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| 1 | Antibacterial and angiogenic chitosan microneedle array patch for promoting wound healing显示文摘A patch with the capability of avoiding wound infection and promoting tissue remolding is of great value for wound healing.In this paper,we develop a biomass chitosan microneedle array(CSMNA)patch integrated with smart responsive drug delivery for promoting wound healing.Chitosan possesses many outstanding features such as the natural antibacterial property and has been widely utilized for wound healing.Besides,the microstructure of microneedles enables the effective delivery of loaded drugs into the target area and avoids the excessive adhesion between the skin and the patch.Also,vascular endothelial growth factor(VEGF)is encapsulated in the micropores of CSMNA by temperature sensitive hydrogel.Therefore,the smart release of the drugs can be controllably realized via the temperature rising induced by the inflammation response at the site of wounds.It is demonstrated that the biomass CSMNA patch can promote inflammatory inhibition,collagen deposition,angiogenesis,and tissue regeneration during the wound closure.Thus,this versatile CSMNA patch is potentially valuable for wound healing in clinical applications. | Junjie Chi Xiaoxuan Zhang Canwen Chen Changmin Shao Yuanjin Zhao Yongan Wang | 2020 | Bioactive Materials2020，5，2： | 25 |
| 2 | Dynamics Analysis of the Baiyun Sag in the Pearl River Mouth Basin,North of the South China Sea显示文摘摘要:Baiyun 下垂是在珍珠河嘴盆的斜坡上发展的深的。它水平地作为合成 graben 发生,并且由二亚 sags 对亚 sags 构成低高举。垂直地,沉积建筑学能被划分成三层,即底部,在中间的差错可锻的拉长层和顶上的 draping 层上的指责的层。sag 的主要 rifting 阶段应当被可锻的扩展描绘并且外壳变瘦。特殊变丑模式可能被归因于事实 Baiyun 下垂位于弱地区,使 sag 成为了一个强烈使变形的区域,由极大地变瘦的岩石圈和活跃 magmatism 描绘了的先存在的转移地区。在 Baiyun 下面的高度升起的披风下垂应该是为可锻的变丑负责的重要机制,它引起了上面的披风的部分融化。Upwelling 到上面的外壳和沉积的层,部分融化材料提供了 extensional 紧张并且引起了非指责的垂直沉淀。岩浆在 rifting 的第一个阶段以后在转移地区下面被收集,并且沿着趋势 NW 基础差错在对对 sag 和 upwelled 的 ENE 和 WSW 部分的扩展垂直的一个方向旁边地转了,在的地方趋势 WNW 砍差错在群发展了。指责的活动和 Baiyun 的沉积历史下垂可能被海洋山脉影响了在 24 妈和海地板在 16 妈附近传播的停止附近跳。 | SUN Zhen ZHONG Zhihong ZHOU Di PANG Xiong HUANG Chunju CHEN Changmin HE Min XU Hehua | 2008 | Acta Geologica Sinica(English Edition)2008，82，1： | 13 |
| 3 | Chinese herb microneedle patch for wound healing显示文摘Traditional Chinese medicine and Chinese herbs have a demonstrated value for disease therapy and sub-health improvement.Attempts in this area tend to develop new forms to make their applications more convenient and wider.Here,we propose a novel Chinese herb microneedle(CHMN)patch by integrating the herbal extracts,Premna microphylla and Centella asiatica,with microstructure of microneedle for wound healing.Such path is composed of sap extracted from the herbal leaves via traditional kneading method and solidified by plant ash derived from the brine induced process of tofu in a well-designed mold.Because the leaves of the Premna microphylla are rich in pectin and various amino acids,the CHMN could be imparted with medicinal efficacy of heat clearing,detoxicating,detumescence and hemostatic.Besides,with the excellent pharmaceutical activity of Asiatic acid extracted from Centella asiatica,the CHMN is potential in promoting relevant growth factor genes expression in fibroblasts and showing excellent performance in anti-oxidant,anti-inflammatory and anti-bacterial activity.Taking advantages of these pure herbal compositions,we have demonstrated that the derived CHMN was with dramatical achievement in anti-bacteria,inhibiting inflammatory,collagen deposition,angiogenesis and tissue reconstruction during the wound closure.These results indicate that the integration of traditional Chinese herbs with progressive technologies will facilitate the development and promotion of traditional Chinese medicine in modern society. | Junjie Chi Lingyu Sun Lijun Cai Lu Fan Changmin Shao Luoran Shang Yuanjin Zhao | 2021 | Bioactive Materials2021，6，10： | 8 |
| 4 | Tofu-inspired microcarriers from droplet microfluidics for drug delivery显示文摘Microcarriers have attracted increasing interests in drug delivery. In order to develop this technique, it is prone to focus on the generation of functional particles through using simple approaches and novel but accessible materials. Here, inspired by the formation mechanism of tofu that through the mixing of soymilk and brine for cross-linking soybean proteins, we present novel soybean protein microcarriers by using microfluidic generation approach for drug delivery. Since the soybean protein droplets are generated by microfluidic emulsification method, the tofu microparticles present highly monodisperse and homogeneous morphologies. Because of the excellent biocompatibility of the soybean protein and the interconnected porous structures throughout the whole microparticles after freeze-drying, various kinds of drugs and active molecules could be absorbed and loaded in the microcarriers, which makes them versatile for drug delivery. It can be anticipated that the microfluidic-generated tofu microcarriers will have great potential in the biomedical field. | Han Zhang Yuxiao Liu Jie Wang Changmin Shao Yuanjin Zhao | 2019 | Science China Chemistry2019，62，1： | 5 |
| 5 | Cu Nanoparticles Embedded in N-Doped Carbon Materials for Oxygen Reduction Reaction显示文摘Summary of main observation and conclusion Development of eco-friendly,cost-effective,and high-performance electrocatalysts to replace precious metal platinum for oxygen reduction reaction(ORR)has received increasing attention.Herein,we adopt a facile one-pot strategy to embed Cu nanoparticles onto N-doped carbon-graphene(Cu@NC-700).The Cu@NC-700 exhibits robust and efficient ORR catalysis with positive half-wave potential(-0.86 V vs.RHE)and lowTafel slope(33.9 mV-dec^-1)in 0.1 M KOH solution.Meanwhile,it manifests remarkable electrochemical stability,and strong tolerance to methanol crossover and carbon monoxide poisoning.The synergistic effect between Cu-N-C sites,Cu nanoparticles,and N-doped carbon support speeds up ORR electrocatalysis. | Xudong Wen Hui Qi Yan Cheng Qiaoqiao Zhang Changmin Hou Jingqi Guan | 2020 | Chinese Journal of Chemistry2020，38，9： | 5 |
| 6 | Large eddy simulation of hydrogen/air scramjet combustion using tabulated thermo-chemistry approach显示文摘Large eddy simulations(LES) have been performed to investigate the flow and combustion fields in the scramjet of the German Aerospace Center(DLR). Turbulent combustion is modeled by the tabulated thermo-chemistry approach in combination with the presumed probability density function(PDF). A b-function is used to model the distribution of the mixture fraction, while two different PDFs, d-function(Model I) and b-function(Model II), are applied to model the reaction progress. Temperature is obtained by solving filtered energy transport equation and the reaction rate of the progress variable is rescaled by pressure to consider the effects of compressibility. The adaptive mesh refinement(AMR) technique is used to properly capture shock waves,boundary layers, shear layers and flame structures. Statistical results of temperature and velocity predicted by Model II show better accuracy than that predicted by Model I. The results of scatter points and mixture fraction-conditional variables indicate the significant differences between Model I and Model II. It is concluded that second moment information in the presumed PDF of the reaction progress is very important in the simulation of supersonic combustion. It is also found that an unstable flame with extinction and ignition develops in the shear layers of bluff body and a fuelrich partially premixed flame stabilizes in the central recirculation bubble. | Cao Changmin Ye Taohong Zhao Majie | 2015 | Chinese Journal of Aeronautics2015，28，5： | 5 |
| 7 | Responsive Inverse Opal Scaffolds with Biomimetic Enrichment Capability for Cell Culture显示文摘Three-dimensional(3D)porous scaffolds have a demonstrated value for tissue engineering and regenerative medicine.Inspired by the predation processes of marine predators in nature,we present new photocontrolled shrinkable inverse opal graphene oxide(GO)hydrogel scaffolds for cell enrichment and 3D culture.The scaffolds with adjustable pore sizes and morphologies were created using a GO and N-isopropylacrylamide dispersed solution as a continuous phase of microfluidic emulsions for polymerizing and replicating.Because of the interconnected porous structures and the remotely controllable volume responsiveness of the scaffolds,the suspended cells could be enriched into the inner spaces of the scaffolds through predator-like swallowing and discharging processes.Hepatocyte cells concentrated in the scaffold pores could form denser 3D spheroids more quickly via the controlled compression force caused by the shrinking of the dynamic scaffolds.More importantly,with a program of scaffold enrichment with different cells,an unprecedented 3D multilayer coculture system of endothelial-cellencapsulated hepatocytes and fibroblasts could be generated for applications such as liver-on-a-chip and bioartificial liver.It was demonstrated that the resultant multicellular system offered significant improvements in hepatic functions,such as albumin secretion,urea synthesis,and cytochrome P450 expression.These features of our scaffolds make them highly promising for the biomimetic construction of various physiological and pathophysiological 3D tissue models,which could be used for understanding tissue level biology and in vitro drug testing applications. | Changmin Shao Yuxiao Liu Junjie Chi Jie Wang Ze Zhao Yuanjin Zhao | 2019 | Research2019，，1： | 4 |
| 8 | Red carbon dots as label-free two-photon fluorescent nanoprobes for imaging of formaldehyde in living cells and zebrafishes显示文摘Direct,in situ selective detection of intracellular formaldehyde(FA)is of great significance for understanding its function in FA-related diseases.Herein,red carbon dots(RCD)are reported as label-free two-photon fluorescent nanoprobes for detecting and imaging of FA.Upon addition of FA,the-NH2 groups of RCD could quickly and specially react with aldehydes to form Schiff base and then the strong fluorescence of RCD with blue-shift emission is recovery due to the destruction of the hydrogen bond interaction between RCD and water.In addition,the nanoprobes exhibit outsta nding photo stability,rapid response(<1 min),high sensitivity(~9.9μmol/L)and excellent selectivity toward FA over other aldehyde group compounds.Notably,owing to the good cell-membrane permeability and biocompatibility,as well as the large two-photon absorption cross-section,the as-prepared RCD can be used as label-free nanoprobes for selectively detecting and imaging FA in living cells and zebrafishes through one-photon and two-photon excitation.Moreover,RCD could stain the tissue of zebrafishes at depths interval of up to 240μm under two-photon excitation.This research implied that RCD are promising tools for directly and in situ imaging FA in vivo,thus providing critical insights into FA-related pathophysiological processes. | Hong Wang Jing Wei Chonghua Zhang Yuan Zhang Yubin Zhang Lin Li Changmin Yu Peisheng Zhang Jian Chen | 2020 | Chinese Chemical Letters2020，31，3： | 3 |
| 9 | OGT Mediated Histone H2B S112 Glc NAcylation Regulates DNA Damage Response显示文摘O-GlcNAcylation is an important post-translational modification and has been implicated in many fundamental cellular processes. Recent studies showed that O-linked N-acetylglucosamine(GlcNAc) transferase(OGT) mediated O-Glc NAcylation of histone H2B Ser 112(H2B S112 Glc NAcylation) plays an important role in gene transcription. However, the role of this histone modification in DNA damage response has not been studied yet. In this study, we found that OGT and OGT mediated H2B S112 Glc NAcylation are involved in DNA damage response for maintaining genomic stability and are required for resistance to many DNA-damaging and replication stressinducing agents. OGT mediated H2B S112 GlcNAcylation increased locally upon the induction of double-strand breaks(DSBs), and depletion of OGT or overexpression of H2B S112A mutant impaired homologous recombination(HR) and nonhomologous end-joining(NHEJ). Mechanistically, H2B S112 GlcNAcylation could bind Nijmegen breakage syndrome 1(NBS1) and regulate NBS1 foci formation. Taken together, our results demonstrate a new function of histone O-GlcNAcylation in DNA damage response(DDR). | Panfei Wang Changmin Peng Xia Liu Hailong Liu Yali Chen Li Zheng Baolin Han Huadong Pei | 2015 | Journal of Genetics and Genomics2015，42，9： | 3 |
| 10 | Forming Condition and Geology Prediction Techniques of Deep Clastic Reservoirs显示文摘1 Introduction As new exploration domain for oil and gas,reservoirs with low porosity and low permeability have become a hotspot in recent years(Li Daopin,1997).With the improvement of technology,low porosity and | QIAN Wendao YIN Taiju ZHANG Changmin HOU Guowei HE Miao Xia Min Wang Hao | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 2 |
| 11 | Recent progress in small molecule fluorescent probes for nitroreductase显示文摘Nitroreductase(NTR) is a member of flavin-containing enzymes that exists widely in bacteria. Hypoxia,which is a characteristic of locally advanced solid tumors, resulting from an imbalance between oxygen consumption and supply, can result in NTR overexpression. Using either nicotinamide adenine dinucleotide(NADH) or nicotinamide adenine dinucleotide phosphate(NADPH) as a source of reducing equivalents, NTR can catalyze the reduction of nitroaromatic compounds to the corresponding amines.Based on this reduction mechanism, NTR can be applied not only in the bioremediation and degradation of organic nitrogen compounds, but also in the development of NTR-targeted fluorescent probes to detect the hypoxic status of cancer cells. This review aims to provide a summary of the progress in fluorescent probes for NTR in recent years and elucidate the main fluorescent mechanisms that have been applied to design probes. | Wenjing Qin Chenchen Xu Yanfei Zhao Changmin Yu Sheng Shen Lin Li Wei Huang | 2018 | Chinese Chemical Letters2018，29，10： | 2 |
| 12 | Influences of Tibetan Plateau uplift on provenance evolution of the paleo-Pearl River显示文摘A comparative analysis of the geochemical characteristics of sediments from the Oligocene Zhuhai Formation(32-23.8 Ma),the Miocene Zhujiang Formation(23.8-16.5 Ma),and the Hanjiang Formation(16.5—10.5 Ma) and a comprehensive analysis of the geochemical characteristics of rocks surrounding the paleo-Pearl River drainage contribute to understanding the influences of the Tibetan Plateau uplift on provenance evolution of the paleo-Pearl River.The results show that the geochemical characteristics of sediments from the Oligocene Zhuhai Formation are very different from the geochemical characteristics of sediments from the Miocene Zhujiang and Hanjiang Formations.The ∑ rare earth elements(REE) of mudstone is relatively high in the Zhuhai Formation,204.07-293.88 ppm(average 240.46 ppm),and low in the Zhujiang and Hanjiang Formations,181.32-236.73 ppm(average 203.83 ppm) and 166.84-236.65 ppm(average199.04 ppm),respectively.The chemical index of alteration(CIA) for these samples has a similar trend to the∑ REE:the CIA of the Zhuhai Formation is relatively high and the CIA of the Zhujiang and Hanjiang Formations is relatively low.The uplift of the Tibetan Plateau is crucial to the westward expansion of the paleo-Pearl River drainage. | Ye Yu Changmin Zhang Shaohua Li Rui Zhu Jiangyan Liu Chenggang Qin Zhongtao Zhang | 2015 | Chinese Journal Of Geochemistry2015，34，2： | 2 |
| 13 | Use of blind placements of peripherally inserted central catheters in burn patients: A retrospective analysis显示文摘 | Younghwan Choia Changmin Songa Eunok Parka | 2015 | Burns2015，41，： | 1 |
| 14 | Natural gas sources,migration and accumulation in the shallow water area of the Panyu lower uplift:an insight into the deep water prospects of the Pearl River Mouth basin,South China sea显示文摘 | CHEN Changmin PANG Xiong | 2006 | Journal of Geochemical Exploration2006，89，： | 1 |
| 15 | Application and improvement of stamping automation technology 显示文摘 | Li Zhenkui Liu Changmin | 2012 | Forging & Metalforming2012，，16： | 1 |
| 16 | Rapid and automated determination o{ rusted sur{ace areas o{ a steel bridge for robotic maintenance systems显示文摘 | Hyojoo Son Nahyae Hwang Changmin Kim | 2014 | Au- tomation in Construction2014，42，6： | 1 |
| 17 | Fatigue and mechanical characteristics of nano-structured tool steel by ultrasonic cold forging technology显示文摘 | Sun Changmin Song Gilho Sun Minsoo | 2007 | Materials Science and Engineering A2007，443，： | 1 |
| 18 | COST REDUCTION OF CEMENTING FILL IN KANGJIAWAN MINE显示文摘COSTREDUCTIONOFCEMENTINGFILLINKANGJIAWANMINEWangXinmin,ZhangQinliDepartmentofResourcesExploitationEnginering,CentralSouthUniv... | Wang, Xinmin Zhang, Qinli Chen, Changmin Li, Yanping | 1997 | 中国有色金属学会会刊:英文版1997，7，1： | 1 |
| 19 | Characterization of atmospheric plasma spray NiCr-Cr2O3-Ag-CaF2/BaF2 coatings显示文摘 | HANSHIN C CHANGMIN H | 2005 | Surface Coating and Technology2005，195，： | 1 |
| 20 | Porous hydrogel arrays for hepatoma cell spheroid formation and drug resistance investigation显示文摘Drug resistance is one of the major obstacles in the drug therapy of cancers.Efforts in this area in pre-clinical research have focused on developing novel platforms to evaluate and decrease drug resistance.In this paper,inspired by the structure of hives where swarms live and breed,we propose porous hydrogel arrays with a uniform pore structure for the generation of hepatoma cell spheroids and the investigation of drug resistance.The porous hydrogel arrays were fabricated using polyeth-ylene glycol diacrylate(PEGDA)hydrogel to negatively replicate a well-designed template.Benefiting from the elaborate processing of the template,the prepared porous hydrogel arrays possessed a uniform pore structure.Due to their anti-adhesion properties and the excellent biocompatibility of the PEGDA hydrogel,the hepatoma cells could form well-defined and uni-form hepatoma cell spheroids in the porous hydrogel arrays.We found that the resistant hepatoma cell spheroids showed more significant Lenvatinib resistance and a migratory phenotype compared with a two-dimensional(2D)cell culture,which reveals the reason for the failure of most 2D cell-selected drugs for in vivo applications.These features give such porous hydrogel arrays promising application prospects in the investigation of tumor cell spheroid culture and in vitro drug resistance. | Xin Lei Changmin Shao Xin Shou Keqing Shi Liang Shi Yuanjin Zhao | 2021 | Bio-Design and Manufacturing2021，4，4： | 1 |
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