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| 1 | Granulite Genesis and Tectonic Evolution in Tongbai Area:Single Zircon Evaporation Ages and Nd Isotopic Geochemistry显示文摘INTRODUCTIONTongbaiareainCentralChinaisanimportantregionforstudyinggenesisrelationbetweenQinlingorogenicbeltandDabieorogenicb... | Zhang Hongfei Gao Shan Zhang Li Zhong Zengqiu Ling Wenli Wang Linsen Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074 | 1998 | Journal of Earth Science1998，17，3： | 6 |
| 2 | Improved dissolution and oral absorption by co-grinding active drug probucol and ternary stabilizers mixtures with planetary beads-milling method显示文摘The objective of this work is to construct a nanosuspension drug delivery system of probucol,a BCS II drug,in order to improve its dissolution and oral bioavailability.The wet milling procedure using planetary beads-milling equipment was utilized to grind the raw probucol to ultrafine nanoparticle/nanocrystal aqueous suspension that was further solidified by freeze-drying process.Cellulose derivatives of different substitution groups and molecular weights,including HPMC,HPC,and MC,were evaluated as the primary stabilizer of probucol nanosuspension.Ternary stabilizers system composed of a primary stabilizer(cellulose derivative,i.e.HPC),a nonionic surfactant(Pluronic R F68),and an anionic surfactant(SDS)was employed to obtain probucol nanosuspension of finer particle size and enhanced dissolution in aqueous media.The probucol nanosuspension with good physical stability showed no obvious change of particle size even after storing over 7 d at 4°C or 25°C.The solidified probucol nanosuspension with trehalose as the cryoprotectant showed the highest dissolution rate(>60%at 2 h)compared to other cryoprotectant.The in vivo pharmacokinetic evaluation indicated about 15-folds higher AUC value of the probucol nanosuspension compared to that of coarse probucol suspension after oral administration to rats.The probucol nanosuspension prepared by wet-milling and ternary stabilizers system may find wide applications for improving the dissolution and oral absorption of water-insoluble drugs. | Fang Li Linsen Li Shaoning Wang Yan Yang Jia Li Dongchun Liu Sijie Zhang Siling Wang Hui Xu | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，6： | 5 |
| 3 | Engineering optimization approach of nonaqueous electrolyte for sodium ion battery with long cycle life and safety显示文摘Electrolyte design strategies are closely related to the capacities, cycle life and safety of sodium–ion batteries. In this study, we aimed to optimize electrolyte with the focus on engineering aspects. The basic physicochemical properties including ionic conductivity, viscosity,wettability and thermochemical stability of the electrolytes using Na PF6 as the solute and the mixed solvent with different components of EMC,DMC or DEC in PC or EC were systematically measured. Ah pouch cell with NaNi_(1/3)Fe_(1/3)Mn_(1/3)O_(2)/hard carbon electrodes was used to evaluate the performance of the prepared electrolytes. By using the Inductive Coupled Plasma Emission Spectrometer(ICP), X-ray photoelectron spectroscopy(XPS), Thermogravimetric-differential scanning calorimetry(TG-DSC) and Accelerating Rate Calorimeter(ARC), we show that an optimized electrolyte can effectively promote the formation of a protective interfacial layer on two electrodes, which not only retards parasitic reactions between the electrodes and electrolyte but also suppresses dissolution of metal ions from the cathode. With an optimized electrolyte, a NaNi_(1/3)Fe_(1/3)Mn_(1/3)O_(2)/hard carbon cell can attain 56.16% capacity retention under the low temperature of -40℃, and can be able to retain 80%capacity retention after more than 2500 cycles while presenting excellent thermal safety. | Haiying Che Xinrong Yang Yan Yu Chaoliang Pan Hong Wang Yonghong Deng Linsen Li Zi-Feng Ma | 2021 | Green Energy & Environment2021，6，2： | 4 |
| 4 | Chaperone proteins identified from synthetic proteasome inhibitor-induced inclusions in PC12 cells by proteomic analysis显示文摘女伴蛋白质在 Lewy 身体是重要的,但是女伴蛋白质的侧面不完全地被解开。Proteomic 分析被用来为进一步的学习决定蛋白质候选人。这里,从导致代理人的包括识别潜在的女伴蛋白质,我们执行了包括在为 48 h 暴露于 10 M 希腊语的第二十三个字母的 PC12 房间形成了的导致的人工地合成的 proteasome 禁止者(希腊语的第二十三个字母) 的 proteomic 分析。用通过指纹对多重蛋白质数据库寻找了的肽质量的生物化学的分别, 2-D 电气泳动,和鉴定,我们反复从导致希腊语的第二十三个字母的包括识别了八可再现的女伴蛋白质。这些, 58 kDa 葡萄糖调整了蛋白质, 75 kDa 葡萄糖调整了蛋白质,并且钙绑定蛋白质 1 是最新识别了。其它五被报导了是 Lewy 身体的一致部件。这些调查结果建议三潜在的女伴蛋白质可能在 proteasome 抑制下面在 PC12 房间被招募到导致希腊语的第二十三个字母的包括。 | Xing'an Li Yingjiu Zhang Yihong Hu Ming Chang Tao Liu Danping Wang Yu Zhang Lei Zhang Linsen Hu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，5： | 4 |
| 5 | The Inhibition Effect of Tert-Butyl Alcohol on the TiO_2 Nano Assays Photoelectrocatalytic Degradation of Different Organics and Its Mechanism显示文摘The inhibition effect of tert-butyl alcohol(TBA), identified as the·OH radical inhibitor, on the TiO_2 nano assays(TNA) photoelectrocatalytic oxidation of different organics such as glucose and phthalate was reported. The adsorption performance of these organics on the TNA photoelectrode was investigated by using the instantaneous photocurrent value, and the degradation property was examined by using the exhausted reaction. The results showed that glucose exhibited the poor adsorption and easy degradation performance, phthalate showed the strong adsorption and harddegradation, but TBA showed the weak adsorption and was the most difficult to be degraded. The degradation of both glucose and phthalate could be inhibited evidently by TBA. But the effect on glucose was more obvious. The different inhibition effects of TBA on different organics could be attributed to the differences in the adsorption and the degradation property. For instance, phthalate of the strong adsorption property could avoid from the capture of·OH radicals by TBA in TNA photoelectrocatalytic process. | Xuejin Li Jinhua Li Jing Bai Yifan Dong Linsen Li Baoxue Zhou | 2016 | Nano-Micro Letters2016，8，3： | 4 |
| 6 | Pb Isotope Mapping in the Tongbai-Dabie Orogenic Belt, Central China显示文摘摘要:在华中的 Tongbai-Dabie orogenic 带是在 Yangtze 和诺思中国 cratons 之间的 collisional 带的部分。它代表之一最广泛超离频压力(UHP ) 并且高压(HP ) 在世界上的变形岩石。在这个区域印射的 Pb 同位素是一个重要方法抑制外壳的结构和构造进化并且在垂直的构造的栈以内识别构造边界。把 Dabie 的作文基于 Pb 同位素建筑群( DBC ), Tongbai 建筑群( TBC ), UHP 和 HP 变形岩石和联系 foliated 花岗石,从北方 Huaiyang ( NHY )的更低的变形岩石在 Tongbai-Dabie orogenic 的构造的带,和白垩纪花岗石系上带子,我们决定了 Tongbai-Dabie orogenic 带的 Pb 同位素 geochemical 地图。Pb 同位素作文在每地质的身体或 lithotectonic 单位以内是类似的 Pb 同位素地图表演,而是不同 lithotectonic 单位的 Pb 同位素作文在 Tongbai-Dabie orogenic 带显示出系统的变化。NHY 构造的带在 Pb 同位素作文与 Tongbai-Dabie UHP-HP 变形的带强烈形成对照。沿着 Xiaotian-Mozitan 的线指责,这被建议, Tongbai-Dabie UHP 和 HP 的北方限制变形岩石,代表一条重要构造边界。在 Tongbai-Dabie HP-UHP 变形的带以内,到 Xiaotian-Mozitan 差错的南方,以在不同主要 lithotectonic 单位之中的不同 lithotectonic 单位和空间关系的 Pb 同位素作文的垂直变化被抑制了。 | ZHANG Li ZHONG Zengqiu WANG Linsen Zhang Benren | 2008 | Acta Geologica Sinica(English Edition)2008，82，1： | 3 |
| 7 | Geochemical Characteristics of Pb Isotope of High-Pressure Metamorphic Rocks and Foliated Granites from HP Unit of Tongbai-Dabie Orogenic Belt显示文摘Whole-rock Pb isotopic compositions of the high-pressure (HP) metamorphic rocks, consisting of two-mica albite gneisses and eclogites, and foliated granites from the HP metamorphic unit of the Tongbai-Dabie orogenic belt are firstly reported in this paper. The results show that the HP metamorphic rocks in different parts of this orogenic belt have similar Pb isotopic compositions. The two- mica albite gneisses have 206 Pb/ 204 Pb=17.657-18.168, 207 Pb/ 204 Pb=15.318-15.573, 208 Pb/ 204 Pb=38.315-38.990, and the eclogites have 206 Pb/ 204 Pb=17.599-18.310, 207 Pb/ 204 Pb=15.465- 15.615 , 208 Pb/ 204 Pb=37.968-39.143. The HP metamorphic rocks are characterized by upper crustal Pb isotopic composition. Although the Pb isotopic composition of the HP metamorphic rocks partly overlaps that of the ultrahigh-pressure (UHP) metamorphic rocks, as a whole, the former is higher than the latter. The high radiogenic Pb isotopic composition for the HP metamorphic rocks confirms that the subducted Yangtze continental crust in the Tongbai-Dabie orogenic belt has the chemical structure of increasing radiogenic Pb isotopic composition from lower crust to upper crust. The foliated granites, intruded in the HP metamorphic rocks post the HP/UHP metamorphism, have 206 Pb/ 204 Pb=17.128-17.434, 207 Pb/ 204 Pb=15.313-15.422 and 208 Pb/ 204 Pb=37.631-38.122, which are obviously different from the Pb isotopic compositions of the HP metamorphic rocks but similar to those of the UHP metamorphic rocks and the foliated garnet-bearing granites in the UHP unit. This shows that the foliated granites from the HP and UHP units have common magma source. Combined with the foliated granites having the geochemical characteristics of A-type granites, it is suggested that the magma for the foliated granites in the UHP and HP unit would be derived from the partial melting of the retrometamorphosed UHP metamorphic rocks exhumed into middle to lower crust, and partial magmas were intruded into the HP unit. | Zhang Li Zhang Hongfei Zhong Zengqiu Zhang Benren Wang Linsen Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074 | 2003 | Journal of China University of Geosciences2003，14，4： | 3 |
| 8 | Lipids and membrane-associated proteins in autophagy显示文摘Autophagy is essential for the maintenance of cellular homeostasis and its dysfunction has been linked to various diseases.Autophagy is a membrane driven process and tightly regulated by membrane-associated proteins.Here,we summarized membrane lipid composition,and membrane-associated proteins relevant to autophagy from a spatiotemporal perspective.In particular,we focused on three important membrane remodeling processes in autophagy,lipid transfer for phagophore elongation,membrane scission for phago-phore closure,and autophagosome-lysosome membrane fusion.We discussed the significance of the discoveries in this field and possible avenues to follow for future studies.Finally,we summarized the membrane-associated biochemical techniques and assays used to study membrane properties,with a discussion of their applications in autophagy. | Linsen Li Mindan Tong Yuhui Fu Fang Chen Shen Zhang Hanmo Chen Xi Ma Defa Li Xiaoxia Liu Qing Zhong | 2021 | Protein & Cell2021，12，7： | 3 |
| 9 | The onset of deep recycling of supracrustal materials at the Paleo-Mesoarchean boundary显示文摘The recycling of supracrustal materials, and in particular hydrated rocks, has a profound impact on mantle composition and thus on the formation of continental crust, because water modifies the physical properties of lithological systems and the mechanisms of partial melting and fractional fractionation. On the modern Earth, plate tectonics offers an efficient mechanism for mass transport from the Earth’s surface to its interior, but how far this mechanism dates back in the Earth’s history is still uncertain. Here, we use zircon oxygen(O) isotopes to track recycling of supracrustal materials into the magma sources of early Archean igneous suites from the Kaapvaal Craton, southern Africa. The mean δ^(18)O values of zircon from TTG(tonalite–trondhjemite–granodiorite) rocks abruptly increase at the Paleo-Mesoarchean boundary(ca.3230 million years ago;Ma), from mantle zircon values of 5‰–6‰ to approaching 7.1‰, and this increase occurs in ≤3230 Ma rocks with elevated Dy/Yb ratios. The^(18)O enrichment is a unique signature of low-temperature water–rock interaction on the Earth’s surface. Because the later phase was emplaced into the same crustal level as the older one and TTG magmas would derive from melting processes in the garnet stability field(>40 km depth), we suggest that this evident shift in TTG zircon O isotopic compositions records the onset of recycling of the mafic oceanic crust that underwent seawater hydrothermal alteration at low temperature. The onset of the enhanced recycling of supracrustal materials may also have developed elsewhere in other Archean cratons and reflects a significant change in the tectonic realm during craton formation and stabilization, which may be important processes for the operation of plate tectonics on early Earth. | Xiaolei Wang Ming Tang Jeff Moyen Di Wang Alfred Kröner Chris Hawkesworth Xiaoping Xia Hangqiang Xie Carl Anhaeusser Axel Hofmann Junyong Li Linsen Li | 2022 | National Science Review2022，9，3： | 3 |
| 10 | Scalable synthesis of Na_(3)V_(2)(PO_(4))_(3)/C with high safety and ultrahigh-rate performance for sodium-ion batteries显示文摘NASICON-type Na_(3)V_(2)(PO_(4))_(3) is a promising electrode material for developing advanced sodium-ion batteries.Preparing Na_(3)V_(2)(PO_(4))_(3) with good performance by a cost-effective and large-scale method is significant for industrial applications.In this work,a porous Na_(3)V_(2)(PO_(4))_(3)/C cathode material with excellent electrochemical performance is successfully prepared by an agar-gel combined with freeze-drying method.The Na_(3)V_(2)(PO_(4))_(3)/C cathode displayed specific capacities of 113.4 mAh·g^(-1),107.0 mAh·g^(-1) and 87.1 mAh·g^(-1) at 0.1 C,1 C and 10 C,respectively.For the first time,the 500-mAh soft-packed symmetrical sodium-ion batteries based on Na_(3)V_(2)(PO_(4))_(3)/C electrodes are successfully fabricated.The 500-mAh symmetrical batteries exhibit outstanding low temperature performance with a capacity retention of 83%at 0℃ owing to the rapid sodium ion migration ability and structural stability of Na_(3)V_(2)(PO_(4))_(3)/C.Moreover,the thermal runaway features are revealed by accelerating rate calorimetry(ARC)test for the first time.Thermal stability and safety of the symmetrical batteries are demonstrated to be better than lithium-ion batteries and some reported sodium-ion batteries.Our work makes it clear that the soft-packed symmetrical sodium ion batteries based on Na_(3)V_(2)(PO_(4))_(3)/C have a prospect of practical application in high safety requirement fields. | Guijia Cui Hong Wang Fengping Yu Haiying Che Xiaozhen Liao Linsen Li Weimin Yang Zifeng Ma | 2022 | Chinese Journal of Chemical Engineering2022，35，6： | 2 |
| 11 | Design,Modeling and Experimentation of a Biomimetic Wall-climbing Robot for Multiple Surfaces显示文摘Wall-climbing robots can work on steep terrain and obtain environment information in three dimensions for human in real time,which can improve operation efficiency.However,traditional single-mode robots cannot ensure the stable attachment on complex wall surfaces.Inspired by the structure characteristics of flies and clingfishes,three bionic structures including the flexible spine wheel,the adhesive material and the adsorption system are proposed.Aiming at task requirements on multiple walls and based on the above three bionic structures,a wall-climbing robot with the composed mode of“grabbing+adhesion+adsorption”is presented v/a the law of mechanism configuration synthesis.Using static analysis,the safe attachment conditions for the robot on smooth and rough walls are that the adsorption force is 30 N or more.Based on Newton's Euler and Lagrange formulas,the dynamic equations of the robot on vertical walls are established to deduce that the maximum theoretical torque of the driving motor is 1.43 N·m at a uniform speed.Finally,the prototype of the wall-climbing robot is manufactured and tested on the vertical lime wall,coarse sandpaper wall and acrylic ceiling wall.Meanwhile,experiment results imply that the average maximum moving speed and the corresponding load are 7.19 cm·s-1 and 0.8 kg on the vertical lime wall,7.78 cm·s-1 and 0.6 kg on the coarse sandpaper wall,and 5.93 cm·s-1 and 0.2 kg on the acrylic ceiling wall respectively.These findings could provide practical reference for the robot’s application on walls. | Jinfu Liu Linsen Xu Jiajun Xu Tao Li Shouqi Chen Hong Xu Gaoxin Cheng Marco Ceccarelli | 2020 | Journal of Bionic Engineering2020，17，3： | 2 |
| 12 | Mathematical Model and Geometrical Model of Double Pitch ZN-type Worm Gear Set Based on Generation Mechanism显示文摘The current researches on the tooth surface mathematical equations and the theory of gearing mainly pay attention to the ordinary type worm gear set(e.g., ZN, ZA, or ZK). The research of forming mechanism and three-dimensional modeling method for the double pitch worm gear set is not enough. So there are some difficulties in mathematical model deducing and geometry modeling of double pitch ZN-type worm gear set based on generation mechanism. In order to establish the mathematical model and the precise geometric model of double pitch ZN-type worm gear set, the structural characteristics and generation mechanism of the double pitch ZN-type worm gear set are investigated. Mathematical model of the ZN-type worm gear set is derived based on its generation mechanism and the theory of gearing. According to the mathematical model of the worm gear set which has been developed, a geometry modeling method of the double pitch ZN-type worm and worm gear is presented. Furthermore, a geometrical precision calculate method is proposed to evaluate the geometrical quality of the double pitch worm gear set. As a result, the maximum error is less than 6′10–4 mm in magnitude, thus the model of the double pitch ZN-type worm gear set is available to meet the requirements of finite element analysis and engineering application. The derived mathematical model and the proposed geometrical modeling method are helpful to guiding the design, manufacture and contact analysis of the worm gear set. | SHU Linsen CAO Huajun LI Xianchong ZHANG Chenglong LI Yuxia | 2015 | Chinese Journal of Mechanical Engineering2015，28，3： | 2 |
| 13 | A general and simple method for evaluating the electrical transport performance of graphene by the van der Pauw–Hall measurement显示文摘Expected for many promising applications in the field of electronics and optoelectronics, a reliable method for the characterization of graphene electrical transport properties is desired to predict its device performance or provide feedback for its synthesis.However, the commonly used methods of extracting carrier mobility from graphene field effect transistor or Hall-bar is time consuming, expensive, and significantly affected by the device fabrication process other than graphene itself.Here we reported a general and simple method to evaluate the electrical transport performance of graphene by the van der Pauw–Hall measurement.By annealing graphene in vacuum to remove the adsorbed dopants and then exposing it in ambient surroundings, carrier mobility as a function of density can be measured with the increase of carrier density due to the dopant re-adsorption from the surroundings.Further, the relationship between the carrier mobility and density can be simply fitted with a power equation to the first level approximation, with which any pair of measured carrier mobility and density can be normalized to an arbitrary carrier density for comparison.We experimentally demonstrated the reliability of the method, which is much simpler than making devices and may promote the standard making for graphene characterization. | Fangzhu Qing Yang Shu Linsen Qing Yuting Niu He Guo Shuyi Zhang Chunlin Liu Changqing Shen Wanli Zhang Samuel S.Mao Wenjuan Zhu Xuesong Li | 2018 | Science Bulletin2018，63，22： | 2 |
| 14 | Prognostic Role and Potential Mechanisms of N6-methyladenosine-related Long Noncoding RNAs in Hepatocellular Carcinoma显示文摘Background and Aims:Numerous studies have explored the important role of N6-methyladenosine(m^(6)A)in cancer.Nonetheless,the interaction between m^(6)A and long noncoding RNAs(lncRNAs)is poorly investigated.Herein,we systematically analyzed the role and prognostic value of m^(6)A-related lncRNAs in hepatocellular carcinoma(HCC).Methods:The m^(6)A-related lncRNAs were identified based on the correlation coefficients with m^(6)A-related genes in HCC from The Cancer Genome Atlas.Subsequently,a novel risk score model was determined using the least absolute shrinkage and selection operator Cox regression analyses.Univariate and multivariate Cox analyses were used to identify independent prog-nostic factors for overall survival(OS)of HCC;thereafter,a prognostic nomogram was constructed.Results:A total of 259 lncRNAs showed significant correlations with m^(6)A in HCC,while 29 lncRNAs had prognostic significance.Further,six critical m^(6)A-related lncRNAs(NRAV,SNHG3,KDM4A-AS1,AC074117.1,AC025176.1,and AL031985.3)were screened out to construct a novel risk score model which classified HCC patients into high-and low-risk groups.Survival analy-ses revealed that patients in the high-risk group exhibited worse OS,both in the training and validation groups.The risk score was also identified as an independent prognostic factor of OS,and a nomogram was established and verified with superior prediction capacity.Besides,the risk score signifi-cantly correlated with the expression of immune checkpoint genes and immune subtypes.Conclusions:These findings indicated the significant role of m^(6)A-related lncRNAs in HCC and the potential application of the novel risk score model for prognostic prediction. | Tianxing Dai Jing Li Linsen Ye Haoyuan Yu Mingbin Deng Wei Liu Hua Li Yang Yang Guoying Wang | 2022 | Journal of Clinical and Translational Hepatology2022，10，2： | 1 |
| 15 | EQUIVALENT THEOREMS ON SIMULTANEOUS APPROXIMATION BY COMBINATIONS OF BERNSTEIN OPERATORES显示文摘在这篇论文,我们由光滑ω _ 的 r-th Ditzian-Totik 模量为伯恩斯坦操作员的联合在同时的近似上给相等的定理(φ ~ λ)~ r (f, t )(0 ≤λ≤ 1 ) 。我们也调查在联合 ofBernstein 操作符的衍生物和函数的衍生物的光滑之间的关系。 | Li Cheng Linsen Xie | 2006 | Analysis in Theory and Applications2006，22，3： | 1 |
| 16 | Progress of electrochemical capacitor electrode materials: A review显示文摘 | Yong Zhang Hui Feng Xingbing Wu Lizhen Wang Aiqin Zhang Tongchi Xia Huichao Dong Xiaofeng Li Linsen Zhang | 2009 | International Journal of Hydrogen Energy2009，，11： | 1 |
| 17 | Optimizationsynthesis on water running mechanism of biped robot 显示文摘 | XU Linsen LI Bing XU Feng | 2011 | Advanced Materials Research2011，，： | 1 |
| 18 | A method for judging decay or growth of the magnetic field of pulsar 显示文摘 | Li Linsen | 2009 | Journal of Astrophysics & Astronomy2009，30，3： | 1 |
| 19 | Organic light-emitting diodes with integrated inorganic photo detector for near-infrared optical up-conversion显示文摘 | Min Guan LinSen Li GuoHua Cao Yang Zhang BaoQiang Wang XinBo Chu ZhanPing Zhu YiPing Zeng | 2011 | Organic Electronics2011，，12： | 1 |
| 20 | Bta-miR-34b controls milk fat biosynthesis via the Akt/mTOR signaling pathway by targeting RAI14 in bovine mammary epithelial cells显示文摘Background:The biosynthesis of milk fat affects both the technological properties and organoleptic quality of milk and dairy products.MicroRNAs(miRNAs)are endogenous small non-coding RNAs that inhibit the expression of their mRNA targets and are involved in downstream signaling pathways that control several biological processes,including milk fat synthesis.miR-34b is a member of the miR-34 miRNA cluster,which is differentially expressed in the mammary gland tissue of dairy cows during lactation and dry periods.Previous studies have indicated miR-34b is a potential candidate gene that plays a decisive role in regulating milk fat synthesis;therefore,it is important to focus on miR-34b and investigate its regulatory effect on the biosynthesis of milk fat in bovine mammary epithelial cells(BMECs).Results:In this study,elevated miR-34b levels reduced milk fat synthesis,upregulated 1,999 genes,and downregulated 2,009 genes in BMECs.Moreover,Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis of differentially expressed genes suggested that miR-34b may play an inhibitory role in milk fat synthesis via the protein kinase B(Akt)/mammalian target of rapamycin(mTOR)signaling pathway by reducing phosphorylation levels.Notably,the mTOR activator MHY1485 rescued the inhibitory effect of miR-34b.Furthermore,we demonstrated that retinoic acid-induced protein 14(RAI14)is a target of miR-34b via TargetScan and immunofluorescence assays.RAI14 mRNA and protein levels were significantly decreased by the miR-34b mimic and increased by the miR-34b inhibitor.Moreover,the reduction in RAI14 levels led to the inhibition of the Akt/mTOR signaling pathway.Conclusions:Overall,our results identified a miR-34b-RAI14-Akt/mTOR regulatory network,while also providing a theoretical basis for the molecular breeding of dairy cows. | Yujuan Wang Xiaoyu Wang Meng Wang Li Zhang Linsen Zan Wucai Yang | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 1 |
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