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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | An overview of the use of plastic-film mulching in China to increase crop yield and water-use efficiency显示文摘Since 1990,crop yields have stagnated in many parts of the world,posing a significant challenge to global food security[1].As such;innovative solutions are needed to increase the resource-use efficiency of cropping systems to produce more grains per unit area. | Dongbao Sun Haigang Li Enli Wang Wenqing He Weiping Hao Changrong Yan Yuzhong Li Xurong Mei Yanqing Zhang Zhanxiang Sun Zhikuan Jia Huaiping Zhou Tinglu Fan Xucheng Zhang Qin Liu Fengju Wang Chaochun Zhang Jianbo Shen Qingsuo Wang Fusuo Zhang | 2020 | National Science Review2020，7，10： | 19 |
| 3 | High-throughput 3D reconstruction of stochastic heterogeneous microstructures in energy storage materials显示文摘Stochastic heterogeneous microstructures are widely applied in structural and functional materials,playing a crucial role in determining their performance.X-ray tomography and focused ion beam serial sectioning are frequently used methods to reconstruct three-dimensional(3D)microstructures,yet are demanding techniques and are resolution-limited.Here,a highthroughput multi-stage 3D reconstruction method via distance correlation functions is developed using a single representatively large-sized 2D micrograph for stochastic microstructures,and verified by X-ray micro-tomography datasets of isotropic and anisotropic solid oxide fuel cell electrodes.This method provides an economic,easy-to-use and high-throughput approach for reconstructing stochastic heterogeneous microstructures for energy conversion and storage devices,and can readily be extended to other materials. | Yanxiang Zhang Mufu Yan Yanhong Wan Zhenjun Jiao Yu Chen Fanglin Chen Changrong Xia Meng Ni | 2019 | npj Computational Materials2019，，1： | 3 |
| 4 | γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer显示文摘 | Pin Wu Dang Wu Chao Ni Jun Ye Wuzhen Chen Guoming Hu Zhen Wang Changrong Wang Zhigang Zhang Wenjie Xia Zhigang Chen Ke Wang Tao Zhang Jinghong Xu Yuehua Han Ting Zhang Xianguo Wu Jianwei Wang Weihua Gong Shu Zheng Fuming Qiu Jun Yan Jian Huang | 2014 | Immunity2014，，5： | 2 |
| 5 | Long-term effect of chemical fertilizer, straw, and manure on soil chemical and biological properties in northwest China显示文摘 | Enke Liu Changrong Yan Xurong Mei | 2010 | Geoderma2010，，158： | 1 |
| 6 | Plastic-film mulch in Chinese agriculture: Importance and problems显示文摘 | Yan Changrong He Wenqing Neil C Turner | 2014 | World Agriculture2014，4，2： | 1 |
| 7 | Long-term effect of chemical fertilizer, straw, and manure on soil chemical and biological properties in northwest China显示文摘 | Enke Liu Changrong Yan Xurong Mei Wenqing He So Hwat Bing Linping Ding Qin Liu Shuang Liu Tinglu Fan | 2010 | Geoderma2010，，3： | 1 |
| 8 | Long-term effect of chemical fertilizer, straw, and manure on soil chemical and biological properties in northwest China显示文摘 | Enke Liu Changrong Yan Xurong Mei Wenqing He So Hwat Bing Linping Ding Qin Liu Shuang Liu Tinglu Fan | 2010 | Geoderma2010，，3： | 1 |
| 9 | \'White revolution\' to \'white pollution\'-agricultural plastic film mulch in China显示文摘 | Liu Enke He Wenqing Yan Changrong | 2014 | Environmental Research Letters2014，9，09： | 1 |
| 10 | Effects of Conservation Agriculture on Land and Water Productivity in Yellow River Basin, China显示文摘In the dryland regions of North China,water is the limiting factor for rainfed crop production.Conservation agriculture(featuring reduced or zero tillage,mulching,crop rotations and cover crops)has been proposed to improve soil and water conservation and enhance yields in these areas.Conservation agriculture systems typically result in increased crop water availability and agro-ecosystem productivity,and reduced soil erosion.To evaluate the potential of conservation agriculture to improve soil water balance and agricultural productivity,the DSSAT crop model was calibrated using the data of a field experiment in Shouyang County in the semi-arid northeastern part of the Yellow River Basin.The average annual precipitation at the site is 472 mm,75%of which falls during the growing season.The site had a maize-fallow-maize rotation.data from two crop seasons(2005 and 2006)and four treatments for calibration and analysis were used.The treatments were:conventional tillage(CT),no-till with straw mulching(NTSM),all-straw incorporated(ASRT)and one-third residue left on the surface with no-till(RRT).The calibration results gave satisfactory agreement between field observed and model predicted values for crop yield for all treatments except RRT treatment,and for soil water content of different layers in the 150 cm soil profile for all treatments.The difference between observed and predicted values was in the range of 3%-25%for maize yield and RMSE was in the range of 0.03-0.06 cm^(3)/cm^(3) for soil water content measured periodically each cropping season.While these results are encouraging,more rigorous calibration and independent model evaluation are warranted prior to making recommendations based on model simulations.Medium-term simulations(1995-2004)were conducted for three of the treatments using the calibrated model.The NTSM and ASRT treatments had similar or higher yields(by up to 36%),higher crop water productivity by up to 28%and reduced runoff of up to 93%or 43 mm compared to CT treatment. | Vinay Nangia Mobin-ud-Din Ahmad Du Jiantao Yan Changrong Gerrit Hoogenboom Mei Xurong He Wenqing Liu Shuang Liu Qin | 2010 | International Journal of Agricultural and Biological Engineering2010，3，2： | 0 |
| 11 | BRIEF COMMUNICATION ARISING Geng et al.reply显示文摘The accompanying comment by Dr.Rao,suggests that there is an omission of citation of 12 previous publications in our Wang et al.paper.1 We disagree with the suggestion for the following reasons.We believe that the 12 publications cited by Dr.Rao do not have sufficient relevance to the Wang et al.paper.1 The past decades have witnessed an explosive growth in our understanding of the pathogenesis of Alzheimer's disease(AD),which is a very complicated process.The Wang et al. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2020 | Cell Research2020，30，9： | 0 |
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