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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Stem cell differentiation and human liver disease显示文摘Human stem cells are scalable cell populations capable of cellular differentiation.This makes them a very attractive in vitro cellular resource and in theory provides unlimited amounts of primary cells.Such an approach has the potential to improve our understanding of human biology and treating disease.In the future it may be possible to deploy novel stem cell-based approaches to treat human liver diseases.In recent years,eff icient hepatic differentiation from human stem cells has been achieved by several research groups including our own.In this review we provide an overview of the f ield and discuss the future potential and limitations of stem cell technology. | Wen-Li Zhou Claire N Medine Liang Zhu David C Hay | 2012 | World Journal of Gastroenterology2012，18，17： | 3 |
| 3 | Triterpenes and other constituents of Nassauvia axillaris显示文摘 | CLAUDIA KOTOWICZ CESAR A N CATALAN CLAIRE L GRIFFIN | 2005 | Biochemical Systematics and Ecology2005，33，： | 1 |
| 4 | Caseinomacropeptides specifically stimulates exocrine pancreatic secretion in the anesthetized rat显示文摘 | Nathalie L R Claire N D Sylvain M | 2000 | Science Direct-Peptides2000，21，10： | 1 |
| 5 | Risk Factors and Causes of Death in MEN1 Disease. A GTE (Groupe d’Etude des Tumeurs Endocrines) Cohort Study Among 758 Patients显示文摘 | Pierre Goudet Arnaud Murat Christine Binquet Christine Cardot-Bauters Annie Costa Philippe Ruszniewski Patricia Niccoli Fabrice Ménégaux Georges Chabrier Fran?oise Borson-Chazot Antoine Tabarin Philippe Bouchard Brigitte Delemer Alfred Beckers Claire Boni | 2010 | World Journal of Surgery2010，，2： | 1 |
| 6 | Controlling persistent organic pollutants–what next? 1 Correspondence to: Nicole G Weavers, ETAF, European Training and Assessment Foundation, PO Box 182, 6700 AD, Wageningen, The Netherlands. Tel.: +31-317-484924; Fax: +31-317-484941 1显示文摘 | Harry W. Vallack Dick J. Bakker Ingvar Brandt Eva Brostr?m-Lundén Abraham Brouwer Keith R. Bull Clair Gough Ramon Guardans Ivan Holoubek Bo Jansson Rainer Koch Johan Kuylenstierna André Lecloux Donald Mackay Patrick McCutcheon Paolo Mocarelli Rob D.F. Taa | 1998 | Environmental Toxicology and Pharmacology1998，，3： | 1 |
| 7 | Risk Factors and Causes of Death in MEN1 Disease. A GTE (Groupe d’Etude des Tumeurs Endocrines) Cohort Study Among 758 Patients显示文摘 | Pierre Goudet Arnaud Murat Christine Binquet Christine Cardot-Bauters Annie Costa Philippe Ruszniewski Patricia Niccoli Fabrice Ménégaux Georges Chabrier Fran?oise Borson-Chazot Antoine Tabarin Philippe Bouchard Brigitte Delemer Alfred Beckers Claire Boni | 2010 | World Journal of Surgery2010，，2： | 1 |
| 8 | Getting ready for REDD+ in Tanzauia : a case study of progress and challenges 显示文摘 | Burgess N D Bahane B Clairs T | 2010 | Oryx2010，44，3： | 1 |
| 9 | Tourism experiences within an attributional framework显示文摘 | Mervyn S Jackson Gerard N White Claire L Schmierer | 1996 | Annals of Tourism Research1996，23，4： | 1 |
| 10 | CD80 and CD86 differentially modulate the suppressive function of human regulatory T cells 显示文摘 | Yong Z Claire N M Michael L | 2004 | J Immunol2004，172，5： | 1 |
| 11 | Prospective evaluation of a new ultrathin one-plane bending videoendoscope for transnasal EGD: a comparative study on performance and tolerance显示文摘 | Jér?me Dumortier Claire Josso Sabine Roman Fabien Fumex Vincent Lepilliez Bénédicte Prost Muriel Olivier Guillaud Fabien Petit-Laurent Marie-George Lapalus Thierry Ponchon | 2007 | Gastrointestinal Endoscopy2007，，1： | 1 |
| 12 | Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells显示文摘 | Ivanov Andrei Beers Stephen A Walshe Claire A Honeychurch Jamie Alduaij Waleed Cox Kerry L Potter Kathleen N Murray Stephen Chan Claude H T Klymenko Tetyana Erenpreisa Jekaterina Glennie Martin J Illidge Tim M Cragg Mark S | 2009 | Journal of Clinical Investigation2009，，8： | 1 |
| 13 | What's the difference between CD80 and CD86?显示文摘 | David M S Claire N M Yong Z | 2003 | Trends Immunol2003，24，6： | 1 |
| 14 | From boutique to basic:a callfor standardised medical education in global health 显示文摘 | Brewer TF Saba N Clair V | 2009 | MedEduc2009，43，10： | 1 |
| 15 | Lack of correlation between serum soluble Fas/APO - 1 levels and autoimmune disease显示文摘 | Goel N Ulrich DT St Clair EW | 1995 | Arthritis Rheum1995，38，12： | 1 |
| 16 | Cross-linked protein crys- tals for vaccine delivery显示文摘 | Clair N S Shenoy B Jacob L D | 1999 | Proceedings of the National Academy of Sciences of the United States of America1999，96，17： | 1 |
| 17 | Outbreak of car- bapenem-resistant Acinetobacter baumannii produc- ing the carbapenemase OXA-23 in a tertiary care hospital of Papeete ,French Polynesia显示文摘 | Thierry N Mare L Claire H | 2005 | J Clin Mi- crobiol2005，43，9： | 1 |
| 18 | Writing patient case reports for peer-reviewed journals:secrets of the trade显示文摘 | Bart N Green Claire D Johnson | 2000 | Journal of Sports Chiropractic & rehabilitation2000，14，3： | 1 |
| 19 | Pharmacological treatment of neuropathic painin older persons显示文摘 | Clair H Turo N | 2008 | Clinical interventions in aging2008，3，： | 1 |
| 20 | Local Persistence of Large Benthic Foraminifera(LBF)under Increasing Urban Development:A Case Study from Zanzibar(Unguja),East Africa显示文摘Coastal marine management is vital for socio-ecological sustainability of developing,tropical ecosystems,which calls for diverse tools to monitor and assess water quality.The carbonatedominated habitats off Zanzibar were chosen for study due to potential water quality degradation in a rapidly developing tourist destination heavily reliant on its coral reefs.These reefs are largely unmonitored and subject to local and global stressors.A widely used method for assessing reef health,as an early detection method of ecological changes,is the application of large benthic foraminiferal bioindicators,i.e.,the Fo RAM Index.We expected to find poor water quality conditions in the unmanaged reefs supported by stress-toelerant(opportunistic)foraminiferal assemblages.The dissolved inorganic nitrogen and phosphate values derived from untreated sewage effluent from Stone Town were highly variable(ranging 0.05–3.77 and 0.05–1.45μM,respectively),moderate,and occasionally approached or exceeded critical threshold values for oligotrophic ecosystems.The analysis of total assemblages indicated an abundance of symbiont-bearing large benthic foraminifera,dominated by prolific Amphistegina species,comparatively low-moderate diversity,high FI values(7.6 on average),and high coral cover.A water quality gradient was reflected by subtle assemblage differences,suggesting that LBF can provide early warning signals of benthic changes,indicating the importance of long-term monitoring programs in vulnerable,rapidly developing coastal ecosystems exposed to increasing pressures. | Gita R.Narayan Natalia Herrán Claire E.Reymond Yohanna W.Shaghude Hildegard Westphal | 2022 | Journal of Earth Science2022，33，6： | 1 |
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