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| 1 | Electrodeposition of calcium phosphate onto polyethylene terephthalate artificial ligament enhances graft-bone integration after anterior cruciate ligament reconstruction显示文摘It is a big challenge to develop a polyethylene terephthalate(PET)artificial ligament with excellent osteogenetic activity to enhance graft-bone integration for ligament reconstruction.Herein,we evaluated the effect of biomineralization(BM)and electrodeposition(ED)method for depositing calcium-phosphate(CaP)on the PET artificial ligament in vitro and in vivo.Scanning electron microscopy and energy-dispersive X-Ray spectrometer mapping analysis revealed that the ED-CaP had more uniform particles and element distribution(Ca,P and O),and thermogravimetric analysis showed there were more CaP on the PET/ED-CaP than the PET/BM-CaP scaffold.Moreover,the hydrophilicity of PET scaffolds was significantly improved after CaP deposition.In vitro study showed that CaP coating via BM or ED method could improve the attachment and proliferation of MC3T3-E1 cells,and ED-CaP coating significantly increased osteogenic differentiation of the cells,in which the Wnt/β-catenin signaling pathway might be involved.In addition,radiological,histological and immunohistochemical results of in vivo study in a rabbit anterior cruciate ligament(ACL)reconstruction model demonstrated that the PET/BM-CaP and PET/ED-CaP scaffolds significantly improved graft-bone integration process compared to the PET scaffold.More importantly,larger areas of new bone ingrowth and the formation of fibrocartilage tissue were observed at 12 weeks in the PET/ED-CaP group,and the biomechanical tests showed increased ultimate failure load and stiffness in PET/ED-CaP group compared to PET/BM-CaP and PET group.Therefore,ED of CaP is an effective strategy for the modification of PET artificial ligament and can enhance graft-bone integration both in vitro and in vivo. | Jiangyu Cai Qianqian Zhang Jiebo Chen Jia Jiang Xiumei Mo Chuanglong He Jinzhong Zhao | 2021 | Bioactive Materials2021，6，3： | 4 |
| 2 | Doxorubicin-Ioaded Fe3O4@MoS2-PEG-2DG nanocubes as a theranostic platform for magnetic resonance imaging- guided chemo-photothermal therapy of breast cancer显示文摘 | Wensheng Xie Qin Gao Dan Wang Zhenhu Guo Fei Gao Xiumei Wang Qiang Cai Si-shen Feng Haiming Fan Xiaodan Sun Lingyun Zhao | 2018 | Nano Research2018，11，5： | 4 |
| 3 | HER3 intracellular domains play a crucial role in HER3/HER2 dimerization and activation of downstream signaling pathways显示文摘Dimerization among the EGFR family of tyrosine kinase receptors leads to allosteric activation of the kinase domains of the partners.Unlike other members in the family,the kinase domain of HER3 lacks key amino acid residues for catalytic activity.As a result,HER3 is suggested to serve as an allosteric activator of other EGFR family members which include EGFR,HER2 and HER4.To study the role of intracellular domains in HER3 dimerization and activation of downstream signaling pathways,we constructed HER3/HER2 chimeric receptors by replacing the HER3 kinase domain(HER3-2-3)or both the kinase domain and the C-terminal tail(HER3-2-2)with the HER2 counterparts and expressed the chimeric receptors in Chinese hamster ovary(CHO)cells.While over expression of the intact human HER3 transformed CHO cells with oncogenic properties such as AKT/ERK activation and increased proliferation and migration,CHO cells expressing the HER3-2-3 chimeric receptor showed significantly reduced HER3/HER2 dimerization and decreased phosphorylation of both AKT and ERK1/2 in the presence of neuregulin-1(NRG-1).In contrast,CHO cells expressing the HER3-2-2 chimeric receptor resulted in a total loss of downstream AKT activation in response to NRG-1,but maintained partial activation of ERK1/2.The results demonstrate that the intracellular domains play a crucial role in HER3’s function as an allosteric activator and its role in downstream signaling. | Byung-Kwon Choi Xiumei Cai Bin Yuan Zhao Huang Xuejun Fan Hui Deng Ningyan Zhang Zhiqiang An | 2012 | Protein & Cell2012，3，10： | 3 |
| 4 | Metabonomic study of biochemical changes in the serum of type 2 diabetes mellitus patients after the treatment of metformin hydrochloride显示文摘 | Taoguang Huo Shuang Cai Xiumei Lu Yi Sha Mingyang Yu Famei Li | 2009 | Journal of Pharmaceutical and Biomedical Analysis2009，，4： | 1 |
| 5 | Association between Functional Polymorphisms of Foxp3 Gene and the Occurrence of Unexplained Recurrent Spontaneous Abortion in a Chinese Han Population显示文摘 | Zaigui Wu Zeshan You Cai Zhang Zhuyu Li Xiumei Su Xiuming Zhang Yinguang Li Raivo Uibo | 2011 | Clinical and Developmental Immunology2011，，： | 1 |
| 6 | Fabrication of chitosan/silk fibroin composite uanofibers for wound-dressing applications 显示文摘 | Cai Zengxiao Mo Xiumei Zhang Kuihua | 2010 | International Journal of Molecular Sciences2010，11，9： | 1 |
| 7 | Dynamic model of computer viruses under the effect of removable media and external computers显示文摘This paper investigates the propagation of computer viruses and establishes a novel propagation model. In contrast to the existing models,this model can directly indicate the impact of removable media and external computers on the propagation of computer virus. The stability results of equilibrium point are derived by Hurwitz criterion and Bendixson Dulac criterion. The effectiveness of the proposed results is shown by numerical simulation. In order to show the superiority of the proposed model,some comparisons with the existing models are presented. The acceptable threshold and the reasonable strategies for suppressing the propagation of computer virus are also suggested,respectively. | Cai Xiumei Liu Chao Huang Xianying Liu Xiaoyang Cao Qiong Yang Hongyu | 2018 | The Journal of China Universities of Posts and Telecommunications2018，25，4： | 1 |
| 8 | Fabrication of chitosan/silk fibroin composite nanofibers for wound-dressing applications显示文摘 | CAI Zengxiao MO Xiumei ZHANG Kuihua | 2010 | International Journal of Molecular Sciences2010，11，9： | 1 |
| 9 | Metabonomic study of biochemical changes in the serum of type 2 diabetes mellitus patients after thetreatment of metformin hydrochloride 显示文摘 | HUO Taoguang CAI Shuang LU Xiumei | 2009 | J Pharm Biomed Anal2009，49，4： | 1 |
| 10 | Fractional order distance regularized level set method with bias correction显示文摘The existing level set segmentation methods have drawbacks such as poor convergence,poor noise resistance,and long iteration times.In this paper,a fractional order distance regularized level set segmentation method with bias correction is proposed.This method firstly introduces fractional order distance regularized term to punish the deviation between the level set function(LSF)and the signed distance function.Secondly a series of covering template is constructed to calculate fractional derivative and its conjugate of image pixel.Thirdly introducing the offset correction term and fully using the local clustering property of image intensity,the local clustering criterion of image intensity is defined and integrated with the neighborhood center to obtain the global criterion of image segmentation.Finally,the fractional distance regularization,offset correction,and external energy constraints are combined,and the energy optimization segmentation method for noisy image is established by level set.Experimental results show that the proposed method can accurately segment the image,and effectively improve the efficiency and robustness of exiting state of the art level set related algorithms. | Cai Xiumei He Ningning Wu Chengmao Liu Xiao Liu Hang | 2024 | The Journal of China Universities of Posts and Telecommunications2024，31，1： | 0 |
| 11 | The Status Quo Analysis of New Ventures in China显示文摘 | Li Cai Xiumei Zhu Qiguo Cui | 2004 | Chinese Business Review2004，3，9： | 0 |
| 12 | Extraction Process and Content Determination of Total Flavonoids in Lonicera japonica显示文摘[Objectives]To optimize the extraction process of total flavonoids of Lonicerae japonica and establish a method for its extraction and content determination.[Methods]The total flavonoids of L.japonica were extracted by reflux extraction method.Through a single factor experiment,the effects of extraction method,extraction solvent concentration,extraction volume and extraction time on the total flavonoids content of medicinal materials were investigated to select the optimal extraction process of the total flavonoids of L.japonica.[Results]The optimal extraction process of the total flavonoids of L.japonica was 70%ethanol,1∶30 of solid-to-liquid ratio,and 1.0 h of reflux extraction time.[Conclusions]This method can effectively determine the content of total flavonoids in L.japonica and is expected to provide a certain scientific basis for the study of the quality standard of L.japonica.This method has high reproducibility.It is stable and feasible in extraction of total flavonoids from L.japonica. | Yao HUANG Xiumei MA Chao ZENG Xiaoling CAI Jie HE Xi FENG Jiangcun WEI Hongxia CHEN | 2020 | Medicinal Plant2020，11，6： | 0 |
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