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| 1 | The Tea Tree Genome Provides Insights into Tea Flavor and Independent Evolution of Caffeine Biosynthesis显示文摘茶是世界有巨大的经济、药用、文化的重要性的最旧、很流行的包含咖啡因的饮料。这里,我们在场第一个高质量的核苷酸序列充满重复(80.9%) ,栽培的茶树山茶 sinensis 的 3.02-Gb 染色体。我们证明茶树的一种非常地大的染色体尺寸从一些 LTR retrotransposon 家庭的慢、稳定、长期的扩大被结果。除了一个最近的整个染色体的复制事件,基因的系特定的扩大把新陈代谢的生合成与 flavonoid 联系了被发现,它提高 catechin 生产,萜烯酶激活,和应力公差,为茶风味和改编的重要特征。我们相对可可子和咖啡表明一个独立人士和茶咖啡因合成小径的快速的进化。在 25 山茶种类之中的比较研究表明那更高的表情大多数 flavonoid- 和咖啡因铺平 -- 然而并非 theanine 相关的基因贡献 catechins 和咖啡因的增加的生产并且因此提高处理茶的适用性和茶质量。这些新奇调查结果为进一步的 metabolomic 和典型生合成小径的功能的 genomic 精炼铺平道路并且将帮助开发将最后满足并且吸引世界范围的更多的茶喝酒者的茶风味的一个更多样化的集合。 | En-Hua Xia Hai-Bin Zhang Jun Sheng Kui Li Qun-Jie Zhang Changhoon Kim Yun Zhang Yuan Liu Ting Zhu Wei Li Hui Huang Yan Tong Hong Nan Cong Shi Chao Shi Jian-Jun Jiang Shu-Yan Mao Jun-Ying Jiao Dan Zhang Yuan Zhao You-Jie Zhao Li-Ping Zhang Yun-Long Liu Ben-Ying Liu Yue Yu Sheng-Fu Shao De-Jiang Ni Evan E. Eichler Li-Zhi Gao | 2017 | Molecular Plant2017，10，6： | 113 |
| 2 | The Serum Exosome Derived MicroRNA-135a,-193b, and-384 Were Potential Alzheimer's Disease Biomarkers显示文摘Objective MicroR NAs(mi Rs) are attractive molecules to be considered as one of the blood-based biomarkers for neurodegenerative disorders such as Alzheimer's disease(AD). The goal of this study was to explore their potential value as biomarkers for the diagnosis of AD. Methods The expression levels of exosomal miR-135 a,-193 b, and-384 in the serum from mild cognitive impairment(MCI), dementia of Alzheimer-type(DAT), Parkinson's disease with dementia(PDD), and vascular dementia(VaD) patients were measured with a real-time quantitative reverse transcriptase PCR(qR T-PCR) method. Results Both serum exosome mi R-135 a and miR-384 were up-regulated while miR-193 b was down-regulated in serum of AD patients compared with that of normal controls. Exosome miR-384 was the best among the three miR s to discriminate AD, VaD, and PDD. Using the cut-off value could better interpret these laboratory test results than reference intervals in the AD diagnosis. ROC curve showed that the combination of mi R-135 a,-193 b, and-384 was proved to be better than a particular one for early AD diagnosis. Conclusion Our results indicated that the exosomal miR s in the serum were not only potential biomarker of AD early diagnosis, but might also provide novel insights into the screen and prevention of the disease. | YANG Ting Ting LIU Chen Geng GAO Shi Chao ZHANG Yi WANG Pei Chang | 2018 | Biomedical and Environmental Sciences2018，31，2： | 35 |
| 3 | VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex显示文摘肺癌症是与高发生和死亡世界范围的大多数破坏疾病之一。河马(Hpo ) 小径是在果蝇和哺乳动物的机关尺寸的一个保存管理者。新兴的证据在癌症开发建议了 Hpo 小径的意义。在这研究,我们通过否定地调整 YAP-TEAD 建筑群的形成在肺 carcinogenesis 作为新奇肿瘤 suppressor 识别 VGLL4, Hpo 的核心部件小径。我们 VGLL4 经常被观察低层的数据表演在老鼠和人的肺癌症标本表示了。VGLL4 的宫外的表示显著地在 vitro 压制肺癌症房间的生长。更重要地, VGLL4 显著地在 de novo 老鼠模型禁止肺癌症前进。我们进一步发现 VGLL4 禁止 YAP-TEAD transcriptional 建筑群的活动。我们 VGLL4 直接在绑定与笨蛋竞争到 TEAD 并且执行的数据表演它通过二 TDU 域的生长禁止的函数。一起,我们的学习证明 VGLL4 是为通过否定地调整 YAP-TEAD 复杂形成并且这样的肺癌症的新奇肿瘤 suppressor Hpo 小径。 | Wenjing Zhang Yijun Gao Peixue Li Zhubing Shi Tong Guo Fei Li Xiangkun Han Yan Feng Chao Zheng Zuoyun Wang Fuming Li Haiquan Chen Zhaocai Zhou Lei Zhang Hongbin Ji | 2014 | Cell Research2014，24，3： | 25 |
| 4 | Subsoiling and Ridge Tillage Alleviate the High Temperature Stress in Spring Maize in the North China Plain显示文摘High temperature stress(HTS)on spring maize(Zea mays L.)during the filling stage is the key factor that limits the yield increase in the North China Plain(NCP).Subsoiling(SS)and ridge tillage(R)were introduced to enhance the ability of spring maize to resist HTS during the filling stage.The field experiments were conducted during the 2011 and 2012 maize growing seasons at Wuqiao County,Hebei Province,China.Compared with rotary tillage(RT),the net photosynthetic rate,stomatal conductance,transpiration rate,and chlorophyll relative content(SPAD)of maize leaves was increased by 40.0,42.6,12.8,and 29.7%under SS,and increased by 20.4,20.0,5.4,and 14.2%under R,repectively.However,the treatments reduce the intercellular CO2concentration under HTS.The SS and R treatments increased the relative water content(RWC)by 11.9 and6.2%,and the water use efficiency(WUE)by 24.3 and 14.3%,respectively,compared with RT.The SS treatment increased the root length density and soil moisture in the 0-80 cm soil profile,whereas the R treatment increased the root length density and soil moisture in the 0-40 cm soil profile compared with the RT treatment.Compared with 2011,the number of days with temperatures 33°C was more 2 d and the mean day temperature was higher 0.9°C than that in 2012,whereas the plant yield decreased by 2.5,8.5 and 10.9%,the net photosynthetic rate reduced by 7.5,10.5 and 18.0%,the RWC reduced by 3.9,5.6 and6.2%,and the WUE at leaf level reduced by 1.8,5.2 and 13.1%in the SS,R and RT treatments,respectively.Both the root length density and the soil moisture also decreased at different levels.The yield,photosynthetic rate,plant water status,root length density,and soil moisture under the SS and R treatments declined less than that under the RT treatment.The results indicated that SS and R can enhance the HTS resistance of spring maize during the filling stage,and led to higher yield by directly improving soil moisture and root growth and indirectly improving plant water status,photosynthesis and grain filling.The study can provide a theoretical basis for improving yield of maize by adjusting soil tillage in the NCP. | TAO Zhi-qiang SUI Peng CHEN Yuan-quan LI Chao NIE Zi-jin YUAN Shu-fen SHI Jiang-tao GAO Wang-sheng | 2013 | Journal of Integrative Agriculture2013，12，12： | 20 |
| 5 | Infection with novel coronavirus(SARS-CoV-2)causes pneumonia in Rhesus macaques显示文摘The 2019 novel coronavirus(SARS-CoV-2)outbreak is a major challenge for public health.SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases,with a mortality rate of^6.4%worldwide(based on World Health Organization daily situation report).However,the dynamics of viral infection,replication and shedding are poorly understood.Here,we show that Rhesus macaques are susceptible to the infection by SARS-CoV-2.After intratracheal inoculation,the first peak of viral RNA was observed in oropharyngeal swabs one day post infection(1 d.p.i.),mainly from the input of the inoculation,while the second peak occurred at 5 d.p.i.,which reflected on-site replication in the respiratory tract.Histopathological observation shows that SARS-CoV-2 infection can cause interstitial pneumonia in animals,characterized by hyperemia and edema,and infiltration of monocytes and lymphocytes in alveoli.We also identified SARS-CoV-2 RNA in respiratory tract tissues,including trachea,bronchus and lung;and viruses were also re-isolated from oropharyngeal swabs,bronchus and lung,respectively.Furthermore,we demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a second-round challenge by SARS-CoV-2.The non-human primate model that we established here provides a valuable platform to study SARS-CoV-2 pathogenesis and to evaluate candidate vaccines and therapeutics. | Chao Shan Yan-Feng Yao Xing-Lou Yang Yi-Wu Zhou Ge Gao Yun Peng Lian Yang Xue Hu Jin Xiong Ren-Di Jiang Hua-Jun Zhang Xiao-Xiao Gao Cheng Peng Juan Min Ying Chen Hao-Rui Si Jia Wu Peng Zhou Yan-Yi Wang Hong-Ping Wei Wei Pang Zheng-Fei Hu Long-Bao Lv Yong-Tang Zheng Zheng-Li Shi Zhi-Ming Yuan | 2020 | Cell Research2020，30，8： | 19 |
| 6 | The Chromosome-Based Rubber Tree Genome Provides New Insights into Spurge Genome Evolution and Rubber Biosynthesis显示文摘The rubber tree,Hevea brasiliensis,produces natural rubber that serves as an essential industrial raw material.Here,we present a high-quality reference genome for a rubber tree cultivar GT1 using single-molecule real-time sequencing(SMRT)and Hi-C technologies to anchor the~1.47-Gb genome assembly into 18 pseudochromosomes.The chromosome-based genome analysis enabled us to establish a model of spurge chromosome evolution,since the common paleopolyploid event occurred before the split of Hevea and Manihot.We show recent and rapid bursts of the three Hevea-specific LTR-retrotransposon families during the last 10 million years,leading to the massive expansion by~65.88%(~970 Mbp)of the whole rubber tree genome since the divergence from Manihot.We identify large-scale expansion of genes associated with whole rubber biosynthesis processes,such as basal metabolic processes,ethylene biosynthesis,and the activation of polysaccharide and glycoprotein lectin,which are important properties for latex production.A map of genomic variation between the cultivated and wild rubber trees was obtained,which contains~15.7 million high-quality single-nucleotide polymorphisms.We identified hundreds of candidate domestication genes with drastically lowered genomic diversity in the cultivated but not wild rubber trees despite a relatively short domestication history of rubber tree,some of which are involved in rubber biosynthesis.This genome assembly represents key resources for future rubber tree research and breeding,providing novel targets for improving plant biotic and abiotic tolerance and rubber production. | Jin Liu Cong Shi Cheng-Cheng Shi Wei Li Qun-Jie Zhang Yun Zhang Kui Li Hui-Fang Lu Chao Shi Si-Tao Zhu Zai-Yun Xiao Hong Nan Yao Yue Xun-Ge Zhu Yu Wu Xiao-Ning Hong Guang-Yi Fan Yan Tong Dan Zhang Chang-Li Mao Yun-Long Liu Shi-Jie Hao Wei-Qing Liu Mei-Qi Lv Hai-Bin Zhang Yuan Liu Ge-Ran Hu-tang Jin-Peng Wang Jia-Hao Wang Ying-Huai Sun Shu-Bang Ni Wen-Bin Chen Xing-Cai Zhang Yuan-Nian Jiao Evan E.Eichler Guo-Hua Li Xin Liu Li-Zhi Gao | 2020 | Molecular Plant2020，13，2： | 15 |
| 7 | Prostate cancer antigen 3 moderately improves diagnostic accuracy in Chinese patients undergoing first prostate biopsy显示文摘(PCA3 ) 前列腺癌症抗原 3 是为诊断在白种人人口识别的前列腺癌症(PCa ) 的 biomarker。我们在在经历起始的前列腺活体检视的 500 个人预言活体检视结果评估了尿 PCA3 的有效性。PCA3 分数的预兆的力量在操作特征(巨鸟) 曲线(AUC ) 的接收装置下面并且由决定曲线分析由区域被评估。PCA3 分数足够了区别从否定前列腺活体检视结果积极但是没与 PCa 的攻击性被相关。巨鸟分析比 % fPSA 为 PCA3 分数显示出更高的 AUC (0.750 对 0.622, P = 0.046 ) 在有 4.0-10.0 ng 的 PSA 的病人, ml-1,而是基于 PCA3 的模型不比基础模型显著地好。决定曲线分析显示基于 PCA3 的模型比有为几乎所有阀值可能性的一个更高的网络好处的基础模型优异,在有 4.0-10.0 ng ml-1 的 PSA 的病人的 25%-40% 的特别阀值可能性。然而, PCA3 分数(0.712 ) 的 AUC 不在有 PSA 的病人比 % fPSA (0.698 ) 或 PSAD (0.773 ) 优异 > 10.0 ng ml-1。我们的结果证实 RT-PCR-based PCA3 测试中等在与 4.0-10.0 ng ml-1 的 PSA 经历第一前列腺活体检视的中国病人改进了诊断精确性。 | Fu-Bo Wang Rui Chen Shan-Cheng Ren Xiao-Lei Shi Ya-Sheng Zhu Wei Zhang Tai-Le Jing Chao Zhang Xu Gao Jian-Guo Hou Chuan-Liang Xu Ying-Hao Sun | 2017 | Asian Journal of Andrology2017，19，2： | 10 |
| 8 | Comparative analysis on grain quality and yield of different panicle weight indica-japonica hybrid rice(Oryza sativa L.) cultivars显示文摘Indica-japonica hybrid rice(Oryza sativa L.) cultivars showed high yield potential and poor tasting quality when compared with common japonica rice cultivars. Large panicle is a prominent factor of high yield for indica-japonica hybrid rice cultivars, and the panicle weight varies greatly among different indica-japonica hybrid rice cultivars. It is important to research on yield and grain quality of different panicle weight indica-japonica hybrid rice cultivars. In this study, two different panicle types indica-japonica hybrid cultivars were used to research on the relation of yield and grain quality. The yields of two heavy panicle weights indica-japonica hybrid cultivars were significantly higher than that of two medium panicle weight rice cultivars. The cooking and eating quality and starch properties of different panicle type cultivars were evaluated. Yongyou 6715(medium panicle) and Yongyou 1852(heavy panicle) got the relatively higher cooking and eating quality. Rice cultivars with medium panicle weight had more large starch granules and higher relative crystallinity than cultivars with heavy panicle weight. Transition temperature and retrogradation enthalpy(ΔHret) of medium panicle type cultivars were significantly higher than that of heavy panicle type cultivars. There was no significant difference in amylose content among different panicle type cultivars. Protein content of heavy panicle type cultivar was higher than that of medium panicle type cultivar, and protein content is the main factor affect cooking and eating quality in this study. The cultivar Yongyou 6715 got the highest taste value with the lowest protein content. Thus, it is suggested that the emphasis on improving rice cooking and eating quality of indica-japonica hybrid rice cultivars is how to reduce the protein content in rice grain. According to the results of this study, medium panicle type with high grain weight is the desired panicle type for high quality indica-japonica hybrid rice breeding. | BIAN Jin-long REN Gao-lei HAN Chao XU Fang-fu QIU Shi TANG Jia-hua ZHANG Hong-cheng WEI Hai-yan GAO Hui | 2020 | Journal of Integrative Agriculture2020，19，4： | 8 |
| 9 | Systematic characterization of transport and thermoelectric properties of a macroscopic graphene fiber显示文摘Graphene,有非凡的电、热、有弹性的性能的二维的材料,是未来技术的一个潜在的候选人。然而, graphene 的优异性质还没为 graphenederived 被认识到宏观的结构象 graphene 纤维那样。在这研究,我们系统地调查了温度(T) 依赖者运输和 graphene 纤维的热电的性质,包括热传导性() ,电的电导率() ,并且 Seebeck 系数(S) 。从 45.8 ~ 149.7 Wd | Weigang Ma Yingjun Liu Shen Yan Tingting Miao Shaoyi Shi Mincheng Yang Xing Zhang Chao Gao | 2016 | Nano Research2016，9，11： | 6 |
| 10 | Chemically doped macroscopic graphene fibers with significantly enhanced thermoelectric properties显示文摘当与突出的热电的性质结合了时,灵活便携电子学为收获系统的未来精力正在答应候选人。Graphene 和它的宏观的集会(例如,基于 graphene 的纤维和电影) 因为他们的非凡的电、机械的性质,因此是众多的研究的题目。然而,这些集会没由于他们的高内在的热传导性为热电的应用程序被认为合适。在这研究,溴做被表明是为显著地提高 graphene 纤维的热电的性质的一个有效方法。做提高声子由于增加的缺点散布并且因此减少热传导性,当电的传导性和 Seebeck 系数被费密增加时,铺平换至较低排挡。作为结果,优点的最大的数字是 2. | Weigang Ma Yingjun Liu Shen Yan Tingting Miao Shaoyi Shi Zhen Xu Xing Zhang Chao Gao | 2018 | Nano Research2018，11，2： | 6 |
| 11 | Design biodegradable Zn alloys: Second phases and their significant influences on alloy properties显示文摘Alloying combined with plastic deformation processing is widely used to improve mechanical properties of pure Zn.As-cast Zn and its alloys are brittle.Beside plastic deformation processing,no effective method has yet been found to eliminate the brittleness and even endow room temperature super-ductility.Second phase,induced by alloying,not only largely determines the ability of plastic deformation,but also influences strength,corrosion rate and cytotoxicity.Controlling second phase is important for designing biodegradable Zn alloys.In this review,knowledge related to second phases in biodegradable Zn alloys has been analyzed and summarized,including characteristics of binary phase diagrams,volume fraction of second phase in function of atomic percentage of an alloying element,and so on.Controversies about second phases in Zn-Li,Zn-Cu and Zn-Fe systems have been settled down,which benefits future studies.The effects of alloying elements and second phases on microstructure,strength,ductility,corrosion rate and cytotoxicity have been neatly summarized.Mg,Mn,Li,Cu and Ag are recommended as the major alloying elements,owing to their prominent beneficial effects on at least one of the above properties.In future,synergistic effects of these elements should be more thoroughly investigated.For other nutritional elements,such as Fe and Ca,refining second phase is a matter of vital concern. | Zhang-Zhi Shi Xi-Xian Gao Hai-Jun Zhang Xue-Feng Liu Hui-Yan Li Chao Zhou Yu-Xia Yin Lu-Ning Wang | 2020 | Bioactive Materials2020，5，2： | 5 |
| 12 | Prevalence of Metabolic Syndrome and Risk Factors Among Chinese Adults:Results from a Population-Based Study—Beijing,China,2017–2018显示文摘Summary What is already known about this topic?Metabolic syndrome(MetS)is one of the most easily available health indicative markers for cardiovascular diseases,and it has become a major public health problem worldwide due to increasing urbanization and aging populations.The prevalence of MetS increased dramatically in China,however,there are no records of MetS defined by the 2017 Chinese Diabetes Society for Beijing by far.What is added by this report?In this study,the data of 24,412 participants aged 18–74 years from a large population-based study in Beijing was collected.The overall prevalence of MetS among Beijing residents was 24.5%.The prevalence was 35.2%in males and 15.4%in females.What are the implications for public health practice?Effective public health strategies should target males,people with older age,lower education,higher body mass index,smokers,those who drink alcohol,those who are unemployed or retired,and those who live in rural areas on MetS prevention and control. | Jufen Liu Qingping Liu Zhiwen Li Jing Du Chao Wang Yanlin Gao Zaihua Wei Jing Wang Yunping Shi Jianting Su Yang Liu Ping Wang Chunyan Xie Gang Li Bing Shao Le Zhang | 2022 | China CDC weekly2022，4，29： | 4 |
| 13 | Relationships Between Icariin and Anti-Apoptotic miRNA-21 in Mouse Blastocyst Development In vitro显示文摘In this study, the effect of icariin, a flavonoid from the Chinese traditional medicine epimedium, on miRNA-21 of mouse developmental blastocysts in vitro and the development of preimplantation embryos were studied. The possible effective targets of icariin promoting preimplantation embryo development in vitro and anti-apoptosis were determined. The embryos were cultured in modified CZB medium (mCZB) as control group. The experimental group (Ica group) was supplemented with 0.6μmL-1 icariin. Mouse pronuclear embryos were cultured in vitro until blastocysts. The development rates of preimplantation embryos were observed. The total cell number, apoptotic cell number and the rate of apoptotic cells in blastocysts were analysed by the staining of Hoechst33342 and labeling of TUNEL and detected under a laser confocal scanning microscope. The miRNA-21 expression, the mRNA levels of pro-apoptotic Caspase3, and the target genes of miRNA-21: pro-apoptotic PTEN, anti-apoptotic Bcl-2 were detected by real-time RT-PCR. The results showed that percentages of morulaes and blastocysts in Ica group were both extremely higher than control group ((85.14?.57)% vs. (72.04?1.58)%; (82.50?.11)% vs. (66.80?1.70)%, respectively, P<0.01). The total cell number of blastocysts had extreme difference between Ica group and control group ((61.40?.64) vs. (46.23?.50), P<0.01). The apoptotic cell number and rate of apoptotic cells of blastocysts were both reduced in Ica group ((1.47?.51) vs. (2.94?.66); (2.40?.27)% vs. (6.25?.62)%, respectively, P<0.01). Compared to control group, addition of icariin into mCZB extremely increased the expression of anti-apoptotic miRNA-21 (P<0.01), down-regulated pro-apoptotic Caspase3 (P<0.05) and PTEN (P<0.01), up-regulated anti-apoptotic Bcl-2 (P<0.01). In conclusion, icariin could reduce the apoptosis, promote the embryo development in vitro by enhancing miRNA-21 expression to up-regulated anti-apoptotic genes and down-regulated pro-apoptotic genes. These apoptosis-related genes were regulated by miRNA-21. | SHI Ya-ran WANG Zhan-he CAO Yong-chun LU Yan TIAN Jin-ling ZhANG Chao JIA Zi-ye CHEN Wu GAO Jian-ming | 2013 | Journal of Integrative Agriculture2013，12，4： | 4 |
| 14 | The improvement of cross-calibration of IIM data and band selection for FeO inversion显示文摘Chang’E-1(CE-1)Interference Imaging Spectrometer(IIM)dataset suffers from the weak response in the near infrared(NIR)bands,which are the important wavelength for retrieving the minerals and elements of the Moon.In this paper,the cross-calibration was implemented to the IIM hyperspectral data for improving the weak response in NIR bands.The results show that the cross-calibrated IIM spectra were consistent to the Earth-based telescopic spectra,which suggests that the cross-calibration yields acceptable results.For further validating the influence of the cross-calibration on the FeO inversion and searching the optimal bands to retrieve lunar FeO contents,four band selection schemes were designed to retrieve FeO using the original and cross-calibrated IIM spectra.By comparing the distribution patterns and histograms of the IIM derived FeO contents with the Clementine derived FeO,the IIM 891 nm band after cross-calibration showed a higher accuracy in the FeO inversion,hence most useful for lunar FeO inversion. | WANG Chao WU YunZhao SHI RunHe GAO Wei | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，11： | 4 |
| 15 | Decreasing nitrogen assimilation under drought stress by suppressing DST-mediated activation of Nitrate Reductase 1.2 in rice显示文摘Nitrogen is an essential nutrient for plant growth and development,and plays vital roles in crop yield.Assimilation of nitrogen is thus fine-tuned in response to heterogeneous environments.However,the regulatory mechanism underlying this essential process remains largely unknown.Here,we report that a zinc-finger transcription factor,drought and salt tolerance(DST),controls nitrate assimilation in rice by regulating the expression of OsNR1.2.We found that loss of function of DSTresults in a significant decrease of nitrogen use efficiency(NUE)in the presence of nitrate.Furtherstudy revealed that DST is required for full nitrate reductase activity in rice and directly regulates the expression of OsNR1.2,a gene showing sequence similarity to nitrate reductase.Reverse genetics and biochemistry studies revealed that OsNR1.2 encodes an NADH-dependent nitrate reductase that is required for high NUE of rice.Interestingly,the DST-OsNR1.2 regulatory module is involved in the suppression of nitrate assimilation under drought stress,which contributes to drought tolerance.Considering the negative role of DST in stomata closure,as revealed previously,the positive role of DST in nitrogen assimilation suggests a mechanism couplingni-trogen metabolism and stomata movement.The discovery of this coupling mechanism will aid the engi-neering of drought-tolerant crops with high NUE in the future. | Mei-Ling Han Qiao-Yan Lv Jing Zhang Tao Wang Chao-Xing Zhang Ru-Jiao Tan Ya-Ling Wang Li-Yuan Zhong Yi-Qun Gao Zhen-Fei Chao Qian-Qian Li Gen-Yun Chen Zai Shi Hong-Xuan Lin Dai-Yin Chao | 2022 | Molecular Plant2022，15，1： | 4 |
| 16 | Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-Human Primates显示文摘The ongoing coronavirus disease 2019(COVID-19)pandemic caused more than 96 million infections and over 2 million deaths worldwide so far.However,there is no approved vaccine available for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the disease causative agent.Vaccine is the most effective approach to eradicate a pathogen.The tests of safety and efficacy in animals are pivotal for developing a vaccine and before the vaccine is applied to human populations.Here we evaluated the safety,immunogenicity,and efficacy of an inactivated vaccine based on the whole viral particles in human ACE2 transgenic mouse and in non-human primates.Our data showed that the inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in mice and non-human primates,and subsequently provided partial(in low dose)or full(in high dose)protection of challenge in the tested animals.In addition,passive serum transferred from vaccine-immunized mice could also provide full protection from SARS-CoV-2 infection in mice.These results warranted positive outcomes in future clinical trials in humans. | Yan-Feng Yao Ze-Jun Wang Ren-Di Jiang Xue Hu Hua-Jun Zhang Yi-Wu Zhou Ge Gao Ying Chen Yun Peng Mei-Qin Liu Ya-Nan Zhang Juan Min Jia Lu Xiao-Xiao Gao Jing Guo Cheng Peng Xu-Rui Shen Qian Li Kai Zhao Lian Yang Xin Wan Bo Zhang Wen-Hui Wang Jia Wu Peng Zhou Xing-Lou Yang Shuo Shen Chao Shan Zhi-Ming Yuan Zheng-Li Shi | 2021 | Virologica Sinica2021，36，5： | 4 |
| 17 | Isolation of toxic compounds from wild Phaeocystis globosa显示文摘Two new compounds, namely taenialactam C and globorin A(1 and 2), as well as six known compounds,cornoside(3), 2-phenylethyl-b-D-glucoside(4), 3-isopropyl-5-acetoxycyclohexene-2-one-1(5), 4-methyl-phenol(6), 5-[(2S)-2-aminobutyl]-2-methyl-phenol(7), and 1-(4-methylphenyl)-1-propanone(8) were isolated from wild Phaeocystis globosa. The structures of the new compounds were established by detailed spectroscopic analysis and by comparison with spectral data of related known compounds.The structures of the known compounds were identified by comparing their spectroscopic data with those reported in the literature. This paper also reports toxicity properties of the eight compounds against the brine shrimp Artemia salina and juvenile Epinephelus akaara fish. Some of these compounds showed significant lethality on the brine shrimp A. salina and the juvenile E. akaara fish. | Chao Long Wan-Ci Luo He-Ying Zhou Yu-Feng Shi Cheng-Hai Gao Ri-Ming Huang | 2016 | Chinese Chemical Letters2016，27，2： | 3 |
| 18 | Rapid Urbanization Induced Extensive Forest Loss to Urban Land in the Guangdong-Hong Kong-Macao Greater Bay Area, China显示文摘China has experienced rapid urbanizations with dramatic land cover changes since 1978. Forest loss is one of land cover changes, and it induces various eco-environmental degradation issues. As one of China’s hotspot regions, the Guangdong-Hong KongMacao Greater Bay Area(GBA) has undergone a dramatic urban expansion. To better understand forest dynamics and protect forest ecosystem, revealing the processes, patterns and underlying drivers of forest loss is essential. This study focused on the spatiotemporal evolution and potential driving factors of forest loss in the GBA at regional and city level. The Landsat time-series images from 1987 to2017 were used to derive forest, and landscape metrics and geographic information system(GIS) were applied to implement further spatial analysis. The results showed that: 1) 14.86% of the total urban growth area of the GBA was obtained from the forest loss in1987–2017;meanwhile, the forest loss area of the GBA reached 4040.6 km2, of which 25.60%(1034.42 km2) was converted to urban land;2) the percentages of forest loss to urban land in Dongguan(19.14%), Guangzhou(18.35%) and Shenzhen(15.81%) were higher than those in other cities;3) the forest became increasingly fragmented from 1987–2007, and then the fragmentation decreased from2007 to 2017);4) the landscape responses to forest changes varied with the scale;and 5) some forest loss to urban regions moved from low-elevation and gentle-slope terrains to higher-elevation and steep-slope terrains over time, especially in Shenzhen and Hong Kong.Urbanization and industrialization greatly drove forest loss and fragmentation, and, notably, hillside urban land expansion may have contributed to hillside forest loss. The findings will help policy makers in maintaining the stability of forest ecosystems, and provide some new insights into forest management and conservation. | YANG Chao LIU Huizeng LI Qingquan CUI Aihong XIA Rongling SHI Tiezhu ZHANG Jie GAO Wenxiu ZHOU Xiang WU Guofeng | 2021 | Chinese Geographical Science2021，31，1： | 3 |
| 19 | Flower Development and Photoperiodic Control of Flowering in Rice显示文摘Floral transition,which is referred to as a plant's transition from vegetative stage to reproductive stage,is considered to be a critical developmental switch in higher plants,for a timely flowering is a major factor of reproductive success.Endogenous and environmental cues,such as photoperiod,light quality,plant hormones concentrations and temperature,provide information to the plants whether the environment is favorable for flowering.These cues promote,or prevent,flowering through a complex genetic network,mediated by a careful orchestration of temporal and spatial gene expression.One of such cues is photoperiod.Rice(Oryza sativa L.) serves as a powerful model species for the understanding of flowering in higher plants,including flower development and photoperiodic control of flowering.In this review,we overviewed and discussed the flower development and its model.We also overviewed the photoperiodic pathways in rice flowering control,and summarized the pathways at molecular level. | XIANG Chao QU Li-jun GAO Yong-ming SHI Ying-yao | 2013 | Rice science2013，20，2： | 3 |
| 20 | The first data release(DR1) of the LAMOST regular survey显示文摘The Large sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST) general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio(SNR) ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters: late A,FGK-type stars with high quality spectra(1 061 918 entries), A-type stars(100 073 entries), and M-type stars(121 522 entries). This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided. | A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai Deng Xiao-Wei Liu Yi-Peng Jing Gang Wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Li Chen Xue-Lei Chen Xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng Jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-Liang He Jin-Liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua Jiang Xiang Jiang Zhi-Bo Jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li Guang-Wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li Yin-Bi Li Ye-Ping Li Yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao Yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang Guo-Min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-Ling Wang Jian-Ping Wang Jun-Xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-Qing Wang Xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang Hai-Feng Yang Hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang Jian-Nan Zhang Li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo | 2015 | Research in Astronomy and Astrophysics2015，15，8： | 2 |
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