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| 1 | 2,3-Diaryl-3H-imidazo[4,5-b]pyridine derivatives as potential anticancer and anti-inflammatory agents显示文摘In this study we examined the suitability of the 3H-imidazo[4,5-b]pyridine ring system in developing novel anticancer and anti-inflammatory agents incorporating a diaryl pharmacophore. Eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives retrieved from our in-house database were evaluated for their cytotoxic activity against nine cancer cell lines. The results indicated that the compounds showed moderate cytotoxic activity against MCF-7, MDA-MB-468, K562 and SaOS2 cells, with K562 being the most sensitive among the four cancer cell lines. The eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives were also evaluated for their COX-1 and COX-2 inhibitory activity in vitro. The results showed that compound 3f exhibited 2-fold selectivity with IC_(50) values of 9.2 and 21.8 mmol/L against COX-2 and COX-1, respectively. Molecular docking studies on the most active compound 3f revealed a binding mode similar to that of celecoxib in the active site of the COX-2 enzyme. | Erin Marie Kirwen Tarun Batra Chandrabose Karthikeyan Girdhar Singh Deora Vandana Rathore Chaitanya Mulakayala Naveen Mulakayala Amy Catherine Nusbaum Joel Chen Haneen Amawi Kyle Mc Intosh Sahabjada Neelam Shivnath Deepak Chowarsia Nisha Sharma Md Arshad Piyush Trivedi Amit KTiwari | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 3 |
| 2 | Design, synthesis and bio- logical evaluation of novel arylidinemalononitrile deriv- atives as non - carboxylic inhibitors of protein tyrosine phosphatase 1B 显示文摘 | Girdhar Singh Deora Chandrabose Karthikeyan Hari Narayana Moorthy N S | 2013 | Med Chem Res2013，22，： | 1 |
| 3 | Iron phosphonium combination tanning:towards a win-win approach显示文摘 | Fathima NN Chandrabose M Aravindhan R | 2005 | Am Leather Chem Assoc2005，100，： | 1 |
| 4 | Hepatitis B orheptitis C con-infection in individuals infected with humanimmunodeficieney virus and effect of anti-tuberculosis drugs onliver function显示文摘 | Padmapriyadarsini C Chandrabose J Victor L et a1 | 2006 | Postgrad Med2006，52，： | 1 |
| 5 | Iron-Phosphonium Combination Tanning: Towards a Win-Win Approach显示文摘 | Fathirna N Nishad Chandrabose M Aravindhan R | 2005 | Journal of the American Leather Chemists Association2005，，100： | 1 |
| 6 | Molecular assessment of c-H-ras p21 expression in Helicobacter pylori -mediated gastric carcinogenesis显示文摘 | Chandrabose Sureka Thiyagarajan Ramesh | 2012 | Molecular and Cellular Biochemistry2012，，1： | 1 |
| 7 | Enhancement of current density using effective membranes electrode assemblies for water electrolyser system显示文摘The goal of this study was to develop and design a composite proton exchange membrane(PEM) and membrane electrode assembly(MEA) that are suitable for the PEM based water electrolysis system. In particular,it focuses on the development of sulphonated polyether ether ketone(SPEEK) based membranes and caesium salt of silico-tungstic acid(Cs Si WA) matrix compared with one of the transition metal oxides such as titanium dioxide(TiO_2), silicon dioxide(SiO_2) and zirconium dioxide(ZrO_2). The resultant membranes have been characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, ion exchange capacity(IEC), water uptake and atomic force microscopy. Comparative studies on the performance of MEAs were also conducted utilizing impregnation-reduction and conventional brush coating methods. The PEM electrolysis performance of SPEEK-Cs Si WA-ZrO_2 composite membrane was more superior than that of other membranes involved in this study. Electrochemical characterization shows that a maximum current density of 1.4 A/cm^2 was achieved at 60 °C, explained by an increased concentration of protonic sites available at the interface. | Swaminathan Seetharaman Subash Chandrabose Raghu Kambiz Ansari Mahabadi | 2016 | Journal of Energy Chemistry2016，25，1： | 1 |
| 8 | Iron-Phosphonium Combination Tanning: Towards a Win-Win Approach显示文摘 | Fathima N Nishad Chandrabose M Aravindhan R | 2005 | Journal of the American Leather Chemists Association2005，100，： | 1 |
| 9 | The Promise of Human Induced Pluripotent Stem Cells in Dental Research显示文摘 | Thekkeparambil Chandrabose Srijaya Padmaja Jayaprasad Pradeep Rosnah Binti Zain Sabri Musa Noor Hayaty Abu Kasim Vijayendran Govindasamy Rajarshi Pal | 2012 | Stem Cells International2012，，： | 1 |
| 10 | High energy density aqueous electrochemical capacitors with a KI-KOH electrolyte显示文摘 | Wang X Chandrabose R S Chun S E | 2015 | ACS Applied Materials&Interfaces2015，7，19： | 1 |
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