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| 1 | Cyclin A2:At the crossroads of cell cycle and cell invasion显示文摘Cyclin A2 is an essential regulator of the cell division cycle through the activation of kinases that participate to the regulation of S phase as well as the mitotic entry. However,whereas its degradation by the proteasome in mid mitosis was thought to be essential for mitosis to proceed,recent observations show that a small fraction of cyclin A2 persists beyond metaphase and is degraded by autophagy. Its implication in the control of cytoskeletal dynamics and cell movement has unveiled its role in the modulation of Rho A activity. Since this GTPase is involved in both cell rounding early in mitosis and later,in the formation of the cleavage furrow,this suggests that cyclin A2 is a novel actor in cytokinesis. Taken together,these data point to this cyclin as a potential mediator of cell-niche interactions whose dysregulation could be taken as a hallmark of metastasis. | Abdelhalim Loukil Caroline T Cheung Nawal Bendris Bénédicte Lemmers Marion Peter Jean Marie Blanchard | 2015 | World Journal of Biological Chemistry2015，6，4： | 6 |
| 2 | Possible role of Cdx2 in the serrated pathway of colorectal cancer characterized by BRAF mutation, high‐level CpG Island methylator phenotype and mismatch repair‐deficiency显示文摘 | Heather Dawson José A. Galván Melina Helbling Dominique‐Elisabeth Muller Eva Karamitopoulou Viktor H. Koelzer Mary Economou Caroline Hammer Alessandro Lugli Inti Zlobec | 2014 | Int. J. Cancer2014，，10： | 2 |
| 3 | A comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia显示文摘This is a retrospective cohort study comparing blastocyst transfer outcomes following intracytoplasmic sperm injection utilizing epididymal versus testicular sperm for men with obstructive azoospermia.All cases at a single center between 2012 and 2016 were included.Operative approach was selected at the surgeon’s discretion and included microepididymal sperm aspiration or testicular sperm extraction.Blastocyst culture was exclusively utilized prior to transfer.The primary outcome was live birth rate.Secondary outcomes included fertilization rate,blastulation rate,euploidy rate,and implantation rate.A mixed effects model was performed.Seventy-six microepididymal sperm aspiration cases and 93 testicular sperm extraction cases were analyzed.The live birth rate was equivalent(48.6%vs 50.5%,P=0.77).However,on mixed effects model,epididymal sperm resulted in a greater likelihood of fertilization(adjusted OR:1.37,95%CI:1.05–1.81,P=0.02)and produced a higher blastulation rate(adjusted OR:1.41,95%CI:1.1–1.85,P=0.01).As a result,the epididymal sperm group had more supernumerary blastocysts available(4.3 vs 3,P<0.05).The euploidy rate was no different.Pregnancy rates were no different through the first transfer cycle.However,intracytoplasmic sperm injection following microepididymal sperm aspiration resulted in a greater number of usable blastocysts per patient.Thus,the true benefit of epididymal sperm may only be demonstrated via a comparison of cumulative pregnancy rates after multiple transfers from one cohort. | Scott J Morin Brent M Hanson Caroline R Juneau Shelby A Neal Jessica N Landis Richard T Scott Jr James M Hotaling | 2020 | Asian Journal of Andrology2020，22，2： | 2 |
| 4 | Erlotinib inhibits progression to dysplasia in a colitis-associated colon cancer model显示文摘AIM:To investigate the role of epidermal growth factor receptor(EGFR) in colitis-associated dysplasia using the EGFR tyrosine kinase inhibitor erlotinib.METHODS:Sprague-Dawley rats received trinitrobenzene sulfonic acid(TNBS;30 mg in 50% ethanol,ic),followed 6 wk later by reactivation with TNBS(5 mg/kg,iv) for 3 d.To induce colitis-associated dysplasia,rats then received TNBS(iv) twice a week for 10 wk.One group received erlotinib(10 mg/kg,ip) for 1 wk before the start of the reactivation of the colitis and 2 wk after(21 d);the rest received the vehicle.After rats were euthanized,the colons were removed and analyzed for damage and expression of the EGFR downstream effectors Erk1/2 and c-Myc.RESULTS:Ninety percent of the vehicle-treated animals had dysplasia in any region of the colon.Erlotinib-treated animals had a significant decrease in the incidence of dysplasia compared to vehicle-treated animals in all regions of the colon(50.00% ± 11.47% vs 90.00% ± 10.00% in proximal,P < 0.05;15.00% ± 8.19% vs 50.00% ± 16.67% in mid,P < 0.05;and 20.00% ± 9.17% vs 70.00% ± 15.28% in distal,P < 0.01).Erlotinib-treated animals also had reduced cell proliferation,reduced active Erk1/2,and reduced c-Myc in colon epithelium compared with the vehicle-treated animals.In vitro,erlotinib treatment was shown to markedly decrease c-Myc and pErk1/2 levels in rat epithelial cells.Proliferation of rat epithelial cells was stimulated by epidermal growth factor and inhibited by erlotinib(P < 0.05).CONCLUSION:Erlotinib can decrease the development of colitis-associated dysplasia,suggesting a potential therapeutic use for erlotinib in patients with long-standing colitis. | Beatriz Pagán Angel A Isidro Myrella L Cruz Domenico Coppola Caroline B Appleyard | 2011 | World Journal of Gastroenterology2011，17，44： | 1 |
| 5 | The intra-and inter-la- boratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro : results of a ring- study in five laboratories显示文摘 | Andreas N Caroline B Leslie F | 2011 | Toxicol In Vitro2011，25，3： | 1 |
| 6 | Success factors for sustainable urban brownfield development显示文摘 | Peter N Caroline A Rodenburg | 2002 | Ecological Economics2002，40，： | 1 |
| 7 | Mycoplasma ovipneu- moniae can predispose bighorn sheep to fatal Mannheimia hae- molytica pneumonia 显示文摘 | Rohana P Sudarvili Caroline N | 2010 | Veterinary Microbiology2010，145，3： | 1 |
| 8 | Long distance running increases plantar pressures beneath the metatarsal heads: A barefoot walking investigation of 200 marathon runners显示文摘 | Arne N Frauke F Carolin K | 2008 | Gait Posture2008，27，1： | 1 |
| 9 | Patient satisfaction after MRCP and ERCP显示文摘 | Krishna Menon Alan N Barkun Joseph Romagnuolo Gad Friedman Shailesh N Mehta Caroline Reinhold Patrice M Bret | 2001 | The American Journal of Gastroenterology2001，，9： | 1 |
| 10 | A Meta-Analysis of Pedometer-Based Walking Interventions and Weight Loss显示文摘 | Caroline R R Tiffany L N Jobby J A | 2008 | Annals of Family Medicine2008，6，： | 1 |
| 11 | Dry coating in a rotary fluid bed显示文摘 | CAROLINE D K KIM H URBANETZ N A | 2006 | Eur J Pharm Sci2006，27，23： | 1 |
| 12 | Cyclin A2, a novel regulator of EMT显示文摘 | Nawal Bendris Caroline T. Cheung Hon Sing Leong John D. Lewis Ann F. Chambers Jean Marie Blanchard Bénédicte Lemmers | 2014 | Cellular and Molecular Life Sciences2014，，24： | 1 |
| 13 | Cyclin A2: a genuine cell cycle regulator?显示文摘 | Nawal Bendris Abdelhalim Loukil Caroline Cheung Nikola Arsic Cosette Rebouissou Robert Hipskind Marion Peter Bénédicte Lemmers Jean Marie Blanchard | 2012 | BioMolecular Concepts2012，，6： | 1 |
| 14 | Protein oxidation in muscle foods A review 显示文摘 | Marianne N L Marina H Caroline P B | 2011 | Mol Nutr Food Res2011，55，： | 1 |
| 15 | Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice显示文摘 | Sonveaux Pierre Végran Frédérique Schroeder Thies Wergin Melanie C Verrax Julien Rabbani Zahid N De Saedeleer Christophe J Kennedy Kelly M Diepart Caroline Jordan Bénédicte F Kelley Michael J Gallez Bernard Wahl Miriam L Feron Olivier Dewhir | 2008 | Journal of Clinical Investigation2008，，12： | 1 |
| 16 | Rapid DNA extraction for specific detection and quantitation of Mycobacterium tuberculosis DNA in sputum specimens using Taqman assays显示文摘 | Diana I. Gomez Caroline S. Mullin Francisco Mora-Guzmán J. Gonzalo Crespo-Solis Susan P. Fisher-Hoch Joseph B. McCormick Blanca I. Restrepo | 2011 | Tuberculosis2011，，： | 1 |
| 17 | Intralaboratory valida- tion of four in vitro assays for the prediction of the skin sensitizing potential of chemicals显示文摘 | Caroline B Susanne N K Eric F | 2011 | Toxicol In Vitro2011，25，： | 1 |
| 18 | Mycoplasma ovipneumoniae can predispose bighorn sheep to fatal Mannheimia haemolytica pneumonia显示文摘 | Rohana P Sudarvili Caroline N | | 0，，： | 1 |
| 19 | Colonization of the meat extracellular matrix proteins by O157 and non - O157 Entero- hemorrhagic Escherichia coli 显示文摘 | CAROLINE C CACCIA N LOUKIADIS E | 2014 | Int J Food M icrobiol2014，，188： | 1 |
| 20 | High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy显示文摘BACKGROUND Liver transplantation(LT)presents a curative treatment option in patients with early stage hepatocellular carcinoma(HCC)who are not eligible for resection or ablation therapy.Due to a risk of up 30%for waitlist drop-out upon tumor progression,bridging therapies are used to halt tumor growth.Transarterial chemoembolization(TACE)and less commonly stereotactic body radiation therapy(SBRT)or a combination of TACE and SBRT,are used as bridging therapies in LT.However,it remains unclear if one of those treatment options is superior.The analysis of explant livers after transplantation provides the unique opportunity to investigate treatment response by histopathology.AIM To analyze histopathological response to a combination of TACE and SBRT in HCC in comparison to TACE or SBRT alone.METHODS In this multicenter retrospective study,27 patients who received liver transplantation for HCC were analyzed.Patients received either TACE or SBRT alone,or a combination of TACE and SBRT as bridging therapy to liver transplantation.Liver explants of all patients who received at least one TACE and/or SBRT were analyzed for the presence of residual vital tumor tissue by histopathology to assess differences in treatment response to bridging therapies.Statistical analysis was performed using Fisher-Freeman-Halton exact test,Kruskal-Wallis and Mann-Whitney-U tests.RESULTS Fourteen patients received TACE only,four patients SBRT only,and nine patients a combination therapy of TACE and SBRT.There were no significant differences between groups regarding age,sex,etiology of underlying liver disease or number and size of tumor lesions.Strikingly,analysis of liver explants revealed that almost all patients in the TACE and SBRT combination group(8/9,89%)showed no residual vital tumor tissue by histopathology,whereas TACE or SBRT alone resulted in significantly lower rates of complete histopathological response(0/14,0%and 1/4,25%,respectively,P value<0.001).CONCLUSION Our data suggests that a combination of TACE and SBRT increases the rate of complete histopathological response compared to TACE or SBRT alone in bridging to liver transplantation. | Ulrike Bauer Sabine Gerum Falk Roeder Stefan Münch Stephanie E Combs Alexander B Philipp Enrico N De Toni Martha M Kirstein Arndt Vogel Carolin Mogler Bernhard Haller Jens Neumann Rickmer F Braren Marcus R Makowski Philipp Paprottka Markus Guba Fabian Geisler Roland M Schmid Andreas Umgelter Ursula Ehmer | 2021 | World Journal of Gastroenterology2021，27，24： | 1 |
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