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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Hyper-X Post-Flight Trajectory Reconstruction显示文摘 | Christopher D K Paul V T Robert C B | 2006 | Journal of Spacecraft and Rockets2006，43，1： | 1 |
| 3 | New approaches to nonlinear dif- fractive field propagation 显示文摘 | Christopher P T Parker K J | 1991 | Journal of the Acoustical Society of America1991，90，1： | 1 |
| 4 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 5 | Analysis of the innate and adaptive phases of allograft rejection by cluster analysis of transcriptional profiles显示文摘 | Christopher K Mueller T F Ma C Y | 2002 | J Immunol2002，169，： | 1 |
| 6 | Metal-organic framework materials with ultrahigh surface areas: is the sky the limit?显示文摘 | Farha Omar K Eryazici Ibrahim Jeong Nak Cheon Hauser Brad G Wilmer Christopher E Sarjeant Amy A Snurr Randall Q Nguyen SonBinh T Ozgox Yazaythn A Hupp Joseph T | 2012 | Journal of the American Chemical Society2012，134，15： | 1 |
| 7 | High density lipoprotein reduces renal ischemia/reperfusion injury 显示文摘 | Christoph T Hristoph T Espen K | 2003 | J Am Soc Nephrol2003，14，7： | 1 |
| 8 | Investigation o{ the strain trans{er for surface-attached optical {iber strain sensors显示文摘 | Wan K T Christopher K L Noah G O | 2008 | Smart Materials and Structures2008，，17： | 1 |
| 9 | Vascular endothelial growth factor165 gene transfer augments circulating endothelial progenitor cells in human subjects显示文摘 | Christoph K Haruchika M Tomono T | 2000 | Circ Res2000，86，10： | 1 |
| 10 | Hyper-X post-flight trajectory reconstruction显示文摘 | CHRISTOPHER D K PAUL V T | 2006 | Journal of Spacecraft and Rockets2006，43，1： | 1 |
| 11 | Pimecrolimus for the treatment of vulva lichen sclerosus:a report of 4 cases显示文摘 | Goldstein A T Marinoff S C Christopher K | 2004 | J Reprod Med2004，49，10： | 1 |
| 12 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 13 | Safety of acute normovolemic haemodilution with hydroxyethyl starch during intracranial surgery 显示文摘 | KIRAN P K M DEVARAGUDI T S CHRISTOPHER R | 2000 | Neurol India2000，48，： | 1 |
| 14 | Natural area visitors' place meaning and place attachment ascribed to a marine setting 显示文摘 | Christopher J W Gerard T K Stephen G S | 2012 | Journal of Environmental Psychology2012，32，4： | 1 |
| 15 | Coagulation monitoring:current techniques and clinical use of viscoelastic point-of-care coagulation devices显示文摘 | Michael T Ganter Christoph K Hofer | 2008 | Anesthesia and analgesia2008，，5： | 1 |
| 16 | Melnikov theory for finite-time vector fields 显示文摘 | Bjorn Sandstede Sanjeeva Balasuriya Christopher K R T Jones | 2000 | Nonlinearity2000，13，： | 1 |
| 17 | Protection of mice against challenge with homologous and heterologous servoars of Actinobacillus pleuropneumoniae after live vaccination 显示文摘 | Christopher T Lesley P Jolanta K | 1998 | Current Microbiology1998，37，： | 1 |
| 18 | Per fectly Matched Layer as an Absorbing Boundary Condition for the Linearized Euler Equations in Open and Ducted Domains显示文摘 | Christopher K W T Laurent A Prancesco C | 1998 | Journal of Compu- tational Physics1998，144，： | 1 |
| 19 | Analysis of phospholipids fatty acids(PLFA) to characterize microbial communities in aquifers显示文摘 | CHRISTOPHER T GREEN K SCOW M | 2000 | Hydrogeology Journal2000，8，1： | 1 |
| 20 | Influence of thrombolytic therapy, with or without intra-aortic balloon counterpulsation, on 12-month survival in the SHOCK trial显示文摘 | John K French Henry A Feldman Susan F Assmann Timothy Sanborn Sebastian T Palmeri David Miller Jean Boland Christopher E Buller Richard Steingart Lynn A Sleeper Judith S Hochman | 2003 | American Heart Journal2003，，： | 1 |
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