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| 1 | Meteorin-β/Meteorin like/IL-41 attenuates airway inflammation in house dust mite-induced allergic asthma显示文摘We sought to examine the regulatory effect of Meteorin-β(Metrnβ)/Meteorin like(Metrnl)/IL-41 on lung inflammation in allergic asthma.We found that Metrnβwas elevated significantly in asthmatic patients and in mice with allergic asthma induced by house dust mite(HDM)extract.Upon exposure to HDM,Metrnβwas secreted predominantly by airway epithelial cells and inflammatory cells,including macrophages and eosinophils.The increased Metrnβeffectively blocked the development of airway hyperreactivity(AHR)and decreased inflammatory cell airway infiltration and type 2 cytokine production,which was associated with downregulated DC-mediated adaptive immune responses.Moreover,Metrnβimpaired the maturation and function of bone marrow-derived dendritic cells in vitro.Asthmatic mice adoptively transferred with dendritic cells isolated from Metrnβ-treated allergic mice displayed decreased AHR,airway inflammation,and lung injury.Metrnβalso displayed anti-inflammatory properties in immunodeficient SCID mice with allergic asthma and in in vitro 3D ALI airway models.Moreover,blockade of Metrnβby anti-Metrnβantibody treatment promoted the development of allergic asthma.These results revealed the unappreciated protective roles of Metrnβin alleviating DC-mediated Th2 inflammation in allergic asthma,providing the novel treatment strategy of therapeutic targeting of Metrnβin allergic asthma. | Xun Gao Ting-Fan Leung Gary Wing-Kin Wong Wing-Hung Ko Mengyun Cai Ellie Jiayi He Ida Miu-Ting Chu Miranda Sin-Man Tsang Ben Chung-Lap Chan Jiawei Ling Xiao Fan Liwei Lu Christopher Wai-Kei Lam Chun-Kwok Wong | 2022 | Cellular & Molecular Immunology2022，19，2： | 5 |
| 2 | Elective groin irradiation is not indicated for patients with adenocarcinoma of the rectum extending to the anal canal显示文摘 | Noah Taylor Christopher Crane John Skibber Barry Feig Lee Ellis Jean-Nicholas Vauthey Stanley Hamilton Karen Cleary Ronelle Dubrow Thomas Brown Robert Wolff Paulo Hoff Nicholas Sanfilippo Nora Janjan | 2001 | International Journal of Radiation Oncology Biology Physics2001，，3： | 1 |
| 3 | Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin显示文摘 | Eileen M. Moore Alastair G. Mander David Ames Mark A. Kotowicz Ross P. Carne Henry Brodaty Michael Woodward Karyn Boundy Kathryn A. Ellis Ashley I. Bush Noel G. Faux Ralph Martins Cassandra Szoeke Christopher Rowe David A. Watters | 2013 | Diabetes Care2013，，10： | 1 |
| 4 | Human capital and voluntaryunemployment显示文摘 | Christopher J Ellis | 1985 | Economics Letters1985，19，04： | 1 |
| 5 | 1-[3-Aminobenzisoxazol-5′-yl]-3-trifluoromethyl-6-[2′-(3-( R )-hydroxy- N -pyrrolidinyl)methyl-[1,1′]-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4- c ]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor o显示文摘 | Donald J.P. Pinto Michael J. Orwat Mimi L. Quan Qi Han Robert A. Galemmo Eugene Amparo Brian Wells Christopher Ellis Ming Y. He Richard S. Alexander Karen A. Rossi Angela Smallwood Pancras C. Wong Joseph M. Luettgen Alan R. Rendina Robert M. Knabb Lawrenc | 2006 | Bioorganic & Medicinal Chemistry Letters2006，，15： | 1 |
| 6 | Phase II Trial of Neoadjuvant Bevacizumab, Capecitabine, and Radiotherapy for Locally Advanced Rectal Cancer显示文摘 | Christopher H. Crane Cathy Eng Barry W. Feig Prajnan Das John M. Skibber George J. Chang Robert A. Wolff Sunil Krishnan Stanley Hamilton Nora A. Janjan Dipen M. Maru Lee M. Ellis Miguel A. Rodriguez-Bigas | 2010 | International Journal of Radiation Oncology Biology Physics2010，，3： | 1 |
| 7 | Partisan Moods: Polarization and the Dynamics of Mass Party Preferences显示文摘 | Joseph Daniel Ura Christopher R. Ellis | 2012 | The Journal of Politics2012，，1： | 1 |
| 8 | Dynamic knowledge map: reusing experts' tacit knowledge in the AEC industry 显示文摘 | JEONG HAN WOO MARK J CLAYTON ROBERT E JOHNSON BENITO E FLORES CHRISTOPHER ELLIS | 2004 | Automation in Construction2004，，13： | 1 |
| 9 | The economic evolution of democracy显示文摘 | Christopher J. Ellis John Fender | 2009 | Economics of Governance2009，，2： | 1 |
| 10 | A Carbon-Free Sandwich Complex2-显示文摘 | Eugenijus Urnezius William W Brennessel Christopher J Cramer John E Ellis Paul von Ragué Schleyer | 2002 | Science2002，295，： | 1 |
| 11 | Color preferences according to gender and sexual orientation显示文摘 | Lee Ellis Christopher Ficek | 2001 | Personality and Individual Differences2001，，8： | 1 |
| 12 | British Bus dereg- ulation: competition and demand coordination显示文摘 | Christopher J Ellis Emilson C D Silva | 1998 | Journal of Uthan Economies1998，，43： | 1 |
| 13 | Outcome After Curative Resection for Locally Recurrent Rectal Cancer显示文摘 | Isabelle Bedrosian M.D. Geoffrey Giacco M.S. Lee Pederson M.D. Miguel A. Rodriguez-Bigas M.D. Barry Feig M.D. Kelly K. Hunt M.D. Lee Ellis M.D. Steven A. Curley M.D. Jean Nicolas Vauthey M.D. Marc Delclos M.D. Christopher H. Crane M.D. Nora Janjan M.D. Jo | 2006 | Diseases of the Colon & Rectum2006，，2： | 1 |
| 14 | Dynamic Knowledge Map:reusing experts'tacit knowledge in the AEC industry显示文摘 | Jeong-Han Woo* Mark J.Clayton Robert E.Johnson Benito E.Flores Christopher Ellis | | 0，，： | 1 |
| 15 | Diabetes and the Tortuosity of Vessels of the Bulbar Conjunctiva显示文摘 | Christopher G. Owen Richard S.B. Newsom Alicja R. Rudnicka Sarah A. Barman E. Geoffrey Woodward Tim J. Ellis | 2008 | Ophthalmology2008，，6： | 1 |
| 16 | Climatic control of blanket mire development at kentra Moss,North-west Scotland显示文摘 | Christopher J Ellis John Htallis | 2000 | Journal of Ecology2000，88，： | 1 |
| 17 | Towards scarless surgery: An endoscopic ultrasound navigation system for transgastric access procedures显示文摘 | Raúl San José Estépar Nicholas Stylopoulos Randy Ellis Eigil Samset Carl-Fredrik Westin Christopher Thompson Kirby Vosburgh | 2007 | Computer Aided Surgery2007，，6： | 1 |
| 18 | Corruption and Transparency in a Growth Model显示文摘 | Christopher James Ellis John Fender | | 0，，： | 1 |
| 19 | The association of A?2 amyloid and composite cognitive measures in healthy older adults and MCI显示文摘 | Karra D. Harrington Yen Ying Lim Kathryn A. Ellis Carly Copolov David Darby Michael Weinborn David Ames Ralph N. Martins Greg Savage Cassandra Szoeke Christopher Rowe Victor L. Villemagne Colin L. Masters Paul Maruff | 2013 | International Psychogeriatrics2013，，10： | 1 |
| 20 | Prospective trial of preoperative concomitant boost radiotherapy with continuous infusion 5-fluorouracil for locally advanced rectal cancer显示文摘 | Nora A Janjan Christopher N Crane Barry W Feig Karen Cleary Ronelle Dubrow Steven A Curley Lee M Ellis Jean-Nicolas Vauthey Renato Lenzi Patrick Lynch Robert Wolff Thomas Brown Richard Pazdur James Abbruzzese Paulo M Hoff Pamela Allen Barry Brown John Ski | 2000 | International Journal of Radiation Oncology Biology Physics2000，，3： | 1 |
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