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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Enzymatic hydrolysis of sardine (Sardina pilchardus) by-products and lipid recovery 显示文摘 | Irineu B Cristina R Rita M | 2009 | Journal of Aquatic Food Product Technology2009，18，12： | 1 |
| 3 | Effects of heavy metals on microbial activity of water and sediment communities 显示文摘 | Cristina R M Mercedes G E Estela B D | 1999 | Water Air&Soil Pollution1999，15，2： | 1 |
| 4 | Decol- orization of synthetic dyes by solid state cultures of Lentinula (Lentinus) edodes producing manganese peroxidase as the main ligninolytic enzyme显示文摘 | CINTHIA G B LARISSA O CRISTINA G M S | 2004 | Bioresouree Technology2004，94，2： | 1 |
| 5 | Electronic transport properties of individual chemically reduced graphene oxide sheets 显示文摘 | CRISTINA G N WEITA R T ALEXANDER M B | 2007 | 7(11):3499-35032007，7，11： | 1 |
| 6 | Biotransformations of cinnamic and ferulic acid with actinomycetes显示文摘 | Flavia M Cristina B | 2004 | Enzyme and Microbial Technology2004，34，： | 1 |
| 7 | Tetracycline-inducibleexpression systems for the generation oftransgenic animals:a comparison ofvarious induciblesystems carried in a single vector显示文摘 | CRISTINA M B ZHANG Y J BARRY J H | 2004 | Journal of Neuros-cience Methods2004，139，： | 1 |
| 8 | Specific-based im-munoassays for sulfathiazole显示文摘 | Nuria P N Cristina G B Angel M | | 0，，12： | 1 |
| 9 | Byproducts from different citrus processes as a source of customized functional fibres显示文摘 | FRANCISCO R M CRISTINA S R OBDULIO B G | 2007 | Food Chemistry2007，100，： | 1 |
| 10 | Progress in analysis of residual antibacterials in food显示文摘 | CRISTINA B CARMEN M T YOLANDA P | 2007 | Trends in Analytical Chemistry2007，26，9： | 1 |
| 11 | Last trends in pesticide residue determination by liquid chromatography-mass spectrometry显示文摘 | Ana M Cristina B Yolanda P | 2014 | Trends in Environmental Analytical Chemistry2014，2，： | 1 |
| 12 | Specific-based Immunoassays for sulfathiazole 显示文摘 | Nuria P N Cristina G B Angel M | 2004 | Analytical Biochemistry2004，，12： | 1 |
| 13 | Specificpolyclonal-based immunoassays for sulfathiazole显示文摘 | Cristina G B (A)ngel M | 2004 | Anal Bioanal Chem2004，379，： | 1 |
| 14 | You can' t manage right what you can' t measure well: technological innovation efficlency显示文摘 | Claudio C C Cristina B S Teresa G M | 2013 | Research Policy2013，，42： | 1 |
| 15 | Insulin resistante and lipid disorders 显示文摘 | ROBERTO M CRISTINA B GIUSEPPE P | 2008 | Future Lipidology2008，3，6： | 1 |
| 16 | Characterization of used alkaline batteries powder and analysis of zinc recovery by acid leaching显示文摘 | CLEUSA CRISTINA B M S DENISE C O JORGE ALBERTO S T | 2001 | Journal of Power Sources2001，103，8： | 1 |
| 17 | Specific polyclonal-based immunoassays for sulfathiazole 显示文摘 | Nuria P N Cristina G B Angel M | 2004 | Anal Bioanal Chem2004，379，： | 1 |
| 18 | Byproducts from different citrus processes as a source of customized func-tional fibres显示文摘 | FRANCISCO R M CRISTINA S R OBDULIO B G | 2007 | Food Chemistry2007，100，2： | 1 |
| 19 | Child’s Personality and perception of parental relationship as correlates of optimal experience显示文摘 | Mesurado B Cristina M de Minzi R | 2013 | Journal of Happiness Studies2013，14，1： | 1 |
| 20 | The coat protein of Rabbit hemorrhagic disease virus contains a molecular switch at the N-terminal region facing the inner surface of the capsid显示文摘 | Juan Bárcena Nuria Verdaguer Ramón Roca Mónica Morales Iván Angulo Cristina Risco José L. Carrascosa Juan M. Torres José R. Castón | 2004 | Virology2004，，1： | 1 |
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