|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Serum vitamin D and colonic vitamin D receptor in inflammatory bowel disease显示文摘AIM: To determine serum vitamin D levels and colonic vitamin D receptor(VDR) expression in inflammatory bowel disease(IBD) and non-IBD patients and correlate these with histopathology.METHODS: Puerto Rican IBD(n = 10) and non-IBD(n = 10) patients ≥ 21 years old scheduled for colonoscopy were recruited. Each patient completed a questionnaire and provided a serum sample and a colonic biopsy of normal-appearing mucosa. For IBD patients, an additional biopsy was collected from visually diseased mucosa. Serum vitamin D levels were measured by ultra-performance liquid chromatography and mass spectrometry. Hematoxylin and eosin stained tissue sections from colonic biopsies were classified histologically as normal or colitis(active/inactive), and scored for the degree of inflammation present(0-3, inactive/absent to severe). Tissue sections from colonic biopsies were also stained by immunohistochemistry for VDR, for which representative diagnostic areas were photographed and scored for staining intensity using a 4-point scale.RESULTS: The IBD cohort was significantly younger(40.40 ± 5.27, P < 0.05) than the non-IBD cohort(56.70 ± 1.64) with a higher prevalence of vitamin D deficiency(40% vs 20%, respectively) and insufficiency(70% vs 50%, respectively). Histologic inflammation was significantly higher in visually diseased mucosa from IBD patients(1.95 ± 0.25) than in normalappearing mucosa from control patients(0.25 ± 0.08, P < 0.01) and from IBD patients(0.65 ± 0.36, P < 0.05) and correlated inversely with VDR expression in visually diseased colonic tissue from IBD patients(r =-0.44, P < 0.05) and from IBD patients with Crohn's disease(r =-0.69, P < 0.05), but not in normal-appearing colonic tissue from control patients or IBD patients. Control and IBD patient serum vitamin D levels correlated positively with VDR expression in normal colon from control and IBD patients(r = 0.38, P < 0.05) and with patient age(r = 0.54, P < 0.01). CONCLUSION: Levels of serum vitamin D correlate positively with colonic VDR expression in visually normal mucosa whereas inflammation correlates negatively with colonic VDR expression in visually diseased mucosa in Puerto Rican patients. | Yamilka Abreu-Delgado Raymond A Isidro Esther A Torres Alexandra González Myrella L Cruz Angel A Isidro Carmen I González-Keelan Priscilla Medero Caroline B Appleyard | 2016 | World Journal of Gastroenterology2016，22，13： | 5 |
| 2 | MLtraviolet resonance Raman study of the avidin biotin complex 显示文摘 | John Clarkson Caroline Sudworth Sergiu I Masca | 2000 | Raman Spectrosc2000，31，5： | 1 |
| 3 | Rapid DNA extraction for specific detection and quantitation of Mycobacterium tuberculosis DNA in sputum specimens using taqman assays显示文摘 | Diana I Gomez Caroline S | 2011 | Tuberculosis (Edinb)2011，911，： | 1 |
| 4 | Polyactones:31,Sn (Ⅱ)Octoate-initiated Polymerization of L-lactide:A Mechanistic Study显示文摘 | KRICHELDORF I CAROLINE B | 1995 | Polymer1995，6，36： | 1 |
| 5 | Re- duction of Indicator and Pathogenic Microorgan- ismsby Psychrophilic Anaerobic Digestion in Swine Slurries显示文摘 | Caroline C6te Daniel I Mass6 Sylvain Quessy | 2006 | Bioresource Technology2006，97，4： | 1 |
| 6 | Integrated Control of Clubroot显示文摘 | Caroline Donald I P | 2009 | Plant Growth Regul2009，28，： | 1 |
| 7 | How surface fire in Siberian Scots pine forests affects soil organic carbon in the forest floor:Stocks,molecular structure,and conversion to black carbon (charcoal)显示文摘 | Claudia I Czimczik Caroline M | 2003 | Global Biogeochemical Cycles2003，17，1： | 1 |
| 8 | Animal models for porphyromonas gingivalis mediated periodontal disease 显示文摘 | I CAROLINE A GENCO R J THOMASH V D | 1998 | Trends in Microbiology1998，6，11： | 1 |
| 9 | Serum paraoxonase activity, concentration, and phenotype distribution in diabetes mellitus and its relationship to serum fipids and lipoproteins 显示文摘 | ABBOTT M I CAROLINE A ANDRE W J | 1995 | Arteriosclerosis Thrombosis & Vascular Biology1995，15，11： | 1 |
| 10 | Expression of Haemonchus contortus pepsinogen in Caenorhabditis elegans显示文摘 | Caroline C Johnstone I L | 2001 | Molecul Biochemical Parasitol2001，112，： | 1 |
| 11 | Serum paraoxonaseactivity concentration and phenotype distribution in diabetes mellitus andits relationship to serum lipids and lipoproteins显示文摘 | Caroline A Abbott M I Andrew J | 1996 | Arterioscler ThrombVasc Biol1996，15，： | 1 |
| 12 | Imaging modalities in high-grade gliomas: pseudoprogression, recurrence, or necrosis 显示文摘 | Caroline I Rosenthal MA | 2012 | J Clin Neurosci2012，19，： | 1 |
| 13 | Effect of Single Oral Doses of Sitagliptin, a Dipeptidyl Peptidase-4 Inhibitor, on Incretin and Plasma Glucose Levels after an Oral Glucose Tolerance Test in Patients with Type 2 Diabetes显示文摘 | Gary A. Herman Arthur Bergman Catherine Stevens Paul Kotey Bingming Yi Peng Zhao Bruno Dietrich George Golor Andreas Schrodter Bart Keymeulen Kenneth C. Lasseter Mark S. Kipnes Karen Snyder Deborah Hilliard Michael Tanen Caroline Cilissen Marina De Smet I | 2006 | The Journal of Clinical Endocrinology & Metabolism2006，，11： | 1 |
| 14 | Determination and influence of the main parameters for the launch and recovery of an unmanned underwater vehicle from a submarine 显示文摘 | Denis Chapuis C F Etat-Major de la Marine Caroline Dehhetl T H Didier Leandri I C N CTSN/DLSM | 1996 | IEEE1996，，： | 1 |
| 15 | The synthetic rock mass approach for jointed rock mass modelling显示文摘 | DIEGO I MATTHEW P CAROLINE D | 2011 | International Joumal of Rock Mechanics and Mining Sciences2011，48，2： | 1 |
| 16 | Imaging modalities in high grade glio- ma : pseudoprogression, recurrence or necrosis显示文摘 | Caroline I Rosenthal MA | 2012 | J Clin Neurosci2012，19，5： | 1 |
| 17 | Women's perspective of maternity care in Cambodia 显示文摘 | 1%nndara I Dawson A Caroline S | 2011 | Women Birth2011，26，1： | 1 |
| 18 | Detection and identification of mycobacterium tuberculosis directly from sputum sediments by amplification of mRNA显示文摘 | Caroline A K Martha J A Janis I C | 1993 | J Clin Microbid1993，31，9： | 1 |
| 19 | Mathematical modeling and simulation of inulinase adsorption in expanded bed column 显示文摘 | Caroline C M Marcio A M Maria I R | 2009 | J Chromatogr A2009，1216，： | 1 |
| 20 | Factors That Influence Tax Avoidance in Indonesia Stock Exchange显示文摘 | Yuniarwati I Cenik Ardana Sofia Prima Dewi Caroline Lin | 2017 | Chinese Business Review2017，16，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员