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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | IGF-1 Signaling is Essential for Differentiation of Mesenchymal Stem Cells for Peak Bone Mass显示文摘Survival of children with chronic medical illnesses is leading to an increase in secondary osteoporosis due to impaired peak bone mass(PBM).Insulin-like growth factor type 1(IGF-1) levels correlate with the pattern of bone mass accrual and many chronic illnesses are associated with low IGF-1 levels.Reduced serum levels of IGF-1 minimally affect the integrity of the skeleton,whereas recent studies suggest that skeletal IGF-I regulates PBM.To determine the role of IGF-1 in postnatal bone mass accrual regardless of source,we established an inducible type 1 Igf receptor Cre/lox knockout mouse model,in which the type 1 Igf receptor was deleted inducibely in the mesenchymal stem cells(MSCs) from 3-7 weeks of age.The size of the mouse was not affected as knockout and wild type mice had similar body weights and nasoanal and femoral lengths.However,bone volume and trabecular bone thickness were decreased in the secondary spongiosa of female knockout mice relative to wild type controls,indicating that IGF-1 is critical for bone mass.IGF-1 signaling in MSCs in vitro has been implicated to be involved in both migration to the bone surface and differentiation into bone forming osteoblasts.To clarify the exact role of IGF-1 in bone,we found by immunohistochemical analysis that a similar number of Osterix-positive osteoprogenitors were on the bone perimeter,indicating migration of MSCs was not affected.Most importantly,56% fewer osteocalcin-positive mature osteoblasts were present on the bone perimeter in the secondary spongiosa in knockout mice versus wild type littermates.These in vivo data demonstrate that the primary role of skeletal IGF-1 is for the terminal differentiation of osteoprogenitors,but refute the role of IGF-1 in MSC migration in vivo.Additionally,these findings confirm that impaired IGF-1 signaling in bone MSCs is sufficient to impair bone mass acquisition. | Janet L. Crane Luo Zhao Joseph S. Frye Lingling Xian Tao Qiu Xu Cao | 2013 | Bone Research2013，1，2： | 8 |
| 3 | Pancreaticoduodenectomy with vascular resection: margin status and survival duration显示文摘 | Jennifer F. Tseng M.D. Chandrajit P. Raut M.D. Jeffrey E. Lee M.D. Peter W. T. Pisters M.D. Jean-Nicolas Vauthey M.D. Eddie K. Abdalla M.D. Henry F. Gomez M.D. Charlotte C. Sun Dr.P.H. Christopher H. Crane M.D. Robert A. Wolff M.D. Douglas B. Evans M.D | 2004 | Journal of Gastrointestinal Surgery2004，，8： | 6 |
| 4 | Human immunodeficiency virus infection and the liver显示文摘Liver disease in human immunodeficiency virus(HIV)-infected individuals encompasses the spectrum from abnormal liver function tests,liver decompensation,with and without evidence of cirrhosis on biopsy,to non-alcoholic liver disease and its more severe form,non-alcoholic steatohepatitis and hepatocellular cancer.HIV can infect multiple cells in the liver,leading to enhanced intrahepatic apoptosis,activation and fibrosis.HIV can also alter gastro-intestinal tract permeability,leading to increased levels of circulating lipopolysaccharide that may have an impact on liver function.This review focuses on recent changes in the epidemiology,pathogenesis and clinical presentation of liver disease in HIV-infected patients,in the absence of co-infection with hepatitis B virus or hepatitis C virus,with a specific focus on issues relevant to low and middle income countries. | Megan Crane David Iser Sharon R Lewin | 2012 | World Journal of Hepatology2012，4，3： | 5 |
| 5 | Borderline Resectable Pancreatic Cancer: Definitions, Management, and Role of Preoperative Therapy显示文摘 | Gauri R. Varadhachary MD Eric P. Tamm MD James L. Abbruzzese MD Henry Q. Xiong MD Christopher H. Crane MD Huamin Wang MD Jeffrey E. Lee MD Peter W. T. Pisters MD Douglas B. Evans MD Robert A. Wolff MD | 2006 | Annals of Surgical Oncology2006，，8： | 4 |
| 6 | Conserving our global botanical heritage:The PSESP plant conservation program显示文摘It is a fundamental truth of ecology that most species are rare.And this rarity extends beyondmeasures of abundance to geographic distribution.In a global context,very few species are truly abundant,and most are more or less restricted geographically.In the world of plants,where there are several hundred thousand species,the number of species with especially small population sizes and small fragmentary ranges is extremely large.One recent assessment,the most exhaustive undertaken so far,based on 200 million observations taken from herbarium records,ecological surveys and other sources,suggests that of the more than 400,000 species of land plants,ca.36%are“exceedingly rare”(Enquist et al.,2019). | Peter Crane | 2020 | Plant Diversity2020，42，4： | 4 |
| 7 | The Shenzhen Declaration on Plant Sciences Uniting plant sciences and society to build a green, sustainable Earth显示文摘 | Peter R. Crane Song Ge De-Yuan Hong Hong-Wen Huang Gen-Lin Jiao Sandra Knapp W. John Kress Harold Mooney Peter H. Raven Jun Wen Wei-Hua Wu Huan-Ming Yang Wei-Hua Zhu Yu-Xian Zhu | 2017 | Journal of Systematics and Evolution2017，55，5： | 3 |
| 8 | The Cost-Effectiveness of Neoadjuvant Chemoradiation is Superior to a Surgery-First Approach in the Treatment of Pancreatic Head Adenocarcinoma显示文摘 | Daniel E. Abbott Ching-Wei David Tzeng Ryan P. Merkow Scott B. Cantor George J. Chang Matthew Harold Katz David J. Bentrem Karl Y. Bilimoria Christopher H. Crane Gauri R. Varadhachary James L. Abbruzzese Robert A. Wolff Jeffrey E. Lee Douglas B. Evans Jas | 2013 | Annals of Surgical Oncology2013，，3： | 3 |
| 9 | Anticoagulation in simultaneous pancreas kidney transplantation - On what basis?显示文摘BACKGROUND Despite technical refinements,early pancreas graft loss due to thrombosis continues to occur.Conventional coagulation tests(CCT)do not detect hypercoagulability and hence the hypercoagulable state due to diabetes is left untreated.Thromboelastogram(TEG)is an in-vitro diagnostic test which is used in liver transplantation,and in various intensive care settings to guide anticoagulation.TEG is better than CCT because it is dynamic and provides a global hemostatic profile including fibrinolysis.AIM To compare the outcomes between TEG and CCT(prothrombin time,activated partial thromboplastin time and international normalized ratio)directed anticoagulation in simultaneous pancreas and kidney(SPK)transplant recipients.METHODS A single center retrospective analysis comparing the outcomes between TEG and CCT-directed anticoagulation in SPK recipients,who were matched for donor age and graft type(donors after brainstem death and donors after circulatory death).Anticoagulation consisted of intravenous(IV)heparin titrated up to a maximum of 500 IU/h based on CCT in conjunction with various clinical parameters or directed by TEG results.Graft loss due to thrombosis,anticoagulation related bleeding,radiological incidence of partial thrombi in the pancreas graft,thrombus resolution rate after anticoagulation dose escalation,length of the hospital stays and,1-year pancreas and kidney graft survival between the two groups were compared.RESULTS Seventeen patients who received TEG-directed anticoagulation were compared against 51 contemporaneous SPK recipients(ratio of 1:3)who were anticoagulated based on CCT.No graft losses occurred in the TEG group,whereas 11 grafts(7 pancreases and 4 kidneys)were lost due to thrombosis in the CCT group(P=0.06,Fisher’s exact test).The overall incidence of anticoagulation related bleeding(hematoma/gastrointestinal bleeding/hematuria/nose bleeding/re-exploration for bleeding/post-operative blood transfusion)was 17.65%in the TEG group and 45.10%in the CCT group(P=0.05,Fisher’s exact test).The incidence of radiologically confirmed partial thrombus in pancreas allograft was 41.18%in the TEG and 25.50%in the CCT group(P=0.23,Fisher’s exact test).All recipients with partial thrombi detected in computed tomography(CT)scan had an anticoagulation dose escalation.The thrombus resolution rates in subsequent scan were 85.71%and 63.64%in the TEG group vs the CCT group(P=0.59,Fisher’s exact test).The TEG group had reduced blood product usage{10 packed red blood cell(PRBC)and 2 fresh frozen plasma(FFP)}compared to the CCT group(71 PRBC/10 FFP/2 cryoprecipitate and 2 platelets).The proportion of patients requiring transfusion in the TEG group was 17.65%vs 39.25%in the CCT group(P=0.14,Fisher’s exact test).The median length of hospital stay was 18 days in the TEG group vs 31 days in the CCT group(P=0.03,Mann Whitney test).The 1-year pancreas graft survival was 100%in the TEG group vs 82.35%in the CCT group(P=0.07,log rank test)and,the 1-year kidney graft survival was 100%in the TEG group vs 92.15%in the CCT group(P=0.23,log tank test).CONCLUSION TEG is a promising tool in guiding judicious use of anticoagulation with concomitant prevention of graft loss due to thrombosis,and reduces the length of hospital stay. | Jeevan Prakash Gopal Frank JMF Dor Jeremy S Crane Paul E Herbert Vassilios E Papalois Anand SR Muthusamy | 2020 | World Journal of Transplantation2020，10，7： | 2 |
| 10 | A displacement analysis of the general 7-link 7R mechanism 显示文摘 | Duffy J Crane C | 1980 | Mechanism and Machine Theory1980，15，2： | 2 |
| 11 | Review of application of mass spectrometry for analyses of anterior eye proteome显示文摘Proteins have important functional roles in the body, which can be altered in disease states. The eye is a complex organ rich in proteins; in particular, the anterior eye is very sophisticated in function and is most commonly involved in ophthalmic diseases. Proteomics, the large scale study of proteins, has greatly impacted our knowledge and understanding of gene function in the post-genomic period. The most significant breakthrough in proteomics has been mass spectrometric identification of proteins, which extends analysis far beyond the mere display of proteins that classical techniques provide. Mass spectrometry functions as a 'mass analyzer' which simplifies the identification and quantification of proteins extracted from biological tissue. Mass spectrometric analysis of the anterior eye proteome provides a differential display for protein comparison of normal and diseased tissue. In this article wepresent the key proteomic findings in the recent literature related to the cornea, aqueous humor, trabecular meshwork, iris, ciliary body and lens. Through this we identified unique proteins specific to diseases related to the anterior eye. | Sherif Elsobky Ashley M Crane Michael Margolis Teresia A Carreon Sanjoy K Bhattacharya | 2014 | World Journal of Biological Chemistry2014，5，2： | 2 |
| 12 | Pancreaticoduodenectomy with vascular resection: margin status and survival duration显示文摘 | Jennifer F. Tseng Chandrajit P. Raut Jeffrey E. Lee Peter W.T. Pisters Jean-Nicolas Vauthey Eddie K. Abdalla Henry F. Gomez Charlotte C. Sun Christopher H. Crane Robert A. Wolff Douglas B. Evans | 2004 | Journal of Gastrointestinal Surgery2004，，8： | 2 |
| 13 | Air pollution removal by urban trees and shrubs in the United States显示文摘 | David J. Nowak Daniel E. Crane Jack C. Stevens | 2006 | Urban Forestry & Urban Greening2006，，3： | 2 |
| 14 | Nanoscale zero-valent iron: Future prospects for an emerging water treatment technology显示文摘 | R.A. Crane T.B. Scott | 2011 | Journal of Hazardous Materials2011，，： | 2 |
| 15 | 血管外科的新进展显示文摘本文讨论了血管外科角色的转变以及血管内干预和静脉曲张治疗新技术等的进展。 | Jeremy Crane Nick Cheshire 单月宏 | 2004 | 英国医学杂志中文版2004，7，6： | 2 |
| 16 | 支持虚拟学习环境情境时空维度的用户研究显示文摘随着可用的无线移动设备的不断增长,人们对信息检索的需求也越来越大。基于时间的调度服务和基于坐标的定位服务被视为情境感知应用的两个基本点。目前,基于时间的情境感知服务已经应用较多,但存在不能个性化测量等问题。基于坐标的定位服务能否成为常用的基于时间服务系统的替代方法?基于时间和空间维度的RSS信息检索小应用程序的用户研究显示:两种应用程序都有助于接收信息、支持学生组织自己的学习,但是在个人空间中不论基于空间的服务还是基于时间的服务,效果均不突出,而且位置信息被视作不太适宜的环境信息。 | Laura Crane Phillip Benachour Paul Coulton 吴亚婕 | 2012 | 现代远程教育研究2012，24，2： | 2 |
| 17 | An analysis of urban development and its environmental impact on the Tampa Bay watershed显示文摘 | George Xian Mike Crane Junshan Su | 2006 | Journal of Environmental Management2006，，4： | 2 |
| 18 | Response of borderline resectable pancreatic cancer to neoadjuvant therapy is not reflected by radiographic indicators显示文摘 | Matthew H. G. Katz Jason B. Fleming Priya Bhosale Gauri Varadhachary Jeffrey E. Lee Robert Wolff Huamin Wang James Abbruzzese Peter W. T. Pisters Jean‐Nicolas Vauthey Chusilp Charnsangavej Eric Tamm Christopher H. Crane Aparna Balachandran | 2012 | Cancer2012，，23： | 2 |
| 19 | Pregnancy outcome after loop electrosurgical excision procedure: a systematic review显示文摘 | Joan M.G Crane | 2003 | Obstetrics & Gynecology2003，，： | 2 |
| 20 | Analysis of curing kinetics in polymer composites显示文摘 | Crane L W Dynes P J Kaelble D H | 1973 | Journal of Polymer Science1973，11，8： | 1 |
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