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| 1 | Retinol binding protein 4 correlates with and is an early predictor of carotid atherosclerosis in type 2 diabetes mellitus patients显示文摘The association of retinol binding protein 4(RBP4) with atherosclerosis of the carotid artery in type 2 diabetes mellitus(T2DM) remains undefined.We aimed to investigate the correlation of RBP4 expression with atherosclerosis of the carotid artery in T2 DM.A total of 1,076 subjects were investigated for intima-media thickness of the bilateral common carotid arteries,and they were divided into three groups:in group Ⅰ,patients had normal neck vascular ultrasound,in group Ⅱ,intimal carotid artery media thickness was equal to or more than 1 mm,and in group Ⅲ,carotid artery plaque was present.Height,weight,blood pressure(BP),fasting plasma glucose(FPG),hemoglobin Alc(HbAlc),total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),apolipoprotein A-l(apoA-1),apolipoprotein B(apoB) and lipoprotein(a)[Lp(a)]were determined by routine laboratory methods.RBP4 and high sensitivity C reactive protein(HsCRP) were measured by an enzyme-linked immuno-sorbent assay,and insulin concentration was measured by an electrochemiluminescence sandwich immunoassay.Duration of diabetes,waist and BP,FPG,HbAlc,TG,TC,LDL-C,APOB,Lp(a),HsCRP,RBP4 and homeostasis model assessment insulin resistance index(HOMA-IR) were significantly lower in group I than in the other two groups(P<0.01,P<0.01).Plasma levels of HbAlc,RBP4,LDL-C,TC,HOMA-IR,HsCRP and Lp(a),waist and BP were significantly increased in group Ⅲ than in group Ⅱ(F<0.01),Multivariate logistic regression analysis showed that there were seven factors associated with the occurrence of carotid artery atherosclerosis and its risks in descending order were:high LDL-C,high waist,high HsCRP,duration of diabetes,high HOMA-IR,HbAlc and high RBP4.Our finding supported that RBP4 was positively correlated with carotid atherosclerosis in patients with T2 DM and could be used as an early predictor of cardiovascular disease. | Shangyong Feng Yan Zhu Caifeng Yan Yan Wang Zhenweng Zhang | 2015 | The Journal of Biomedical Research2015，29，6： | 15 |
| 2 | Synthesis,structure and physical properties of the one-dimensional chain complex of tetrathiafulvalene carboxylate显示文摘A new Co(Ⅱ) coordination polymer bearing TTF carboxylate group, [{Co2(trioTTF)2(H2O)6}·5H2O]n (1) (trioTTF=2-(5,6,8,9,11,12,14,15-octahydro-[1,3]dithiolo[4,5-h][1,4,13,7,10]trioxadithiacyclopentadecin-2-ylidene)-1,3-dithiole-4,5-dicarboxylate), has been prepared and characterized. In the structure of 1, shorter intermolecular S····S contacts (3.565 △) are found between the trioTTF groups from neighboring chains. The electric conductivity of 1 is poor due to the bulky crown-ether group, but it exhibits ferromagnetic interaction at low temperature. | CHEN Ya LI ChengHui WANG CaiFeng WU Di ZUO JingLin YOU XiaoZeng | 2009 | Science China Chemistry2009，52，10： | 4 |
| 3 | GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis显示文摘Intestinal epithelium serves as the first barrier against the infections and injuries that mediate colonic inflammation.Colorectal cancer is often accompanied with chronic inflammation.Differed from its well-known oncogenic role in many malignancies,we present here that Golgi membrane protein 1(G0LM1,also referred to as GP73)suppresses colorectal tumorigenesis via maintenance of intestinal epithelial barrier.G0LM1 deficiency in mice conferred susceptibility to mucosal inflammation and colitis-induced epithelial damage,which consequently promoted colon cancer.Mechanistically,depletion of G0LM1 in intestinal epithelial cells(lECs)led to aberrant Notch activation that interfered with IEC differentiation,maturation,and lineage commitment in mice.Pharmacological inhibition of Notch pathway alleviated epithelial lesions and restrained pro-tumorigenic inflammation in G0LM1-deficient mice.Therefore,G0LM1 maintains IEC homeostasis and protects against colitis and colon tumorigenesis by modulating the equilibrium of Notch signaling pathway. | Yang Pu Ya Song Mengdi Zhang Caifeng Long Jie Li Yanan Wang Yinzhe Xu Fei Pan Na Zhao Xinyu Zhang Yanan Xu Jianxin Cui Hongying Wang Yan Li Yong Zhao Di Jin Hongbing Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 2 |
| 4 | Effect of simvastatin on the atherosclerotic plaque stability and the angiogenesis in the atherosclerotic plaque of rabbits显示文摘In this study, the effect of simvastatin on the atherosclerotic plaque stability and the angiogenesis in the atherosclerotic plaque of rabbits was observed. Thirty New Zealand rabbits were randomly divided into the normal control group, the model control group and the simvastatin group, 10 in each group. Rabbits in the normal control group were fed with normal forage, while rabbits in the rest two groups were fed with high fat forage. The balloon injury was performed two weeks later to establish an abdominal aortic atherosclerosis model, and then high fat forage was successively fed to them. Meanwhile, simvastatin at the daily dose of 2.5 mg/kg body weight was administered to rabbits in the simvastatin group. After 6 weeks of successive administration, levels of blood lipids were measured after blood sampling, and the serum high sensitivity C-reactive protein (hsCRP) and matrix metalloproteinase-3,-9 (MMP-3,-9) were detected using enzyme-linked immunosorbent assay. The macroscopically pathological indices of the plaque tissue were observed using hematoxylin and eosin (HE) staining of abdominal aorta specimens under a light microscope, and the plaque area (PA), cross-sectional vascular area (CVA) and correcting plaque area (PA/CVA) were determined quantitatively using imaging software. The protein expressions of the vascular endothelial growth factor (VEGF), factor VIII related antigen (FVIIIRAg), MMP-3 and cluster of differentiation antigen 40 ligand (CD40L) in the plaque were detected with the immunohistochemical method. Compared with the model control group, the levels of VEGF, FVIIIRAg, MMP-3, CD40L protein expression and the serum expression levels of hsCRP, MMP-3, MMP-9 in the simvastatin group were significantly reduced (P<0.05, P<0.01). The ratio PA/CVA in the simvastatin group was more significantly reduced when compared with that in the model control group (P<0.01). The levels of serum total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL) were significantly reduced in the simvastatin group when compared with those in the model control group (P<0.05, P<0.01). Simvastatin plays a certain role in stabilizing the atherosclerotic plaque, and inhibiting the angiogenesis in the atherosclerotic plaque may be one of possible mechanisms. | ZHANG Lu JIANG YueRong XUE Mei WU CaiFeng WANG JingShang YIN HuiJun | 2009 | Chinese Science Bulletin2009，54，17： | 2 |
| 5 | Delayed ischemic postconditioning protects hippocampal CA1 neurons by preserving mitochondrial integrity via Akt/GSK3β signaling显示文摘 | Caifeng Zhou Jingyi Tu Quanguang Zhang Dongshuang Lu Ying Zhu Wenli Zhang Fang Yang Darrell W. Brann Ruimin Wang | 2011 | Neurochemistry International2011，，6： | 1 |
| 6 | Extraction of Strain Characteristic Signals from Wind Turbine Blades Based on EEMD-WT显示文摘Analyzing the strain signal of wind turbine blade is the key to studying the load of wind turbine blade,so as to ensure the safe and stable operation of wind turbine in natural environment.The strain signal of the wind turbine blade under continuous crosswind state has typical non-stationary and unsteady characteristics.The strain signal contains a lot of noise,which makes the analysis error.Therefore,it is very important to denoise and extract features of measured signals before signal analysis.In this paper,the joint algorithm of ensemble empirical mode decomposition(EEMD)and wavelet transform(WT)is used for the first time to achieve sufficient noise reduction and effectively extract the feature signals of non-stationary strain signals.The application process of EEMD-WT is optimized.This optimization can avoid the repeated selection of wavelet basis function and the number of decomposition layers due to different crosswind conditions.EEMD adaptively decomposes the strain signal into intrinsic mode functions,to judge the frequency of IMFs,remove the high-frequency noise components,retain the useful components.The useful components are denoised twice by the wavelet transform,the components and residual terms after the secondary denoising are reconstructed to obtain the characteristic signal.The EEMD-WT was applied to process the simulating signals andmeasured the strain signals.The results were compared with the results of the EEMD.The results showed that the EEMD-WTmethod has better noise reduction performance,and can effectively extract the characteristics of strain signals,which lays a solid foundation for accurate analysis of wind turbine blade strain signals under crosswind conditions. | Jin Wang Zhen Liu Ying Wang Caifeng Wen Jianwen Wang | 2023 | Energy Engineering2023，120，5： | 1 |
| 7 | Chemical Synthesis and Optical Properties of Cds Poly(lactic acid) Nanocomposites and Their Transparent Fluorescent Films显示文摘 | Wang Caifeng Xie Heyi Cheng Yupeng | 2011 | Colloid and Polym Science2011，289，4： | 1 |
| 8 | Effect of filler size distribution on the mechanical and physical properties of a- lumina-filled silicone rubber显示文摘 | Zhou Wenying Yu Demei Wang Caifeng | 2008 | Polymer Engineering and Sci- ence2008，48，7： | 1 |
| 9 | Evaluation of breast lesions by contrast enhanced ultrasound: Qualitative and quantitative analysis显示文摘 | Caifeng Wan Jing Du Hua Fang Fenghua Li Lin Wang | 2011 | European Journal of Radiology2011，，4： | 1 |
| 10 | A Release- Induced Response For the Rapid Recognition of Latent Fingerprints and Formation of Inkjet-Printed Patterns 显示文摘 | Yang Shengyang Wang Caifeng Chen Su | 2011 | AngewandteChemie: IntemationalEdition2011，50，16： | 1 |
| 11 | Evaluation of breast lesions by contrast enhanced ultrasound: Qualitative and quantitative analysis显示文摘 | Caifeng Wan Jing Du Hua Fang Fenghua Li Lin Wang | 2011 | European Journal of Radiology2011，，4： | 1 |
| 12 | Variation in cadmium accumulation and translocation among peanut cultivars as affected by iron deficiency显示文摘 | Ying Su Xüming Wang Caifeng Liu Gangrong Shi | 2013 | Plant and Soil2013，，1： | 1 |
| 13 | Coordi- nation polymer of zinc based on chiral non-racemic trans-N, N'- bis-(2-hydroxy-l-naphthalidehydene)-(1R, 2R)-cyclohexa-nedia- mine: Synthesis, crystal structure, novel coordinational models and anticancer activity 显示文摘 | SHUANGYU BI AIDONG WANG CAIFENG BI | 2012 | Inorganic Chemistry Communica- tions2012，15，16： | 1 |
| 14 | Facile synthesis of fluorescent quantum dot-polymer nanocomposites via frontal polymerization显示文摘 | Juan Fang Li Chen CaiFeng Wang | 2010 | Journal of Polymer Science: Part A: Polymer Chemistry2010，48，： | 1 |
| 15 | Poly(ADP-ribose) polymerases regulate cell division and development in Arabidopsis roots显示文摘Root organogenesis involves cell division,differentiation and expansion. The molecular mechanisms regulating root development are not fully understood.In this study, we identified poly(adenosine diphosphate(ADP)-ribose) polymerases(PARPs) as new players in root development. PARP catalyzes poly(ADP-ribosyl)ation of proteins by repeatedly adding ADP-ribose units onto proteins using nicotinamide adenine dinucleotide(NADt)as the donor. We found that inhibition of PARP activities by3-aminobenzomide(3-AB) increased the growth rates of both primary and lateral roots, leading to a more developed root system. The double mutant of Arabidopsis PARPs, parp1parp2, showed more rapid primary and lateral root growth. Cyclin genes regulating G1-to-S and G2-to-Mtransition were up-regulated upon treatment by 3-AB.The proportion of 2C cells increased while cells with higher DNA ploidy declined in the roots of treated plants, resulting in an enlarged root meristematic zone. The expression level of PARP2 was very low in the meristematic zone but high in the maturation zone, consistent with a role of PARP in inhibiting mitosis and promoting cell differentiation. Our results suggest that PARPs play an important role in root development by negatively regulating root cell division. | Caifeng Liu Qiao Wu Weiwei Liu Zongyin Gu Wenjing Wang Ping Xu Hong Ma Xiaochun Ge | 2017 | Journal of Integrative Plant Biology2017，59，7： | 1 |
| 16 | Facile synthesis of N- vinylimidazole-based hydrogels via frontal polymerization and investigation of their performance on adsorption of cop per ions显示文摘 | J un Tu J in Zhou Caifeng Wang | 2010 | Journal of Polymer Science= Part A: Polymer Chemistry2010，79，： | 1 |
| 17 | A novel fiber-reinforced polyethylene composite with added silicon nitride particles for enhanced thermal conductivity显示文摘 | Wenying Zhou Caifeng Wang Tao Ai Ke Wu Fenjuan Zhao Hongzhi Gu | 2009 | Composites Part A2009，，6： | 1 |
| 18 | Responses and sensitivity of N, P and mobile carbohydrates of dominant species to increased water, N and P availability in semi- arid grasslands in northern China显示文摘Aims We aimed to improve the understanding of the carbon and nutri-ent physiological responses and adaptation of semi-arid grassland plants to environmental changes.Methods We investigated plant leaf non-structural carbohydrate(NSC=solu-ble sugars+starch),nitrogen(N)and phosphorus(P)levels in an Inner Mongolian semi-arid grassland community treated with water,N and P additions for 8 years.Two dominant grasses(Agropyron cris-tatum(L.)Gaertn.,Stipa krylovii Roshev.)and two forbs(Artemisia frigida Willd.,Potentilla bifurca L.)were analyzed.Important Findings Water addition decreased plant leaf N and P concentrations,whereas N and P addition increased them,indicating that the semi-arid grassland studied suffers from a shortage of N and P sup-ply.Both N and P addition decreased the levels of soluble sugars,starch and thus also NSC in plant leaves,which may be attributed to(i)increased carbohydrate consumption associated with a higher growth rate,and(ii)a dilution effect of greater plant size under N and P addition.Water addition tended to increase the leaf NSC levels both in the grasses(+9.2%)and forbs(+0.6%only),which may be a result of increased photosynthesis of plants with increased water availability.Under conditions of ambient and increased water supply in the present study,N addition resulted in an N/P ratio of>16 in the grasses but a significantly lower N/P ratio of<11 in the forb species.This finding implies that growth of the two grass spe-cies will be limited mainly by P availability but the forbs will still be mainly limited by N supply if N deposition,alone or in combination with summer precipitation,continues to increase as predicted in Inner Mongolia. | Xue Wang Zhuwen Xu Caifeng Yan Wentao Luo Ruzhen Wang Xingguo Han Yong Jiang Mai-He Li | 2017 | Journal of Plant Ecology2017，10，3： | 1 |
| 19 | Fast fabrication of superabsorbent polyampholytic nanocomposite hydrogels via plasma-Ignited frontal polymerization显示文摘 | Shao Huan Wang Caifeng Chen Su | 2014 | Polymer Chemistry2014，52，7： | 1 |
| 20 | Versatile den- drimer-derived nanocrystal microreactors towards fluorescence colloidal photonic crystals显示文摘 | Zhang Jing Ling Luting Wang Caifeng | 2014 | Journal of Materials Chemistry C2014，2，18： | 1 |
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