|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mesenchymal stem cells derived from human placenta suppress allogeneic umbilical cord blood lymphocyte proliferation显示文摘ABSTRACTHuman placenta-derived mononuclear cells (MNC) were isolated by a Percoll density gradient and cultured in mesen-chymal stem cell (MSC) maintenance medium. The homogenous layer of adherent cells exhibited a typical fibroblast-like morphology, a large expansive potential, and cell cycle characteristics including a subset of quiescent cells. In vitrodifferentiation assays showed the tripotential differentiation capacity of these cells toward adipogenic, osteogenic andchondrogenic lineages. Flow cytometry analyses and immunocytochemistry stain showed that placental MSC was ahomogeneous cell population devoid of hematopoietic cells, which uniformly expressed CD29, CD44, CD73, CD105,CD166, laminin, fibronectin and vimentin while being negative for expression of CD31, CD34, CD45 and α-smoothmuscle actin. Most importantly, immuno-phenotypic analyses demonstrated that these cells expressed class I majorhistocompatibility complex (MHC-I), but they did not express MHC-II molecules. Additionally these cells could sup-press umbilical cord blood (UCB) lymphocytes proliferation induced by cellular or nonspecific mitogenic stimuli. Thisstrongly implies that they may have potential application in allograft transplantation. Since placenta and UCB arehomogeneous, the MSC derived from human placenta can be transplanted combined with hematopoietic stem cells(HSC) from UCB to reduce the potential graft -versus-host disease (GVHD) in recipients. | Chang Dong LI Wei Yuan ZHANG He Lian LI Xiao Xia JIANG Yi ZHANG Pei Hsien TANG Ning MAO | 2005 | Cell Research2005，15，7： | 36 |
| 2 | The Serum Exosome Derived MicroRNA-135a,-193b, and-384 Were Potential Alzheimer's Disease Biomarkers显示文摘Objective MicroR NAs(mi Rs) are attractive molecules to be considered as one of the blood-based biomarkers for neurodegenerative disorders such as Alzheimer's disease(AD). The goal of this study was to explore their potential value as biomarkers for the diagnosis of AD. Methods The expression levels of exosomal miR-135 a,-193 b, and-384 in the serum from mild cognitive impairment(MCI), dementia of Alzheimer-type(DAT), Parkinson's disease with dementia(PDD), and vascular dementia(VaD) patients were measured with a real-time quantitative reverse transcriptase PCR(qR T-PCR) method. Results Both serum exosome mi R-135 a and miR-384 were up-regulated while miR-193 b was down-regulated in serum of AD patients compared with that of normal controls. Exosome miR-384 was the best among the three miR s to discriminate AD, VaD, and PDD. Using the cut-off value could better interpret these laboratory test results than reference intervals in the AD diagnosis. ROC curve showed that the combination of mi R-135 a,-193 b, and-384 was proved to be better than a particular one for early AD diagnosis. Conclusion Our results indicated that the exosomal miR s in the serum were not only potential biomarker of AD early diagnosis, but might also provide novel insights into the screen and prevention of the disease. | YANG Ting Ting LIU Chen Geng GAO Shi Chao ZHANG Yi WANG Pei Chang | 2018 | Biomedical and Environmental Sciences2018，31，2： | 35 |
| 3 | Tetramethylpyrazine suppresses HIF-1α,TNF-α,and activated caspase-3 expression in middle cerebral artery occlusion-induced brain ischemia in rats显示文摘瞄准:检验详细机制位于禁止的效果 oftetramethylpyrazine (TMPZ ) 下面在煽动性并且 apoptotic 回答在 rats.Methods 由中间的服的 arteryocclusion (MCAO ) 导致了:在老鼠的导致 MCAO 的焦点的服的局部缺血在 thisstudy.The 被使用组织缺氧可诱导的 factor-1alpha (HIF-1alpha ) , caspase-3 的激活,和在 ischemic 区域的 TNF-alpha mRNAtranscription 被 immunoblotting andRT-PCR 检测, respectively.Anti 氧化的活动用 thiobarbituric acid-reactivesubstance (TBARS ) 被调查老鼠大脑 homogenate preparations.Results 的测试:我们显示出溶剂的梗塞区域的 statisticalresults --并且 TMPZ ( 20 mg/kg )在在在有 TMPZ ( 20 mg/kg )的 rats.Treatment 的 导致MCAO 的焦点的服的局部缺血的正面的杆显著地减少了的各种各样的 distancesfrom 对待组在所有区域的梗塞区域,在特别,第三显著地与 ischemic regions.These expressionswere 的 caspase-3 ,以及 TNF-alpha 抄写的 HIF-1alpha 和 theactivation 的增加被联系到 导致fifthsections.MCAO 的焦点的服的局部缺血我 neuroprotective effectof TMPZ 可以至少被 EOF-1alpha 和 TNF-alphaactivations 的抑制的部分调停,由 apoptosis 形成(活跃 caspase-3 )的抑制列在后面,在 ischemia-reperfusion 大脑 injury.Thus 在梗塞体积导致 areduction , TMPZ 处理 mayrepresent 在 ischemia-reperfusionbrain 降低风险或改善功能的一条理想的途径损害相关的混乱。 | Yi CHANG George HSIAO Seu-hwa CHEN Yi-cheng CHEN Jiing-han LIN Kuang-hung LIN Duen-suey CHOU Joen-rong SHEU | 2007 | Acta Pharmacologica Sinica2007，28，3： | 30 |
| 4 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 5 | Effect of pre-moxibustion on apoptosis and proliferation of gastric mucosa cells显示文摘瞄准:与导致压力的溃疡在老鼠在胃的粘膜房间的 apoptosis 和增长上观察艾灸前的效果,并且分析在那些效果和热吃惊蛋白质 70 的表示(HSP70 ) 之间的关系。方法:六十只健康 Sprague Dawley 老鼠随机被分配进四个组,也就是组织 A, B, C 和 D。压力溃疡的动物模型走水路被建立沉浸和抑制应力。分别地,当那些在 Zusanli 和 Liangmen 点在组 C 收到了艾灸时,在组 A, B,和 D 的老鼠用作抑制,模型,和 non-acupoint 控制。Immunohistochemical 方法论被用来检测 HSP70 的表示, apoptosis 索引(AI,乘 10-6/mum2 ) 并且增长索引(PCNA-LI,乘 10-6/mum2 ) 。转变生长因素高山的粘膜表示哈(TGF-alpha ) 被放射性免疫测定检测。结果:在 Zusanli 和 Liangmen 点的艾灸显著地减少了胃的损害和胃的粘膜房间的 apoptosis,当显著地增加了时象胃的粘膜房间的增长一样的 TGF-alpha 和 HSP70 的粘膜表示。与组 A 相比,溃疡索引( UI )( 26.8 +/- 9.8 对 12.0 +/- 5.9 , P <
0.01 ), AI ( 9.6 +/- 4.2 对 4.4 +/- 2.6 , P <
0.05 )并且 HSP70 的表示( 9.6 +/- 4.2 对 4.4 +/- 2.6 , P <
0.05 )显著地被增加,但是 TGF-alpha 的内容( 104.7 +/- 51.2 pg/mL 对 254.0 +/- 86.9 pg/mL , P <
0.01 )并且 PCNA-LI ( 6.9 +/- 4.7 对 14.9 +/- 4.6 , P <
0.05 )显著地在组 B 被减少。然而,溃疡索引价值(UI ) 和 AI 在与组 B 和 D 相比的组 C 显然是更低的(14.1 +/- 5.4 对 26.8 +/- 9.8 和 26.2 +/- 7.7, P <
0.01; 3.0 +/- 1.6 对 9.6 +/- 4.2 和 8.2 +/- 5.2 , P <
0.05 ,分别地),但是 TGF-alpha 的内容( 237.0 +/- 72.6 pg/mL 对 104.7 +/- 51.2 pg/mL 和 154.1 +/- 61.3 pg/mL , P <
0.01 )并且 HSP70 的表示( 0.13 +/- 0.03 对 0.08 +/- 0.06 和 0.06 +/- 0.04 , P <
0.05 )在组 C 是更高的。而且, PCNA-LI 比在组 B 在组 C 是显著地更高的(21.6 +/- 4.1 对 6.9 +/- 4.7, P <
0.01 ) 。结论:在 Zusanli 和 Liangmen 点的艾灸在支持 TGF-alpha 的合成和胃的粘膜房间的增长与它的行动有关仔细在导致压力的胃溃疡在老鼠胃粘膜上有保护的效果,它是,压制胃的粘膜房间 apoptosis,和起来调整的 HSP70 表示。 | Shou-Xiang Yi Yan Peng Xiao-Rong Chang Na Peng Jie Yan Yap-Ping Lin | 2007 | World Journal of Gastroenterology2007，13，15： | 25 |
| 6 | Effect of acupuncture at Foot-Yangming Meridian on gastric mucosal blood flow, gastric motiiity and brain-gut peptide显示文摘瞄准:在胃的粘膜血流(GMBF ) 上在 Foot-Yangming 顶点观察针灸的效果,胃的活动性和大脑勇气肽。方法:六十只 SD 老鼠随机被划分成 6 个组:正常控制组,为组建模(有胃的粘膜损坏的组, GMD ), Sibai 组(在在 Sibai 点+ GMD 的针灸方面), Tianshu 组(在在 Tianshu 点+ GMD 的针灸方面), Zusanli 组(在在 Zusanli 点+ GMD 的针灸方面)并且 non-acupoint 组(在在 non-acupoint + GMD 的针灸方面)。GMD 模型组被灌输纯酒精进胃的洞劝诱。H2 煤气的清理测试(HGCT ) 被用来测量胃的活动性的 GMBF,频率和振幅被飞行器的包囊的方法测量,在湾穴 ventriculi 和灯泡的大脑勇气肽的内容我们髓被放射性免疫测定检测。结果:频率的禁止的效果和胃的活动性的振幅在模型组被显示出,并且频率的率和振幅变化与正常控制组显著地不同(- 19.41 +/- 17.21 对 -4.71 +/- 10.32, P <
0.05;-51.61 +/- 29.02 对 1.81 +/- 14.12, P <
0.01 ) 。与控制组比较, GMBF 是 0.52 +/- 0.161 mL 对 1.03 +/- 0.255 mL 每 100g tissue/min , P <
0.01 ,在湾穴 ventriculi 和灯泡的 motilin 的内容我们髓是 63.04 +/- 7.77 pg/mL 对 72.91 +/- 8.42 pg/mL , P <
0.05 和 50.96 +/- 8.77 pg/mL 对 60.76 +/- 8.05 pg/mL , P <
0.05 ,但是在湾穴 ventriculi 和灯泡的 somatostatin 的内容我们髓是 179.85 +/- 43.13 ng/g 对 90.54 +/- 40.42 ng/g , P <
0.01 和 532.86 +/- 122.58 ng/g 对 370.91 +/- 76.29 ng/g , P <
0.05 分别地。与模型组比较,胃的活动性的振幅是 1.52 +/- 20.13 , -6.52 +/- 23.31 , 6.92 +/- 25.21 对 -51.61 +/- 29.02 , P <
0.01 并且 GMBF 是 0.694 +/- 0.160 mL 对 0.893 +/- 0.210 mL , 1.038 +/- 0.301 mL 对 0.52 +/- 0.161 mL 每 100g tissue/min , P <
0.01 ,分别地在 Tianshu , Sibai 和 Zusanli 组织,在湾穴 ventriculi 和灯泡的 motilin 的内容我们髓是 71.64 +/- 9.35 pg/mL 对 63.04 +/- 7.77 pg/mL , P <
0.05 ; 58.96 +/- 6.69 pg/mL 对 50.96 +/- 8.77 pg/mL , 0.05 在 Zusanli 组织的 P <
和 72.84 +/- 8.62 pg/mL 对 63.04 +/- 7.77 pg/mL ,, 0.05 在 Sibai 组织的 P <
在灯泡的 somatostatin 的内容我们在 Tianshu , Sibai 和 Zusanli 组的髓是 480.62 +/- 151.69 ng/g , 388.53 +/- 155.04 ng/g , 365.76 +/- 143.93 ng/g 对 532.86 +/- 122.58 ng/g , P <
0.05 分别地。结论:电镀物品 -- 在 Foot-Yangming 顶点的 acupoints 的针灸能提高胃的活动性,改进 GMBF,并且调整在湾穴 ventriculi 和灯泡的 motilin 和 somatostatin 的内容我们。GMBF 和胃的活动性上的针灸的效果可能与大脑勇气肽的内容有关。 | Ya-Ping Lin Shou-Xiang Yi Jie Yan Xiao-Rong Chang | 2007 | World Journal of Gastroenterology2007，13，15： | 26 |
| 7 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 8 | Association of high expression in rat gastric mucosal heat shock protein 70 induced by moxibustion pretreatment with protection against stress injury显示文摘AIM:To study the effect of moxibustion on Zusanli or Liangmeng point on gastric mucosa injury in stress-induced ulcer rats and its correlation with the expression of heat shock protein 70 (HSP70). METHODS:Sixty healthy SD rats (30 males,30 females) were divided into control group,injury model group,Zushanli point group,Liangmeng point group. Stress gastric ulcer model was induced by binding cold stress method. Gastric mucosa ulcer injury (UI) index was calculated by Guth method. Gastric mucosa blood flow (GMBF) was recorded with a biological signal analyzer. Protein content and gene expression in gastric mucosal HSP70 were detected by immunohistochemistry (IHC) and reverse transcription polymerase chain reaction (RT-PCR). Thiobarbital method was used to determine malondialdehyde (MDA) content. Gastric mucosal endothelin (ET) and prostaglandin E2 (PGE2) were analyzed by radioimmunoassay. RESULTS:High gastric mucosal UI index,high HSP70 expression,low GMBF and PGF2,elevated MDA and ET were observed in gastric mucosa of rats subjected to cold stress. Moxibustion on Zusanli or Liangmeng point decreased rat gastric mucosal UI index,MDA and ET. Conversely,the expression of HSP70,GMBF,and PGE2 was elevated in gastric mucosa after pretreatment with moxibustion on Zusanli or Liangmeng point. The observed parameters were significantly different between Zusanli and Liangmeng points. CONCLUSION:Pretreatment with moxibustion on Zusanli or Liangmeng point protects gastric mucosa against stress injury. This protection is associated with the higher expression of HSP70 mRNA and protein,leading to release of PGE2 and inhibition of MDA and ET,impairment of gastric mucosal index. | Xiao-Rong Chang La Peng Shou-Xiang Yi Yan Peng Jie Yan | 2007 | World Journal of Gastroenterology2007，13，32： | 22 |
| 9 | Improved ant colony optimization algorithm for the traveling salesman problems显示文摘Ant colony optimization(ACO) is a new heuristic algorithm which has been proven a successful technique and applied to a number of combinatorial optimization problems.The traveling salesman problem(TSP) is among the most important combinatorial problems.An ACO algorithm based on scout characteristic is proposed for solving the stagnation behavior and premature convergence problem of the basic ACO algorithm on TSP.The main idea is to partition artificial ants into two groups:scout ants and common ants.The common ants work according to the search manner of basic ant colony algorithm,but scout ants have some differences from common ants,they calculate each route's mutation probability of the current optimal solution using path evaluation model and search around the optimal solution according to the mutation probability.Simulation on TSP shows that the improved algorithm has high efficiency and robustness. | Rongwei Gan Qingshun Guo Huiyou Chang Yang Yi | 2010 | Journal of Systems Engineering and Electronics2010，21，2： | 22 |
| 10 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 11 | Review of MXenes as new nanomaterials for energy storage/delivery and selected environmental applications显示文摘Energy and environmental issues presently attract a great deal of scientific attention. Recently, two-dimensional MXenes and MXene-based nanomaterials have attracted increasing interest because of their unique properties (e.g., remarkable safety, a very large interlayer spacing, environmental flexibility, a large surface area, and thermal conductivity). In 2011, multilayered MXenes (Ti3C2Tx, a new family of two-dimensional (2D) materials) produced by etching an A layer from a MAX phase of Ti3AlC2, were first described by researchers at Drexel University. The term “MXene” was coined to distinguish this new family of 2D materials from graphene, and applies to both the original MAX phases and MXenes fabricated from them. We present a comprehensive review of recent studies on energy and environmental applications of MXene and MXene-based nanomaterials, including energy conversion and storage, adsorption, membrane, photocatalysis, and antimicrobial. Future research needs are discussed briefly with current challenges that must be overcome before we completely understand the extraordinary properties of MXene and MXene-based nanomaterials. | Byung-Moon Jun Sewoon Kim Jiyong Heo Chang Min Park Namguk Her Min Jang Yi Huang Jonghun Han Yeomin Yoon | 2019 | Nano Research2019，12，3： | 18 |
| 12 | Transmission Network Expansion Planning Considering Uncertainties in Loads and Renewable Energy Resources显示文摘This paper proposes a novel method for transmission network expansion planning(TNEP)that take into account uncertainties in loads and renewable energy resources.The goal of TNEP is to minimize the expansion cost of candidate lines without any load curtailment.A robust linear optimization algorithm is adopted to minimize the load curtailment with uncertainties considered under feasible expansion costs.Hence,the optimal planning scheme obtained through an iterative process would be to serve loads and provide a sufficient margin for renewable energy integration.In this paper,two uncertainty budget parameters are introduced in the optimization process to limit the considered variation ranges for both the load and the renewable generation.Simulation results obtained from two test systems indicate that the uncertainty budget parameters used to describe uncertainties are essential to arrive at a compromise for the robustness and optimality,and hence,offer a range of preferences to power system planners and decision makers. | Jinyu Wen Xingning Han Jiaming Li Yan Chen Haiqiong Yi Chang Lu | 2015 | CSEE Journal of Power and Energy Systems2015，1，1： | 17 |
| 13 | Effect of electro-acupuncture at Foot-Yangming Meridian on somatostatin and expression of somatostatin receptor genes in rabbits with gastric ulcer显示文摘瞄准:为了与胃溃疡在兔子在胃的粘膜损害, somatostatin (SS ) 和 SS 受体基因(SSR (1 ) mRNA ) 的表示上在 Foot-Yangming 顶点讨论电镀物品针灸的保护的效果并且推进,在基因表示水平探索顶点和内脏的相对特性。方法:四十只兔子随机被划分成控制组(A) ,胃溃疡模型组(B) , Foot-Yangming 顶点组(C) , Foot-Shaoyang 顶点组(D) 和 Foot-Taiyang 顶点组(E) 。胃溃疡模型被灌输酒精进胃准备。组 C-E 用分别地为 7 d 刺激仪器的顶点沿着上述顶点在点与电镀物品针灸被对待。在处理底,胃溃疡的索引被决定,表皮的生长因素(EGF ) 的数量和 somatostatin 被放射性免疫测定(RIA ) 测量。在胃粘膜的 SS-R (1 ) mRNA 表示被 RT-PCR 决定。结果:在模型组的 EGF 的值显然更低(73.6+/-14.8 对 91.3+/-14.9 pg/mL, P<0.01 ) 比那在控制组。胃溃疡的索引, SS 的内容和在胃粘膜的 SSR1mRNA 的表示比在控制组的那些显著地高(24.88+/-6.29 对 8.50+/-2.98 分数, P<0.01;2978.6+/-587.6 对 1852.4+/-361.7 mIU/mL, P<0.01;2.56+/-0.25 对 1.04+/-0.36, P<0.01 ) 。在 Foot-Yangming 顶点组的 EGF 的价值在模型组比那高(92.2+/-6.7 对 73.6+/-14.8 pg/mL, P<0.01 ) 。胃溃疡的索引, SS 的内容和在胃粘膜的 SS-R (1 ) mRNA 的表示是比在控制组的那些显著地低的(10.88+/-3.23 对 24.88+/-6.29 分数, P<0.01;1800.2+/-488 对 2978.6+/-587.6 mIU/mL, P<0.01;1.07+/-0.08 对 2.56+/-0.25 mIU/mL, P<0.01 ) 。比作模型组, SS 的内容和在在 Foot-Shaoyang 顶点组的胃粘膜的 SSR1mRNA 的表示减少了(2441.0+/-488 .vs 2978.6+/-587.6 mIU/mL, P<0.05; 1.73+/-0.16 对 2.56+/-0.25 mIU/mL, P<0.01 ) 。但是在 Foot-Taiyang 顶点组的上述参数没改善并且与在 Foot-Yangming 顶点组(P<0.05 ) 的那些显著地不同。结论:在 Foot-Yangming 顶点的电镀物品针灸能保护胃粘膜免于损害。机制可能与大脑勇气肽的规定和 SSR (1 ) mRNA 的表示有关。 | Shou-Xiang Yi Ren-Da Yang Jie Yan Xiao-Rong Chang Ya-Ping Ling | 2006 | World Journal of Gastroenterology2006，12，11： | 16 |
| 14 | Intense exercise can cause excessive apoptosis and synapse plasticity damage in rat hippocampus through Ca2+ overload and endoplasmic reticulum stress-induced apoptosis pathway显示文摘 | Ding Yi Chang Cunqing Xie Lan Chen Zhimin Ai Hua | 2014 | Chinese Medical Journal2014，，18： | 15 |
| 15 | Effect of acupuncture at different meridian acupoints on changes of related factors for rabbit gastric mucosal injury显示文摘AIM: To explore the regularity of multi-meridians controlling a same viscus (MMCSV).METHODS: The rabbit gastric ulcer model was established by ethanol intragastric instillation. Fifty-six rabbits were randomly divided into normal group, model group (MG), model plus acupuncture at Foot Yangming Meridian group (YMG), model plus acupuncture at Foot Taiyin Meridian group (TYG), model plus acupuncture at Foot Shaoyang Meridian group (SYG), model plus acupuncture at Foot Jueyin Meridian group (JYG), model plus acupuncture at Foot Taiyang Meridian group (TYMG),with eight rabbits in each group. Gastric mucosal nitric oxide (NO) and nitric oxide synthase (NOS) were assayed by the nitric acid reductase method, and prostaglandin E2 (PGE2) and epidermal growth factor (EGF) were measured by radioimmunoassay. The comprehensive effects were analyzed by weighing method.RESULTS: Compared to MG, SYG, JYG and TYMG, the rabbits gastric mucosal injury index (GMⅡ) reduced very significantly in YMG (P<0.01). Compared to MG, the GMⅡ also reduced significantly in TYG (P<0.05). NO,NOS, PGE2 and EGF increased very significantly in YMG (P<0.01). The EGF in YMG also increased significantly than that in TYG compared to those in MG, SYG, JYG and TYMG (P<0.05). The PGE2 and EGF also increased very significantly in TYG than those in MG, JYG and TYMG (P<0.01). While compared to SYG, the NOS increased significantly in TYG (P<0.05). NOS was thehighest in YMG (P<0.01), and was higher in TYG than in MG (P<0.01).CONCLUSION: MMCSV is common. The Foot Yangming Meridian is most closely related to the stomach, followed by Foot Taiyin Meridian, Foot Shaoyang Meridian and Foot Jueyin Meridian. Foot Taiyang Meridian has no correlation with the stomach. | Jie Yan Ren-Da Yang Jun-Feng He Shou-Xiang Yi Xiao-Rong Chang Ya-Ping Lin | 2005 | World Journal of Gastroenterology2005，11，41： | 14 |
| 16 | PGC-1α induces apoptosis in human epithelial ovarian cancer cells through a PPARy-dependent pathway显示文摘Peroxisome 激活 proliferator 的受体鲸鱼群妈(PPAR γ) coactivator-1 高山哈(PGC-1 α) coactivates 多重抄写因素并且调整几个代谢过程。Thecurrent 学习在人的上皮的卵巢的癌症房间在 apoptosis 的正式就职调查了 PGC-1 α的角色。在人的卵巢和人的卵巢的上皮的肿瘤之间的 PGC-1 α信使 rna 水平被量的 RT-PCR 检验。更少的 PGC-1 α表示与正常卵巢相比在恶意的肿瘤的表面上皮被发现。在人的上皮的卵巢的癌症房间线 Ho-8910 的 PGC-1 α的 Overexpression 通过 Bcl-2 和 Bax 表示的协调规定导致了房间 apoptosis。Microarray 分析证实 PGC-1 α戏剧性地在 Ho-8910 房间影响了 apoptosis 相关的基因。 Mitochondrial 功能的试金证明 apoptosis 的正式就职通过由细胞色素 c.Furthermore 的版本的终端阶段,导致的 apoptosis 部分是,然而并非完全,由 PPAR γa ntagonist ( GW9662 )堵住了的 PGC-1 α-,并且由 siRNA 的 PPAR γ 表示的抑制也在 Ho-8910 房间禁止了 PGC-1 α- inducedapoptosis 。这些数据建议 PGC-1 α通过 aPPAR γ - 依赖者小径施加了它的效果。我们的调查结果显示 PGC-1 α涉及 apoptotic signaltransduction 小径, PGC-1 α的 down 规定可以是在支持上皮的卵巢的癌症生长和前进的一个关键点。 | Yan Zhang Yi Ba Chang Liu Guoxun Sun Li Ding Songyuan Gao Jihui Hao Zhentao Yu Junfeng Zhang Ke Zen Zhongsheng Tong Yang Xiang Chen-Yu Zhang | 2007 | Cell Research2007，17，4： | 14 |
| 17 | Human Acyl-CoA:cholesterol Acyltransferase (ACAT) and its Potential as a Target for Pharmaceutical Intervention against Atherosclerosis显示文摘Acyl-CoA:cholesterol acyltransferase (ACAT ) 从胆固醇和长链的 fatty-acyl-coenzyme A 催化 cholesteryl 酉旨的形成。在单个房间的水平, ACAT 用作细胞内部的胆固醇动态平衡的一个管理者。另外, ACAT 在肝和小肠为脂蛋白汇编供应 cholesteryl 酉旨。在病理学的条件下面, ACAT 在巨噬细胞生产的 cholesteryl 酉旨的累积贡献泡沫房间形成,动脉粥样硬化的早阶段的一个特点。探讨 ACAT 和 ACAT 禁止者的各种各样的方面的几评论是可得到的。这评论简短在人的 ACAT 的生物化学的性质上构画出当前的知识,然后集中于对动脉粥样硬化为药品的干预作为一个药目标讨论 ACAT 的优点。 | Catherine CHANG Ruhong DONG Akira MIYAZAKI Naomi SAKASHITA Yi ZHANG Jay LIU Michael GUO Bo-Liang LI Ta-Yuan CHANG | 2006 | Acta Biochimica et Biophysica Sinica2006，38，3： | 13 |
| 18 | Knockdown of FoxM1 by siRNA interference decreases cell proliferation, induces cell cycle arrest and inhibits cell invasion in MHCC-97H cells in vitro显示文摘 | Qi-fei WU Chang LIU Ming-hui TAI Dong LIU Lei LEI Rui-tao WANG Min TIAN Yi Lü | 2010 | Acta Pharmacologica Sinica2010，31，3： | 13 |
| 19 | Changing Proportions of HIV-1 Subtypes and Transmitted Drug Resistance Among Newly Diagnosed HIV/AIDS Individuals—China,2015 and 2018显示文摘Introduction:With the expansion of human immunodeficiency virus(HIV)antiretroviral therapy(ART),HIV drug resistance is becoming more and more serious.This study describes the changing prevalence of HIV-1 subtypes and transmitted drug resistance(TDR)among newly diagnosed individuals in China,2015 and 2018.Methods:A total of 8,980 individuals in 2015 and 2018 from 31 provincial-level administrative divisions(PLADs)were enrolled in this study.Viral RNAs were amplified and sequenced using an in-house polymerase chain reaction(PCR)protocol.The Stanford HIV Drug Resistance Database(HIVdb)was used to predict susceptibility to 12 antiretroviral drugs.Results:The prevalence of TDR was not significantly increased over time.The prevalence of TDR was 3.8%and 4.4%in 2015 and 2018,respectively(P=0.13).The prevalence of CRF55_01B increased from 2.3%in 2015 to 3.9%in 2018(P<0.001).The drug resistance prevalence of nonnucleoside reverse transcriptase inhibitors(NNRTI)increased from 2.4%in 2015 to 3.3%in 2018(P<0.01).The prevalence of E138(P<0.001),H221(P=0.03),and V179(P<0.001)mutations increased from 0.30%,0.09%,and 0.70%in 2015 to 1.10%,0.30%,and 1.70%in 2018,respectively.Conclusions:HIV drug resistance affects the effect of antiretroviral treatment,so the monitoring of HIV TDR should be strengthened to control the transmission of HIV drug resistance. | Jingjing Hao Shan Zheng Mengze Gan Aobo Dong Ruihua Kang Miaomiao Li Shuai Zhao Jing Hu Chang Song Lingjie Liao Yi Feng Yiming Shao Yuhua Ruan Hui Xing | 2021 | China CDC weekly2021，3，53： | 13 |
| 20 | Antioxidation Activities of Low-Molecular-Weight Gelatin Hydrolysate Isolated from the Sea Cucumber Stichopus japonicus显示文摘Gelatin extracted from the body wall of the sea cucumber (Stichopus japonicus) was hydrolyzed with flavourzyme.Low-molecular-weight gelatin hydrolysate (LMW-GH) of 700-1700 Da was produced using an ultrafiltration membrane bioreactor system.Chemiluminescence analysis revealed that LMW-GH scavenges high free radicals in a concentration-dependent manner;IC50 value for superoxide and hydroxyl radicals was 442 and 285 μg mL-1,respectively.LMW-GH exhibited excellent inhibitory characteristics against melanin synthesis and tyrosinase activity in B16 cells.Furthermore,LMW-GH notably increased intracellular glutathione (GSH),which in turn suppressed melanogenesis.LMW-GH performs antioxidation activity,holding the potential of being used as a valuable ingredient in function foods,cosmetics and pharmaceuticals or nutriceuticals. | WANG Jingfeng WANG Yuming TANG Qingjuan WANG Yi CHANG Yaoguang ZHAO Qin XUE Changhu | 2010 | Journal of Ocean University of China2010，9，1： | 13 |
您所在的机构暂未开通此部分的功能，请联系管理员