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| 1 | Response of runoff in the headwater region of the Yellow River to climate change and its sensitivity analysis显示文摘在到气候变化和它的敏感的黄河的 headwater 区域的流量的反应在时期期间在四个水文学车站和十个气象站基于测量数据被分析 19592008。结果显示在这个区域的温度的那个变化与全球温暖和在在这个区域的每个分区的温度一直在介绍的年度一般水准的变化有一种明显的相应关系过去的 50 年里的一个变动、升起的状态。因为不同地理位置和环境的影响,然而,降水的变化在总体上生产流量的区域一直在介绍的年度降水的各种各样的区域,和变化是比在这个区域的温度的变化更复杂的过去的 50 年里的一个变动、减少的状态。并且在这个区域在流量和降水和温度之间有一种显著非线性的相互关系。因为,自从 1990,在这个区域的流量连续地一直在减少降水总体上生产流量的区域显然减少,年度平均温度连续地升起。总体上,当在在 Jimai 上面的分区的流量相应地在在这个区域的其它比那对温度变化更敏感时,在黄河的 headwater 区域的每个分区的流量对降水变化相当敏感。 | LAN Yongchao ZHAO Guohui ZHANG Yaonan WEN Jun HU Xinglin LIU Jinqi GU Minglin CHANG Junjie MA Jianhua | 2010 | Journal of Geographical Sciences2010，20，6： | 20 |
| 2 | Advanced Space-based Solar Observatory(ASO-S):an overview显示文摘The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar community.The scientific objectives are to study the relationships between the solar magnetic field,solar flares and coronal mass ejections(CMEs).Three payloads are deployed:the Full-disk vector Magneto Graph(FMG),the Lyman-αSolar Telescope(LST)and the Hard X-ray Imager(HXI).ASO-S will perform the first simultaneous observations of the photospheric vector magnetic field,non-thermal imaging of solar flares,and the initiation and early propagation of CMEs on a single platform.ASO-S is scheduled to be launched into a 720 km Sun-synchronous orbit in 2022.This paper presents an overview of the mission till the end of Phase-B and the beginning of Phase-C. | Wei-Qun Gan Cheng Zhu Yuan-Yong Deng Hui Li Yang Su Hai-Ying Zhang Bo Chen Zhe Zhang Jian Wu Lei Deng Yu Huang Jian-Feng Yang Ji-Jun Cui Jin Chang Chi Wang Ji Wu Zeng-Shan Yin Wen Chen Cheng Fang Yi-Hua Yan Jun Lin Wei-Ming Xiong Bin Chen Hai-Chao Bao Cai-Xia Cao Yan-Ping Bai Tao Wang Bing-Long Chen Xin-Yu Li Ye Zhang Li Feng Jiang-Tao Su Ying Li Wei Chen You-Ping Li Ying-Na Su Hai-Yan Wu Mei Gu Lei Huang Xue-Jun Tang | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 17 |
| 3 | Analysis of air quality characteristics of Beijing–Tianjin–Hebei and its surrounding air pollution transport channel cities in China显示文摘Beijing–Tianjin–Hebei(BTH)and its surrounding areas are very important to air pollution control in China.To analyze the characteristics of BTH and its surrounding areas of China,we collected 5,641,440 air quality data from 161 air monitoring stations and 37,123,000 continuous monitoring data from air polluting enterprises in BTH and surrounding cities to establish an indicator system for urban air quality portraits.The results showed that particulate matter with aerodynamic diameters of<2.5μm(PM2.5),particulate matter with aerodynamic diameters of<10μm(PM10)and SO2 improved significantly in 31 cities from2015 to 2018,but ozone deteriorated.Air quality in BTH and the surrounding areas showed obvious seasonal characteristics,among which PM2.5,PM10,SO2,and NO2 showed a'U'type distribution from January to December,while O3 had an'inverted U'distribution.The hourly changes in air quality revealed that peaks of PM2.5,PM10 and NO2 appeared from 8:00 to 10:00,while those for O3 appeared at 15:00–16:00.The exposure characteristics of the 31 cities showed that six districts in Beijing had the highest air quality population exposure,and that exposure levels in Zhengzhou,Puyang,Anyang,Jincheng were higher than the average of the 31 investigated cities.Additionally,multiple linear regression revealed a negative correlation between meteorological factors(especially wind and precipitation)and air quality,while a positive correlation existed between industrial pollution emissions and air quality in most of BTH and its surrounding cities. | Cuicui Xiao Miao Chang Peikun Guo Meifeng Gu Yang Li | 2020 | Journal of Environmental Sciences2020，32，1： | 15 |
| 4 | Distally based perforator sural flaps for foot and ankle reconstruction显示文摘Distally based perforator sural flaps from the posterolateral or posteromedial lower leg aspect are initially a neurofasciocutaneous flap that can be transferred reversely to the foot and ankle region with no need to harvest and sacrifice the deep major artery. These flaps are supplied by a perforating artery issued from the deep peroneal artery or the posterior tibial artery, and the chainlinked adipofascial neurovascular axis around the sural/saphenous nerve. It is a versatile and reliable technique for soft-tissue reconstruction of the heel and ankle region with 180-degrees rotation. In this paper, we present its developing history, vascular basis, surgical techniques including flap design and elevation, flap variations in pedicle and component, surgical indications, and illustrative case reports with different perforating vessels as pivot points for foot and ankle coverage. | Shi-Min Chang Xiao-Hua Li Yu-Dong Gu | 2015 | World Journal of Orthopedics2015，6，3： | 14 |
| 5 | AtPRK2 Promotes ROP1 Activation via RopGEFs in the Control of Polarized Pollen Tube Growth显示文摘ROP1 在 Arabidopsis 花粉试管的基于 GTPase 的发信号网络控制尖端生长。我们的以前的研究暗示 ROP1 可能被 RopGEF1 直接激活,它属于一可以被一个未知因素 plant-specificfamily 通过 releasingRopGEF1s 汽车抑制 Rho guanine 核苷酸交换因素(RopGEFs ) 并且接着激活。在这研究,我们发现 RopGEF1 与 ROP1 和 AtPRK2 形成建筑群,以前显示出与 RopGEFs 交往的像受体的 proteinkinase。在 vitro 和 atprk1,2,5 三元组异种的 AtPRK2 phosphorylated RopGEF1 显示出有缺点的花粉试管生长,类似于 ropgef1,9,12,14 的显型四倍的异种。AtPRK2 (DN-PRK2 ) 的一种主导的否定形式的 Overexpression 在 Arabidopsis 禁止了花粉萌芽并且在烟草减少了花粉延伸。DN-PRK2-induced 花粉萌芽缺点被 overexpressing 救 RopGEF1 的一种 constitutivelyactive 形式, RopGEF1 (90457 ) ,暗示那 RopGEF1 AtPRK2 下游地行动。而且,而 DN-PRK2 减少了 ROP1, AtPRK2 在顶端的血浆膜增加了 ROP1activity 活动。最后,在 RopGEF1 (RopGEF1S460A 和 RopGEF1S480A ) 的 C 终端 putativephosphorylation 地点的二个变化在 vivo 消除了 RopGEF1 的功能。一起拿,我们的结果支持 AtPRK2 作为由通过 phosphorylation.Key 词激活 RopGEF1 多半表明 pathwaymost 的 ROP1 的一个积极管理者扮演的假设: | Fang Chang Ying Gu Hong Ma Zhenbiao Yang | 2013 | Molecular Plant2013，6，4： | 14 |
| 6 | Binding Activity Difference of Anti-CD20 scFv-Fc Fusion Protein Derived from Variable Domain Exchange显示文摘Two novel engineered antibody fragments binding to antigen CD20 were generated by fusing a murine IgM-type anti-CD20 single-chain Fv fragment (scFv) to the human IgG1 CH2 (i.e., Cγ2) and CH3 (i.e., Cγ3) domains with the human IgG1 hinge (i.e. Hγ). Given the relationship between structure and function of protein, the 3-D structures of the two engineered antibody fragments were modeled using computer-aided homology modeling method. Furthermore, the relationship between 3-D conformation and their binding activity was evaluated theoretically. Due to the change of active pocket formed by CDRs, the HL23 (VH-Linker-VL-Hγ-Cγ2-Cγ3) remained its activity because of its preserved conformation, while the binding activity of the LH23 (VL-Linker-VH-Hγ-Cγ2-Cγ3) was impaired severely. Experimental studies by flow cytometry and fluorescence microscopy showed that HL23 possessed significantly superior binding activity to CD20-expressing target cells than LH23. That is to say, the order of variable regions could influence the binding activity of the fusion protein to CD20+ cell lines, which was in accordance with the theoretical results. The study highlights the potential relationship between the antibody binding activity and their 3-D conformation, which appears to be worthwhile in providing direction for future antibody design of recombinant antibody. | Shusheng Geng Jiannan Feng Yan Li Yingxun Sun Xin Gu Ying Huang Yugang Wang Xianjiang Kang Hong Chang Beifen Shen | 2006 | Cellular & Molecular Immunology2006，3，6： | 13 |
| 7 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 8 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 9 | A new mutation in the thyroid hormone receptor gene of a Chinese family with resistance to thyroid hormone显示文摘到甲状腺荷尔蒙(RTH ) 的背景抵抗是到甲状腺荷尔蒙的减少的织物应答的主导的继承症候群。它通常由于在 ligand 有约束力的领域和甲状腺荷尔蒙受体(TR ) 的邻近的绞链区域定位的变化。我们报导临床并且实验室特征和有这稀罕混乱和他的家庭 members.Methods 的一个病人的基因分析包括垂体的磁性的回声成像(MRI ) 的甲状腺功能测试(TFT ) 和另外的实验室测试的临床的演讲和变化被分析。他的家庭的成员的 TFT 也被检测。TR 基因定序的直接 DNA 与 RTH 孩子有的反常 TFTs.Results 为那些被做甲状腺肿,易怒,攻击性,和 sudoresis。他的 TFT 显示出传播免费甲状腺荷尔蒙(FT4 和 FT3 ) 和正常刺激甲状腺的荷尔蒙(TSH ) 的高水平集中。当与 thiamazole 当作了甲状腺机能亢进(严重疾病) ,当没有明显的广告效果,与 bromocriptine 当作了 RTH 时,他的临床的演讲变得显然改进了时,他感觉到更坏。我们识别了一个新奇错误感觉变化, A317D,在 exon 定位了这个男孩和他的母亲的 9 基因。他没有的母亲任何临床的演讲,而是这个病人这里报导了的有的反常 TFT results.Conclusions 与 RTH 的标准是一致的。特征是 hypothalamus-pituitary-thyroid 轴的机能障碍。一个新奇变化在 TR 被发现, A317D,这个家庭。这研究验证了在不同 RTH 病人的一样的变化以内有临床的异质的现象。 | DONG Qian GONG Chun-xiu GU Yi SU Chang | 2011 | Chinese Medical Journal2011，，12： | 10 |
| 10 | Six-long non-coding RNA signature predicts recurrence-free survival in hepatocellular carcinoma显示文摘BACKGROUND Recent evidence shows that long non-coding RNAs(lncRNAs) are closely related to hepatogenesis and a few aggressive features of hepatocellular carcinoma(HCC). Increasing studies demonstrate that lncRNAs are potential prognostic factors for HCC. Moreover, several studies reported the combination of lncRNAs for predicting the overall survival(OS) of HCC, but the results varied. Thus,more effort including more accurate statistical approaches is needed for exploring the prognostic value of lncRNAs in HCC.AIM To develop a robust lncRNA signature associated with HCC recurrence to improve prognosis prediction of HCC.METHODS Univariate COX regression analysis was performed to screen the lncRNAs significantly associated with recurrence-free survival(RFS) of HCC in GSE76427 for the least absolute shrinkage and selection operator(LASSO) modelling. The established lncRNA signature was validated and developed in The Cancer Genome Atlas(TCGA) series using Kaplan-Meier curves. The expression values of the identified lncRNAs were compared between the tumor and non-tumor tissues. Pathway enrichment of these lncRNAs was conducted based on the significantly co-expressed genes. A prognostic nomogram combining the lncRNA signature and clinical characteristics was constructed.RESULTS The lncRNA signature consisted of six lncRNAs: MSC-AS1, POLR2 J4, EIF3 J-AS1,SERHL, RMST, and PVT1. This risk model was significantly associated with the RFS of HCC in the TCGA cohort with a hazard ratio(HR) being 1.807(95%CI[confidence interval]: 1.329-2.457) and log-rank P-value being less than 0.001. The best candidates of the six-lncRNA signature were younger male patients with HBV infection in relatively early tumor-stage and better physical condition but with higher preoperative alpha-fetoprotein. All the lncRNAs were significantly upregulated in tumor samples compared to non-tumor samples(P < 0.05). The most significantly enriched pathways of the lncRNAs were TGF-β signaling pathway, cellular apoptosis-associated pathways, etc. The nomogram showed great utility of the lncRNA signature in HCC recurrence risk stratification.CONCLUSION We have constructed a six-lncRNA signature for prognosis prediction of HCC.This risk model provides new clinical evidence for the accurate diagnosis and targeted treatment of HCC. | Jing-Xian Gu Xing Zhang Run-Chen Miao Xiao-Hong Xiang Yu-Nong Fu Jing-Yao Zhang Chang Liu Kai Qu | 2019 | World Journal of Gastroenterology2019，25，2： | 9 |
| 11 | Rapid Detection of Haemophilus influenzae and Haemophilus parainfluenzae in Nasopharyngeal Swabs by Multiplex PCR显示文摘Objective To establish multiplex PCR-based assays for detecting H.influenzae and H.parainfluenzae.And the PCR-based assays were applied to detect the carriage rates of H.influenzae and H.parainfluenzae in nasopharyngeal swab specimens which were collected from healthy children.Methods Multiplex primers for species-specific PCR were designed by using DNAstar soft based on the sequences of 16S rRNA genes from genus Haemophilus to detect H.influenzae and H.parainfluenzae.Results The sensitivity of the 16S rRNA PCR assay for detecting H.influenzae and H.parainfluenzae was 97.53% and 100% respectively,and the specificity was 95.89% and 96.63% respectively.Youden's Index on the ability to detect H.influenzae and H.parainfluenzae was 0.9342 and 0.9663 respectively.666 nasopharyngeal swab specimens were collected from healthy children.The detection rates of H.influenzae and H.parainfluenzae were 14.11% and 16.07% respectively by using isolation and culture methods.The detection rates of H.influenzae and H.parainfluenzae were 43.54% and 57.96% respectively by 16S rRNA PCR assays.The carriage rates of serotypes a,b,c,d,e,f and non-typeable isolates were 0% (0/666),0.15% (1/666),1.20% (8/666),0.15% (1/666),1.20% (8/666),1.80% (12/666),95.50% (636/666) respectively.Conclusion The multiplex PCR assays were very rapid,reliable and feasible methods for detection of H.influenzae and H.parainfluenzae in pharyngeal swab specimens which were compared to conventional isolation and culture methods.95.5% of H.influenzae strains in healthy children were nontypeable.The encapsulated or typable strains were mainly three serotypes which was c,e,and f serotype. | TIAN Guo Zhong ZHANG Li Juan WANG Xiao Lei ZHANG Li LI Shu Feng GU Chang Mei SUN Jian CUI Bu Yun | 2012 | Biomedical and Environmental Sciences2012，25，3： | 8 |
| 12 | CIECIA:A new climate change integrated assessment model and its assessments of global carbon abatement schemes显示文摘From the perspective of global economic general equilibrium, this study developed a new climate change IAM named CIECIA. The economic core of this IAM is a multi-country-sector general equilibrium model. The endogenous technology progress mode is introduced into CIECIA. Based on this model, three assessment principles of the global cooperating abatement scheme are proposed, including effectiveness, feasibility, and fairness. This study simulated and analyzed six types of primary global cooperating abatement schemes. The simulated results indicate that all of the selected schemes can satisfy the climate mitigation targets by 2100. Thus, they are all effective schemes. However, the schemes have quite different feasibilities and fairness. The Stern Scheme benefits the developed countries, but is unfair to the developing countries. The Nordhaus Scheme promotes the developments of the developing countries. However, it leads to negative impacts on the interests of the developed countries. The principle of convergence on accumulated carbon emissions per capita and the principle of convergence on carbon emissions per capita benefit the economic developments of the middle and low developing countries most. However, these two types of schemes cause tremendous losses to the main economic entities in the world including China. The Pareto Improvement Scheme, which was developed from the Global Economic Growth Scheme, balances the fairness and feasibility in the carbon abatement process and realizes the Pareto improvement of accumulated utilities in all the participating countries. Thus, the Pareto Improvement Scheme is the most reasonable global cooperating carbon abatement scheme. | WANG Zheng GU Gao Xiang WU Jing LIU Chang Xin | 2016 | Science China Earth Sciences2016，59，1： | 8 |
| 13 | Genetic aberration in primary hepatocellular carcinoma:correlation between p53 gene mutation and loss-of-heterozygosity on chromosome 16q21-q23 and 9p21-p23显示文摘To elucidate the molecular pathology underlying the development of hepatocellular carcinoma (HCC), we used 41 highly polymorphic microsatellite markers to examine 55 HCC and corresponding non-tumor liver tissues on chromosome 9, 16 and 17. Loss-of-heterozygosity (LOH) is observed with high frequency on chromosomal region 17p13 (36/55, 65%), 9p21-p23 (28/55, 51%), 16q21-q23 (27/55, 49%) in tumors. Meanwhile, microsatellite instability is rarely found in these microsatellite loci. Direct sequencing was performed to detect the tentative mutation of tumor suppressor genes in these regions: p53, MTS1/p16, and CDH1/E-cadherin. Within exon 5-9 of p53 gene, 14 out of 55 HCC specimens (24%) have somatic mutations, and nucleotide deletion of this gene is reported in HCC for the first time. Mutation in MTS1/pl6 is found only in one tumor case. We do not find mutations in CDH1/E-cadherin. Furthermore, a statistically significant correlation is present between p53 gene mutation and loss of chromosome region 16q21q23 and 9p21-p23, which indicates that synergism between p53 inactivation and deletion of 16q21-q23 and 9p21-p23 may play a role in the pathogenesis of HCC. Genetic aberration in hepatocellular | WANG GANG CHANG HUI HUANG YAN ZHAO LING CAI YING WANG SHI JIN XIU ZHENG WEN JIANG SHUANG YANG XIN TAI ZHAO WEI HUANG JIAN REN GU | 2000 | Cell Research2000，10，4： | 7 |
| 14 | Integrating BDS and GPS for precise relative orbit determination of LEO formation flying显示文摘Low-Earth-Orbit(LEO) formation-flying satellites have been widely applied in many kinds of space geodesy. Precise Relative Orbit Determination(PROD) is an essential prerequisite for the LEO formation-flying satellites to complete their mission in space. The contribution of the BeiDou Navigation Satellite System(BDS) to the accuracy and reliability of PROD of LEO formation-flying satellites based on a Global Positioning System(GPS) is studied using a simulation method. Firstly, when BDS is added to GPS, the mean number of visible satellites increases from9.71 to 21.58. Secondly, the results show that the 3-Dimensional(3 D) accuracy of PROD, based on BDS-only, GPS-only and BDS + GPS, is 0.74 mm, 0.66 mm and 0.52 mm, respectively. When BDS co-works with GPS, the accuracy increases by 29.73%. Geostationary-Earth-Orbit(GEO) satellites and Inclined Geosynchronous-Orbit(IGSO) satellites are only distributed over the Asia-Pacific region; however, they could provide a global improvement to PROD. The difference in PROD results between the Asia-Pacific region and the non-Asia-Pacific region is not apparent. Furthermore, the value of the Ambiguity Dilution Of Precision(ADOP), based on BDS + GPS, decreases by 7.50% and 8.26%, respectively, compared with BDS-only and GPS-only. Finally, if the relative position between satellites is only a few kilometres, the effect of ephemeris errors on PROD could be ignored. However, for a several-hundred-kilometre separation of the LEO satellites, the SingleDifference(SD) ephemeris errors of GEO satellites would be on the order of centimetres. The experimental results show that when IGSO satellites and Medium-Earth-Orbit(MEO) satellites co-work with GEO satellites, the accuracy decreases by 17.02%. | Bin YI Defeng GU Xiao CHANG Kai SHAO | 2018 | Chinese Journal of Aeronautics2018，31，10： | 7 |
| 15 | Hydrogen-rich water protects against inflammatory bowel disease in mice by inhibiting endoplasmic reticulum stress and promoting heme oxygenase-1 expression显示文摘AIM To investigate the therapeutic effect of hydrogen-rich water(HRW) on inflammatory bowel disease(IBD) and to explore the potential mechanisms involved.METHODS Male mice were randomly divided into the following four groups: control group, in which the mice received equivalent volumes of normal saline(NS) intraperitoneally(ip); dextran sulfate sodium(DSS) group, in which the mice received NS ip(5 m L/kg body weight, twice per day at 8 am and 5 pm) for 7 consecutive days after IBD modeling; DSS + HRW group, in which the mice received HRW(in the same volume as the NS treatment) for 7 consecutive days after IBD modeling; and DSS + HRW + Zn PP group, in which the mice received HRW(in the same volume as the NS treatment) and ZnP P [a heme oxygenase-1(HO-1) inhibitor, 25 mg/kg] for 7 consecutive days after IBD modeling. IBD was induced by feeding DSS to the mice, and blood and colon tissues were collected on the 7th d after IBD modeling to determine clinical symptoms, colonic inflammation and the potential mechanisms involved.RESULTS The DSS + HRW group exhibited significantly attenuated weight loss and a lower extent of disease activity index compared with the DSS group on the 7th d(P < 0.05). HRW exerted protective effects against colon shortening and colonic wall thickening in contrast to the DSS group(P < 0.05). The histological study demonstrated milder inflammation in the DSS + HRW group, which was similar to normal inflammatory levels, and the macroscopic and microcosmic damage scores were lower in this group than in the DSS group(P < 0.05). The oxidative stress parameters, including MDA and MPO in the colon, were significantly decreased in the DSS + HRW group compared with the DSS group(P < 0.05). Simultaneously, the protective indicators, superoxide dismutase and glutathione, were markedly increased with the use of HRW. Inflammatory factors were assessed, and the results showed that the DSS + HRW group exhibited significantly reduced levels of TNF-α, IL-6 and IL-1β compared with the DSS group(P < 0.05). In addition, the pivotal proteins involved in endoplasmic reticulum(ER) stress, including p-e IF2α, ATF4, XBP1 s and CHOP, were dramatically reduced after HRW treatment in contrast to the control group(P < 0.05). Furthermore, HRW treatment markedly up-regulated HO-1 expression, and the use of Zn PP obviously reversed the protective role of HRW. In the DSS + HRW + ZnP P group, colon shortening and colonic wall thickening were significantly aggravated, and the macroscopic damage scores were similar to those of the DSS + HRW group(P < 0.05). The histological study also showed more serious colonic damage that was similar to the DSS group.CONCLUSION HRW has a significant therapeutic potential in IBD by inhibiting inflammatory factors, oxidative stress and ER stress and by up-regulating HO-1 expression. | Nai-Ying Shen Jian-Bin Bi Jing-Yao Zhang Si-Min Zhang Jing-Xian Gu Kai Qu Chang Liu | 2017 | World Journal of Gastroenterology2017，23，8： | 7 |
| 16 | Comparative proteomic analysis of differentially expressed proteins between K562 and K562/ADM cells显示文摘背景:到化学疗法的代理人的 Multidrug 抵抗在白血病的治疗期间是一个重要临床的问题。抵抗过程是多因素的。为了认识到全部的因素,包含了在多药抵抗,我们分析了表示的差别 K562 的蛋白质和 K562/ADM 房间和我们用 siRNA 调查了起来调整的蛋白质(CRKL ) 之一在 K562/ADM 房间决定它的角色。方法:在 K562/S (K562 ADM 敏感的房间线) 和 K562/ADM (多,抵抗房间衬里的药由 adriamycin 导致了的 K562 ) 之间的改变的蛋白质表情被结合的 2D-DIGE 识别集体分光术。同时,我们由西方的污点分析在 K562 和 K562/ADM 房间证实了 CRKL 和 Stathmin 的微分表示。而且,我们使用了 RNA 干扰到沉默 CRKL 基因表示。结果:在 9 差别之中表示了蛋白质, 3 在 K562/ADM 房间是起来调整的,当 6 与它的父母房间相比在 K562/ADM 房间是下面调整的时,排队。CRKL 的表示在 K562/ADM 房间显著地是起来调整的,并且它能被 recombinant lentivirus 减少。而且,多, K562/ADM 房间的药抵抗被 CRKL 的沉默高效地颠倒基因表示。结论:数据提供了在 K562 和它的抵抗房间的表示蛋白质衬里的差别和热点为在癌症的抵抗标记的发现的 2D-DIGE 的力量。我们发现 CRKL 可以是涉及的新蛋白质多白血球过多症房间的药抵抗。 | SHEN Shao-hua GU Long-jun LIU Pei-qing YE Xin CHANG Wei-shan LI Ben-shang | 2008 | Chinese Medical Journal2008，，5： | 6 |
| 17 | Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres显示文摘人单个海滨(ss ) DNA 有约束力的蛋白质 1 和 2 (hSSB1 并且 2 ) hSSB1/2-INTS3-C9orf80 heterotrimeric 蛋白质建筑群的部件被显示参予 DNA 损坏反应和染色体稳定性的维护。然而,他们在 telomeres 的角色仍然保持未知。这里,我们产生了鼠科的 SSB1 有条件的猛烈老鼠和房间并且发现 mSSB1 在 telomere 结束保护起一个关键作用。mSSB1 和 mSSB2 本地化到 telomeres 的一个子集并且被要求修理 TRF2 缺乏的 telomeres。mSSB1 的删除导致了包含的增加的染色单体类型熔化领先海滨并且落后海滨 telomeric DNA,建议它为 G 悬于的保护被要求。mSSB1 和 INTS3 的相互作用为它的本地化被要求到损坏 DNA。mSSB1 与 Pot1a,然而并非 Pot1b 交往,并且它有 telomeric ssDNA 的协会要求 Pot1a。mSSB1 Δ/Δ 老鼠与发展畸形在出生死,当时有 hypomorphic mSSB1 F/F 等位基因活出生并且显示增加了敏感到电离放射(红外) 。我们的结果建议 mSSB1 被要求维持染色体稳定性,并且在保护为 mSSB1/2 记录一个以前未被认出的角色最新复制了领先海滨并且落后海滨 telomeres。 | Peili Gu Wei Deng Ming Lei Sandy Chang | 2013 | Cell Research2013，23，5： | 6 |
| 18 | Genetic and Antibiotic Resistance Characteristics ofCampylobacterjejuni Isolated from Diarrheal Patients,Poultry and Cattle in Shenzhen显示文摘Objective To investigate genetic and antibiotic resistance characteristics of Campylobacter jejuni(C. jejuni) isolated from Shenzhen. Methods Multilocs sequence typing and agar dilution methods were used to define the genotype and antibiotic resistance of C. jejuni, respectively. Results In total, 126 C. jejuni strains were isolated. The prevalence of C. jejuni was 5.3% in diarrheal patients. The prevalence in poultry meat(36.5%) was higher than that in cattle meat(1.1%). However, the prevalence in poultry cloacal swabs(27.0%) was lower than that in cattle stool(57.3%). Sixty-two sequence types were obtained, among which 27 of the STs and 10 alleles were previously unreported. The most frequently observed clonal complexes were ST-21(11.9%), ST-22(10.3%), and ST-403(7.1%). ST-21, ST-45, ST-354, ST-403, and ST-443 complexes overlapped between isolates from patients and cattle, whereas ST-45 and ST-574 complexes overlapped between isolates from patients and poultry. All C. jejuni were resistant to at least one antibiotic. The highest resistance rate was toward ciprofloxacin(89.7%), followed by tetracycline(74.6%), and nalidixic acid(69.0%). Conclusion This is the first report of the genotypes and antibiotic resistance of C. jejuni in Shenzhen. Overlapping clonal complexes were found between isolates from patients and cattle, and between patients and poultry. | JU Chang Yan ZHANG Mao Jun MA Yan Ping LU Jing Rang YU Mu Hua CHEN Hui LIU Chu Yun GU Yi Xin FU Yan Yan DUAN Yong Xiang | 2018 | Biomedical and Environmental Sciences2018，31，8： | 5 |
| 19 | Experimental investigation on the cavity-based scramjet model显示文摘The present work focused on improving the engine performance with different fuel equivalence ratios and fuel injections. A scramjet model with strut/cavity integrated configurations was tested under Mach 5.8 flows. The results showed that the strut may sreve as an effective tool in a kerosene-fueled scramjet. The integration of strut/cavities also had great effect on stablizing the combustion in a wide range of fuel equivalence ratio. The one-sdimensional analysis method was used to analyze the main characteristics of the model. The two-stage fuel injection should have better performance in increasing the chemical reaction rate in the first cavity region. | GU HongBin CHEN LiHong CHANG XinYu | 2009 | Chinese Science Bulletin2009，54，16： | 5 |
| 20 | 泌尿生殖系统小细胞癌:11年临床治疗经验显示文摘当前对于泌尿生殖系统的小细胞癌治疗及判断预后的影响因素尚存在较大争议。本研究回顾性分析了在2002年至2013年在复旦大学附属肿瘤医院诊治的18例泌尿生殖系统小细胞癌患者的临床资料,其中有10例来源于前列腺,7例来源于膀胱,1例来源于肾上腺。平均随访时间为15.5个月,平均无疾病进展时间为9.3个月。对其中的13例患者施行原发病灶切除术,在诊断为局限性泌尿生殖系统小细胞癌的患者中6例接受了根治性手术治疗,13例患者接受了以顺铂为基础的化疗。经统计学分析发现与乳酸脱氢酶较高的患者相比,乳酸脱氢酶处于正常范围的患者无疾病进展时间及总生存时间都明显延长(P=0.030,P=0.010),对于局限性小细胞癌患者,接受根治性手术治疗的患者与未接受根治手术的患者相比在无疾病进展时间上无统计学差异,但是在总生存时间上有明显差别。因此血液中乳酸脱氢酶高于正常值往往预示着患者的预后较差,对于诊断为局限性泌尿生殖系统小细胞肿瘤的患者,强烈推荐及早对患者施行根治性手术并联合以顺铂为基础的化疗。 | Kun Chang | 2014 | Asian Journal of Andrology2014，16，5： | 5 |
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