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| 1 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 2 | Bioassay-directed purification of an acidic phospholipase A 2 from Agkistrodon halys pallas venom显示文摘 | Yuwei Wang Guohui Cui Ming Zhao Jian Yang Chao Wang Roger W. Giese Shiqi Peng | 2008 | Toxicon2008，，7： | 1 |
| 3 | A fault-tolerant control method for distributed flight control system facing wing damage显示文摘With the strong battlefield application environment of the next generation fighter,based on the design of distributed vehicle management system,a fault diagnosis and fault-tolerant control(FTC)method for wing surface damage is proposed in this paper.Aiming at three kinds of wing damage modes,this paper proposes a diagnosis method based on the fault decision tree and forms a fault decision tree for wing damage from the aspects of sample database construction,feature parameter extraction,and fault decision tree construction.Based on the fault diagnosis results,the longitudinal control law based on dynamic inverse and the lateral-directional robust control laws based on linear quadratic regulator(LQR)are proposed.From the simulation examples,the fault diagnosis algorithm based on the decision tree can complete the judgment of three wing surface damage modes within 2 ms,and the FTC law can make the fighter quickly return to a stable flight state after a short transient of 1 s,which achieves the fault-tolerant goal. | CUI Yuwei LI Aijun MENG Xianfeng | 2021 | Journal of Systems Engineering and Electronics2021，32，5： | 1 |
| 4 | Superplastic forming technology of aircraft structures for Al–Li alloy and high-strength Al alloy显示文摘 | Xun Yuwei Zhun Yiyuan Mao Wenfeng Cui Jainzhong | 1997 | Journal of Materials Processing Tech1997，，2： | 1 |
| 5 | Graphene oxide nanoplatelets as excellent electrochemical active materials for VO 2+ / VO 2 + and V 2+ /V 3+ redox couples for a vanadium redox flow battery显示文摘 | Pengxian Han Haibo Wang Zhihong Liu Xiao Chen Wen Ma Jianhua Yao Yuwei Zhu Guanglei Cui | 2010 | Carbon2010，，2： | 1 |
| 6 | Near-infrared (NIR) controlled reversible cell adhesion on a responsive nano-biointerface显示文摘激活光的动态变化支持了聪明的接口的发展,特别 nano-biointerfaces。在这篇文章,在红外线附近(NIR ) 为控制房间粘附的应答的表面被 grafting 设计热应答的聚合物(poly (N-isopropylacrylamide ) , PNIPAM ) 到硅 nanowires (SiNWs ) 上而不是传统的感光性的一半。NIR 导致了 SiNWs 的 photothermal 效果,并且本地热导致了 PNIPAM 的热力学的阶段转变。用 NIR 放射的应用程序,表面转到一个恐水病的状态,并且当 NIR 被关上时,恢复了到吸水的状态,导致可逆房间粘附和版本。表面和房间粘附 / 版本的可切换的 wettability 甚至在 20 个周期以后高效地发生了。蛋白质用 NIR 经由恐水病的相互作用在表面上被抛锚;一个房间俘获代理人的进一步的连接在完成特定的房间俘获帮助了。经由 NIR 的房间粘附的这动态控制可以为设计功能的 nano-biointerfaces 提供新线索。 | Haijun Cui | 2017 | Nano Research2017，10，4： | 1 |
| 7 | Highly uniform Co-Cu bimetallic sulfides for rechargeable alkaline aqueous zinc batteries显示文摘Rechargeable alkaline aqueous zinc batteries(RAZBs)have attracted increasing attention.However,most RAZBs are hindered by the limited availability of cathode materials.The practical electrochemical performance of most cathode materials is lower than the theoretical value due to their poor electrical conductivity and low utilization capacity.In this work,we develop a facile hydrothermal procedure to prepare highly uniform bimetallic sulfides as novel cathode materials for RAZBs.Copper-cobalt binary metallic oxides materials possess higher conductivity and larger capacity compared with their mono-metal oxides compounds due to bimetallic synergistic effects and multiple oxidation states.Furthermore,bimetallic sulfide compounds have smaller bond energy and longer bond length than their oxides,leading to less structural damage,faster kinetics of electrochemical reactions,and better stability.The as-prepared Co-Cu bimetallic sulfides show enhanced electrochemical performance due to various valences of Co and Cu as well as the existence of S.As a result,aqueous Zn/CuCo_(2)S_(4) battery shows a high specific capacity of 117.4 mAh/g at 4 A/g and a good cycle life of over 8000 cycles.Based on PANa hydrogel electrolytes,a flexible Zn/CuCo_(2)S_(4) battery demonstrates excellent cycling stability.This battery can also meet the requirements of electronic devices with different shapes and performs well in extreme environments,such as freezing,drilling,and hammering.This work opens new avenues to obtain high-rate and long-life cathode materials for RAZBs by utilizing the synergistic effects of bimetallic sulfides and provides a new platform for flexible energy storage devices. | Xiaofang Bai Yuwei Zhao Mangwei Cui Tianshuo Guo Zijie Tang Chuan Li Heng Gao Shuo Yang Lingzhi Zhao Chunyi Zhi Hongfei Li | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
| 8 | Wearable and interactive multicolored photochromic fiber display显示文摘Endowing flexible and adaptable fiber devices with light-emitting capabilities has the potential to revolutionize the current design philosophy of intelligent,wearable interactive devices.However,significant challenges remain in developing fiber devices when it comes to achieving uniform and customizable light effects while utilizing lightweight hardware.Here,we introduce a mass-produced,wearable,and interactive photochromic fiber that provides uniform multicolored light control.We designed independent waveguides inside the fiber to maintain total internal reflection of light as it traverses the fiber.The impact of excessive light leakage on the overall illuminance can be reduced by utilizing the saturable absorption effect of fluorescent materials to ensure light emission uniformity along the transmission direction.In addition,we coupled various fluorescent composite materials inside the fiber to achieve artificially controllable spectral radiation of multiple color systems in a single fiber.We prepared fibers on mass-produced kilometer-long using the thermal drawing method.The fibers can be directly integrated into daily wearable devices or clothing in various patterns and combined with other signal input components to control and display patterns as needed.This work provides a new perspective and inspiration to the existing field of fiber display interaction,paving the way for future human–machine integration. | Pan Li Yuwei Wang Xiaoxian He Yuyang Cui Jingyu Ouyang Ju Ouyang Zicheng He Jiayu Hu Xiaojuan Liu Hang Wei Yu Wang Xiaoling Lu Qian Ji Xinyuan Cai Li Liu Chong Hou Ning Zhou Shaowu Pan Xiangru Wang Huamin Zhou Cheng-Wei Qiu Yan-Qing Lu Guangming Tao | 2024 | Light(Science & Applications)2024，13，3： | 0 |
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