|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Activatingα7nAChR ameliorates abdominal aortic aneurysm through inhibiting pyroptosis mediated by NLRP3 inflammasome显示文摘Abdominal aortic aneurysm(AAA)is defined as a dilated aorta in diameter at least 1.5 times of a normal aorta.Our previous studies found that activatingα7 nicotinic acetylcholine receptor(α7nAChR)had a protective effect on vascular injury.This work was to investigate whether activatingα7nAChR could influence AAA formation and explore its mechanisms.AAA models were established by angiotensin II(Ang II)infusion in ApoE^(-/-)mice or in wild type andα7nAChR^(-/-)mice.In vitro mouse aortic smooth muscle(MOVAS)cells were treated with tumor necrosis factor-α(TNF-α).PNU-282987 was chosen to activateα7nAChR.We found that cell pyroptosis effector GSDMD and NLRP3 inflammasome were activated in abdominal aorta,and inflammatory cytokines in serum were elevated in AAA models of ApoE^(-/-)mice.Activatingα7nAChR reduced maximal aortic diameters,preserved elastin integrity and decreased inflammatory responses in ApoE^(-/-)mice with Ang II infusion.Whileα7nAChR^(-/-)mice led to aggravated aortic injury and increased inflammatory cytokines with Ang II infusion when compared with wild type.Moreover,activatingα7nAChR inhibited NLRP3/caspase-1/GSDMD pathway in AAA model of ApoE^(-/-)mice,whileα7nAChR deficiency promoted this pathway.In vitro,N-acetylcysteine(NAC)inhibited NLRP3 inflammasome activation and NLRP3 knockdown reduced GSDMD expression,in MOVAS cells treated with TNF-α.Furthermore,activatingα7nAChR inhibited oxidative stress,reduced NLRP3/GSDMD expression,and decreased cell pyroptosis in MOVAS cells with TNF-α.In conclusion,our study found that activatingα7nAChR retarded AAA through inhibiting pyroptosis mediated by NLRP3 inflammasome.These suggested thatα7nAChR would be a potential pharmacological target for AAA. | Hui Fu Qi-rui Shen Yi Zhao Min Ni Can-can Zhou Ji-kuai Chen Chen Chi Dong-jie Li Guang Liang Fu-ming Shen | 2022 | Acta Pharmacologica Sinica2022，43，10： | 3 |
| 2 | Ten‐Day Quadruple Therapy Comprising Proton‐Pump Inhibitor, Bismuth, Tetracycline, and Levofloxacin Achieves a High Eradication Rate for H elicobacter pylori Infection after Failure of Sequential Therapy显示文摘 | Ping‐I Hsu Wen‐Chi Chen Feng‐Woei Tsay Chih‐An Shih Sung‐Shuo Kao Huay‐Min Wang Hsien‐Chung Yu Kwok‐Hung Lai Hui‐Hwa Tseng Nan‐Jing Peng Angela Chen Chao‐Hung Kuo Deng‐Chyang Wu | 2014 | Helicobacter2014，，1： | 3 |
| 3 | Efficacy of texture analysis of pre-operative magnetic resonance imaging in predicting microvascular invasion in hepatocellular carcinoma显示文摘BACKGROUND Presence of microvascular invasion(MVI)indicates poorer prognosis postcurative resection of hepatocellular carcinoma(HCC),with an increased chance of tumour recurrence.By present standards,MVI can only be diagnosed postoperatively on histopathology.Texture analysis potentially allows identification of patients who are considered‘high risk’through analysis of pre-operative magnetic resonance imaging(MRI)studies.This will allow for better patient selection,improved individualised therapy(such as extended surgical margins or adjuvant therapy)and pre-operative prognostication.AIM This study aims to evaluate the accuracy of texture analysis on pre-operative MRI in predicting MVI in HCC.METHODS Retrospective review of patients with new cases of HCC who underwent hepatectomy between 2007 and 2015 was performed.Exclusion criteria:No preoperative MRI,significant movement artefacts,loss-to-follow-up,ruptured HCCs,previous hepatectomy and adjuvant therapy.Fifty patients were divided into MVI(n=15)and non-MVI(n=35)groups based on tumour histology.Selected images of the tumour on post-contrast-enhanced T1-weighted MRI were analysed.Both qualitative(performed by radiologists)and quantitative data(performed by software)were obtained.Radiomics texture parameters were extracted based on the largest cross-sectional area of each tumor and analysed using MaZda software.Five separate methods were performed.Methods 1,2 and 3 exclusively made use of features derived from arterial,portovenous and equilibrium phases respectively.Methods 4 and 5 made use of the comparatively significant features to attain optimal performance.RESULTS Method 5 achieved the highest accuracy of 87.8%with sensitivity of 73%and specificity of 94%.CONCLUSION Texture analysis of tumours on pre-operative MRI can predict presence of MVI in HCC with accuracies of up to 87.8%and can potentially impact clinical management. | Jordan Zheng Ting Sim Terrence Chi Hong Hui Tong Kuan Chuah Hsien Min Low Cher Heng Tan Vishal GShelat | 2022 | World Journal of Clinical Oncology2022，13，11： | 3 |
| 4 | Is High Serum Uric Acid a Risk Marker or a Target for Treatment? Examination of its Independent Effect in a Large Cohort With Low Cardiovascular Risk显示文摘 | Chi Pang Wen Ting-Yuan David Cheng Hui Ting Chan Min Kuang Tsai Wen-Shen Isabella Chung Shan Pou Tsai Mark L. Wahlqvist Yi Chen Yang Shiuan Be Wu Po Huang Chiang Sung Feng Wen | 2010 | American Journal of Kidney Diseases2010，，2： | 2 |
| 5 | Notch2‐induced COX‐2 expression enhancing gastric cancer progression显示文摘 | Yun‐Chien Tseng Yu‐Hui Tsai Min‐Jen Tseng Kai‐Wen Hsu Min‐Chieh Yang Kuo‐Hung Huang Anna Fen‐Yau Li Chin‐Wen Chi Rong‐Hong Hsieh Hung‐Hai Ku Tien‐Shun Yeh | 2011 | Mol Carcinog2011，，12： | 2 |
| 6 | Factors affecting quality of life in Korean patients with chronic heart failure显示文摘 | Sang Hui CHU Won Hee LEE Ji Soo YOO So Sun KIM Il Sun KO Eui Geum OH JuHee LEE Mona CHOI Joo Young CHEON Chi Young SHIM Seok‐Min KANG | 2014 | Japan Journal of Nursing Science2014，，1： | 1 |
| 7 | Gene-Environment Interactions between Environmental Noise and Apo E4 Causes AD-Like Neuropathology in the Hippocampus in Male Rats显示文摘Experimental evidence has demonstrated that environmental hazards can induce neurodegeneration such as Alzheimer's disease(AD)^([1]).The pathogenesis of AD,characterized by a gradual cognitive decline,overproduction ofβ-amyloid(Aβ),and hyperphosphorylated tau in specific brain areas,is considered to involve the interaction of several internal(individual)and external environmental factors. | LI Wen Long LI Yuan Yuan LI Yu Xin FU Yu HE Xian Zhi TAO Fei Yan YOU Ruo Lan ZHANG Ruo Yu ZHONG Ming Qing CHI Hui Min ZHAI Qing Feng | 2022 | Biomedical and Environmental Sciences2022，35，3： | 1 |
| 8 | Characteristics of the functionally graded coating fabricated by plasma transferred arc centrifugal cladding显示文摘 | Feng Lu Huiqi Li Qiang Ji Rongchang Zeng Shufeng Wang Jing Chi Min Li Lu Chai Hui Xu | 2011 | Surface & Coatings Technology2011，，19： | 1 |
| 9 | Notch2‐induced COX‐2 expression enhancing gastric cancer progression显示文摘 | Yun‐Chien Tseng Yu‐Hui Tsai Min‐Jen Tseng Kai‐Wen Hsu Min‐Chieh Yang Kuo‐Hung Huang Anna Fen‐Yau Li Chin‐Wen Chi Rong‐Hong Hsieh Hung‐Hai Ku Tien‐Shun Yeh | 2011 | Mol Carcinog2011，，12： | 1 |
| 10 | Statistical study of magnetotail flux ropes near the lunar orbit显示文摘Flux-rope/TCR 事件接近 magnetotail 月亮的轨道(67R E X * R E ) 被学习用磁场并且血浆数据由在 2011 年 1 月和 2012 年 3 月之间的特弥斯 B 和 C 测量了。异常并列 GSM * ,在哪儿 X * 轴被旋转 4 氠湩牥椠 ? 楷桴愠 ? 硥散汬湥 ? 慣慰楢楬祴椠 ? 潣獮牴楡楮杮挠灯数 ? 潩 ? 楤晦獵潩 ? 湡 ? 潭楢敬挠慨杲獥攠敶 ? 湵敤 ? 整瑳琠浥数慲畴敲愠 ? 楨桧愠 ? ㈱搵瑥牥業敮 ? 祢渠湯椭潳桴牥慭? 卄?畣癲? | ZHAO Si Qi TIAN An Min SHI Quan Qi XIAO Chi Jie FU Sui Yan ZONG Qiu Gang WANG Hui Zi ZHANG Shuai ZHAO Shao Jie PAN Dong Xiao TENG Shang Chun LIU Yi Xing TAN Kun | 2016 | Science China(Technological Sciences)2016，59，10： | 1 |
| 11 | Salicyaldehyde-based fluorescent sensors with high sensitivity for amino acids显示文摘在结构上简单基于 salicylaldehyde 荧光灯为氨基酸的传感器被一步舞或二拍子的圆舞合成获得了。这些传感器在象 105 mol/L 一样低的集中面对许多氨基酸显示出重要荧光改进。有到在水的答案的形式 imines 的氨基酸的醛的可逆反应被建议说明观察荧光改进。 | Xi Huai Qiang Zhi Hui Gao Xue Chuan Wang Jian Zheng Li Hui Zong Chi Min Du | 2011 | Chinese Chemical Letters2011，22，8： | 0 |
| 12 | 河乐广场显示文摘地点:中国台湾台南市Location:Tainan,China Taiwan河乐广场是一个都市公共空间设计项目。市中心一处老旧的商场'台南中国城'被改造成植物环绕的城市潟湖,植物长成丛林后将会让城市、自然和水岸重新连结。整体规划在台南运河东侧重塑了一条'T'型轴线,以新的景观策略整合原台南中国城基地和1km长的海安路。除公共广场和都市景观水池外,项目还包括改善公共交通道路,使交通流量减少,并统一从地下突出于公共空间的大型通风井颜色,削弱其视觉存在感。 | Wenchian Shi Jeroen Zuidgeest Hui Hsin Liao Angel Sanchez Navarro Stephan Boon Xiaoting Chen Chi Yi Liao Dong Min Lee Andrea Anselmo Yi-Chien Liao Zuliandi Azli Olivier Sobels Winy Maas Daria Scagliola(摄) 无 | 2020 | 建筑实践2020，3，6： | 0 |
| 13 | Effect of Cu on dehydrogenation and thermal stability of amorphous Mg-Ce-Ni-Cu alloys显示文摘The alloying element component is very crucial in improving the hydrogen storage performance of amorphous alloys.In this work,quaternary amorphous Mg_(70-x)Ce_(10)Ni_(20)Cu_x(x=3,7.5,10)alloys were prepared by meltspinning and the effect of Cu on hydrogenation and dehydrogenation were investigated in comparison with the Mg_(70-x)Ce_(10)Ni_(20)amorphous alloys.The initial hydrogenation kinetics of amorphous Mg_(70-x)Ce_(10)Ni_(20)Cu_x(x=0,3,7.5,10)was improved with the increase of Cu content according to the kinetics measured at a temperature below crystallization temperature.As hydrogen is absorbed,an amorphous-amorphous transition occurred,and relatively high Cu content would lead to phase separation in the hydrogenation process.Amorphous phase have much higher crystallization temperature after it absorbs hydrogen and the addition of Cu could increase the crystallization activation energy of amorphous hydrides.In addition,the increase of Cu content could reduce the dehydrogenation temperature of amorphous hydrides,which gives a significant indication for future improving research of the hydrogen desorption performance of Mg based amorphous hydrides. | Chi Zhang Hui Wang Liu-Zhang Ouyang Huai-Jun Lin Min Zhu | 2017 | Progress in Natural Science:Materials International2017，27，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员