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| 1 | Antioxidant properties of magnesium lithospermate B contribute to the cardioprotection against myocardial ischemia/reperfusion injury in vivo and in vitro显示文摘OBJECTIVE: To determine the cardioprotective effect of magnesium lithospermate B (MLB) on myocardial ischemia/reperfusion (MI/R) injury and to investigate the antioxidant potential in vivo and in vitro. METHODS: MI/R injury was induced by the occlusion of left anterior descending coronary artery for 30 min followed by reperfusion for 3 h in rats. After reperfusion, hearts were harvested to assess infarct size, histopathological damages, the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and malondialdehyde (MDA). Blood samples were col- lected to determine serum levels of creatine kinase-MB (CK-MB), cardiac troponin (cTnI) and lactate dehydrogenase (LDH). Furthermore, simulatedischemia/reperfusion (SI/R) injury in vitro was established by oxygen and glucose deprivation (OGD) for 2 h followed by 24-hour recovery period in cardiomyocytes. The activity of LDH in the cultured supernatant and the levels of intracellular reactive oxygen species (ROS), SOD and MDA in cardiomyocytes were also measured. Finally, cardiomyocytes apoptosis was determined with flow cytometry. RESULTS: MLB significantly limited infarct size, ameliorated histopathological damages and prevented leakage of CK-MB, cTnI and LDH. Additionally, SOD, CAT, GPx and GSH activities were notably increased by MLB, along with the MDA content decreased as compared with the model group in rats. In vitro study, MLB also decreased LDH activity in the cultured supernatant, increased SOD activity in cardiomyocytes, reduced intracellular ROS and MDA levels, and significantly suppressed cardiomyocytes apoptosis. CONCLUSION: MLB possessed remarkably cardioprotective effects on MI/R injury in vivo and in vitro. The protection of MLB may contribute to its antioxidant properties. | Wei Quan Ying Yin Miaomiao Xi Dan Zhou Yanrong Zhu Yue Guan Chao Guo Yanhua Wang Jialin Duan Aidong Wen | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 21 |
| 2 | Construction and Expression of a Single Chain Antibody Mimicing Human Ovarian Cancer Antigen CA125显示文摘为癌症的有免疫力的治疗的一个概念包含抗原的正式就职模仿抗体对肿瘤房间触发有免疫力的反应。对为肿瘤抗原特定的抗体的抗原绑定地点指导的 Anti-idiotypic 抗体可以机能上地并且甚至在结构上模仿抗原并且导致 anti-anti-idiotypic 免疫者反应。Monoclonal 抗体 WJ02 是如此的 anti-idiotypic 抗体之一,它包含 CA125 的内部图象。以便改进 mAb WJ02 的 immunospecificity,我们在 Vl-linker-Vh 取向构造了 mAb WJ02 的单个链。scFv-WJ02 能在 recombinant Pichia pastoris 系统被表示并且藏匿。有 30 kD 的分子的重量的分泌 scFv 蛋白质保留了 mAb WJ02 的生物活动,它被直接有约束力的试金和抑制实验证明。我们的结果显示 scFv-WJ02 能对卵巢的癌症为 idiotypic 治疗被用作一个可能的工具,它可能提高消除 mAb WJ02 导致的 nonspecific 回答的可能性。 | Aidong Li Zheng Li Yinghong Wang Yongming Zhang Jie Ma | 2006 | Cellular & Molecular Immunology2006，3，1： | 5 |
| 3 | Thermal Behavior Investigation of LiNi1/3CO1/3Mn1/3O2-Based Li-ion Battery under Overcharged Test显示文摘它象隔板,电解质,阴极,阳极,和每个文件夹那样的部件的热行为被微分扫描热量测定和热 gravimetric (DSC/TG ) 调查在超载测试下面解释 Li 离子电池的热逃走的机制。DSC 结果显示了在阳极的层在大约 126 漠 ? 桴 ? 潢瑴敬的 SEI (稳固的电解质接口) 的分解反应温度吗? | Wang, Haiyan Tang, Aidong Huang, Kelong | 2011 | Chinese Journal of Chemistry2011，29，1： | 3 |
| 4 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 5 | Genetic diversity of wild barley (Hordeum vulgare ssp. spontaneum) and its utilization for barley improvement显示文摘Wild barley(Hordeum vulgare spp.spontaneum) is the undisputed progenitor of cultivated barley and offers considerable potential as a genetic resource for barley improvement.Naturally occurring populations are distributed primarily across the Fertile Crescent,but secondary areas of diversity are also found in central Asia and Tibet.The pattern of its genetic diversity is non-random,and is structured on a global,regional and local scale.On a global scale,diversity follows ecogeography,while on a regional and local scale,it is more strongly determined by ecology.Populations growing in areas where the climate is unreliable and/or the soil is heterogeneous tend to retain the most diversity.A large number of accessions are currently conserved ex situ,but a high proportion of these have originated from the Fertile Crescent.Given the likelihood of future climate change,conserving germplasm both in situ and ex situ in the various regions where the species' currently existing is a research priority.The value of H.vulgare spp.spontaneum for the improvement of cultivated barley lies largely in its potential contribution to the levels of attainable pathogen resistance and abiotic stress tolerance. | XiaoYing Ma Chao Li AiDong Wang RuiJun Duan GenLin Jiao Eviatar Nevo GuoXiong Chen | 2012 | Research in Cold and Arid Regions2012，4，6： | 2 |
| 6 | Upcycling of phosphogypsum waste for efficient zinc-ion batteries显示文摘Zinc metal is a promising anode material for next-generation aqueous batteries,but its practical application is limited by the formation of zinc dendrite.To prevent zinc dendrite growth,various Zn^(2+)-conducting but water-isolating solid-electrolyte interphase(SEI)films have been developed,however,the required high-purity chemical materials are extremely expensive.In this work,phosphogypsum(PG),an industrial byproduct produced from the phosphoric acid industry,is employed as a multifunctional protective layer to navigate uniform zinc deposition.Theoretical and experimental results demonstrate that PG-derived CaSO_(4)2H_(2)O can act as an artificial SEI layer to provide fast channels for Zn^(2+)transport.Moreover,CaSO_(4)2H_(2)O could release calcium ions(Ca^(2+))due to its relatively high Kspvalue,which have a higher binding energy than that of Zn^(2+)on the Zn surface,thus preferentially adsorbing to the tips of the protuberances to force zinc ions to nucleate at inert region.As a result,the Zn@PG anode achieves a high Coulombic efficiency of 99.5%during 500 cycles and long-time stability over 1000 hours at 1 m A cm^(-2).Our findings will not only construct a low-cost artificial SEI film for practical metal batteries,but also achieve a high-value utilization of phosphogypsum waste. | Huanwen Wang Can Luo Yinyin Qian Caihong Yang Xiaojun Shi Yansheng Gong Rui Wang Beibei He Jun Jin Aidong Tang Edison Huixiang Ang Huaming Yang | 2023 | Journal of Energy Chemistry2023，，6： | 1 |
| 7 | Uniform A1F3 thin layer to improve rate capability of LiNil/3COl/3Mnl/3 02 material {or Li-ion batteries显示文摘 | Wang Haiyan Tang Aidong Huang Kelong | 2010 | Trans Nonferrous Met Soc China2010，20，5： | 1 |
| 8 | Extracting semantic concepts from images: a decisive feature pattern mining approach显示文摘 | WANG WEI ZHANG AIDONG | 2006 | Multimedea Systems2006，11，4： | 1 |
| 9 | Animal stem cells: the engineering development front of 2018显示文摘The Engineering Fronts reports are important guidelines for the future development directions of engineering science and technology. The Chinese Academy of Engineering (CAE) has been conducting studies relevant to Engineering Fronts for two years since 2017. | Wenye YUAN Jianxiang XU Chenying LI Lijuan SHI Aidong YANG Yan WANG Lu XING Shaozhong KANG | 2019 | Frontiers of Agricultural Science and Engineering2019，6，1： | 1 |
| 10 | Coordi- nation polymer of zinc based on chiral non-racemic trans-N, N'- bis-(2-hydroxy-l-naphthalidehydene)-(1R, 2R)-cyclohexa-nedia- mine: Synthesis, crystal structure, novel coordinational models and anticancer activity 显示文摘 | SHUANGYU BI AIDONG WANG CAIFENG BI | 2012 | Inorganic Chemistry Communica- tions2012，15，16： | 1 |
| 11 | Ultrastructure of human neural stem/progenitor cells and neurospheres显示文摘BACKGROUND:Biological and morphological characteristics of neural stem/progenitor cells (NSPCs) have been widely investigated. OBJECTIVE:To explore the ultrastructure of human embryo-derived NSPCs and neurospheres cultivated in vitro using electron microscopy. DESIGN,TIME AND SETTING:A cell biology experiment was performed at the Brain Tumor Laboratory of Soochow University,and Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University between August 2007 and April 2008. MATERIALS:Human fetal brain tissue was obtained from an 8-week-old aborted fetus;serum-free Dulbecco's modified Eagle's medium/F_(12) culture medium was provided by Gibco,USA;scanning electron microscope was provided by Hitachi Instruments,Japan;transmission electron microscope was provided by JEOL,Japan. METHODS:NSPCs were isolated from human fetal brain tissue and cultivated in serum-free Dulbecco's modified Eagle's medium/F_(12) culture medium.Cells were passaged every 5-7 days. After three passages,NSPCs were harvested and used for ultrastructural examination. MAIN OUTCOME MEASURES:Ultrastructural examination of human NSPCs and adjacent cells in neurospheres. RESULTS:Individual NSPCs were visible as spherical morphologies with rough surfaces under scanning electron microscope.Generally,they had large nuclei and little cytoplasm.Nuclei were frequently globular with large amounts of euchromatin and a small quantity of heterochromatin,and most NSPCs had only one nucleolus.The Golgi apparatus and endoplasmic reticulum were underdeveloped;however,autophagosomes were clearly visible.The neurospheres were made up of NSPCs and non-fixiform material inside.Between adjacent cells and at the cytoplasmic surface of apposed plasma membranes,there were vesicle-like structures.Some membrane boundaries with high permeabilities were observed between some contiguous NSPCs in neurospheres,possibly attributable to plasmalemmal fusion between adjacent cells. CONCLUSION:A large number of autophagosomes were observed in NSPCs and gap junctions were visible between adjacent NSPCs. | Yaodong Zhao Tianyi Zhang Qiang Huang Aidong Wang Jun Dong Qing Lan Zhenghong Qin | 2009 | Neural Regeneration Research2009，4，5： | 1 |
| 12 | U- niform AIF3 thin layer to improve rate capability of LiNi1/3Co1/3M1/3 02 material for Li-ion batteries显示文摘 | Wang haiyan Tang Aidong Huang Kelong | 2010 | Tram Nonferrous Met Soc China2010，20，： | 1 |
| 13 | Molecular Study on Differentiation-Associated Genes Involved in Both Malignant Progression of Glioma and Differentiation of Human Fetal Neural Stem Cells显示文摘OBJECTIVE It is unclear whether differentiation disturbances or deregulation of neural stem cells (NSCs) are the early key steps for gliomagenesis and tumor development. Furthermore, relevant molecular changes and gene-regulation pathways are unknown. This study focused on screening and validating differentiation-associated genes from both human NSCs and glioma cells with malignant progression, for the purpose of offering an experimental basis for the cellular origin of gilomas and molecular pathology of gliomagenesis. METHODS The differential-gene expression profiles of malignant progression of gliomas were established, then the differentiation related genes were screened out with a bioinformatics analysis. Expression levels of these genes was further analyzed in cultured human fetal NSCs undergoing differentiation processes with a semi-quantitative RT-PCR assay. RESULTS Eight genes were screened out from the gene-expression profiling of which the expression levels were associated with the differentiation processes of NSCs, namely CXCR4, TN-C, GLT1, IL1-RI, EGFR-8, CDC2, Ndr3 and MAPKK4. Three of them, ie., GLT1, CDC2 and MAPKK4, were further analyzed, showing that expression levels decreased with the differentiation processes of NSCs, and increased with the malignant progression of ganglioglioma. CONCLUSION Three differentiation associated genes were found negatively associated with NSCs differentiation and positively associated with malignant progression of gliomas, suggesting that differentiation disturbances of neural stem cells may be involved in oncogenesis, and that further studies on their roles in gliomagenesis should be conducted. | Jun Dong Yinyan Wu Qiang Huang Fei Wang Aidong Wong Qing Lan | 2006 | Chinese Journal of Clinical Oncology2006，3，6： | 1 |
| 14 | Clinical characteristics of 78 patients with pulmonary tubercu- losis complicated by chronic pulmonary heart disease and analysis of the clinical character- istics of 显示文摘 | Wang Ting Xu Aidong | 2014 | for Chinese modern pharmaceutical applications2014，13，： | 1 |
| 15 | Baseline susceptibility of the diamondback moth ( Lepidoptera: Plutellidae) to chlorantraniliprole in China显示文摘 | Wang Xingliang Li Xingyong Shen Aidong | 2010 | J Econ Entomol2010，103，3： | 1 |
| 16 | Cepharanthine, an Alkaloid from Stephania cepharantha Hayata, Inhibits the Inflammatory Response in the RAW264.7 Cell and Mouse Models显示文摘 | Hailong Huang Guixue Hu Chunfeng Wang Hao Xu Xiaoqing Chen Aidong Qian | 2014 | Inflammation2014，，1： | 1 |
| 17 | Research on Financial Targets Sequence of Impacting on Business Value—— Based on Data Analysis from Chinese High-tech Listed Firms of Unmodified Auditing Opinions显示文摘 | Aidong Liu He Wang | 2004 | Chinese Business Review2004，3，7： | 1 |
| 18 | Synthesis, Characterization and Antibacterial Activity of New Ln(Ⅲ) Complexes with an Unsymmetrical Schiff Base Ligand显示文摘A new unsymmetrical Schiff base ligand (H2LLi) was synthesized using L-lysine, salicylaldehyde and 2-hydroxy-1-naphthaldehyde. Three solid metal complexes of this ligand \[Ln(H2L)(NO3)\] NO3·2H2O (Ln=La, Sm, Ho) have been prepared and characterized by elemental analyses, IR spectra, UV spectra, TG-DTG and molar conductance. The antibacterial activities of the ligand and its complexes are also studied. The antibacterial experiments indicate that the ligand and its complexes possess antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis and that the complexes have higher activity than those of the ligand. | BI Caifeng YAN Liangliang FAN Yuhua ZHANG Xia WANG Aidong | 2006 | Journal of Ocean University of China2006，5，3： | 1 |
| 19 | Haploidentical hematopoietic stem cell transplantation may improve long-term survival for children with high-risk T-cell acute lymphoblastic leukemia in first complete remission显示文摘Background: The role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children with high-risk (HR) T-cell acute lymphoblastic leukemia (T-ALL) in first complete remission (CR1) is still under evaluation. Moreover, relapse is the main factor affecting survival. This study aimed to explore the effect of allo-HSCT (especially haploidentical HSCT [haplo-HSCT]) on improving survival and reducing relapse for HR childhood T-ALL in CR1 and the prognostic factors of childhood T-ALL in order to identify who could benefit from HSCT.Methods: A total of 74 newly diagnosed pediatric T-ALL patients between January 1, 2012 and June 30, 2018 were enrolled in this retrospective study. Patients were stratified into the low-risk chemotherapy cohort (n = 16), HR chemotherapy cohort (n = 31), and HR transplant cohort (n = 27). Characteristics, survival outcomes, and prognostic factors of all patients were then analyzed.Results: Patient prognosis in the HR chemotherapy cohort was significantly worse than that in the low-risk chemotherapy cohort (5-year overall survival [OS]: 58.5%vs. 100%,P = 0.003;5-year event-free survival [EFS]: 54.1%vs. 83.4%,P = 0.010;5-year cumulative incidence of relapse [CIR]: 45.2%vs. 6.3%,P = 0.011). In HR patients, allo-HSCT improved the 5-year EFS and CIR compared to that of chemotherapy (5-year EFS: 80.1%vs. 54.1%,P = 0.041;5-year CIR: 11.6%vs. 45.2%,P = 0.006). The 5-year OS was higher in the HR transplant cohort than that in the HR chemotherapy cohort (81.0%vs. 58.5%,P = 0.084). Minimal residual disease re-emergence was an independent risk factor for 5-year OS, EFS, and CIR;age ≥10 years was an independent risk factor for OS and EFS;and high white blood cell count was an independent risk factor for EFS and CIR.Conclusion: Allo-HSCT, especially haplo-HSCT, could effectively reduce relapse of children with HR T-ALL in CR1. | Zhang Yongzhan Bai Lu Cheng Yifei Lu Aidong Wang Yu Wu Jun Zhang Xiaohui Zuo Yingxi Xu Lanping Jia Yueping Huang Xiaojun Zhang Leping | 2022 | Chinese Medical Journal2022，，8： | 1 |
| 20 | Baseline susceptibility of the diamondback moth (Lepidoptera: Plutelli- dae) to chlorantraniliprole in China显示文摘 | Wang Xinling Li Xiangyong Shen Aidong | 2010 | Journal of Economic Entomology2010，103，： | 1 |
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