intention of employing additive manufacturing.One of the fundamental causes for such issues is the low fluidity of the alloys upon melting,leading to great chemical heterogeneity,high porosity content and residual stresses.This limitation hinders further design and fabrication of high-performance printable alloys from large scale production and application. | Yiping Lu Xiaoxiang Wu Zhenghong Fu Qiankun Yang Yong Zhang Qiming Liu Tianxin Li Yanzhong Tian Hua Tan Zhiming Li Tongmin Wang Tingju Li | 2022 | Journal of Materials Science & Technology2022，，31： | 4 |
| 11 | Analysis of petrophysical cutoffs of reservoir intervals with production capacity and with accumulation capacity in clastic reservoirs显示文摘Methodologies have been developed for calculating cutoffs of reservoir intervals with production capacity(RIPC) and reservoir intervals with accumulation capacity(RIAC) according to the types of pore throat structures and dynamic force by using data from petrophysical analysis, production tests and mercury injection. The data are from clastic reservoirs in the third member(Es3) and the fourth member(Es4) of the Shahejie Formation in the Shengtuo area on the North Slope of the Dongying Sag, Jiyang Depression, China. The method of calculating cutoffs of RIPC is summarized as follows: 1) determination of permeability cutoffs of RIPC; 2) classification of types of pore-throat structures according to mercury injection data and then relating porosity to permeability and determining the relationship between porosity and permeability according to each type of pore-throat structure; and 3) calculating porosity cutoffs of RIPC using established correlation between porosity and permeability according to the type of pore throat structure. The method of calculating cutoffs of RIAC includes: 1) establishing a functional relationship between oil-water interfacial tension and formation temperature; 2) calculating limiting values of maximum connected pore-throat radii according to formation temperature and dynamic forces of each reservoir interval; 3) correlating permeability with maximum connected pore-throat radius and then obtaining permeability cutoffs of RIAC; and 4) calculating porosity cutoffs on the basis of permeability cutoffs according to specific correlations, suitable for the type of porethroat structure. The results of this study show that porosity and permeability cutoffs of clastic reservoirs decrease with depth. For a fixed permeability cutoff, the porosity cutoff of RIPC varies because the type of pore throat is different. At a fixed temperature, porosity and permeability cutoffs of RIAC decrease as dynamic force increases. For a fixed permeability cutoff of effective hydrocarbon accumulation, the porosity cutoff also varies with different types of pore throat. | Wang Yanzhong Cao Yingchang Song Guoqi Song Ling Yang Tian Zhang Shaomin | 2014 | Petroleum Science2014，11，2： | 4 |
| 12 | Development of the New Rural Cooperative Medical System in China显示文摘Based on a survey conducted by our research team at the Chinese Academy of Social Sciences, the present paper reports on the development of China's new rural cooperative medical system set up in late 2002. The new rural cooperative medical system is different from the old system in that it is organized, guided and supported by the government but that rural residents voluntarily participate in its administration. It is financed by individuals, collectives and the government. The new cooperative medical system focuses on serious disease planning and mutual aid and fraternity between rural residents in health care. The results of our survey indicate that the new rural medical system has been successful up to now but that it also has some problems. China needs to pay more attention to overcoming the difficulties and challenges it faces in terms of future medical needs so that a mechanism for its sustainable development can be established. | Yanzhong Wang | 2007 | China & World Economy2007，15，4： | 4 |
| 13 | Buckling of filamentous actin bundles in filopodial protrusion显示文摘The mechanical behaviors of filamentous actin (F-actin) bundles play an essential role in filopodial protrusions at the leading edge of crawling cells. These bundles consist of parallel actin filaments that are hexagonally packed and interconnected via cross-linking proteins including α-actinin, filamin, and fascin. As pushing against the plasma membrane and/or external barriers, the actin bundles in filopodial protrusion inevitably encounter a compressive load. The bending stiffness and buckling stability of actin bundles are therefore important in determining the filopodia architecture and subsequent cell morphology. In this work, we employ a coarse-grained molecular dynamics model to investigate the buckling behaviors of cross-linked actin bundles under compression, which explicitly accounts for the properties of constituent filaments and the mechanical descriptions of cross-linkers. The bending stiffness of actin bundles exhibits a generic size effect depending on the number of filaments in the bundles, explicitly depending on the degree of inter-filament coupling. The distinct buckling modes are analyzed for bundles with different coupling states and strengths of cross-linkers. This study could clarify the stability and buckling mechanisms of parallelly packed actin bundles and the structure-function relations of mechanical components in filopodial protrusion. | Yanzhong Wang Jin Qian | 2019 | Acta Mechanica Sinica2019，35，2： | 3 |
| 14 | miR-122-induced down-regulation of HO-1 negatively affects miR-122-mediated suppression of HBV显示文摘 | Lipeng Qiu Hongxia Fan Wensong Jin Bao Zhao Yanzhong Wang Ying Ju Lizhao Chen Yu Chen Zhongping Duan Songdong Meng | 2010 | Biochemical and Biophysical Research Communications2010，，4： | 2 |
| 15 | NC METHOD FOR GENERATION OF CONJUGATING HYPOID GEARS BASED ON NC’S FLEXIBILITY显示文摘It is known that manufacture of hypoid gears is difficult and complicated, the reason lies on the limitation of traditional mechanical machine tools. With the development of NC machine tools, there should be new ways of cutting this kind of gear. Therefore, an idea to generate gears with conjugating tooth surfaces is proposed, based on the 'flexibility' characteristic of NC that means various motions, in a sense, can be performed arbitrarily on NC machine tools. Using this method, the direction of the contact path on tooth surfaces can be controlled, and also, theoretically, the generated tooth surfaces can transmit motion at specific transmission ratio curve. | Li Zuozhang Zhou Yunfei Wang Yanzhong ZhoujiNational NC System Research Center, Huazhong University of Science and Technology,Wuhan 430074, China | 2002 | Chinese Journal of Mechanical Engineering2002，15，2： | 2 |
| 16 | Research Progress on the Effect of Aflatoxin on Poultry Immunization显示文摘Aflatoxins( AFs) are a major pollution source of grain pollution and are secondary metabolites produced by Aspergillus flavus and A.parasiticus,which are one of the most toxic and carcinogenic substances.Feeding animals with aflatoxin-contaminated food can cause toxicosis,acute liver injury or liver cancer in animals,and also can cause multiple organ damage,decline in production performance and disease resistance,even death,which brings great economic losses to animal husbandry.In addition,AFs can do great harm to the human body.When the body ingests large amounts of AFs,it may suffer from acute poisoning and acute liver damage; and AFs can cause chronic poisoning of the body with continuous intake of trace AFs.This paper briefly analyzed the effect of AFs on the structure and function of poultry immune organs,immune gene expression,immunosuppression and so on. | Xiaolong YU Xinmiao HE Wentao WANG Yanzhong FENG Heshu CHEN Ming TIAN Di LIU | 2018 | Agricultural Biotechnology2018，7，6： | 2 |
| 17 | RANDOM EVOLVING NETWORKS UNDER THE DIAMETER AND AVERAGE CONNECTIVITY CONSTRAINT显示文摘在这糊,在限制下面平均距离和平均的度 仍然保持近似不变,我们学习了随机的规模 -- 免费网络模型。如果网络维持它的度分发和最大的度 k_c 的形式,我们发现了那 isN 依赖的截止功能 k_c (N)< N,度分发将是近似 power-lawwith 在 2 和 3 之间的一个代表。分发代表与平均的度有小关系,由 表示了。直径限制能作为一个环境选择压力被解释,它能解释网络的没有规模的性质。数字结果显示在直径限制下面,优先的附件能生产截止功能 k_c (N)< N 和幂定律度分发。 | Jianguo LIU Zhongtuo WANG Yanzhong DANG | 2007 | Journal of Systems Science and Systems Engineering2007，16，1： | 2 |
| 18 | Optimized production of a novel bioflocculant M-C11 by Klebsiella sp. and its application in sludge dewatering显示文摘The optimized production of a novel bioflocculant M-C11 produced by Klebsiella sp. and its application in sludge dewatering were investigated. The optimal medium carbon source,nitrogen source, metal ion, initial pH and culture temperature for the bioflocculant production were glucose, NaNO3, MgSO4, and pH 7.0 and 25°C, respectively. A compositional analysis indicated that the purified M-C11 consisted of 91.2% sugar, 4.6% protein and 3.9% nucleic acids(m/m). A Fourier transform infrared spectrum confirmed the presence of carboxyl, hydroxyl,methoxyl and amino groups. The microbial flocculant exhibited excellent pH and thermal stability in a kaolin suspension over a pH range of 4.0 to 8.0 and a temperature range of 20 to 60°C.The optimum bioflocculating activity was observed as 92.37% for 2.56 mL M-C11 and 0.37 g/L CaCl2 dosages using response surface methodology. The sludge resistance in filtration(SRF)decreased from 11.6 × 1012 to 4.7 × 1012m/kg, which indicated that the sludge dewaterability was remarkably enhanced by the bioflocculant conditioning. The sludge dewatering performance conditioned by M-C11 was more efficient than that of inorganic flocculating reagents,such as aluminum sulfate and polymeric aluminum chloride. The bioflocculant has advantages over traditional sludge conditioners due to its lower cost, benign biodegradability and negligible secondary pollution. In addition, the bioflocculant was favorably adapted to the specific sludge pH and salinity. | Jiewei Liu Junwei Ma Yanzhong Liu Ya Yang Dongbei Yue Hongtao Wang | 2014 | Journal of Environmental Sciences2014，26，10： | 2 |
| 19 | OsABA8ox2, an ABA catabolic gene, suppresses root elongation of rice seedlings and contributes to drought response显示文摘In rice, OsABA8ox encodes abscisic acid(ABA) 8′-hydroxylase, which catalyzes the committed step of ABA catabolism. The contribution of ABA catabolism in root development remains unclear. We investigated the role of OsABA8ox2 in root growth and development and drought response. GUS staining results showed that OsABA8ox2 was expressed mainly in roots at seedling stage and was strongly expressed in the meristematic zone of the radicle. OsABA8ox2 expression in roots was markedly decreased after 0.5 h polyethylene glycol(PEG) treatment and increased after 0.5 h rehydration, implying that OsABA8ox2 is a drought-responsive gene.OsABA8ox2 knockout mediated by the CRISPR-Cas9 system increased drought-induced ABA and indole-3-acetic acid accumulation in roots, conferred increased ABA sensitivity, and promoted a more vertically oriented root system architecture(RSA) beneficial to drought tolerance.OsABA8ox2 overexpression suppressed root elongation and increased stomatal conductance and transpiration rate. Consequently, OsABA8ox2 knockout dramatically improved rice drought tolerance, whereas OsABA8ox2 overexpression seedlings were hypersensitive to drought stress,suggesting that OsABA8ox2 contributes to drought response in rice. Compared with wild type,functional leaves of OsABA8ox2 knockout seedlings showed higher ABA levels, whereas overexpression lines showed lower ABA levels, suggesting that OsABA8ox2, as an ABA catabolic gene, modulates ABA concentration through ABA catabolism. OsABA8ox2 and OsABA8ox3 were both localized in the endoplasmic reticulum. Together, these results indicate that OsABA8ox2 suppresses root elongation of rice seedlings, increases water transpiration, and contributes to drought response through ABA catabolism, and that OsABA8ox2 knockout dramatically improves rice drought tolerance. They highlight the key role of ABA catabolism mediated by OsABA8ox2 on root growth and development. OsABA8ox2, as a novel RSA gene, would be a potential genetic target for the improvement of rice drought tolerance. | Yan Zhang Xiaoping Wang Yanzhong Luo Lan Zhang Yuan Yao Lu Han Zhenhua Chen Lei Wang Yubin Li | 2020 | The Crop Journal2020，8，3： | 2 |
| 20 | Deep-water gravity flow deposits in a lacustrine rift basin and their oil and gas geological significance in eastern China显示文摘The types,evolution processes,formation mechanisms,and depositional models of deep-water gravity flow deposits in a lacustrine rift basin are studied through core observation and systematic analysis.Massive transport of slide and slump,fluid transport of debris flow and turbidity currents are driven by gravity in deep-water lacustrine environment.The transformation between debris flow and turbidity current,and the transformation of turbidity current between supercritical and subcritical conditions are the main dynamic mechanisms of gravity flow deposits in a lake basin.The erosion of supercritical turbidity current controls the formation of gravity-flow channel.Debris flow deposition gives rise to tongue shape lobe rather than channel.Deep-water gravity flow deposits are of two origins,intrabasinal and extrabasinal.Intrabasinal gravity flow deposits occur as single tongue-shape lobe or fan of stacking multiple lobes.Extrabasinal gravity-flow deposits occur as sublacustrine fan with channel or single channel sand body.However,the nearshore subaqueous fan is characterized by fan of stacking multiple tongue shape lobes without channel.The differential diagenesis caused by differentiation in the nearshore subaqueous fan facies belt results in the formation of diagenetic trap.The extrabasinal gravity flow deposits are one of the important reasons for the abundant deep-water sand bodies in a lake basin.Slide mass-transport deposits form a very important type of lithologic trap near the delta front often ignored.The fine-grained sediment caused by flow transformation is the potential'sweet spot'of shale oil and gas. | CAO Yingchang JIN Jiehua LIU Haining YANG Tian LIU Keyu WANG Yanzhong WANG Jian LIANG Chao | 2021 | Petroleum Exploration and Development2021，48，2： | 2 |
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