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| 1 | Combined obeticholic acid and apoptosis inhibitor treatment alleviates liver fibrosis显示文摘Obeticholic acid(OCA), the first FXR-targeting drug, has been claimed effective in the therapy of liver fibrosis. However, recent clinical trials indicated that OCA might not be effective against liver fibrosis, possibly due to the lower dosage to reduce the incidence of the side-effect of pruritus. Here we propose a combinatory therapeutic strategy of OCA and apoptosis inhibitor for combating against liver fibrosis. CCl4-injured mice, D-galactosamine/LPS(GalN/LPS)-treated mice and cycloheximide/TNFα(CHX/TNFα)-treated HepG2 cells were employed to assess the effects of OCA, or together with IDN-6556, an apoptosis inhibitor. OCA treatment significantly inhibited hepatic stellate cell(HSC)activation/proliferation and prevented fibrosis. Elevated bile acid(BA) levels and hepatocyte apoptosis triggered the activation and proliferation of HSCs. OCA treatment reduced BA levels but could not inhibit hepatocellular apoptosis. An enhanced anti-fibrotic effect was observed when OCA was co-administrated with IDN-6556. Our study demonstrated that OCA inhibits HSCs activation/proliferation partially by regulating BA homeostasis and thereby inhibiting activation of HSCs. The findings in this study suggest that combined use of apoptosis inhibitor and OCA at lower dosage represents a novel therapeutic strategy for liver fibrosis. | Jiyu Zhou Ningning Huang Yitong Guo Shuang Cui Chaoliang Ge Qingxian He Xiaojie Pan Guangji Wang Hong Wang Haiping Hao | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 13 |
| 2 | Synthesis, properties and applications of one- and two- dimensional gold nanostructures显示文摘因为金 nanomaterials 的性质和功能高度依赖于他们的粒子尺寸,形状,和维数,金 nanocrystals 的控制合成是集中的研究的题目十年了。特别,各向异性的金 nanocrystals 例如 nanowires, nanobelts, nanoplates 和 nanosheets,在电子学由于他们的惹人注目的性质和有希望的应用吸引了许多注意,催化作用, photonics,察觉到并且 biomedicine。在这评论,我们将总结 onedimensional (1D ) 的最近的开发并且二维(2D ) 金 nanostructures。为这些 1D 和 2D 金牌 nanocrystals 的准备的合成方法的各种各样的类型将被描述。而且,我们将简短也介绍性质和这些 1D 和 2D 金牌 nanocrystals 的潜在的应用。 | Xun Hong Chaoliang Tan Junze Chen Zhichuan Xu Hua Zhang | 2015 | Nano Research2015，8，1： | 9 |
| 3 | Engineering optimization approach of nonaqueous electrolyte for sodium ion battery with long cycle life and safety显示文摘Electrolyte design strategies are closely related to the capacities, cycle life and safety of sodium–ion batteries. In this study, we aimed to optimize electrolyte with the focus on engineering aspects. The basic physicochemical properties including ionic conductivity, viscosity,wettability and thermochemical stability of the electrolytes using Na PF6 as the solute and the mixed solvent with different components of EMC,DMC or DEC in PC or EC were systematically measured. Ah pouch cell with NaNi_(1/3)Fe_(1/3)Mn_(1/3)O_(2)/hard carbon electrodes was used to evaluate the performance of the prepared electrolytes. By using the Inductive Coupled Plasma Emission Spectrometer(ICP), X-ray photoelectron spectroscopy(XPS), Thermogravimetric-differential scanning calorimetry(TG-DSC) and Accelerating Rate Calorimeter(ARC), we show that an optimized electrolyte can effectively promote the formation of a protective interfacial layer on two electrodes, which not only retards parasitic reactions between the electrodes and electrolyte but also suppresses dissolution of metal ions from the cathode. With an optimized electrolyte, a NaNi_(1/3)Fe_(1/3)Mn_(1/3)O_(2)/hard carbon cell can attain 56.16% capacity retention under the low temperature of -40℃, and can be able to retain 80%capacity retention after more than 2500 cycles while presenting excellent thermal safety. | Haiying Che Xinrong Yang Yan Yu Chaoliang Pan Hong Wang Yonghong Deng Linsen Li Zi-Feng Ma | 2021 | Green Energy & Environment2021，6，2： | 4 |
| 4 | A fast and versatile cross-linking strategy via o-phthalaldehyde condensation for mechanically strengthened and functional hydrogels显示文摘Fast and catalyst-free cross-linking strategy is of great significance for construction of covalently cross-linked hydrogels.Here,we report the condensation reaction between o-phthalaldehyde(OPA)and N-nucleophiles(primary amine,hydrazide and aminooxy)for hydrogel formation for the first time.When four-arm poly(ethylene glycol)(4 a PEG)capped with OPA was mixed with various N-nucleophile-terminated 4 aPEG as building blocks,hydrogels were formed with superfast gelation rate,higher mechanical strength and markedly lower critical gelation concentrations,compared to benzaldehyde-based counterparts.Small molecule model reactions indicate the key to these cross-links is the fast formation of heterocycle phthalimidine product or isoindole(bis)hemiaminal intermediates,depending on the N-nucleophiles.The second-order rate constant for the formation of phthalimidine linkage(4.3 M-1s-1)is over 3000 times and 200 times higher than those for acylhydrazone and oxime formation from benzaldehyde,respectively,and comparable to many cycloaddition click reactions.Based on the versatile OPA chemistry,various hydrogels can be readily prepared from naturally derived polysaccharides,proteins or synthetic polymers without complicated chemical modification.Moreover,biofunctionality is facilely imparted to the hydrogels by introducing amine-bearing peptides via the reaction between OPA and amino group. | Zhen Zhang Chaoliang He Yan Rong Hui Ren Tianran Wang Zheng Zou Xuesi Chen | 2021 | National Science Review2021，8，4： | 4 |
| 5 | Bioactive polypeptide hydrogels modified with RGD and N-cadherin mimetic peptide promote chondrogenic differentiation of bone marrow mesenchymal stem cells显示文摘Cell-material and cell-cell interactions represent two crucial aspects of the regulation of cell behavior.In the present study,poly(L-glutamic acid)(PLG)hydrogels were prepared by catalyst-free click crosslinking via a strain-promoted azide-alkyne cycloaddition(SPAAC)reaction between azido-grafted PLG(PLG-N3)and azadibenzocyclooctyne-grafted PLG(PLG-ADIBO).The bioactive peptides c(RGDfK)and N-cadherin mimetic peptide(N-Cad)were both conjugated to the PLG hydrogel(denoted PLG+RGD/N-Cad)in order to regulate cell-material and cell-cell interactions.Gelation time and storage modulus of the hydrogels were tunable through variations in the concentration of polypeptide precursors.The hydrogels degraded gradually in the presence of proteinases.The viability of bone marrow mesenchymal stem cells(BMSCs)was maintained when cultured with extracts of the hydrogels or encapsulated within the hydrogels.Degradation was observed within 10 weeks following the subcutaneous injection of hydrogel solution in rats,displaying excellent histocompatibility in vivo.The introduction of RGD into the PLG hydrogel promoted the adhesion of BMSCs onto the hydrogels.Moreover,when encapsulated within the PLG+RGD/NCad hydrogel,BMSCs secreted cartilage-specific matrix,in addition to chondrogenic gene and protein expression being significantly enhanced in comparison with BMSCs encapsulated in hydrogels without N-Cad modification.These findings suggest that these biodegradable,bioactive polypeptide hydrogels have great potential for use in 3D cell culture and in cartilage tissue engineering. | Yan Rong Zhen Zhang Chaoliang He Xuesi Chen | 2020 | Science China Chemistry2020，63，8： | 4 |
| 6 | DOX/IL-2/IFN-g co-loaded thermo-sensitive polypeptide hydrogel for efficient melanoma treatment显示文摘Melanoma has been a serious threat to the human health;however,effective therapeutic methods of this cancer are still limited.Combined local therapy is a crucial approach for achieving a superior anti-tumor efficacy.In this paper,a chemo-immunotherapy system of DOX,IL-2 and IFN-g based on poly(g-ethyl-Lglutamate)-poly(ethylene glycol)-poly(g-ethyl-L-glutamate)(PELG-PEG-PELG)hydrogel was developed for local treatment of melanoma xenograft.The drug release process of this system exhibited a short term of burst release(the first 3 days),followed by a long-term sustained release(the following 26 days).The hydrogel degraded completely within 3 weeks without obvious inflammatory responses in the subcutaneous layer of rats,showing a good biodegradability and biocompatibility.The DOX/IL-2/IFN-g co-loaded hydrogel also showed enhanced anti-tumor effect against B16F10 cells in vitro,through increasing the ratio of cell apoptosis and G2/S phage cycle arrest.Moreover,the combined strategy presented improved therapy efficacy against B16F10 melanoma xenograft without obvious systemic side effects in a nude mice model,which was likely related to both the enhanced tumor cell apoptosis and the increased proliferation of the CD3t/CD4t T-lymphocytes and CD3t/CD8t T-lymphocytes.Overall,the strategy of localized co-delivery of DOX/IL-2/IFN-g using the polypeptide hydrogel provided a promising approach for efficient melanoma therapy. | Qiang Lv Chaoliang He Fenli Quan Shuangjiang Yu Xuesi Chen | 2018 | Bioactive Materials2018，3，1： | 4 |
| 7 | Biocompatible in situ-forming glycopolypeptide hydrogels显示文摘A lack of biological activity hinders the application of synthetic hydrogels in tissue engineering and regenerative medicine.However,the use of glycopolypeptides in hydrogel synthesis may provide the materials with the desired biological activities.Herein,we prepared three in situ-forming hydrogels from various phenol-functionalized glycopolypeptides.The gelation time,mechanical properties,degradation properties,and biocompatibility of the hydrogels were assessed.Gelation time ranged from 11 to 380s,depending on the concentration of horseradish peroxidase.The galactose-modified polypeptide hydrogel showed the highest storage modulus with an obvious stress relaxation phenomenon.The prepared hydrogels exhibited good degradation properties and compatibility to cells and tissues.Furthermore,the rate of immune cell accumulation around the mannosemodified polypeptide hydrogel was the fastest among the hydrogels. | SHI Shun YU ShuangJiang LI Gao HE ChaoLiang CHEN XueSi | 2020 | Science China(Technological Sciences)2020，63，6： | 3 |
| 8 | Effect of interleukin-33 on Th1/Th2 cytokine ratio in peripheral lymphocytes in asthmatic mice显示文摘 | He Xinliang Wu Wei Lu Yan Guo Yali Hu Chaoliang Huang Yuyun Xu Yuzu Xie Jungang Zhao Jianping | 2014 | Chinese Medical Journal2014，，8： | 2 |
| 9 | 0.5981μm Sum Frequency Mixing in KTP Crystal显示文摘Based on accurate values of refractive indices,the phase matching angles(θ_(m))and effective nonlinear coeficients(d_(eff))for type I and I I sum frequency mixing of 1.0795 and 1.3414μm radiations were calculated in KTP crystal.The optimum phase matching conditions are thatθm=75.74o in the XZ plane(Ф=0)and deff=17.42 × 10^(-9) esu.The calculated results agree well with the experimental results.Thus,the cw 0.5981μm sum frequency radiation was achieved in KTP crystal using a 1.0795 and 1.3414μm double-wavelength Nd:YAP cw laser. | SHEN Hongyuan ZHOU Yuping LIN Wenxiong ZENG Ruirong YU Guifang HUANG Chenghui ZENG Zhengdong ZHANG Weijia JIA Shouquan JIANG Peizhi XIAO Chaoliang | 1991 | Chinese Physics Letters1991，8，4： | 2 |
| 10 | Crystal phase-controlled growth of PtCu and PtCo alloys on 4H Au nanoribbons for electrocatalytic ethanol oxidation reaction显示文摘Crystal phase can greatly affect the physicochemical properties and applications of nanomaterials.However,it stil remains a great challenge to synthesize nanostructures with the same composition and morphology but different phases in order to explore the phase-dependent properties and applications.Herein,we report the crystal phase-controlled synthesis of PtCu alloy shells on 4H Au nanoribbons(NRBs),referred to as 4H-Au NRBs,to form the 4H-Au@PtCu core-shell NRBs.By tuning the thickness of PtCu,4H-PtCu and face-centered cubic(cc)phase PICu(cc-PtCu)alloy shells are successtully grown on the 4H-Au NRB cores.This thickness-dependent phase-controlled growth strategy can also be used to grow PtCo alloys with 4H or fcc phase on 4H-Au NRBs.Significantly,when used as electrocatalysts for the ethanol oxidation reaction(EOR)in alkaline media,the 4H-Au@4H-PtCu NRBs show much better EOR performance than the 4H-Au@fcc-PtCu NRBs,and both of them possess superior performance compared to the commercial Pt black.Our study provides a strategy on phase-contolled synthesis of nanomaterials used for crystal phase-dependent applications. | Jie Wang Jian Zhang Guigao Liu Chongyi Ling Bo Chen Jingtao Huang Xiaozhi Liu Bing Li An-Liang Wang Zhaoning Hu Ming Zhou Ye Chen Hongfei Cheng Jiawei Liu Zhanxi Fan Nailiang Yang Chaoliang Tan Lin Gu Jinlan Wang Hua Zhang | 2020 | Nano Research2020，13，7： | 2 |
| 11 | Biomedical polymers: synthesis, properties, and applications显示文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation. | Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen | 2022 | Science China Chemistry2022，65，6： | 2 |
| 12 | Detrimental effects of excessive fatty acid secretion on female sperm storage in chickens显示文摘Background:Female sperm storage(FSS),the maintenance of sperm inside the female reproductive tract for an extended period of time,is pervasive among organisms with internal fertilization.Because FSS enables asynchronous mating and fertilization,it could be extremely important to reproduction.However,the physiological mechanisms underlying prolonged preservation and maintenance are poorly understood.Here,we used chicken,a typical oviparous animal,to determine the mechanisms ensuring sperm functionality in sperm storage tubules(SSTs).Results:We performed an insemination experiment on over two thousand hens at two periods,and found that the FSS capabilities varied widely among individuals.Except for the differences in the SST density between the two groups with distinct FSS abilities,we quantitatively profiled small-molecule metabolites derived from SST cells,and identified 28 metabolites with differential expression.In particular,high levels of lipids,fatty acids and lipid peroxidation product were observed in hens with low FSS capability.Pathway analysis showed that these differential metabolites were significantly enriched in the biosynthesis of unsaturated fatty acids.Moreover,we detected the total antioxidant capacity and lipid peroxidation level of SSTs,and found that chickens with a lower FSS ability had a significantly higher content of lipid peroxidation end-product,which was 2.4-fold greater than chickens with a higher FSS capability,and no significant difference was found in the total antioxidant capacity between these two groups.Conclusions:Our findings reveal that the long-term storage of sperm and the maintenance of their function in the female reproductive tract require an adequate microenvironment.The superabundance of fatty acids secreted by SST cells had detrimental effects on sperm storage in the female reproductive tract.Lipid peroxidation produces toxic biological substances that may cause irreversible damage to resident spermatozoa,resulting in short-term sperm retention and decreased fertility.Our findings provide new avenues for studying sperm storage and sustaining fertility. | Chaoliang Wen Chunning Mai Bin Wang Junying Li Congjiao Sun Ning Yang | 2020 | Journal of Animal Science and Biotechnology2020，11，3： | 2 |
| 13 | Bias correction of sea surface temperature retrospective forecasts in the South China Sea显示文摘Offline bias correction of numerical marine forecast products is an effective post-processing means to improve forecast accuracy. Two offline bias correction methods for sea surface temperature(SST) forecasts have been developed in this study: a backpropagation neural network(BPNN) algorithm, and a hybrid algorithm of empirical orthogonal function(EOF) analysis and BPNN(named EOF-BPNN). The performances of these two methods are validated using bias correction experiments implemented in the South China Sea(SCS), in which the target dataset is a six-year(2003–2008) daily mean time series of SST retrospective forecasts for one-day in advance, obtained from a regional ocean forecast and analysis system called the China Ocean Reanalysis(CORA),and the reference time series is the gridded satellite-based SST. The bias-correction results show that the two methods have similar good skills;however, the EOF-BPNN method is more than five times faster than the BPNN method. Before applying the bias correction, the basin-wide climatological error of the daily mean CORA SST retrospective forecasts in the SCS is up to-3°C;now, it is minimized substantially, falling within the error range(±0.5°C) of the satellite SST data. | Guijun Han Jianfeng Zhou Qi Shao Wei Li Chaoliang Li Xiaobo Wu Lige Cao Haowen Wu Yundong Li Gongfu Zhou | 2022 | Acta Oceanologica Sinica2022，41，2： | 2 |
| 14 | Study of the synthesis, crystallization, and morphology of poly(ethylene glycol)-poly(ε-caprolactone) diblock eopolymers显示文摘 | He Chaoliang Sun Jingru Deng Chao | 2004 | Biomacro- molecules2004，5，5： | 1 |
| 15 | Imaging Microdomain Ca^2+ in Muscle Cells 显示文摘 | Wang Shiqiang Wei Chaoliang Zhao Guiling | 2004 | Circ Res2004，94，8： | 1 |
| 16 | Prothymosin a promotes cell proliferation in NIH3T3 cells 显示文摘 | WU Chaoliang SHIAU Aili LIN Cheinsheng | 1997 | LifeSci1997，61，21： | 1 |
| 17 | A General Method for the Synthesis of Hybrid Nanostructures Using MoSe_(2) Nanosheet-Assembled Nanospheres as Templates显示文摘The layered transition metal dichalcogenides(TMDs)and transition metal phosphides are low-cost,earth-abundant,and robust electrocatalysts for hydrogen evolution reaction(HER).Integrating them into hybrid nanostructures is potentially promising to further boost the catalytic activity toward HER based on their synergistic effects.Herein,we report a general method for the synthesis of a series of MoSe_(2)-based hybrid nanostructures,including MoSe_(2)-Ni_(2)P,MoSe_(2)-Co_(2)P,MoSe_(2)-Ni,MoSe_(2)-Co,and MoSe_(2)-NiS,by postgrowth of Ni_(2)P,Co_(2)P,Ni,Co,and NiS nanostructures on the presynthesized MoSe_(2) nanosheet-assembled nanospheres,respectively,via a colloidal synthesis method.As a proof-of-concept application,the as-synthesized hybrid nanostructures are used as electrocatalysts for HER,exhibiting high activity and stability in acidic media.Among them,the MoSe_(2)-Co_(2)P composite shows the highest HER activity with an overpotential of 167 mV at 10 mA cm^(-2). | Shikui Han Kai Zhou Yifu Yu Chaoliang Tan Junze Chen Ying Huang Qinglang Ma Ye Chen Hongfei Cheng Weijia Zhou Hua Zhang | 2019 | Research2019，，1： | 1 |
| 18 | Hepatitis B virus X protein sensitizes hepatocellular lararcinoma ceils to cytolysis induced byE1 B- deleted adenovirus through the disruption of p53 function显示文摘 | HSIEH J L WU Chaoliang | 2003 | Clin Cancer Res2003，9，1： | 1 |
| 19 | pH and reduction dual responsive polyurethane triblock copolymers for efficient intracellular drug delivery显示文摘 | YU Shuangjiang HE Chaoliang DING Jianxun | 2013 | Soft Matter2013，9，9： | 1 |
| 20 | Recent advances in organic and polymeric carriers for local tumor chemo-immunotherapy显示文摘Combination therapy involves the simultaneous administration of compounds with varying mechanisms of action that can improve the efficacy of antitumor therapy and reduce toxicity.The most widely used combination regimen is chemotherapy combined with focused immunotherapy.This is implemented to induce the apoptosis of tumor cells and can activate immune responses,improving the clearance rate of primary lesions and maintaining the resistance to postoperative tumor recurrence and metastasis.Advances in micro/nanotechnology,nanomedicine and biomaterials have contributed to the development of enhanced local drug co-delivery systems for cancer treatment,improving tumor targeting and ameliorating severe systemic complications.Carrier materials can achieve the local long-term controllable release of multiple drugs,which not only avoids rapid drug diffusion from the pathological site,but can achieve synergistic effects at lower drug concentrations.Polymeric carriers display excellent biocompatibility and biodegradability;especially,some of them also have anti-tumor effects.The aim of this article was to review recent progress in the use of organic and polymeric materials for local tumor chemo-immunotherapy,which can be used as carriers for chemotherapeutic drugs,immune adjuvants and genes,including amphiphilic nanoparticles,nanocapsules,nano-disks,nano-polyplex particles,hydrogels and implantable materials. | BAI YiTing WANG TianRan ZHANG SongLing CHEN XueSi HE ChaoLiang | 2022 | Science China(Technological Sciences)2022，65，5： | 1 |
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