|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 2 | Long-term follow-up of the effects of fecal microbiota transplantation in combination with soluble dietary fiber as a therapeutic regimen in slow transit constipation显示文摘As some studies have reported that strategies targeting the gut microbiota such as fecal microbiota transplantation(FMT) with or without other microecological therapy might have efficacy in treating slow transit constipation(STC), we conducted a singlecenter, open-label trial to study the long-term effect of FMT combined with soluble dietary fiber(pectin) on STC. Thirty-one adult patients with STC were enrolled into the trial. Patients received 6-day FMT procedures repeatedly for the first 3 months and soluble dietary fiber(pectin) daily during the follow-up. The rate of clinical remission and improvement, stool consistency, the Wexner constipation scale, and assessment of constipation-related symptoms were evaluated at week 4 and 1 year later. The clinical remission and improvement rates at week 4 were 69.0%(20/29) and 75.9%(22/29), respectively. At the end of the study,48.3%(14/29) of patients continued to have at least three complete spontaneous bowel movements per week and 58.6%(17/29)of patients showed clinical improvements. Stool consistency, the Wexner constipation scale, and constipation symptoms improved both at short-term and long-term follow-up. The results indicated that FMT in combination with soluble dietary fiber(pectin) had both short-term and long-term efficacy in treating STC. | Xueying Zhang Hongliang Tian Lili Gu Yongzhan Nie Chao Ding Xiaolong Ge Bo Yang Jianfeng Gong Ning Li | 2018 | Science China(Life Sciences)2018，61，7： | 33 |
| 3 | Histological Subtypes of Lung Cancer in Chinese Males from 2000 to 2012显示文摘Objective To characterize the histological and epidemiological features of male lung cancer patients in China. Methods The demographic and histological information about male lung cancer patients identified from 2000-01-01 to 2012-12-31,was collected from the Cancer Hospital of the Chinese Academy of Medical Sciences. Relative frequencies(RF) were estimated for major histological subtypes and compared according to the years of diagnosis and birth. Results The RF of adenocarcinoma(ADC) increased from 21.96% to 43.36% and the RF of squamous cell carcinoma(SCC) decreased from 39.11% to 32.23% from 2000 to 2012 in the 15 427 male lung cancer patients included in this study(Z=17.909,P<0.0001; Z=-6.117,P<0.0001). The RF of ADC increased from 28.72% in 2000-2004,36.88% in 2005-2008 to 48.61% in 2009-2012 in patients born after 1960. The age-adjusted RF of ADC in 2007-2012 increased consistently in all the investigated areas. Conclusion The increased RF of ADC in male lung cancer patients highlights the need for further investigation of the etiologic factors of these tumors. Smoke-free policies rather than modifying tobacco products should be enforced. | ZOU Xiao Nong LIN Dong Mei WAN Xia CHAO Ann FENG Qin Fu DAI Zhen YANG Gong Huan LV Ning | 2014 | Biomedical and Environmental Sciences2014，27，1： | 19 |
| 4 | BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy显示文摘Dysregulation of circadian rhythms associates with cardiovascular disorders.It is known that deletion of the core circadian gene Bma/1 in mice causes dilated car-diomyopathy.However,the biological rhythm regulation system in mouse is very different from that of humans.Whether BMAL1 plays a role in regulating human heart function remains unclear.Here we generated a BMAL1 knockout human embryonic stem cell(hESC)model and further derived human BMAL1 deficient cardiomy-ocytes.We show that BMAL1 deficient hESC-derived cardiomyocytes exhibited typical phenotypes of dilated cardiomyopathy including attenuated contractility,cal-cium dysregulation,and disorganized myofilaments.In addition,mitochondrial fission and mitophagy were suppressed in BMAL1 deficient hESC-cardiomyocytes,which resulted in significantly attenuated mitochondrial oxidative phosphorylation and compromised cardiomy-ocyte function.We also found that BMAL1 binds to the E-box element in the promoter region of BNIP3 gene and specifically controls BNIP3 protein expression.BMAL1 knockout directly reduced BNIP3 protein level,causing compromised mitophagy and mitochondria dysfunction and thereby leading to compromised cardiomyocyte function.Our data indicated that the core circadian gene S/VMLf is critical for normal mitochondria activities and cardiac function.Circadian rhythm disruption may directly link to compromised heart function and dilated cardiomyopathy in humans. | Ermin Li Xiuya Li Jie Huang Chen Xu Qianqian Liang Kehan Ren Aobing Bai Chao Lu Ruizhe Qian Ning Sun | 2020 | Protein & Cell2020，11，9： | 17 |
| 5 | Cone beam computed tomographic analyses of alveolar bone anatomy at the maxillary anterior region in Chinese adults显示文摘To provide an anatomical basis for clinical implant esthetics,we evaluated the morphology of the nasopalatine canal(NPC) and analyzed labial and interproximal bone anatomy at the maxillary anterior region.We sought to investigate the effect of maxillary protrusion and tooth labiolingual inclination on labial bone anatomy in Chinese adults.Three dimensional(3D) images were reconstructed using cone-beam computed tomography(CBCT) images from 80 Chinese subjects and by SimPlant 11.04.The dimensions of the NPC,the thickness and profile of the labial bone,the width and height of the interproximal bone,angle sella-nasion-subspinale(SNA) and angle upper central incisor-nasion,subspinale(U1-NA) were measured.The incisive foramen of the NPC was markedly wider than its nasal foramen.The dimension of its labial bone wall demonstrated an increasing width from the crestal to apical measurements.The labial bone at the maxillary anterior region was rather thin,especially at 3 mm below the cemento-enamel junction(CEJ) and the mid-root level;the profile of the labial bone was more curved at the central incisor,and the interproximal bone became wider and shorter posteriorly.There were significant relationships between maxillary protrusion and labial bone profile,tooth labiolingual inclination and labial bone thickness(P < 0.02).To achieve optimal esthetic outcome of implant,bone augmentation is necessary at the maxillary anterior region.For immediate or early placement at the maxillary anterior region,the implant should be located palatally to reduce labial bone resorption and marginal recession;its apex should be angulated palatally to avoid labial perforation at the apical region.To protect the NPC,implants at the central incisor region should be placed away from NPC. | Zhixuan Zhou Wu Chen Ming Shen Chao Sun Jun Li Ning Chen | 2014 | The Journal of Biomedical Research2014，28，6： | 15 |
| 6 | High levels of serum interleukin-6 increase mortality of hepatitis B virus-associated acute-on-chronic liver failure显示文摘BACKGROUND Patients with hepatitis B virus-associated acute-on-chronic liver failure(HBVACLF)present a complex and poor prognosis.Systemic inflammation plays an important role in its pathogenesis,and interleukin-6(IL-6)as a pro-inflammatory cytokine is related with severe liver impairment and also plays a role in promoting liver regeneration.Whether serum IL-6 influences HBV-ACLF prognosis has not been studied.AIM To determine the impact of serum IL-6 on outcome of patients with HBV-ACLF.METHODS We performed a retrospective study of 412 HBV-ACLF patients.The findings were analyzed with regard to mortality and the serum IL-6 level at baseline,as well as dynamic changes of serum IL-6 within 4 wk.RESULTS The serum IL-6 level was associated with mortality.Within 4 wk,deceased patients had significantly higher levels of IL-6 at baseline than surviving patients[17.9(7.3-57.6)vs 10.4(4.7-22.3),P=0.011].Patients with high IL-6 levels(>11.8 pg/mL)had a higher mortality within 4 wk than those with low IL-6 levels(≤11.8 pg/mL)(24.2%vs 13.2%,P=0.004).The odds ratios calculated using univariate and multivariate logistic regression were 2.10(95%confidence interval[CI]:1.26-3.51,P=0.005)and 2.11(95%CI:1.15-3.90,P=0.017),respectively.The mortality between weeks 5 and 8 in patients with high IL-6 levels at 4 wk was 15.0%,which was significantly higher than the 6.6%mortality rate in patients with low IL-6 levels at 4 wk(hazard ratio=2.39,95%CI:1.05-5.41,P=0.037).The mortality was 5.0%in patients with high IL-6 levels at baseline and low IL-6 levels at 4 wk,7.5%in patients with low IL-6 levels both at baseline and at 4 wk,11.5%in patients with low IL-6 levels at baseline and high IL-6 levels at 4 wk,and 16.7%in patients with high IL-6 levels both at baseline and at 4 wk.The increasing trend of the mortality rate with the dynamic changes of IL-6 was significant(P for trend=0.023).CONCLUSION A high level of serum IL-6 is an independent risk factor for mortality in patients with HBV-ACLF.Furthermore,a sustained high level or dynamic elevated level of serum IL-6 indicates a higher mortality. | Chao Zhou Ning Zhang Ting-Ting He Yao Wang Li-Fu Wang Yong-Qiang Sun Jing Jing Jing-Jing Zhang Shuang-Nan Fu Xuan Wang Xiao-Xiao Liang Xin Li Man Gong Jun Li | 2020 | World Journal of Gastroenterology2020，26，30： | 15 |
| 7 | Effect of microRNA-155 on angiogenesis after cerebral infarction of rats through AT1R/VEGFR2 pathway显示文摘Objective:To explore the function and mechanism of microRNA-155 to regulate the angiogenesis after the cerebral infarction of rats through the angiotensin Ⅱ receptor 1(AT1R)/vascular endothelial growth factor(VEGF) signaling pathway.Methods:Female SD rats were chosen for the construction of cerebral infarction model of rats using the modified right middle cerebral artery occlusion.The real-time PCR(RT-PCR) method was employed to detect the expression of microRNA-155 in each group at different time points after the cerebral infarction(1 h,I d,3 d and 7 d).SD rats were randomly divided into four groups(n=20 rats):sham operation group(Sham group),MACO group,MACO+microRNA-155 mimic group,and MACO+microRNA-155 inhibitor group.Sham group was given the free graft,while MACO+microRNA-155 mimic group and MACO+microRNA-155 inhibitor group were treated with microRNA-155 mimic and microRNA-155 inhibitor respectively.The Zea Longa5-point scale was used to score the neurologic impairment of rats in each group;2,3,5-triphenyl tetrazolium chloride staining to evaluate the volume of cerebral infarction of rats in each group;the immunohistochemistry to detect the expression of CD31;Western blot and RT-PCR to detect the expression of AT1 R and VEGF receptor 2(VEGFR2).Results:The expression of microRNA-155 was increased in the cerebral ischemia tissue after the cerebral infarction.It was significantly increased at 1 d of ischemia and maintained at the high level for a long time.Rats in the Sham group had no symptom of neurologic impairment while rats in the MACO group had the obvious neurologic impairment.After being treated with microRNA-155 inhibitor,the neural function of MACO rats had been improved,with the decreased area of cerebral infarction.But after being treated with microRNA-155 mimic,the neural function was further worsened,with the increased area of cerebral infarction.Results of immunohistoehemical assay indicated that microRNA-155 inhibitor could up-regulate the expression of CD31,while microRNA-155 mimic could down-regulate the expression of CD31.The RT-PCR found that,after being treated with microRNA-155 inhibitor,MACO rats had the increased expression of ATIR and VEGFR2 messenger RNA(mRNA);but after being treated with microRNA-155 mimic,the expression of ATIR and VEGFR2 mRNA was decreased.Results of Western blot showed that,after being treated with microRNA-155 inhibitor,MACO rats had the increased expression of ATIR and VEGFR2 mRNA;but after being treated with microRNA-155 mimic,the expression of ATIR and VEGFR2 mRNA was decreased.Conclusions:The inhibition of microRNA-155 can improve the neurologic impairment of rats with the cerebral infarction,reduce the volume of cerebral infarction and effectively promote the angiogenesis in the region of ischemia,which may be mediated through AT1R/VEGFR2 pathway. | Ying-Chun Meng Zhen-Ying Ding Hai-Quan Wang Li-Ping Ning Chao Wang | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，10： | 10 |
| 8 | The main controlling factors and developmental models of Oligocene source rocks in the Qiongdongnan Basin,northern South China Sea显示文摘Coals developed in the Oligocene Yacheng and Lingshui formations in the Qiongdongnan Basin have high organic matter abundance,and the dark mudstones in the two formations have reached a good source rock standard but with strong heterogeneity.Through the analysis of trace elements,organic macerals and biomarkers,it is indicated that plankton has made little contribution to Oligocene source rocks compared with the terrestrial higher plants.The organic matter preservation depends on hydrodynamics and the redox environment,and the former is the major factor in the study area.During the sedimentary period of the Yacheng Formation,tidal flats were developed in the central uplift zone,where the hydrodynamic conditions were weak and the input of terrestrial organic matter was abundant.So the Yacheng Salient of the central uplift zone is the most favorable area for the development of source rocks,followed by the central depression zone.During the sedimentary period of the Lingshui Formation,the organic matter input was sufficient in the central depression zone due to multiple sources of sediments.The semi-enclosed environment was favorable for organic matter accumulation,so high quality source rocks could be easily formed in this area,followed by the Yacheng salient of central uplift zone.Source rocks were less developed in the northern depression zone owing to poor preservation conditions. | Li Wenhao Zhang Zhihuan Li Youchuan Liu Chao Fu Ning | 2013 | Petroleum Science2013，10，2： | 7 |
| 9 | Solution for polarimetric radar cross section measurement and calibration显示文摘The exact radar cross-section(RCS) measurement is difficult when the scattering of targets is low. Full polarimetric calibration is one technique that offers the potential for improving the accuracy of RCS measurements. There are numerous polarimetric calibration algorithms. Some complex expressions in these algorithms cannot be easily used in an engineering practice. A radar polarimetric coefficients matrix(RPCM) with a simpler expression is presented for the monostatic radar polarization scattering matrix(PSM) measurement. Using a rhombic dihedral corner reflector and a metallic sphere, the RPCM can be obtained by solving a set of equations, which can be used to find the true PSM for any target. An example for the PSM of a metallic dish shows that the proposed method obviously improves the accuracy of crosspolarized RCS measurements. | Peikang Huang Chao Ning Xiaojian Xu Hua Yan Zhaoguo Hou | 2014 | Journal of Systems Engineering and Electronics2014，25，2： | 7 |
| 10 | 粪菌移植应用于慢传输型便秘的临床疗效及疗效影响因素:一项前瞻性研究的长期随访结果显示文摘背景和目的肠道菌群参与结肠动力的调控,菌群失调是便秘是病因之一。粪菌移植被证实可以恢复肠道平衡。本研究旨在评估粪菌移植治疗慢传输型便秘(STC)的临床疗效和预后影响因素。方法:52例STC患者接受标准的粪菌移植入组研究,对其进行至少6个月的随访。记录入组患者的排便习惯、结肠传输时间、便秘相关的症状(PAC-SYM评分)、生活质量(PAC-QOL评分)、治疗满意度和不良反应。主要疗效指标是平均每周完全自主排便≥3次的患者比例。结果:治疗后34周、912周、2124周,每周完全自主排便≥3次患者的比例分别为50.0%、38.5%和32.7%,均较治疗前显著提高(均P<0.01)。其他排便情况、结肠传输时间、便秘相关症状和生活质量方面,治疗后亦有显著改善;但这些短期改善在治疗后12周和24周逐渐减小。治疗前排便不尽是唯一的疗效影响因素。治疗和随访期间未发现任何治疗相关的不良反应。结论:本研究显示粪菌移植治疗STC安全有效,但远期疗效有所降低。治疗前排便不尽感较少甚至没有的患者接受粪菌移植的治疗效果更佳。 | Chao Ding Wenting Fan Lili Gu Hongliang Tian Xiaolong Ge Jianfeng Gong Yongzhan Nie Ning Li | 2018 | Gastroenterology Report2018，6，2： | 7 |
| 11 | Adjuvant Effects of Fermented Red Ginseng Extract on Advanced Non-Small Cell Lung Cancer Patients Treated with Chemotherapy显示文摘Objective: To investigate the adjuvant therapeutic effects of fermented red ginseng(FRG) extract on non-small cell lung cancer(NSCLC) patients treated with chemotherapy. Methods: A total of 60 patients with advanced NSCLC were assigned to two groups using a random number table, i.e., the gemcitabine plus cisplatin(GP) chemotherapy alone group(26 patients) and the FRG + GP chemotherapy group(34 patients), for 60-day treatment. Patients were then assessed according to the Fatigue Symptom Inventory, Chinese medicine symptoms score, Self-Rating Anxiety Scale, Self-Rating Depression Scale, Karnofsky Performance Status Scale, and Functional Assessment of Cancer Therapy-Lung. In addition, chemotherapy toxicity and tumor biomarkers were measured. Results: For NSCLC patients after chemotherapy, FRG extract significantly improved the FSI score, CM symptoms score, psychological status, physical conditions, and quality of life and reduced chemotherapy toxicity(P<0.01), but the expression levels of carcinoembryonic antigen, cytokeratin-19 fragments, and neuron-specific enolase were not significantly different between the chemotherapy alone and the FRG + chemotherapy groups or between pre-and post-treatments(P>0.05). Conclusions: This study demonstrated that FRG extract had an adjuvant effect on advanced NSCLC patients treated with chemotherapy. Further studies with a larger sample size will verify the current findings. | JIANG Shu-long LIU Hong-jie LIU Zhao-chun LIU Ning LIU Rui Young-Reep Kang Joong-Gu Ji ZHANG Chao HUA Bao-jin Shin-Jyung Kang | 2017 | Chinese Journal of Integrative Medicine2017，23，5： | 7 |
| 12 | Structural Nonlinear Flutter Characteristics Analysis for an Actuator-fin System with Dynamic Stiffness显示文摘The flutter characteristics of an actuator-fin system are investigated with structural nonlinearity and dynamic stiffness of the electric motor. The component mode substitution method is used to establish the nonlinear governing equations in time domain and frequency domain based on the fundamental dynamic equations of the electric motor and decelerator. The existing describing function method and a proposed iterative method are used to obtain the flutter characteristics containing preload freeplay nonlinearity when the control command is zero. A comparison between the results of frequency domain and those of time domain is studied. Simulations are carried out when the control command is not zero and further analysis is conducted when the freeplay angle is changed. The results show that structural nonlinearity and dynamic stiffness have a significant influence on the flutter characteristics. Limit cycle oscillations (LCOs) are observed within linear flutter boundary. The response of the actuator-fin system is related to the initial disturbance. In the nonlinear condition, the amplitude of the control command has an influence on the flutter characteristics. | YANG Ning WU Zhigang YANG Chao | 2011 | Chinese Journal of Aeronautics2011，24，5： | 7 |
| 13 | The association between the genetic polymorphisms of LMP2/LMP7 and the outcomes of HCV infection among drug users显示文摘Objective:To investigate a possible association of LMP2/LMP7 genes with chronic hepatitis C virus(HCV) infection,and to assess whether LMP2/LMP7 genes could influence the outcomes of HCV infection among drug users.Methods:Genomic DNAs of 362 anti-HCV sero-positive drug users and 225 control drug users were extracted from the peripheral blood leukocytes.The sero-positive patients were divided into those who had persistent infection and those who had spontaneously cleared the infection.Polymorphisms of LMP genes were determined by PCR combined with restriction fragment length polymorphism(RFLP).Results:The distribution of LMP2 genotypes among the control,persistent infection and spontaneous clearance groups were not different.However,the LMP7 codon 145 Gln/Lys,Lys/Lys,and Gln/Lys+Lys/Lys genotypes were found significantly more frequent in the persistent infection group than in control group(OR=1.75,95%CI=1.06~2.90;OR=3.16,95%CI=1.23-8.12;OR=1.94,95%CI=1.21-3.12,respectively).Similarly,the frequencies of the codon 145 Gln/Lys,Lys/Lys,and Gln/Lys+Lys/Lys genotypes were found significantly more frequent in the persistent infection group than in the spontaneous clearance group(OR=1.64,95%CI=1.04-2.57;OR=2.40,95%CI=1.09-5.28;OR=1.76,95%CI=1.152.69,respectively).Stratified analysis indicated that combined genotype Gln/Lys+Lys/Lys of the LMP7 gene was related to an increasing susceptibility to HCV infection(OR=1.91,95%CI=1.02-3.55;OR=2.19,95%CI=1.243.89;OR=1.91,95%CI=1.05-3.48,OR=2.86,95%CI=1.41-5.78,respectively)and the risk of persistent HCV infection(OR=1.94,95%CI=1.12-3.34;OR=2.02,95%CI=1.21-3.38;OR=1.78,95%CI=1.12-2.85,OR=2.23,95%CI=1.09-4.58,respectively)among>30-year-old,males,the injection drug user(IDU)subjects and/or the shorter duration drug users(≤5 y).Conclusion:These results suggest that polymorphism of the LMP7 gene may have an influence on the outcomes of HCV infection,and is one of the factors accounting for the genetic susceptibility to HCV infection among drug users. | Qian Cui Yongxiang Zhang Jing Su Chao Shi Na Lei Keqin Ding Jun Li Rongbin Yu L u Wang Ning Wang | 2010 | The Journal of Biomedical Research2010，24，5： | 6 |
| 14 | Identification of nonlinear multi-degree-of freedom structures based on Hilbert transformation显示文摘The modeling method and identified method adapted to multi-degree-of-freedom structures with strucrural nonlinearities are established.The component mode synthesis method is used to establish the nonlinear governing equations by extending the connected relationships.Based on the modeling method,the Hilbert transform method is applied to identify the nonlinear stiffness of multi-degree-of-freedom structures.Nonlinear analysis and identification of a typical folding wing configuration with three freeplay hinges are investigated.The nonlinear governing equation is established based on present methods and the computing results of different stiffness are checked by finite element programming.In order to illustrate the influence of the nonlinearities,the frequency response characteristics of the structure are analyzed and Hilbert transform is performed.The Hilbert transform identification method is utilized to identify the nonlinear stiffness of nonlinear hinges in the time domain and several parametric studies are performed.In addition,the comparison of response is made to illustrate the feasibility of the methods.The results show that the extending component mode synthesis method in the present work can be used to establish the governing equation with structural nonlinearities.Based on the modeling method,the Hilbert transform identified method can be extended to multi-degree-of-freedom structures accurately. | WU ZhiGang YANG Ning YANG Chao | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，9： | 6 |
| 15 | Defect engineering: A versatile tool for tuning the activation of key molecules in photocatalytic reactions显示文摘Many photocatalytic reactions such as CO2 reduction and N2 fixation are often limited by the activation of some key molecules. Defects in solid materials can robustly introduce coordinately unsaturated sites to serve as highly active sites for molecular chemisorption and activation. As a result, rational defect engineering has endowed a versatile approach to further develop photocatalytic applications beyond water splitting. The subtly designed defects in photocatalysts can play critical and decisive roles in molecular activation as proven in recent years. The defects cannot only serve as active sites for molecular chemisorption, but also spatially supply channels for energy and electron transfer. In this review, we aim to summarize the diversiform photocatalytic applications using defects as active sites, including but not limited to CO2 reduction, O2 activation,H2O dissociation, N2 fixation as well as activation of other molecules. In particular, we emphatically outline how the parameters of defects (e.g.,concentration,location,geometric and electronic structures) can serve as the knobs for maneuvering molecular adsorption and activation as well as altering subsequent reaction pathway. Moreover, we underline the remaining challenges at the current stage and the potential development in the future.It is anticipated that this review consolidates the in-depth understanding towards the structure-activity relationship between defects and related reactions. | Ning Zhang Chao Gao Yujie Xiong | 2019 | Journal of Energy Chemistry2019，28，10： | 6 |
| 16 | False data injection attacks against smart grid state estimation:Construction, detection and defense显示文摘As a typical representative of the so-called cyber-physical system,smart grid reveals its high efficiency,robustness and reliability compared with conventional power grid.However,due to the deep integration of electrical components and computinginformation in cyber space,smart grid is vulnerable to malicious attacks,especially for a type of attacks named false data injection attacks(FDIAs).FDIAs are capable of tampering meter measurements and affecting the results of state estimation stealthily,which severely threat the security of smart grid.Due to the significantinfluence of FDIAs on smart grid,the research related to FDIAs has received considerable attention over the past decade.This paper aims to summarize recent advances in FDIAs against smart grid state estimation,especially from the aspects of background materials,construction methods,detection and defense strategies.Moreover,future research directions are discussed and outlined by analyzing existing results.It is expected that through the review of FDIAs,the vulnerabilities of smart grid to malicious attacks can be further revealed and more attention can be devoted to the detection and defense of cyber-physical attacks against smart grid. | ZHANG Meng SHEN Chao HE Ning HAN SiCong LI Qi WANG Qian GUAN XiaoHong | 2019 | Science China(Technological Sciences)2019，62，12： | 6 |
| 17 | CNV analysis of Meishan pig by nextgeneration sequencing and effects of AHR gene CNV on pig reproductive traits显示文摘Background:Reproductive performance of livestock is an economically important aspect of global food production.The Chinese Meishan pig is a prolific breed,with an average of three to five more piglets per litter than European breeds;however,the genetic basis for this difference is not well understood.Results:In this study,we investigated copy number variations(CNVs)of 32 Meishan pigs and 29 Duroc pigs by nextgeneration sequencing.A genome-wide analysis of 61 pigs revealed 12,668 copy number variable regions(CNVRs)that were further divided into three categories based on copy number(CN)of the whole population,i.e.,gain(n=7,638),and loss(n=5,030)CNVRs.We then compared Meishan and Duroc pigs and identified 17.17Mb of 6,387 CNVRs that only existing in Meishan pigs CNVRs that overlapped the reproduction-related gene encoding the aryl hydrocarbon receptor(AHR)gene.We found that normal AHR CN was more frequent than CN loss in four different pig breeds.An association analysis showed that AHR CN had a positive effect on litter size(P<0.05)and that a higher CN was associated with higher total number born(P<0.05),number born alive(P<0.05),number of weaned piglets,and birth weight.Conclusions:The present study provides comprehensive CNVRs for Meishan and Duroc pigs through large-scale population resequencing.Our results provide a supplement for the high-resolution map of copy number variation in the porcine genome and valuable information for the investigation of genomic structural variation underlying traits of interest in pig.In addition,the association results provide evidence for AHR as a candidate gene associated with reproductive traits that can be used as a genetic marker in pig breeding programs. | Xianrui Zheng Pengju Zhao Kaijie Yang Chao Ning Haifei Wang Lei Zhou Jianfeng Liu | 2020 | Journal of Animal Science and Biotechnology2020，11，3： | 6 |
| 18 | Effectiveness of Catch-Up Vaccinations after COVID-19 Containment--China,2020显示文摘Introduction:In the early stages of the coronavirus disease 2019(COVID-19)epidemic in China,the highest level of public health emergency response(Level 1 Response)was launched in all province-level administrative divisions(PLADs)across the country.Provision of vaccination services was selectively suspended due to the physical distancing and gathering restrictions required of Level 1 Response.The purpose of this paper is to evaluate the impact of COVID-19 on vaccination services and the effectiveness of selective vaccination service suspension and catch-up vaccinations in China.Methods:Vaccine doses administered,routine vaccination coverage levels,catch-up vaccine doses administered,and coverage levels after the catch-up campaign were determined from individual vaccination records in sampled clinics,standard routine immunization administrative coverage reports,and catch-up vaccination activity reports submitted by PLADs between October 2019 and October 2020.Results:National Immunization Program(NIP)and non-NIP vaccine doses administered in sampled clinics decreased by 80% and 90%,respectively,compared with doses administered before the COVID-19 pandemic.Coverage with the birth dose of hepatitis B vaccine(HepB1)and the Bacillus Calmette-Guérin vaccine(BCG)—two vaccinations recommended to continue throughout the epidemic due to their timecritical nature—were maintained at over 85%,while coverage of other NIP vaccines decreased to below 60%by February 2020.Catch-up vaccination coverage of the 29 PLADs,excluding Xinjiang and Xizang(Tibet),began in April 2020 and exceeded 90%;Hubei catch-up coverage was 95% by October 2020.Conclusions and Implications for Public Health Practice:The COVID-19 pandemic had a great impact on China’s vaccination services.During the epidemic and time of local transmission of the coronavirus,HepB1,BCG,rabies vaccine for postexposure prophylaxis,and tetanus antitoxin(TAT)for wound prophylaxis were maintained at high levels.Of the 69 million vaccine doses postponed during the time of local transmission of the coronavirus,94% were administered in the catch-up campaign.China’s pandemic immunization practices may provide evidence for other countries’immunization programs. | Jing Wu Wenzhou Yu Lei Cao Lingsheng Cao Lance Rodewald Jiakai Ye Yifan Song Li Li Xiaoxue Liu Ning Wen Fuzhen Wang Lixin Hao Yixing Li Hui Zheng Keli Li Chao Ma Dan Wu Yanmin Liu Guomin Zhang Zhijie An Huaqing Wang Zundong Yin | 2020 | China CDC weekly2020，2，50： | 6 |
| 19 | Elevated Resting Heart Rate is Associated with Dyslipidemia in Middle-aged and Elderly Chinese显示文摘Objective To study the relationship between resting heart rate and blood lipid level.Methods A total of 9 415 subjects aged≥40 years were included in the present study.Their resting heart rate was monitored and their serum levels of triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)were measured to define dyslipidemia according to the 2007 Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults.Results The subjects were divided into group A with their resting heart rate<70 beats/min,group B with their resting heart rate=70-79 beats/min,group C with their resting heart rate=80-89 beats/min,and group D with their resting heart rate≥90 beats/min.High TG,TC,and LDL-C were presented across the resting heart rate(Ptrend<0.01).Multiple logistic regression analysis revealed that the risk of high TG and TC was higher in subjects with their resting heart rate≥90 beats/min than in those with their resting heart rate<70 beats/min(OR=1.42;95%CI:1.16-1.74 and OR=1.33;95%CI:1.09-1.64,respectively).Conclusion Elevated resting heart rate is associated with high TG and TC in middle-aged and elderly Chinese subjects. | SUN Ji Chao HUANG Xiao Lin DENG Xin Ru LV Xiao Fei LU Jie Li CHEN Yu Hong BI Yu Fang WANG Wei Qing XU Min NING Guang | 2014 | Biomedical and Environmental Sciences2014，27，8： | 5 |
| 20 | Putrescine, spermidine, and spermine play distinct roles in rice salt tolerance显示文摘Polyamines(PAs) play diverse roles in plant growth and development,as well as responses to environmental stimuli.In this study,the effects of PAs on rice salt tolerance were investigated.Salt stress resulted in the alteration of endogenous PAs levels in rice roots and leaves,where spermidine(Spd) and spermine(Spm) contents were increased,and putrescine(Put) content was decreased.RT-qPCR analysis revealed that PAs biosynthesis-related genes ADC1,ODC,and Arginase were significantly downregulated by salt treatment;however,SAMDC transcription was significantly upregulated.Exogenous Spm enhanced rice salt tolerance remarkably;however,exogenous Put and Spd undermined rice salt tolerance.Transgenic rice plants overexpressing SAMDC display a higher ratio of Spm/(Put+Spd) and enhanced salt tolerance.Salt stress also increased polyamine oxidase activities in rice,resulting in elevated reactive oxygen species(ROS) production.Our findings revealed that accumulation of Put and Spd substantially reduced salt tolerance in rice,likely by facilitating ROS production;whereas,conversion of Put and Spd to Spm contributes to rice salt tolerance. | Md Azizul ISlam PANG Jin-huan MENG Fan-wei LI Ya-wen XU Ning YANG Chao LIU Jun | 2020 | Journal of Integrative Agriculture2020，19，3： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员