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| 1 | Genome Editing and Double-Fluorescence Proteins Enable Robust Maternal Haploid Induction and Identification in Maize显示文摘 | Le Dong Lina Li Changlin Liu Chenxu Liu Shuaifeng Geng Xinhai Li Changling Huang Long Mao Shaojiang Chen Chuanxiao Xie | 2018 | Molecular Plant2018，11，9： | 22 |
| 2 | Undrained shear strength evaluation for hydrate-bearing sediment overlying strata in the Shenhu area, northern South China Sea显示文摘The undrained shear strength of shallow strata is a critical parameter for safety design in deep-water operations.In situ piezocone penetration tests(CPTU) and laboratory experiments are performed at Site W18-19 in the Shenhu area, northern South China Sea, where China's first marine hydrate exploitation operation is due to be located. The validation of the undrained shear strength prediction model based on CPTU parameters. Different laboratory tests, including pocket penetrometer, torvane, miniature vane and unconsolidated undrained triaxial tests, are employed to solve empirical cone coefficients by statistical and mathematical methods. Finally, an optimized model is proposed to describe the longitudinal distribution of undrained shear strength in calcareous clay strata in the Shenhu area. Research results reveal that average empirical cone coefficients based on total cone resistance, effective resistance, and excess-pore pressure are 13.8, 4.2 and 14.4, respectively. The undrained shear strength prediction model shows a good fit with the laboratory results only within specific intervals based on their compaction degree and gas-bearing conditions. The optimized prediction model in piecewise function format can be used to describe the longitudinal distribution of the undrained shear strength for calcareous clay within all depth intervals from the mud-line to the upper boundary of hydrate-bearing sediments(HBS). The optimized prediction result indicates that the effective cone resistance model is suitable for very soft to firm calcareous clays,the excess-pore pressure model can depict the undrained shear strength for firm to very stiff but gas-free clays,while the total cone resistance model is advantageous for evaluating the undrained shear strength for very stiff and gassy clays. The optimized model in piecewise function format can considerably improve the adaptability of empirical models for calcareous clay in the Shenhu area. These results are significant for safety evaluations of proposed hydrate exploitation projects. | Yanlong Li Gaowei Hu Nengyou Wu Changling Liu Qiang Chen Chen'an Li | 2019 | Acta Oceanologica Sinica2019，38，3： | 12 |
| 3 | (a-Diimine)palladium catalyzed ethylene polymerization and (co)polymerization with polar comonomers显示文摘In this review, a recent development of cationic ?-diimine palladium(II) complexes for ethylene polymerization and copolymerization with polar functionalized comonomers was briefly described. First, the polymerization mechanism for this type of catalysts was discussed. Next, recent advances in ligand design were provided with special focus on the influence of ligand structures on the catalytic polymerization properties. Last, the ethylene homopolymerization and copolymerization with various polar comonomers, especially acrylate and vinyl ethers were summarized. | Lihua Guo Changle Chen | 2015 | Science China Chemistry2015，58，11： | 11 |
| 4 | Experimental studies on the P-T stability conditions and influencing factors of gas hydrate in different systems显示文摘The P-T stability conditions of gas hydrate in different systems (i.e., solution, silica sand, and marine sediment) were studied using multi-step decomposition method with our experimental equipment. The effects of different ions with various concentrations and sediment grains on the P-T stability conditions of gas hydrate were investigated. The results show that different ions have different influences on the phase equilibrium of gas hydrate. However, the influence of ions is in a similar trend: the larger the concentration, the bigger the P-T curve shifts to the left. For the silica sand, the influence of pore capillarity of coarse particles (> 460 μm) can be negligible. The P-T curve measured in coarse silica is in agreement with that in pure water. However, the influence of pore capillarity of fine particles (< 35 μm) is significant. The maximum reduction value of temperature is 1.5 K for methane hydrate under stable state. The sediment from the South China Sea significantly affects the P-T stability conditions of methane hydrate, with an average reduction value of 1.9 K within the experimental conditions. This is mainly the result of both the pore water salinity and the pore capillarity of sediment. Because the pore water salinity is keeping diluted by the fresh water released from hydrate dissociation, the measured P-T stability points fall on different P-T curves with the decreasing salinity. | LIU ChangLing YE YuGuang SUN ShiCai CHEN Qiang MENG QingGuo HU GaoWei | 2013 | Science China Earth Sciences2013，56，4： | 11 |
| 5 | Mechanical Properties of Methane Hydrate-Bearing Interlayered Sediments显示文摘The complex distribution of gas hydrate in sediments makes understanding the mechanical properties of hydrate-bearing sediments a challenging task.The mechanical behaviors of hydrate-bearing interlayered sediments are still poorly known.A series of triaxial shearing tests were conducted to investigate the strength parameters and deformation properties of methane hydrate-bearing interlayered sediments at the effective pressure of 1 MPa.The results indicate that the stress-strain curves of hydrate-bearing interlayered sediments are significantly different from that of hydrate-bearing sediments.The peak strength,Young's modulus,initial yielding modulus,and failure mode are deeply affected by the methane hydrate distribution.The failure behaviors and mechanism of strain softening and hardening patterns of the interlayered specimens are more complicated than those of the integrated specimens.This study compares the different mechanical behaviors between integrated and interlayered specimens containing gas hydrate,which can serve as a reference for the prediction and analysis of the deformation behaviors of natural gas hydrate reservoirs. | DONG Lin LI Yanlong LIU Changling LIAO Hualin CHEN Guoqi CHEN Qiang LIU Lele HU Gaowei | 2019 | Journal of Ocean University of China2019，18，6： | 11 |
| 6 | Ag nanoparticles sensitize IR-induced killing of cancer cells显示文摘 | Ruizhi Xu Jun Ma Xinchen Sun ZhongpingChen Xiaoli Jiang Zhirui auo Lan Huang YangLi Meng Wang Changling Wang Jiwei Liu XuFan Jiayu Gu Xi Chen Yu Zhang Ning Gu | 2009 | Cell Research2009，19，8： | 11 |
| 7 | Study of the Surface Morphology of Gas Hydrate显示文摘Study of the surface morphology of gas hydrate is of great importance in understanding its physical properties and occurrence.In order to investigate the surface morphology of different types(sI and sII)and occurrences(pore-filling and fracture-filling)of gas hydrate,both lab-synthesized and drilled-gas hydrate samples were measured using cryo-scanning electron microscopy(cryo-SEM).Results showed that the surface of s I hydrate was relatively smooth,and spongy nano-pores(200–400 nm)gradually occurred at the surface during continuous observation.The surface of sII hydrate was more compact,showing a tier-like structure.Hydrate occurred in quartz sand and usually filled the pores of the sediments and both hydrate and sediments were cemented with each other.SEM observation of the gas hydrates collected from the South China Sea showed that the surface morphology and contact relation with sediments varied with hydrate occurrence.For instance,hydrates dispersed in sediments mainly filled the pores of the sediments.The existence of microorganism shells,such as foraminifera,was beneficial to the formation of gas hydrate.When hydrate occurred as a massive or vein structure,it was easily distinguished from the surrounding sediments.The surface of hydrate with massive or vein structure showed two distinct characters:one was dense and smooth,the other is porous(several to tens of micrometers in diameter).The occurrence of different hydrate morphologies was probably caused by the supplement rates of methane gas. | SUN Jianye LI Chengfeng HAO Xiluo LIU Changling CHEN Qiang WANG Daigang | 2020 | Journal of Ocean University of China2020，19，2： | 9 |
| 8 | Synthesis of silicon-functionalized polyolefins by subsequent cobalt-catalyzed dehydrogenative silylation and nickel-catalyzed copolymerization显示文摘Metal catalyzed olefin hydrosilylation and metal mediated olefin polymerization are both of great academic and industrial importance. In this article, these two aspects are combined to prepare siliconfunctionalized polyolefin materials. First, pyridine-diimine cobalt-catalyzed dehydrogenative silylations of various terminal olefins with alkylsilanes lead to the formation of a variety of allylsilanes at high yields.Then, the allylsilanes are copolymerized with ethylene using an a-diimine nickel catalyst, leading to the formation of branched polyolefins with high molecular weight and moderate comonomer incorporation.This subsequent catalytic process is an efficient strategy for the synthesis of silicon-functionalized polyolefins using widely available and inexpensive starting materials. | Shixin Zhou Changle Chen | 2018 | Science Bulletin2018，63，7： | 5 |
| 9 | Synchrotron radiation X-ray powder diffraction techniques applied in hydrogen storage materials--A review显示文摘Synchrotron radiation is an advanced collimated light source with high intensity. It has particular advantages in structural characterization of materials on the atomic or molecular scale. Synchrotron radiation X-ray powder diffraction(SR-XRPD) has been successfully exploited to various areas of hydrogen storage materials. In the paper, we will give a brief introduction on hydrogen storage materials, X-ray powder diffraction(XRPD), and synchrotron radiation light source. The applications of ex situ and in situ time-resolved SR-XRPD in hydrogen storage materials, are reviewed in detail. Future trends and proposals in the applications of the advanced XRPD techniques in hydrogen storage materials are also discussed. | Honghui Cheng Chen Lu Jingjing Liu Yongke Yan Xingbo Han Huiming Jin Yu Wang Yi Liu Changle Wu | 2017 | Progress in Natural Science:Materials International2017，27，1： | 5 |
| 10 | Effect of rotating magnetic field on the solidification microstructures of Pb-Sn alloys显示文摘The influence of the rotating magnetic field (RMF) on the solidification proc- ess of Pb-Sn binary alloys is studied by comparing the solidification microstructures under the common condition and RMF condition. It is found that the RMF can completely elimi- nate the gravity induced macrosegregation, and result in dendrite fragmentation and promote solute diffusion velocity. These differences are regarded as the effect of compli- cated melt flow caused by RMF. Moreover, when the content of the primary phase is small, many spherical microstructures form under the RMF condition. The analyses indicate that these special microstructures are likely the conjunction action of melt flow and concentra- tion and temperature field uniformity caused by RMF. | MENG Xiaohua CHEN Changle HONG Zhenyu WANG Jianyuan | 2006 | Science China(Technological Sciences)2006，49，3： | 4 |
| 11 | Subdiffraction optical manipulation of the charge state of nitrogen vacancy center in diamond显示文摘As a potential candidate for quantum computation and metrology,the nitrogen vacancy(NV)center in diamond presents both challenges and opportunities resulting from charge-state conversion.By utilizing different lasers for the photon-induced charge-state conversion,we achieved subdiffraction charge-state manipulation.The charge-state depletion(CSD)microscopy resolution was improved to 4.1 nm by optimizing the laser pulse sequences.Subsequently,the electron spin-state dynamics of adjacent NV centers were selectively detected via the CSD.The experimental results demonstrated that the CSD can improve the spatial resolution of the measurement of NV centers for nanoscale sensing and quantum information. | Xiangdong Chen Changling Zou Zhaojun Gong Chunhua Dong Guangcan Guo Fangwen Sun | 2015 | Light(Science & Applications)2015，4，1： | 4 |
| 12 | Investigation of Transformation for Ultrahigh Strength Steel Aermet 100显示文摘The heat-stagnation curves of two quenched and cryogenically treated ultrahigh strength AF1410 and Aermet 100 steels during heating and cooling in furnace have been measured. The results showed that the curve displayed an abnormal terrace in the course of heating, and within the temperature range corresponding to the terrace, the formation and growth of both cementite Fe3C and secondary hardening phase M2C in the steel make the carbon content in matrix ob- viously vary. It is in the region of terrace that the optimum combination of tensile strength and fracture toughness is obtained because of secondary hardening. Based on the measured heat-stagnation curve, several transformation points have been determined and the correctness was also verified by X-ray diffraction (XRD) and transmission electron microscopy (TEM). Furthermore, the influence of heating rate and tempering temperature on the crystal structure and stability of austenite has been studied. | Liuding WANG+, Lin LIU, Chengxi AO, Xiaojun LIU, Changle CHEN and Mokuang KANG (Northwestern Polytechnical University, Xi’an 710072, China) | 2000 | Journal of Materials Science & Technology2000，16，5： | 4 |
| 13 | Microstructure and properties of indium tin oxide thin films deposited by RF-magnetron sputtering显示文摘Tin-doped indium oxide (ITO) thin films were prepared using conventional radio frequency (RF) planar magne-tron sputtering equipped with IR irradiation using a ceramic target of In2O3/SnO2 with a mass ratio of 1:1 at various IR irradiation temperatures TI (from room temperature to 400°C). The refractive index, deposited ratio, and resistivity are functions of the sputtering Ar gas pressure. The microstructure of ITO thin films is related to IR TI, the crystalline seeds appear at TI = 300°C, and the films are amorphous at the temperature ranging from 27°C to 400°C. AFM investigation shows that the roughness value of peak-valley of ITO thin film (Rp-v) and the surface microstructure of ITO thin films have a close relation with TI. The IR irradiation results in a widening value of band-gap energy due to Burstein-Moss effect and the maximum visible transmittance shifts toward a shorter wavelength along with a decrease in the film’s refractive index. The plasma wavelength and the refractive index of ITO thin films are relative to the TI. XPS investigation shows that the photoelectrolytic properties can be deteriorated by the sub-oxides. The deterioration can be decreased by increasing the oxygen flow rate (fo2), and the mole ratio of Sn/In in the samples reduces with an increase in fo2. | LI Shitao QIAO Xueliang CHEN Jianguo JIA Fang WU Changle | 2006 | Rare Metals2006，25，4： | 4 |
| 14 | A CRISPR/Cas12a-empowered surface plasmon resonance platform for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2显示文摘The outbreak of the COVID-19 pandemic was partially due to the challenge of identifying asymptomatic and presymptomatic carriers of the virus,and thus highlights a strong motivation for diagnostics with high sensitivity that can be rapidly deployed.On the other hand,several concerning SARS-CoV-2 variants,including Omicron,are required to be identified as soon as the samples are identified as‘positive’.Unfortunately,a traditional PCR test does not allow their specific identification.Herein,for the first time,we have developed MOPCS(Methodologies of Photonic CRISPR Sensing),which combines an optical sensing technology-surface plasmon resonance(SPR)with the‘gene scissors’clustered regularly interspaced short palindromic repeat(CRISPR)technique to achieve both high sensitivity and specificity when it comes to measurement of viral variants.MOPCS is a low-cost,CRISPR/Cas12a-systemempowered SPR gene-detecting platform that can analyze viral RNA,without the need for amplification,within 38 min from sample input to results output,and achieve a limit of detection of 15 fM.MOPCS achieves a highly sensitive analysis of SARS-CoV-2,and mutations appear in variants B.1.617.2(Delta),B.1.1.529(Omicron)and BA.1(a subtype of Omicron).This platform was also used to analyze some recently collected patient samples from a local outbreak in China,identified by the Centers for Disease Control and Prevention.This innovative CRISPR-empowered SPR platform will further contribute to the fast,sensitive and accurate detection of target nucleic acid sequences with single-base mutations. | Zhi Chen Jingfeng Li Tianzhong Li Taojian Fan Changle Meng Chaozhou Li Jianlong Kang Luxiao Chai Yabin Hao Yuxuan Tang Omar AAl-Hartomy Swelm Wageh Abdullah GAl-Sehemi Zhiguang Luo Jiangtian Yu Yonghong Shao Defa Li Shuai Feng William J.Liu Yaqing He Xiaopeng Ma Zhongjian Xie Han Zhang | 2022 | National Science Review2022，9，8： | 3 |
| 15 | Magnetocaloric and Colossal Magnetoresistance Effect in Layered Perovskite La_(1.4) Sr_(1.6)Mn_2O_7显示文摘Magnetocaloric and colossal magnetoresistance effects of the layered perovskite La 1.4 Sr 1.6 Mn 2 O 7 compound have been studied.A broad peak of magnetic entropy change (-△S M) is found above the Curie temperature (T C =120 K),which can be associated with the existence of two-dimensional short range ferromagnetic order.Additionally,the curvilinear shape of-△S M for layered perovskite is quite different from that of the Ln 1-x A x MnO 3 probably arising from magnetocrystalline anisotropy.At the same time,a wide peak of colossal magnetoresitance effect near T C is found in the layered provskite La 1.4 Sr 1.6 Mn 2 O 7. | Li'an Han Changle Chen | 2010 | Journal of Materials Science & Technology2010，26，3： | 3 |
| 16 | Development and molecular analysis of a novel acetohydroxyacid synthase rapeseed mutant with high resistance to sulfonylurea herbicides显示文摘With the increasing promotion of simplified rapeseed cultivation in recent years,the development of cultivars with high resistance to herbicides is urgently needed.We previously developed M342,which shows sulfonylurea herbicide resistance,by targeting acetohydroxyacid synthase(AHAS),a key enzyme in branched-chain amino acid synthesis.In the present study,we used a progeny line derived from M342 for an additional round of ethyl methane sulfonate mutagenesis,yielding the novel mutant DS3,which harbored two mutations in AHAS genes and showed high sulfonylurea resistance.One mutation was the substitution Trp574 Leu,as in M342,according to Arabidopsis protein sequencing.The other site was a newly recognized substitution,Pro197 Leu.A KASP marker targeting Pro197 Leu was developed and reliably predicted the response to sulfonylurea herbicides in the F2 population.The combination of Trp574 Leu and Pro197 Leu in DS3 produced a synergistic effect that greatly increased herbicide resistance.Analysis of the protein structures of AHAS1 and AHAS3 in wild-type and single-gene mutant plants revealed three-dimensional protein conformational changes that could account for differences in herbicide resistance characteristics including toxicity tolerance,AHAS enzyme activity,and AHAS gene expression. | Yue Guo Changle Liu Weihua Long Jianqin Gao Jiefu Zhang Song Chen Huiming Pu Maolong Hu | 2022 | The Crop Journal2022，10，1： | 3 |
| 17 | Influence of chelate ring size on the properties of phosphine-sulfonate palladium catalysts显示文摘Phosphine-sulfonate based palladium is one of the most extensively studied catalyst systems in olefin polymerization.This type of catalyst features six-membered chelate ring size,and can enable the copolymerizations of ethylene with a wide variety of polar monomers.In this contribution,we decide to investigate the influence of chelate ring size on the properties of phosphinesulfonate palladium catalysts.As such,a series of phosphine-sulfonate ligands and the corresponding seven-membered ring Pd(II)complexes[κ~2-(P,O)-2-(CH_2-PR_1R_2)-4-methylphenyl-sulfonato]Pd(Me)(DMSO)(Pd1,R_1=R_2=Cy,Pd2,R_1=R_2=o-Me O-C_6H_4;Pd3,R_1=Ph,R_2=2-[2,6-(Me O)_2C_6H_3]C_6H_4;DMSO=dimethyl sulfoxide)were designed,prepared and characterized.These palladium complexes are moderately active when they were applied in ethylene polymerization and copolymerizations with methyl acrylate and butyl vinyl ether.However,their properties are greatly reduced from those of the classic six-membered ring phosphine-sulfonate palladium complex Pd2′.The experimental results indicate that the bigger chelate ring size can increase the ligand flexibility and damage the catalytic properties for the phosphine-sulfonate type palladium catalysts. | Chen Zou Wenmin Pang Changle Chen | 2018 | Science China Chemistry2018，61，9： | 3 |
| 18 | Irinotecan-involved regimens for advanced gastric cancer:A pooled-analysis of clinical trials显示文摘AIM:To assess the efficiency and toxicities of irinotecan (CPT-11)-involved regimens in patients with advanced gastric cancer.METHODS:Randomized phases Ⅱ and Ⅲ clinical trials on chemotherapy for advanced gastric cancer were searched from MEDLINE,EMbase,Cochrane Controlled Trials Register,and EBSCO.Relevant abstracts were manually searched.A total of 657 patients were analyzed for their overall response rate (ORR),time to treatment failure (TTF),overall survival (OS) rate,and toxicities.Overall survival rate,reported as hazard ratio (HR) with 95% CI,was used as the primary outcome measure.RESULTS:Four randomized controlled trials on chemotherapy for advanced gastric cancer were detected.The CPT-11-containing combination chemotherapy was not significantly advantageous over the non CPT-11containing combination chemotherapy for OS rate (HR =1.12,95% CI:0.92-1.36,P=0.266) and ORR [risk ratio (RR)=1.23,95% CI:0.71-2.14,P=0.458].However,the CPT-11-containing combination chemotherapy was significantly advantageous over the non CPT-11-containing combination chemotherapy for TTF (HR=1.35,95% CI:1.12-1.64,P=0.002).Grade 3/4 haematological toxicity (thrombocytopenia:RR=0.20,95% CI:0.09-0.48;P < 0.001) and gastrointestinal toxicity (diarrhea:RR=4.09,95% CI:2.42-6.93,P < 0.001) were lower in patients with advanced gastric cancer after CPT11-containing combination chemotherapy than after non CPT-11-containing combination chemotherapy.CONCLUSION:CPT-11-containing combination chemotherapy is advantageous over non CPT-11-containing combination chemotherapy for TTF with no significant toxicity.CPT-11-containing combination chemotherapy can be used in treatment of advanced gastric cancer. | Dan-Ling Wang,Dong-Ying Gu,Hua-Ying Huang,Zhi Xu,Jin-Fei Chen,Department of Oncology,Affiliated Nanjing First Hospital,Nanjing Medical University,68 Changle Road and Medical School of Southeast University,87 Dingjiaqiao,Nanjing 210000,China | 2010 | World Journal of Gastroenterology2010，16，46： | 2 |
| 19 | Positional Electronic Effects in Iminopyridine-N-oxide Nickel Catalyzed Ethylene Polymerization显示文摘A series of dibenzhydryl-based iminopyridine-N-oxide ligands bearing a range of electron-donating or-withdrawing substituents(OMe,H;and NO_(2))and corresponding nickel pre-catalysts are prepared and characterized.The substituents are installed at different positions on the ligand structure,including 4-position of the pyridine-N-oxide moiety(position X)and 4-position of the aniline moiety(position Y).These nickel pre-catalysts are highly active in ethylene polymerization with the addition of very little amount of aluminum cocatalysts,leading to the formation of polyethylenes with molecular weights of well above one million.Electron-donating substituents make the catalysts sensitive to polymerization temperature.In contrast,the catalysts bearing electron-withdrawing NO_(2) substituents show relatively steady performances at different temperatures.Most importantly,we demonstrate that different substituents and different positions both play important roles in determining the properties of nickel catalysts.This provides an alternative strategy for the future design of high-performance polymerization catalyst. | Mingjun Chi Ao Chen Wenmin Pang Chen Tan Changle Chen | 2021 | Chinese Journal of Chemistry2021，39，6： | 2 |
| 20 | Modified ground response curve(GRC)in strain-softening rock mass based on the generalized Zhang-Zhu strength criterion considering over-excavation显示文摘The ground response curve(GRC)depicts the relationship between support reaction force and ground displacement,which improves the understanding of ground-support interaction and provides important references to the tunnel design.However,it is difficult to anticipate the tunneling-induced large deformation with sufficient reliability in soft rock with high geostress since the small strain theory is not applicable.When large deformation occurs,the tunnel needs to be over-excavated.Thus,the GRC should be modified considering the enlarged excavation radius since the actual excavation radius is usually greater than the designed one.To overcome the shortcomings of small strain theory in recognizing ground-support interaction under large deformation circumstances,a new large strain numerical approach for modifying the GRC was proposed considering over-excavation in strain-softening rock masses based on the generalized Zhang-Zhu strength criterion.A case study was conducted based on the Lianchengshan tunnel in China.The modified GRC was employed to investigate the ground-support behavior for different support schemes and to explore the applicability of the stress release measures.Combined with field tests,the proposed approach was validated.By comparing with GRCs proposed by previous work,the present modified GRC was proved to be superior to others.Parametric studies were conducted and it is found that over-excavation,for example,reserving a very large clearance between the surrounding rock and the support,is necessary to reduce ground pressure to a large extent.The yielding supports which can provide high support pressure during the process of deformation are highly recommended when tunneling in high geostress environment.However,if the initial geostress is not very high,it is not necessary to pursue unwarranted overexcavation since the ground pressure applied on the support is mainly the loosening stress when the deformation is large.Ample support stiffness should be provided in the process of deformation to prevent uncontrolled large deformation of surrounding rock. | Chen Xu Caichu Xia Changling Han | 2021 | Underground Space2021，6，5： | 2 |
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