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| 1 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 2 | Internal States Influence the Representation and Modulation of Food Intake by Subthalamic Neurons显示文摘Deep brain stimulation of the subthalamic nucleus(STN)is an effective therapy for motor deficits in Parkinson’s disease(PD),but commonly causes weight gain in late-phase PD patients probably by increasing feeding motivation.It is unclear how STN neurons represent and modulate feeding behavior in different internal states.In the present study,we found that feeding caused a robust activation of STN neurons in mice(GCaMP6 signal increased by 48.4%±7.2%,n=9,P=0.0003),and the extent varied with the size,valence,and palatability of food,but not with the repetition of feeding.Interestingly,energy deprivation increased the spontaneous firing rate(8.5±1.5 Hz,n=17,versus 4.7±0.7 Hz,n=18,P=0.03)and the depolarization-induced spikes in STN neurons,as well as enhanced the STN responses to feeding.Optogenetic experiments revealed that stimulation and inhibition of STN neurons respectively reduced(by 11%±6%,n=6,P=0.02)and enhanced(by 36%±15%,n=7,P=0.03)food intake only in the dark phase.In conclusion,our results support the hypothesis that STN neurons are activated by feeding behavior,depending on energy homeostatic status and the palatability of food,and modulation of these neurons is sufficient to regulate food intake. | Haichuan Wu Xiang Yan Dongliang Tang Weixin Gi Yiwen Luan Haijiang Cai Chunyi Zhou Cheng Xiao | 2020 | Neuroscience Bulletin2020，36，11： | 3 |
| 3 | Optimal Initialization and Starting Approach of Synchronous Condenser Integrated Power Grid显示文摘Synchronous condensers(SCs)are generally used at the receiving-end stations of ultra-high-voltage direct current(UHVDC)transmission systems due to their strong reactive power support and flexible regulation of reactive power according to the interconnected grids operating conditions.In this paper,different starting control schemes of a SC integrated power grid are investigated providing four main contributions:1)The principle of reactive power support of the SC on the interconnected power grid is analytically studied,providing the establishment of mathematical models.2)Four different starting control schemes are developed for the initialization and SC integration,i.e.in Scheme 1,a preset initial falling speed is directly utilized without initialization;in Scheme 2,a black start sequential control approach with a static frequency converter(SFC)is proposed;in Scheme 3,PI/PD/PID controllers are respectively applied for the excitation device at the speed-falling stage;in Scheme 4,a pre-insertion approach of an energy absorption component with R/L/RL is utilized to suppress the surges at the SC integration instant.3)The dynamic behaviors of four different starting schemes at specific operating stages are evaluated.4)The success rate of SC integration is analyzed to evaluate starting control performance.Performance of the SC interconnected system with four different starting control schemes is evaluated in the timedomain simulation environment PSCAD/EMTDC^(TM).The results prove the superiority of the proposed starting control approach in Scheme 4. | Puyu Wang Xing Liu Qingwen Mou Tao Yuan Tianming Gu Hemin Yang Xiao-Ping Zhang Zhengrong Xiang Chunyi Guo | 2024 | CSEE Journal of Power and Energy Systems2024，10，1： | 0 |
| 4 | THE IMPACT OF TROPICAL CYCLONES ON CHINA IN 2016显示文摘In 2016, the Northwest Pacific and the South China Sea registered the genesis of 26 tropical cyclones. 8 of them, including NEPARTAK(1601), MIRINAE(1603), NIDA(1604), DIANMU(1608), MERANTI(1614),MEGI(1617), SARIKA(1621) and HAIMA(1622), made landfall over China's coastal areas. The number one TC of 2016, NEPARTAK, was named on July 3. Although no typhoon generated in the first half of this year,which means 4.6 incidences less compared with the same period of a normal year, more tropical cyclones made landfall over China(the historical average in the same period of 1949-2015 is 6.7). And these 8 tropical cyclones had an averaged intensity up to 40.6 m/s, significantly enhanced compared with the multi-year average of 32.8 m/s.The death toll from the 11 tropical cyclones affected China in 2016 is 206. MERANTI was the most destructive one in 2016, which brought up the largest numbers of affected and evacuated population, damaged houses and direct economic losses. In 2016, China Meteorological Administration(CMA) 24-120 h mean official track forecast errors were 66, 127, 213, 292 and 364 km, respectively. The 24 h track forecast error has been kept within 70 km in two consecutive years. | HUA GU CHUANHAI QIAN SHUANZHU GAO CHUNYI XIANG | 2017 | Tropical Cyclone Research and Review2017，6，1： | 0 |
| 5 | Characteristics of extreme rainfall and rainbands evolution of Super Typhoon Lekima (2019) during its landfall显示文摘As one of the most devastating tropical cyclones over the western North Pacific Ocean,Super Typhoon Lekima(2019)has caused a wide range of heavy rainfall in China.Based on the CMA Multi-source merged Precipitation Analysis System(CMPAS)-hourly data set,both the temporal and spatial distribution of extreme rainfall is analyzed.It is found that the heavy rainfall associated with Lekima includes three main episodes with peaks at 3,14 and 24 h after landfall,respectively.The first two rainfall episodes are related to the symmetric outburst of the inner rainband and the persistence of outer rainband.The third rainfall episode is caused by the influence of cold,dry air from higher latitudes and the peripheral circulation of the warm moist tropical storm.The averaged rainrate of inner rainbands underwent an obvious outburst within 6 h after landfall.The asymmetric component of the inner rainbands experienced a transport from North(West)quadrant to East(South)quadrant after landfall which was related to the storm motion other than the Vertical Wind Shear(VWS).Meanwhile the outer rainband in the vicinity of three times of the Radius of Maximum Wind(RMW)was active over a 12-h period since the decay of the inner rainband.The asymmetric component of the outer rainband experienced two significant cyclonical migrations in the northern semicircle. | Chunyi XIANG Liguang WU Nannan QIN | 2022 | Frontiers of Earth Science2022，16，1： | 0 |
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