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| 1 | Effect of itopride, a new prokinetic, in patients with mild GERD: A pilot study显示文摘AIM: Itopride is a newly developed prokinetic agent, which enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions. The importance of esophageal motor dysfunction in the pathogenesis of gastro-esophageal reflux disease (GERD) makes it interesting to examine the effect of itopride on esophageal acid exposure.METHODS: The effect of itopride on esophageal acid reflux variables for 24 h was studied in 26 patients with GERD symptoms, pre-entry total acid exposure time (pH<4) of more than 5% and mild esophagitis (SavaryMiller grades Ⅰ, Ⅱ) proven by endoscopy. Ambulatory 24-h pH-metry and symptom assessment were performed after treatments with 150 or 300 mg itopride thrice a day (t.i.d.) for 30 d in random order, using an open label method.For evaluating the safety of itopride, blood biochemical laboratory test was performed and the serum prolactin level was also examined before and after treatment.RESULTS: Total symptom score was significantly decreased after treatment in 150- or 300-mg group. Itopride 300mg was significantly effective than 150 mg on decreasing the total per cent time with pH<4, total time with pH<4and DeMeester score. No serious adverse effects were observed with administration of itopride in both groups.CONCLUSION: Itopride 100 mg t.i.d, is effective on decreasing pathologic reflux in patient with GERD and therefore it has the potential to be effective in the treatment of this disease. | Yong Sung Kim Tae Hyeon Kim Chang Soo Choi Young Woo Shon Sang Wook Kim Geom Seog Seo Yong Ho Nah Myung Gyu Choi Suck Chei Choi | 2005 | World Journal of Gastroenterology2005，11，27： | 15 |
| 2 | Programmed death ligand-1 expression and its prognostic role in esophageal squamous cell carcinoma显示文摘AIM To investigate the expression and prognostic role of programmed death ligand-1(PD-L1) in locally advanced esophageal squamous cell carcinoma(ESCC).METHODS A total of 200 patients with ESCC who underwent radical esophagectomy with standard lymphadenectomy as the initial definitive treatment in Seoul National University Hospital from December 2000 to April 2013 were eligible for this analysis. Tissue microarrays were constructed by collecting tissue cores from surgical specimens, and immunostained with antibodies directed against PD-L1, p16, and c-Met. Medical records were reviewed retrospectively to assess clinical outcomes. Patients were divided into two groups by PD-L1 status, and significant differences in clinicopathologic characteristics between the two groups were assessed. RESULTS Tumor tissues from 67 ESCC patients(33.5%) were PDL1-positive. Positive p16 expression was observed in 21 specimens(10.5%). The H-score for c-Met expression was ≥ 50 in 42 specimens(21.0%). Although PDL1-positivity was not significantly correlated with any clinical characteristics including age, sex, smoking/alcoholic history, stage, or differentiation, H-scores for c-Met expression were significantly associated with PDL1-positivity(OR = 2.34, 95%CI: 1.16-4.72, P = 0.017). PD-L1 expression was not significantly associated with a change in overall survival(P = 0.656). In contrast, the locoregional relapse rate tended to increase(P = 0.134), and the distant metastasis rate was significantly increased(HR = 1.72, 95%CI: 1.01-2.79, P = 0.028) in patients with PD-L1-positive ESCC compared to those with PD-L1-negative ESCC.CONCLUSION PD-L1 expression is positively correlated with c-Met expression in ESCC. PD-L1 may play a critical role in distant failure and progression of ESCC. | Ryul Kim Bhumsuk Keam Dohee Kwon Chan-Young Ock Miso Kim Tae Min Kim Hak Jae Kim Yoon Kyung Jeon In Kyu Park Chang Hyun Kang Dong-Wan Kim Young Tae Kim Dae Seog Heo | 2016 | World Journal of Gastroenterology2016，22，37： | 14 |
| 3 | Cerebral and pulmonary embolisms after transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘A cerebral lipiodol embolism is an extremely rare complication of transcatheter arterial chemoem bolization for hepatocellular carcinoma. We present a case of cerebral lipiodol embolism that occurred afte the third arterial chemoembolization, report the clinica and radiological findings, and review the medica literature. | Chang Soo Choi Ki Hoon Kim Geom Seog Seo Eun Young Cho Hyo Jeong Oh Suck Chei Choi Tae Hyeon Kim Haak Cheoul Kim Byung Suk Roh | 2008 | World Journal of Gastroenterology2008，14，30： | 10 |
| 4 | Five-year major clinical outcomes between first-generation ana second- generation drug-eluting stents in acute myocardial infarction patients underwent percutaneous coronary intervention显示文摘 | Yong Hoon Kim Ae-Young Her Seung-Woon Rha Byoung Geol Choi Se Yeon Choi Jae Kyeong Byun Ju Yeol Baek Woong Gil Choi Tae Soo Kang Ji Hoon Ahn Sang-Ho Park Ahmed Mashaly Jin Oh Na Cheol Ung Choi Hong Euy Lim Eung Ju Kim Chang Gyu Park Hong Seog Seo Dong Joo Oh | 2018 | Journal of Geriatric Cardiology2018，15，8： | 8 |
| 5 | Impact of old age on clinical and angiographic characteristics of coronary artery spasm as assessed by acetylcholine provocation test显示文摘吸烟并且另外的风险因素作为变体咽峡炎或冠的动脉痉挛(CAS ) 的重要因素众所周知。然而,与冠的动脉痉挛上的年龄有关的临床的特征是 evaluated.MethodsWe 很少与不足道的冠的动脉损害评估了 3155 个连续病人。病人们经历了醋胆素(Ach ) 为 CAS 的正式就职的挑衅测试。CAS 是被定义 >70% 钠在 Ach 期间变窄冠的动脉挑衅测试。Ach 挑衅测试的结果在年龄组之中被比较;< 45 年(组 1 ) , 45-54 年(组 2 ) , 55-64 年(组 3 ) ,和 .ResultsOlder 病人有高血压,糖尿病,而是更低的发生的更高的发生的 65 年(组 4 ) 与更年轻的病人相比当前的吸烟、男性别评价。积极 Ach 挑衅测试发现经常与老化被显示出(47.36% 对 58.3% 对 62.6% 对 61.5% ;P < 0.001 ) 。Multivariate 逻辑分析证明年龄,男性,和心肌的桥牌是学习显示出的在场的 Ach 挑衅 test.ConclusionOur 导致的 CAS 的独立预言者老年是为导致 Ach 的重要冠的动脉痉挛的独立预言者。 | Woong Gil Choi Soo Hyun Kim Seung-Woon Rha Kang-Yin CHEN Yong-Jian LI Byoung Geol Choi Se Yeon Choi Jin Won Kim Eung Ju Kim Chang Gyu Park Hong Seog Seo Dong Joo Oh | 2016 | Journal of Geriatric Cardiology2016，13，10： | 7 |
| 6 | Calcium channel blocker monotherapy versus combination with reninangiotensin system inhibitors on the development of new-onset diabetes mellitus in hypertensive Korean patients显示文摘Background In real practice, two or more antihypertensive drugs are needed to achieve target blood pressure. We investigated the comparative beneficial actions of combination therapy of renin-angiotensin system inhibitors (RASI), with calcium channel blockers (CCB) over CCB monotherapy on the development of new-onset diabetes mellitus (NODM) in Korean patients during four-year follow-up periods. Methods A total of 3208 consecutive hypertensive patients without a history of diabetes mellitus who had been prescribed CCB were retrospectively enrolled from January 2004 to December 2012. These patients were divided into the two groups according to the additional use of RASI (the RASI group, n = 1221 and the no RASI group, n = 1987). Primary endpoint was NODM, defined as a fasting blood glucose ≥ 126 mg/dL or hemoglobin A1c ≥ 6.5%. Secondary endpoint was major adverse cardiac events (MACE) defined as total death, myocardial infarction (MI) and percutaneous coronary intervention (PCI). Results After propensity score-matched (PSM) analysis, two propensity- matched groups (939 pairs, n = 1878, C-statistic = 0.743) were generated. The incidences of NODM (HR = 1.009, 95% CI: 0.700–1.452, P = 0.962), MACE (HR = 0.877, 95% CI: 0.544–1.413, P = 0.589), total death, MI, PCI were similar between the two groups after PSM during four years. Conclusions The use of RASI in addition to CCB showed comparable incidences of NODM and MACE compared to CCB monotherapy in non-diabetic hypertensive Korean patients during four-year follow-up period. However, large-scaled randomized controlled clinical trials will be required for a more definitive conclusion. | Yong Hoon Kim Ae-Young Her Seung-Woon Rha Byoung Geol Choi Se Yeon Choi Jae Kyeong Byun Yoonjee Park Dong Oh Kang Won Young Jang Woohyeun Kim Woong Gil Choi Tae Soo Kang Jihun Ahn Sang-Ho Park Ji Young Park Min-Ho Lee Cheol Ung Choi Chang Gyu Park Hong Seog Seo | 2019 | Journal of Geriatric Cardiology2019，16，6： | 3 |
| 7 | Panax ginseng induces the expression of CatSper genes and sperm hyperactivation显示文摘精子(CatSper ) 的阳离子隧道蛋白质家庭戏在男复制和不孕的重要角色。这个家庭的四个成员专门在睾丸被表示并且在精子不同地是局部性的。为了在雄的鼠标,精子活动性和 CatSper 基因表示在 CatSper 基因和精子 hyperactivation 的表达式上调查人参属人参处理的效果,用一个帮助计算机的精液分析系统被估计, Fluoroskan 上升估计 Ca 2+流入的 microplate 氟量计,即时聚合酶链反应,西方的弄污和 immunofluorescence 。结果建议精子房间的 Ca 2+ 层次与 P 对待。人参与正常的组相比显著地被增加。P。对待人参的组显示出增加的精子活动性参数,例如侧面的头排水量的曲线的速度和振幅。一起拿,数据建议 CatSper 送信人核糖核酸酸层次在 P 在老鼠睾丸显著地被增加。对待人参的组是蛋白质水平与 CatSper2 的例外。在结论, P。人参在经由 CatSper 基因表示改进精子 hyperactivation 起一个重要作用。 | Eun Hwa Park Do Rim Kim Ha Young Kim Seong Kyu Park Mun Seog Chang | 2014 | Asian Journal of Andrology2014，16，6： | 2 |
| 8 | Five-year clinical outcomes of first-generation versus second-generation drug-eluting stents following coronary chronic total occlusion intervention显示文摘Background There are limited data comparing long-term clinical outcomes between first-generation (1G) and second-generation (2G) drug-eluting stents (DESs) in patients who underwent successful percutaneous coronary intervention (PCI) for coronary chronic total occlusion (CTO) lesion. Methods A total of 840 consecutive patients who underwent PCI with DESs for CTO lesion from January 2004 to November 2015 were enrolled. Finally, a total of 324 eligible CTO patients received 1G-DES (Paclitaxel-eluting stent or Sirolimus-eluting stent, n = 157) or 2G-DES (Zotarolimus-eluting stent or Everolimus-eluting stent, n = 167) were enrolled. The clinical endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause death, recurrent myocardial infarction (re-MI), total repeat revascularization [target lesion revascularization (TLR), target vessel revascularization (TVR), and non-TVR]. We investigated the 5-year major clinical outcomes between 1G-DES and 2G-DES in patient who underwent successful CTO PCI. Results After propensity score matched (PSM) analysis, two well-balanced groups (111 pairs, n = 222, C-statistic = 0.718) were generated. Up to the 5-year follow-up period, the cumulative incidence of all-cause death, re-MI, TLR, TVR and non-TVR were not significantly different between the two groups. Finally, MACE was also similar between the two groups (HR = 1.557, 95% CI: 0.820–2.959, P = 0.176) after PSM. Conclusions In this study, 2G-DES was not associated with reduced long-term MACE compared with 1G-DES following successful CTO revascularization up to five years. | Yong Hoon Kim Ae-Young Her Seung-Woon Rha Byoung Geol Choi Se Yeon Choi Jae Kyeong Byun Yoonjee Park Dong Oh Kang Won Young Jang Woohyeun Kim Ju Yeol Baek Woong Gil Choi Tae Soo Kang Jihun Ahn Sang-Ho Park Ji Young Park Min-Ho Lee Cheol Ung Choi Chang Gyu Park Hong Seog Seo | 2019 | Journal of Geriatric Cardiology2019，16，8： | 1 |
| 9 | Can mean platelet volume predict coronary vasospasm?显示文摘 | Cheol Ung Choi Hong Seog Seo Yun Kyung Kim Jin Oh Na Hong Euy Lim Jin Won Kim Eung Ju Kim Seung-Woon Rha Chang Gyu Park Dong Joo Oh | 2011 | Platelets2011，，3： | 1 |
| 10 | Capecitabine in combination with Oxaliplatin (XELOX) as a first-line therapy for advanced gastric cancer显示文摘 | Yeon Hee Park Jae-Lyun Lee Baek-Yeol Ryoo Min-Hee Ryu Sung Hyun Yang Bong Seog Kim Dong Bok Shin Heung Moon Chang Tae Won Kim Young Jin Yuh Yoon-Koo Kang | 2008 | Cancer Chemotherapy and Pharmacology2008，，4： | 1 |
| 11 | Capecitabine in combination with Oxaliplatin(XELOX)as a first-line therapy for advance gastric cancer显示文摘 | YEON HEE PARK JAE-LYUN LEE BAEK-YEOL RYOO MIN-HEE RYU SUNG HYUN YANG BONG SEOG KIM DONG BOK SHIN HEUNG MOON CHANG TAE WON KIM YOUNG JIN YUH YOON-KOO KANG | 2008 | Cancer Chemotherapy and pharmacology2008，23，4： | 1 |
| 12 | Capecitabine in combination with Oxaliplatin (XELOX) as a first-line therapy for advanced gastric cancer显示文摘 | Yeon Hee Park Jae-Lyun Lee Baek-Yeol Ryoo Min-Hee Ryu Sung Hyun Yang Bong Seog Kim Dong Bok Shin Heung Moon Chang Tae Won Kim Young Jin Yuh Yoon-Koo Kang | 2008 | Cancer Chemotherapy and Pharmacology2008，，4： | 1 |
| 13 | AS-148: Impact of Statins on 12-Month Clinical Outcomes in Acute ST-Segment Elevation Myocardial Infarction Patients Who Received Thrombolytic Therapy显示文摘 | Seung-Woon Rha Lin Wang Ji Young Park Sureshkumar Ramasamy Byoung Geol Choi Ji Bak Kim Seung Yong Shin Cheol Ung Choi Hong Euy Lim Jin Won Kim Eung Ju Kim Chang Gyu Park Hong Seog Seo Dong Joo Oh Young Keun Ahn Myung Ho Jeong | 2010 | The American Journal of Cardiology2010，，： | 1 |
| 14 | Wetting behavior of metal coated SiC/Al composite显示文摘 | Kyung G Lee K U Chang Seog | 2000 | Japan Inst Metals2000，66，1： | 1 |
| 15 | Im- provement of Color and Luminance Uniformity of the Edge-Lit Backlight Using the RGB LEDs显示文摘 | CHANG Gyun Son JONG Hoon Yi JIN Seog Gwag | 2011 | Journal of the Optical Society of Korea2011，15，3： | 1 |
| 16 | Intravenous calcitriol regresses myocardial hypertrophy in hemodialysis patients with secondary hyperparathyroidism显示文摘 | Cheol Whee Park Yong Seog Oh Young Shin Shin Chul-Min Kim Yong-Soo Kim Suk Young Kim Eui Jin Choi Yoon Sik Chang Byung Kee Bang | 1999 | American Journal of Kidney Diseases1999，，1： | 1 |
| 17 | Capecitabine in combination with Oxaliplatin (XELOX) as a first-line therapy for advanced gastric cancer显示文摘 | Yeon Hee Park Jae-Lyun Lee Baek-Yeol Ryoo Min-Hee Ryu Sung Hyun Yang Bong Seog Kim Dong Bok Shin Heung Moon Chang Tae Won Kim Young Jin Yuh Yoon-Koo Kang | 2008 | Cancer Chemotherapy and Pharmacology2008，，4： | 1 |
| 18 | LED beam shaping lens based on the near-field illumination 显示文摘 | JAE Young Joo CHANG Seog Kang SOON Sub Park | 2009 | Optics Express2009，17，23： | 1 |
| 19 | Capecitabine in combination with Oxaliplatin (XELOX) as a first-line therapy for advanced gastric cancer显示文摘 | Yeon Hee Park Jae-Lyun Lee Baek-Yeol Ryoo Min-Hee Ryu Sung Hyun Yang Bong Seog Kim Dong Bok Shin Heung Moon Chang Tae Won Kim Young Jin Yuh Yoon-Koo Kang | 2008 | Cancer Chemotherapy and Pharmacology2008，，4： | 1 |
| 20 | Dual Channel SIS Receiver of Trao Telescope显示文摘We have developed the dual channel receiver with 100GHz and 150GHz band, which is used to make the simultaneous observation with two bands. The SIS mixers are used in both bands. The constructed dewar for receiver has the performance with the vacuum of 10 -8 Torr and the temperature of 4 2K. The receiver noise temperature is 50K (DSB) for 100GHz band and 80K (DSB) for 150GHz band ,respectively. In order to achieve the simultaneous observations, the quasioptical system is precisely designed, and also evaluated by the measurement in the laboratory. We have observed the various sources using this receiver since October 1998. The relative pointing offset between two bands is 3″. | Jong Ae Park 1,2 , Seog Tae Han 1, Tai Seong Kim 1, Kwang Dong Kim 1, Hyo Ryoung Kim 1, Hyun Soo Chung 1, Jae Hoon Jung 1, Chang Hoon Lee 1, Se Hyung Cho 1, Jongmann Yang 2 1. Taeduk Radio Astronomy Observatory (TRAO), Hwaam dong, | 1999 | 天文研究与技术1999，，S1： | 0 |
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