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| 1 | Viral hepatitis prevalence in patients with active and latent tuberculosis显示文摘AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no association between DILI and presence of serological markers of HBV or HCV. Three(5.3%) patients with serological markers of HBV or HCV infection had DILI compared to 25(9.5%) patients without; P = 0.04.CONCLUSION: Viral hepatitis screening should be considered in TB patients. DILI risk was not increased in patients with HBV/HCV. | Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan | 2015 | World Journal of Gastroenterology2015，21，29： | 7 |
| 2 | China organ donation and transplantation update: the Hangzhou Resolution显示文摘The much-anticipated change in the practice of organ donation and transplantation in China is now underway and affirmed by an important Hangzhou Resolution promulgated at the 2013 China Transplant Congress.Support of the National Health and Family Planning Commission On October 29,2013,in a meeting of the National Health and Family Planning Commission (NHFPC)officials with Jie-Fu Huang,Head of National Organ Transplant Committee(OTC), Hai-Bo Wang,Director of China Organ Transplant Response System (COTRS) | Jie-Fu Huang Shu-Sen Zheng Yong-Feng Liu Hai-Bo Wang Jeremy Chapman Philip O'Connell Michael Millis John Fung Francis Delmonico | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，2： | 6 |
| 3 | Malignancies of the Appendix: Beyond Case Series Reports显示文摘 | Marcia L. McGory M.D. Melinda A. Maggard M.D. M.S.H.S. Hakjung Kang M.D. Ph.D. Jessica B. O'Connell M.D. Clifford Y. Ko M.D. M.S. M.S.H.S | 2005 | Diseases of the Colon & Rectum2005，，12： | 5 |
| 4 | 城市结构中的尺度变迁:看用地激化条件下的典型爱尔兰城镇显示文摘本文通过对典型爱尔兰城镇结构尺度变迁的研究,找出地块与街廓形态的整体系统,并探寻这些系统在功能扩展弹性上的未来发展趋势。 | Derry O'Connell 刘中欣 | 2002 | 国外城市规划2002，17，4： | 3 |
| 5 | MicroRNA-155 Promotes Autoimmune Inflammation by Enhancing Inflammatory T Cell Development显示文摘 | Ryan M. O’Connell Daniel Kahn William S.J. Gibson June L. Round Rebecca L. Scholz Aadel A. Chaudhuri Melissa E. Kahn Dinesh S. Rao David Baltimore | 2010 | Immunity2010，，4： | 3 |
| 6 | Preparation and hybridization analysis of DNA/RNA from E. coli on microfabricated bioelectronic chips显示文摘 | Cheng Jing Sheldon E L Wu Lei Uribe A Gerrue L O Carrino J Heller M J O'Connell J P | | 0，，： | 2 |
| 7 | Survival After Resection of Ampullary Carcinoma: A National Population-Based Study显示文摘 | Jessica B. O'Connell MD Melinda A. Maggard MD Jesse Manunga MD James S. Tomlinson MD Howard A. Reber MD Clifford Y. Ko MD O. Joe Hines MD | 2008 | Annals of Surgical Oncology2008，，7： | 2 |
| 8 | Colorectal cancer in the young显示文摘 | Jessica B O’Connell Melinda A Maggard Edward H Livingston Cifford K Yo | 2004 | The American Journal of Surgery2004，，： | 2 |
| 9 | Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of Cardiomyopathies显示文摘 | P. : Richardson W. Rapporteur: McKenna M. Committee: Bristow B. Maisch B. Mautner J. O'Connell E. Olsen G. Thiene J. Consultant: Goodwin I. WHO Staff: Gyarfas I. Martin P. Nordet | 1996 | Circulation1996，，5： | 2 |
| 10 | Radiologic Imaging in Cystic Fibrosis显示文摘 | Oisin J. O’Connell Sebastian McWilliams AnneMarie McGarrigle Owen J. O’Connor Fergus Shanahan David Mullane Joseph Eustace Michael M. Maher Barry J. Plant | 2012 | Chest2012，，： | 2 |
| 11 | Developmet of an amperometric L-ascorbic acid (Vitamin C)sensor based on electropolymerised aniline for pharmaceutical and food analysis显示文摘 | Philip J O' Connell Cicile Gormally Miloslav Pravda | 2001 | Analytica Chimica Acta2001，431，： | 2 |
| 12 | Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of Cardiomyopathies显示文摘 | P. : Richardson W. Rapporteur: McKenna M. Committee: Bristow B. Maisch B. Mautner J. O’Connell E. Olsen G. Thiene J. Consultant: Goodwin I. WHO Staff: Gyarfas I. Martin P. Nordet | 1996 | Circulation1996，，5： | 2 |
| 13 | Malignancies of the Appendix: Beyond Case Series Reports显示文摘 | Marcia L. McGory Melinda A. Maggard Hakjung Kang Jessica B. O’Connell Clifford Y. Ko | 2005 | Diseases of the Colon & Rectum2005，，12： | 2 |
| 14 | 仿生学:世上的聪明设计何其多显示文摘我们人类乐于认为自己精于设计和技术——但我们常常忘记,大自然领先了我们足足360万年。现在,壁虎爬墙或是蜂鸟在空中的悬停正处于一项快速发展的产业的核心,这一产业就是仿生学,即对自然界的奇思妙想“施以逆向工程”的学科。 | Sanjida O’Connell 冯雪 | 2009 | 英语文摘2009，，8： | 2 |
| 15 | Adult polycystic liver disease with cutaneous involvement: a brief report显示文摘 | O'connell JT Lewin KJ | 1998 | Ann Diagn Pathol1998，2，2： | 2 |
| 16 | A MyD88-dependent IFNyR-CCR2 signaling circuit is required for mobilization of monocytes and host defense against systemic bacterial challenge显示文摘 | Eric M Pietras Lloyd S Miller Carl T Johnson Ryan M O'Connell Paul W Dempsey Genhong Cheng | 2011 | Cell Research2011，21，7： | 2 |
| 17 | 【特刊综述】雄激素对骨骼肌的作用:对乏力的发展和治疗的意义显示文摘雄激素对骨骼肌合成有明显影响,随着年龄增大,雄激素的下降常伴随肌量和肌力的下降。这种肌量和肌功能的下降,被称为少肌症或肌体老化,是老年人体质弱化(男性化减退)进展的关键事项。也是导致快速机能衰退及其不良后果的关键。雄激素水平下降对老年男性体质弱化(男性化减退)的潜在影响和对躯体功能的促进治疗作用无疑已经引起了相当的关注。本综述概述了近期关于肌肉老化、少肌症、老年体质弱化的概念、定义,并评估了关于雄激素和老年体质弱化的研究进展。近期源于观测性和介入性研究的证据强烈支持雄激素对老年男性肌量的作用,但雄激素对肌力和特有的躯体功能的效用并不明确。研究显示,雄激素治疗在老年男性中通常有良好的耐受性,而近期的研究则关注于雄激素的高剂量治疗和对于心血管风险较高人群的治疗。雄激素受体调节剂(SARMs)的初期试验研究显示传统雄激素治疗对于老年患者在肌量和肌功能方面有相同的效用。将来的重要研究方向包括利用这类雄激素治疗并结合适用于不同老年患者群体促进躯体功能的运动训练,同时将更多地关注近期关于激素水平、身体成分及躯体功能间关系的观测性(回顾性)研究。 | Matthew DL O'Connell Frederick CW Wu | 2014 | Asian Journal of Andrology2014，16，2： | 2 |
| 18 | IRF3 mediates a TLR3/TLR4-specific antiviral gene program显示文摘 | Doyle S Vaidya S O'Connell R | 2002 | Immunity2002，17，3： | 1 |
| 19 | Vascular factor in intracranial pressure and maintenance of cerebrospinal fluid circulation显示文摘 | O'connel JEA | 1943 | Brain1943，66，： | 1 |
| 20 | Distinct structural and functional properties of the ATPase sites in an asymmetric ABC transporter 显示文摘 | Procko E Ferrin- O' Connell I Ng SL | 2006 | Mol Cell2006，24，1： | 1 |
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