|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Rice CYP703A3, a cytochrome P450 hydroxylase, is essential for development of anther cuticle and pollen exine显示文摘Anther cuticle and pollen exine act as protective envelopes for the male gametophyte or pollen grain, but the mechanism underlying the synthesis of these lipidic polymers remains unclear. Previously, a tapetum‐expressed CYP703A3, a putative cytochrome P450 fatty acid hydroxylase, was shown to be essential for male fertility in rice(Oryza sativa L.). However,the biochemical and biological roles of CYP703A3 has not been characterized. Here, we observed that cyp703a3‐2 caused by one base insertion in CYP703A3 displays defective pollen exine and anther epicuticular layer, which differs from Arabidopsis cyp703a2 in which only defective pollen exine occurs. Consistently, chemical composition assay showed that levels of cutin monomers and wax components were dramatically reduced in cyp703a3‐2 anthers. Unlike the wide range of substrates of Arabidopsis CYP703A2, CYP703A3 functions as an in‐chain hydroxylase only for a specific substrate, lauric acid, preferably generating 7‐hydroxylated lauric acid. Moreover, chromatin immunoprecipitation and expression analyses revealed that the expression of CYP703A3 is directly regulated by Tapetum Degeneration Retardation, a known regulator of tapetum PCD and pollen exine formation. Collectively, our results suggest that CYP703A3 represents a conserved and diversified biochemical pathway for in‐chain hydroxylation of lauric acid required for the development of male organ in higher plants. | Xijia Yang Di Wu Jianxin Shi Yi He Franck Pinot Bernard Grausem Changsong Yin Lu Zhu Mingjiao Chen Zhijing Luo Wanqi Liang Dabing Zhang | 2014 | Journal of Integrative Plant Biology2014，56，10： | 21 |
| 3 | Interactions of OsMADS1 with Floral Homeotic Genes in Rice Flower Development显示文摘在繁殖开发期间,米饭植物开发决定最后的谷物收益的唯一的花器官。OsMADS1,象 SEPALLATA 一样疯盒子的基因之一,被解开了玩关键角色 inrice 花的机关身份说明和花的分裂组织确定性。然而,在调整花开发与另外的花的 homeotic 基因位于 OsMADS1 的相互作用下面的分子的机制 remainslargely 逃犯。在这个工作,我们在他们的蛋白质之中与物理相互作用一起与 B- , C- ,和 D 班基因学习了 OsMADS1 的基因相互作用。我们证明在 OsMADS1 和 OsMADS3 之间的物理、基因的相互作用为花的分裂组织活动维护和机关身份说明是必要的;当 OsMADS1 身体上并且遗传上在调整花的分裂组织确定性和 suppressingspikelet 分裂组织回复与 OsMADS58 交往时。我们提供了重要基因证据在花开发期间支持二米饭 C 班基因(OsMADS3 和 OsMADS58 ) 的 neofunctionalization。基因表示介绍和量的 RT-PCR 分析进一步表明 OsMADS1 影响涉及发信号的花的身份和荷尔蒙的许多基因的表达式,并且染色质 immunoprecipitation (芯片)-PCR 试金进一步证明 OsMADS17 是 OsMADS1 的直接目标基因。一起拿,这些结果表明 OsMADS1 在指定米饭有多样化的规章的功能花的机关和分裂组织身份,可能通过它和不同花的 homeotic 管理者的基因、物理的相互作用。 | Yun Hu Wanqi Liang Changsong Yin Xuelian Yang Baozhe Ping Anxue Li Ru Jia Mingjiao Chen Zhijing Luo Qiang Cai Xiangxiang Zhao Dabing Zhang Zheng Yuan | 2015 | Molecular Plant2015，8，9： | 10 |
| 4 | Development of genome-wide insertion/deletion markers in rice based on graphic pipeline platform显示文摘DNA markers play important roles in plant breeding and genetics.The Insertion/Deletion(InDel) marker is one kind of co-dominant DNA markers widely used due to its low cost and high precision.However,the canonical way of searching for InDel markers is time-consuming and laborintensive.We developed an end-to-end computational solution(InDel Markers Development Platform,IMDP) to identify genome-wide InDel markers under a graphic pipeline environment.IMDP constitutes assembled genome sequences alignment pipeline(AGA-pipe) and next-generation resequencing data mapping pipeline(NGS-pipe).With AGA-pipe we are able to identify 12,944 markers between the genome of rice cultivars Nipponbare and 93-11.Using NGS-pipe,we reported 34,794 InDels from re-sequencing data of rice cultivars Wu-Yun-Geng7 and Guang-Lu-Ai4.Combining AGApipe and NGS-pipe,we developed 205,659 InDels in eight japonica and nine indica cultivars and 2,681 InDels showed a subgroup-specific pattern.Polymerase chain reaction(PCR)analysis of subgroup-specific markers indicated that the precision reached 90%(86 of 95).Finally,to make them available to the public,we have integrated the InDels/markers information into a website(Rice InDel Marker Database,RIMD,http://gffzz71b3756633b74a6ehp00b90ocp9wk6bvw.ffgz.tsg.suse.edu.cn/).The application of IMDP in rice will facilitate efficiency for development of genome-wide InDel markers,in addition it can be used in other species with reference genome sequences and NGS data. | Yang L Xiao Cui Rui Li Piaopiao Huang Jie Zong Danqing Yao Gang Li Dabing Zhang Zheng Yuan | 2015 | Journal of Integrative Plant Biology2015，57，11： | 9 |
| 5 | Regulatory network and genetic interactions established by OsMADS34 in rice inflorescence and spikelet morphogenesis显示文摘Grasses display highly diversified inflorescence architectures that differ in the arrangement of spikelets and flowers and determine cereal yields. However, the molecular basis underlying grass inflorescence morphogenesis remains largely unknown. Here we investigate the role of a functionally diversified SEPALLATA MADS-box transcription factor, OsMADS34, in regulating rice(Oryza sativa L.)inflorescence and spikelet development. Microarray analysis showed that, at the very early stages of inflorescence formation, dysfunction of OsMADS34 caused altered expression of 379 genes that are associated with protein modification and degradation, transcriptional regulation,signaling and metabolism activity. Genetic analysis revealed that OsMADS34 controls different aspects of inflorescence structure, branching and meristem activity synergistically with LAX PANICLE1(LAX1) and FLORAL ORGAN NUMBER4(FON4), as evidenced by the enhanced phenotypes of osmads34 lax1 and osmads34 fon4 compared with the single mutants. Additionally, double mutant between osmads34 and the sterile lemma defective mutant elongated empty glume(ele) displayed an enhanced phenotype, that is,longer and wider sterile lemmas that were converted into lemma/palea-like organs, suggesting that ELE and OsMADS34 synergistically control the sterile lemma development. OsMADS34 may act together with OsMADS15 in controlling sterile lemma development. Collectively, these findings provide insights into the regulatory function of OsMADS34 in rice inflorescence and spikelet development. | Qingcai Meng Xiaofeng Li Wanwan Zhu Li Yang Wanqi Liang Ludovico Dreni Dabing Zhang | 2017 | Journal of Integrative Plant Biology2017，59，9： | 5 |
| 6 | Room-temperature continuous-wave electrically pumped InGaN/GaN quantum well blue laser diode directly grown on Si显示文摘Current laser-based display and lighting applications are invariably using blue laser diodes(LDs)grown on freestanding GaN substrates,which are costly and smaller in size compared with other substrate materials.1–3 Utilizing less expensive and large-diameter Si substrates for hetero-epitaxial growth of indium gallium nitride/gallium nitride(InGaN/GaN)multiple quantum well(MQW)structure can substantially reduce the cost of blue LDs and boost their applications.To obtain a high crystalline quality crack-free GaN thin film on Si for the subsequent growth of a blue laser structure,a hand-shaking structure was formed by inserting Al-composition step down-graded AlN/AlxGa1−xN buffer layers between GaN and Si substrate.Thermal degradation in InGaN/GaN blue MQWs was successfully suppressed with indium-rich clusters eliminated by introducing hydrogen during the growth of GaN quantum barriers(QBs)and lowering the growth temperature for the p-type AlGaN/GaN superlattice optical cladding layer.A continuous-wave(CW)electrically pumped InGaN/GaN quantum well(QW)blue(450 nm)LD grown on Si was successfully demonstrated at room temperature(RT)with a threshold current density of 7.8 kA/cm^(2). | Yi Sun Kun Zhou Meixin Feng Zengcheng Li Yu Zhou Qian Sun Jianping Liu Liqun Zhang Deyao Li Xiaojuan Sun Dabing Li Shuming Zhang Masao Ikeda Hui Yang | 2018 | Light(Science & Applications)2018，7，1： | 5 |
| 7 | Young Genes out of the Male: An Insight from Evolutionary Age Analysis of the Pollen Transcriptome显示文摘 | Xiao Cui Yang Lv Miaolin Chen Zoran Nikoloski David Twell Dabing Zhang | 2015 | Molecular Plant2015，8，6： | 4 |
| 8 | Immunogenicity of recombinant F4 (K88) fimbrial adhesin FaeG expressed in tobacco chloroplast显示文摘到通常对腹泻在植物生产新奇疫苗的可能性在新生、最新断奶的小猪发现了的测试, faeG 基因,编码主要 F4ac fimbrial 子单元蛋白质,被介绍进烟草叶绿体染色体。在在 spectinomycin 下面的二轮选择以后,我们将近获得了转基因的植物 homoplasmic。RNA 胶化污点分析显示了那 faeG 和抗菌素选择基因 aminoglycoside 3 adenylyltransferase (aadA ) 高度作为 dicistron 被抄录,当在 transplastomic 烟草的 recombinant FaeG 的翻译水平是大约 0.15% 全部的可溶的蛋白质时。在烟草叶绿体生产的 recombinant FaeG 的 immunogenicity 被 FaeG 特定的抗体在与导出叶绿体的 recombinant FaeG 刺激的老鼠 sera 能抵销的转基因的植物,以及结果的全部的可溶的蛋白质使免疫的老鼠被得到的观察证实在 vivo 的 F4ac enterotoxigenic Escherichia coli (ETEC ) 。这研究为用叶绿体表达式系统生产 ETEC 疫苗提供一种新选择。 | Huifeng Shen Bingjun Qian Weiwei Chen Zhenhua Liu Litao Yang Dabing Zhang Wanqi Liang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，8： | 3 |
| 9 | Review on the Progress of AlGaN-based Ultraviolet Light-Emitting Diodes显示文摘AlGaN-based materials have exhibited considerable potential for fabricating ultraviolet(UV)light-emitting diodes(LEDs)owing to their direct,wide,and adjustable energy bandgap.AlGaN-based devices have extensive appli-cability owing to their stable physico-chemical properties.With decades of research effort,significant progress has been achieved in enhancing the working efficiency of AlGaN-based LEDs by optimizing the crystalline qual-ity,doping efficiency,and device design.In this review,methods to obtain high-quality AlGaN-based materials,achieve high doping efficiency,and design UV-LED structures are summarized and discussed.Finally,the issues that need to be addressed in AlGaN-based UV-LED devices are highlighted. | Yuxuan Chen Jianwei Ben Fujun Xu Jinchai Li Yang Chen Xiaojuan Sun Dabing Li | 2021 | Fundamental Research2021，1，6： | 3 |
| 10 | Improving the resistance of the rice PTGMS line Feng39S by pyramiding blast,bacterial blight,and brown planthopper resistance genes显示文摘Knowledge of rice(Oryza sativa L.)genes and various DNA markers can be used in genomic breeding programs aimed at developing improved elite rice cultivars.We used an efficient genomic breeding approach to pyramid four resistance genes(Pi2,Xa23,Bph14,and Bph15)in the popular photoperiod-and thermosensitive genic male sterile(PTGMS)rice line Feng39S.We performed foreground selection for the target genes,followed by recombinant selection and background selection.This process reduced the sizes of the genomic segments harboring the target genes(566.8 kb for Pi2,1143.9 kb for Xa23,774.7 kb for Bph14,and 1574.9 kb for Bph15)and accelerated the recovery of the recurrent parent genome to proportions ranging from 98.77%to 99.16%,thus resulting in four near-isogenic lines.To assemble the four resistance genes in Feng39S,we performed a double-way cross combined with foreground and background selection to generate two improved lines of Feng39S(Pi2+Xa23+Bph14+Bph15)with a recurrent parent genome recovery of 98.98%.The two lines showed agronomic performance,grain quality,and fertility–sterility transition characteristics similar to those of the original Feng39S line.The newly developed PTGMS lines and corresponding hybrid combinations were resistant to various field blast isolates and seven representative isolates of bacterial blight.At the seedling stage,the lines also showed resistance against brown planthopper.This study provides an efficient and accurate genomic breeding approach for introducing desirable traits into PTGMS lines. | Dabing Yang Lizhong Xiong Tongmin Mou Jiaming Mi | 2022 | The Crop Journal2022，10，4： | 3 |
| 11 | Polarization-enhanced AlGaN solar-blind ultraviolet detectors显示文摘AlGaN solar-blind ultraviolet detectors have great potential in many fields,although their performance has not fully meet the requirements until now.Here,we proposed an approach to utilize the inherent polarization effect of AlGaN to improve the detector performance.AlGaN heterostructures were designed to enhance the polarization field in the absorption layer,and a high built-in field and a high electron mobility conduction channel were formed.As a result,a high-performance solar-blind ultraviolet detector with a peak responsivity of 1.42 A/W at 10 V was achieved,being 50 times higher than that of the nonpolarization-enhanced one.Moreover,an electron reservoir structure was proposed to further improve the performance.A higher peak responsivity of 3.1 A/W at30 V was achieved because the electron reservoir structure could modulate the electron concentration in the conduction channel.The investigation presented here provided feasible approaches to improve the performance of the AlGaN detector by taking advantage of its inherent property. | Ke Jiang Xiaojuan Sun Zi-Hui Zhang Jianwei Ben Jiamang Che Zhiming Shi Yuping Jia Yang Chen Shanli Zhang Wei Lv Dabing Li | 2020 | Photonics Research2020，8，7： | 3 |
| 12 | Boosting the kinetics of PF_(6)^(-) into graphitic layers for the optimal cathode of dual-ion batteries:The rehearsal of pre-intercalating Li^(+)显示文摘Large anions exhibit slow diffusion kinetics in graphite cathode of dual-ion batteries(DIBs);particularly at high current density,it suffers severely from the largely-reduced interlayer utilization of graphite cathode,which as a bottleneck limits the fast charge application of DIBs.To maximize interlayer utilization and achieve faster anion diffusion kinetics,a fast and uncrowded anion transport channel must be established.Herein,Li^(+)was pre-intercalated into the graphite paper(GP)cathode to increase the interlayer spacing,and then hosted for the PF_(6)^(-)anion storage.Combined with theoretical calculation,it shows that the local interlayer spacing enlargement and the residual Li^(+)reduce the anion intercalation energy and diffusion barrier,leading to better rate stability.The obtained GP with Li^(+)pre-intercalation(GP-Li)electrode exhibits a discharge capacity of 23.1 m Ah g^(-1) at a high current of 1300 m A g^(-1).This work provides a facile method to efficiently improve the interlayer utilization of graphite cathode at large currents. | He Yang Tingting Qin Xinyan Zhou Yu Feng Zizhun Wang Xin Ge Nailin Yue Dabing Li Wei Zhang Weitao Zheng | 2022 | Journal of Energy Chemistry2022，31，8： | 2 |
| 13 | Qualitative and Quantitative PCR Methods for Event-specific Detection of Genetically Modified Cotton Mon1445 and Mon531显示文摘 | Litao Yang Aihu Pan Kewei Zhang Changsong Yin Bingjun Qian Jianxiu Chen Cheng Huang Dabing Zhang | 2005 | Transgenic Research2005，，6： | 1 |
| 14 | Estimating number of transgene copies in transgenic rapeseed by real-time PCR assay withHMG I/Y as an endogenous reference gene显示文摘 | Haibo Weng Aihu Pan Litao Yang Chengmei Zhang Zhili Liu Dabing Zhang | | 0，2004，： | 1 |
| 15 | Molecular variation analysis of porcine reproductive and respiratory syndrome virus in China显示文摘 | Lei Zhou Shuxian Chen Jialong Zhang Jingwen Zeng Xin Guo Xinna Ge Dabing Zhang Hanchun Yang | 2009 | Virus Research2009，，1： | 1 |
| 16 | Estimating number of transgene copies in transgenic rapeseed by real-time PCR assay withHMG I/Y as an endogenous reference gene显示文摘 | Haibo Weng Aihu Pan Litao Yang Chengmei Zhang Zhili Liu Dabing Zhang | 2004 | Plant Molecular Biology Reporter2004，，3： | 1 |
| 17 | Tomato stress-responsive factor TSRF1 interacts with ethylene responsive element GCC box and regulates pathogen resistance to Ralstonia solanacearum显示文摘 | Hongbo Zhang Dabing Zhang Jia Chen Yuhong Yang Zejun Huang Dafang Huang Xue-Chen Wang Rongfeng Huang | 2004 | Plant Molecular Biology2004，，6： | 1 |
| 18 | Qualitative and Quantitative PCR Methods for Event-specific Detection of Genetically Modified Cotton Mon1445 and Mon531显示文摘 | Litao Yang Aihu Pan Kewei Zhang Changsong Yin Bingjun Qian Jianxiu Chen Cheng Huang Dabing Zhang | 2005 | Transgenic Research2005，，6： | 1 |
| 19 | Tomato stress-responsive factor TSRF1 interacts with ethylene responsive element GCC box and regulates pathogen resistance to Ralstonia solanacearum显示文摘 | Hongbo Zhang Dabing Zhang Jia Chen Yuhong Yang Zejun Huang Dafang Huang Xue-Chen Wang Rongfeng Huang | 2004 | Plant Molecular Biology2004，，6： | 1 |
| 20 | Transcriptome profiling reveals phase-specific gene expression in the developing barley inflorescence显示文摘The shape of an inflorescence varies among cereals,ranging from a highly branched panicle in rice to a much more compact spike in barley(Hordeum vulgare L.)and wheat(Triticum aestivum L.).However,little is known about the molecular basis of cereal inflorescence architecture.We profiled transcriptomes at three developmental stages of the barley main shoot apex—spikelet initiation,floral organ differentiation,and floral organ growth—and compared them with those from vegetative seedling tissue.Transcript analyses identified 3688 genes differentially transcribed between the three meristem stages,with a further 1394 genes preferentially expressed in reproductive compared with vegetative tissue.Coexpression assembly and Gene Ontology analysis classified these 4888 genes into 28 clusters,revealing distinct patterns for genes such as transcription factors,histone modification,and cell-cycle progression specific for each stage of inflorescence development.We also compared expression patterns of VRS(SIX-ROWED SPIKE)genes and auxin-,gibberellic acid-and cytokinin-associated genes between two-rowed and six-rowed barley to describe regulators of lateral spikelet fertility.Our findings reveal barley inflorescence phase-specific gene expression,identify new candidate genes that regulate barley meristem activities and flower development,and provide a new genetic resource for further dissection of the molecular mechanisms of spike development. | Huiran Liu Gang Li Xiujuan Yang Hendrik N.J.Kuijer Wanqi Liang Dabing Zhang | 2020 | The Crop Journal2020，8，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员