|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Rationally pairing photoactive materials for high-performance polymer solar cells with efficiency of 16.53%显示文摘The emergence of non-fullerene acceptors(NFA) offers a promising opportunity to develop high-performance donor/acceptor pairs with high power conversion efficiency,as NFAs offer tunable energy levels,broad absorption and suitable aggregation property.In order to enhance light-harvesting capability of active layers,we choose a wide bandgap polymer PTQ10 as the donor to blend with a narrow bandgap NFAY6 as the acceptor.In comparison with PTQ10:IDIC blend,~130 nm red-shifted absorption spectrum is observed in the PTQ10:Y6 blend,which potentially enhance the short-circuit current density(Jsc) for the PSCs.In addition,the optimal PTQ10:Y6 blend shows higher photoluminescence quenching efficiency and more efficient charge separation,higher charge mobilities,as well as weaker bimolecular recombination over the PTQ10:IDIC blend,which leads to an outstanding power conversion efficiency(PCE) of 16.53%,with a notable Jsc of 26.65 mA cm^-2 and fill factor(FF) of 0.751. | Yue Wu Yan Zheng Hang Yang Chenkai Sun Yingying Dong Chaohua Cui He Yan Yongfang Li | 2020 | Science China Chemistry2020，63，2： | 5 |
| 2 | Hepatic focal nodular hyperplasia of muhislice CT diagnosis value 显示文摘 | Huang Chaohua Yang Jiangshuang Hao He etc | 2011 | Chi- nese journal of clinical medical imaging2011，22，9： | 1 |
| 3 | Cu_(2−x)S derived copper nanoparticles:A platform for unraveling the role of surface reconstruction in efficient electrocatalytic CO_(2)-to-C_(2)H_(4)conversion显示文摘Cu-based electrocatalysts have provoked much attention for their high activity and selectivity in carbon dioxide(CO_(2))conversion into multi-carbon hydrocarbons.However,during the electrochemical reaction,Cu catalysts inevitably undergo surface reconstruction whose impact on CO_(2)conversion performance remains contentious.Here we report that polycrystalline Cu nanoparticles(denoted as Cu-s)with rich high-index facets,derived from Cu_(2−x)S through desulphurization and surface reconstruction,offer an excellent platform for investigating the role of surface reconstruction in electrocatalytic CO_(2)conversion.During the formation of Cu-s catalyst,the two stages of desulphurization and surface reconstruction can be clearly resolved by in situ X-ray absorption spectroscopy and OH−adsorption characterizations,which are well correlated with the changes in electrocatalytic performance.It turns out that the high CO_(2)conversion performance,achieved by the Cu-s catalyst(Faradic efficiency of 68.6%and partial current density of 40.8 mA/cm^(2)in H-cell toward C_(2)H_(4)production),is attributed to the increased percentage of high-index facets in Cu-s during the surface reconstruction.Furthermore,the operando electrochemical Raman spectroscopy further reveals that the conversion of the CO_(2)into the C_(2)H_(4)on Cu-s is intermediated by the production of*COCHO.Our findings manifest that the surface reconstruction is an effective method for tuning the reaction intermediate of the CO_(2)conversion toward high-value multicarbon(C2+)chemicals,and highlight the significance of in situ characterizations in enhancing the understanding of the surface structure and its role in electrocatalysis. | Chaohua He Delong Duan Jingxiang Low Yu Bai Yawen Jiang Xinyu Wang Shuangming Chen Ran Long Li Song Yujie Xiong | 2023 | Nano Research2023，16，4： | 1 |
| 4 | Design of CuInS2 hollow nanostructures toward CO2 electroreduction显示文摘The sharp rise of CO2 in the atmosphere has become a potential threat to global climate, which results from the massive utilization of fossil fuel since the industry revolution. CO2 electroreduction provides us a new possibility of utilizing CO2 as a carbon feedstock for fuel and commercial chemicals generation. In this article, a new method is developed for synthesizing CuInS2 hollow nanostructures through the Kirkendall effect. The CuInS2 hollow nanostructures exhibit excellent catalytic activity for electrochemical reduction of CO2 with particular high selectivity, achieving high faradaic efficiency for HCOOH of 72.8% at -0.7 V. To elucidate the mechanisms, operando electrochemical Raman spectroscopy is employed to examine the CO2 reduction process. This work provides new insights into the design of hollow nanostructures toward electrocatalytic CO2 conversion and offers us an effective and reliable way for real-time investigation of electrochemical CO2 reduction reaction processes. | Chaohua He Sijia Chen Ran Long Li Song Yujie Xiong | 2020 | Science China Chemistry2020，63，12： | 1 |
| 5 | Fatigue Life Supervision of Aircraft Structures under Corrosive Conditions显示文摘 | He Yuting Fan Chaohua Zhang Hengxi | 2006 | Key Engineering Materials2006，，324325： | 1 |
| 6 | An effective energycriterion on fatigue crack growth of metal materials显示文摘 | HE Yuling LI Feng FAN Chaohua | 2007 | Key Engineering Materials2007，35，3354355356357358： | 1 |
| 7 | Mutant Huntingtin Causes a Selective Decrease in the Expression of Synaptic Vesicle Protein 2C显示文摘Huntington's disease(HD) is a neurodegenerative disease caused by a polyglutamine expansion in the huntingtin(Htt) protein. Mutant Htt causes synaptic transmission dysfunctions by interfering in the expression of synaptic proteins, leading to early HD symptoms.Synaptic vesicle proteins 2(SV2 s), a family of synaptic vesicle proteins including 3 members, SV2 A, SV2 B, and SV2 C, plays important roles in synaptic physiology. Here,we investigated whether the expression of SV2 s is affected by mutant Htt in the brains of HD transgenic(TG) mice and Neuro2 a mouse neuroblastoma cells(N2 a cells)expressing mutant Htt. Western blot analysis showed that the protein levels of SV2 A and SV2 B were not significantly changed in the brains of HD TG mice expressing mutant Htt with 82 glutamine repeats. However, in the TG mouse brain there was a dramatic decrease in the protein level of SV2 C, which has a restricted distribution pattern in regions particularly vulnerable in HD. Immunostaining revealed that the immunoreactivity of SV2 C was progressively weakened in the basal ganglia and hippocampus of TG mice. RT-PCR demonstrated that the mRNA level of SV2 C progressively declined in the TG mouse brain without detectable changes in the mRNA levels of SV2 A and SV2 B, indicating that mutant Htt selectively inhibits the transcriptional expression of SV2 C. Furthermore, we found that only SV2 C expression was progressively inhibited in N2 a cells expressing a mutant Htt containing120 glutamine repeats. These findings suggest that the synaptic dysfunction in HD results from the mutant Httmediated inhibition of SV2 C transcriptional expression.These data also imply that the restricted distribution and decreased expression of SV2 C contribute to the brain region-selective pathology of HD. | Chaohua Peng Gaochun Zhu Xiangqian Liu He Li | 2018 | Neuroscience Bulletin2018，34，5： | 0 |
| 8 | Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells显示文摘Here,we present a gene regulation strategy enabling programmable control over eukaryotic translational initiation.By excising the natural poly-adenylation(poly-A)signal of target genes and replacing it with a synthetic control region harboring RNA-binding protein(RBP)-specific aptamers,cap-dependent translation is rendered exclusively dependent on synthetic translation initiation factors(STIFs)containing different RBPs engineered to conditionally associate with different eIF4F-binding proteins(eIFBPs).This modular design framework facilitates the engineering of various gene switches and intracellular sensors responding to many user-defined trigger signals of interest,demonstrating tightly controlled,rapid and reversible regulation of transgene expression in mammalian cells as well as compatibility with various clinically applicable delivery routes of in vivo gene therapy.Therapeutic efficacy was demonstrated in two animal models.To exemplify disease treatments that require on-demand drug secretion,we show that a custom-designed gene switch triggered by the FDA-approved drug grazoprevir can effectively control insulin expression and restore glucose homeostasis in diabetic mice.For diseases that require instantaneous sense-and-response treatment programs,we create highly specific sensors for various subcellularly(mis)localized protein markers(such as cancer-related fusion proteins)and show that translation-based protein sensors can be used either alone or in combination with other cell-state classification strategies to create therapeutic biocomputers driving self-sufficient elimination of tumor cells in mice.This design strategy demonstrates unprecedented flexibility for translational regulation and could form the basis for a novel class of programmable gene therapies in vivo. | Jiawei Shao Shichao Li Xinyuan Qiu Jian Jiang Lihang Zhang Pengli Wang Yaqing Si Yuhang Wu Minghui He Qiqi Xiong Liuqi Zhao Yilin Li Yuxuan Fan Mirta Viviani Yu Fu Chaohua Wu Ting Gao Lingyun Zhu Martin Fussenegger Hui Wang Mingqi Xie | 2024 | Cell Research2024，34，1： | 0 |
| 9 | A specific assay for JmjC domain-containing lysine demethylase and its application to inhibitor screening显示文摘Dear Editor, Chromatin is the macromolecular complex of DNA and histone proteins, which provides the scaffold for the packaging of our entire genome. In the basic unit of chromatin, the nucleosomes contain 147 base pairs of DNA, which is wrapped around a histone octamer, with two each of histones H2A, H2B, H3, and H4. Several types of post-translational modifications, including acetylation, phosphorylation, ubiquitination, and methylation, are possible on the tails of histones (Zhang et al., 2015). Combinations of these modifications determine the chromatin structure and transcriptional regulation of genes. Histone methylation is highlighted because of the specific dynamics related to gene regulation. Aberrant histone methylation has been observed in many types of tumors (Albert and Helin, 2010) and may contribute to the neoplastic transformation of cells (Chi et al., 2010). Histone lysine methylation is regulated by two classes of enzymes that have opposing activities: histone lysine methyltransferases (KMTs) and histone lysine demethylases (KDMs). To date, a number of mammalian KDMs have been discovered (Kooistra and Helin, 2012), and they have been separated into two classes: flavin adenine dinucleotide dependent oxidases, which were first discovered in 2004 (Shi et al., 2004), and Jumonji-C (JmjC) domain-containing enzymes, first identified in 2006 (Tsukada et al., 2006). | He Wen Guo Li Yongcan Chen Meiting Li Yafei Lv Zhiming Li Yinglu Li Tianyun Hou Hui Wang Chaohua Liu Xiaopeng Lu Qian Zhu Yantao Bao Ge Liu Xiaofan Li Wei-Guo Zhu | 2019 | Science China(Life Sciences)2019，62，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员