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| 1 | Soliton bursts and deterministic dissipative Kerr soliton generation in auxiliary-assisted microcavities显示文摘Dissipative Kerr solitons in resonant frequency combs offer a promising route for ultrafast mode-locking,precision spectroscopy and time-frequency standards.The dynamics for the dissipative soliton generation,however,are intrinsically intertwined with thermal nonlinearities,limiting the soliton generation parameter map and statistical success probabilities of the solitary state.Here,via use of an auxiliary laser heating approach to suppress thermal dragging dynamics in dissipative soliton comb formation,we demonstrate stable Kerr soliton singlet formation and soliton bursts.First,we access a new soliton existence range with an inverse-sloped Kerr soliton evolution—diminishing soliton energy with increasing pump detuning.Second,we achieve deterministic transitions from Turinglike comb patterns directly into the dissipative Kerr soliton singlet pulse bypassing the chaotic states.This is achieved by avoiding subcomb overlaps at lower pump power,with near-identical singlet soliton comb generation over twenty instances.Third,with the red-detuned pump entrance route enabled,we uncover unique spontaneous soliton bursts in the direct formation of low-noise optical frequency combs from continuum background noise.The burst dynamics are due to the rapid entry and mutual attraction of the pump laser into the cavity mode,aided by the auxiliary laser and matching well with our numerical simulations.Enabled by the auxiliary-assisted frequency comb dynamics,we demonstrate an application of automatic soliton comb recovery and long-term stabilization against strong external perturbations.Our findings hold potential to expand the parameter space for ultrafast nonlinear dynamics and precision optical frequency comb stabilization. | Heng Zhou Yong Geng Wenwen Cui Shu-Wei Huang Qiang Zhou Kun Qiu Chee Wei Wong | 2019 | Light(Science & Applications)2019，8，1： | 16 |
| 2 | Biochemical sensing in graphene-enhanced microfiber resonators with individual molecule sensitivity and selectivity显示文摘Photonic sensors that are able to detect and track biochemical molecules offer powerful tools for information acquisition in applications ranging from environmental analysis to medical diagnosis.The ultimate aim of biochemical sensing is to achieve both quantitative sensitivity and selectivity.As atomically thick films with remarkable optoelectronic tunability,graphene and its derived materials have shown unique potential as a chemically tunable platform for sensing,thus enabling significant performance enhancement,versatile functionalization and flexible device integration.Here,we demonstrate a partially reduced graphene oxide(prGO)inner-coated and fiber-calibrated Fabry-Perot dye resonator for biochemical detection.Versatile functionalization in the prGO film enables the intracavity fluorescent resonance energy transfer(FRET)to be chemically selective in the visible band.Moreover,by measuring the intermode interference via noise canceled beat notes and locked-in heterodyne detection with Hz-level precision,we achieved individual molecule sensitivity for dopamine,nicotine and single-strand DNA detection.This work combines atomic-layer nanoscience and high-resolution optoelectronics,providing a way toward high-performance biochemical sensors and systems. | Zhongxu Cao Baicheng Yao Chenye Qin Run Yang Yanhong Guo Yufeng Zhang Yu Wu Lei Bi Yuanfu Chen Zhenda Xie Gangding Peng Shu-Wei Huang Chee Wei Wong Yunjiang Rao | 2019 | Light(Science & Applications)2019，8，1： | 8 |
| 3 | Optomechanically-induced-transparency cooling of massive mechanical resonators to the quantum ground state显示文摘Ground state cooling of massive mechanical objects remains a difficult task restricted by the unresolved mechanical sidebands. We propose an optomechanically-induced-transparency cooling scheme to achieve ground state cooling of mechanical motion without the resolved sideband condition in a pure optomechanical system with two mechanical modes coupled to the same optical cavity mode. We show that ground state cooling is achievable for sideband resolution ωm/κ as low as~0.003. This provides a new route for quantum manipulation of massive macroscopic devices and high-precision measurements. | LIU Yong-Chun XIAO Yun-Feng LUAN Xing-Sheng WONG Chee Wei | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，5： | 3 |
| 4 | Lower circulating irisin is associated with type 2 diabetes mellitus显示文摘 | Jian-Jun Liu Melvin D.S. Wong Wan Ching Toy Clara S.H. Tan Sylvia Liu Xiao Wei Ng Subramaniam Tavintharan Chee Fang Sum Su Chi Lim | 2013 | Journal of Diabetes and Its Complications2013，，4： | 1 |
| 5 | Real-time dynamics and cross-correlation gating spectroscopy of free-carrier Drude slow-light solitons显示文摘Optical solitons—stable waves balancing delicately between nonlinearities and dispersive effects—have advanced the field of ultrafast optics and dynamics,with contributions spanning from supercontinuum generation to soliton fission,optical event horizons,Hawking radiation and optical rogue waves,among others.Here,we investigate picojoule soliton dynamics in silicon slow-light,photonic-bandgap waveguides under the influence of Drude-modeled,free-carrier-induced nonlinear effects.Using real-time and single-shot amplified dispersive Fourier transform spectroscopy simultaneously with high-fidelity cross-correlation frequency resolved optical gating at femtojoule sensitivity and femtosecond resolution,we examine the soliton stability limits,the soliton dynamics including free-carrier quartic slow-light scaling and acceleration,and the Drude electron–hole plasma-induced perturbations in the Cherenkov radiation and modulation instability.Our real-time single-shot and time-averaged cross-correlation measurements are matched with our detailed theoretical modeling,examining the reduced group velocity free-carrier kinetics on solitons at the picojoule scale. | Heng Zhou Shu-Wei Huang Xiujian Li James F McMillan Chi Zhang Kenneth Kin-Yip Wong Mingbin Yu Guo-Qiang Lo Dim-Lee Kwong Kun Qiu Chee Wei Wong | 2017 | Light(Science & Applications)2017，6，1： | 1 |
| 6 | Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, Predict Survival and Respond Differently to Chemotherapy显示文摘 | Iain Beehuat Tan Tatiana Ivanova Kiat Hon Lim Chee Wee Ong Niantao Deng Julian Lee Sze Huey Tan Jeanie Wu Ming Hui Lee Chia Huey Ooi Sun Young Rha Wai Keong Wong Alex Boussioutas Khay Guan Yeoh Jimmy So Wei Peng Yong Akira Tsuburaya Heike Grabsch Han Chon | 2011 | Gastroenterology2011，，2： | 1 |
| 7 | Lower circulating irisin is associated with type 2 diabetes mellitus显示文摘 | Jian-Jun Liu Melvin D.S. Wong Wan Ching Toy Clara S.H. Tan Sylvia Liu Xiao Wei Ng Subramaniam Tavintharan Chee Fang Sum Su Chi Lim | 2013 | Journal of Diabetes and Its Complications2013，，4： | 1 |
| 8 | Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, Predict Survival and Respond Differently to Chemotherapy显示文摘 | Iain Beehuat Tan Tatiana Ivanova Kiat Hon Lim Chee Wee Ong Niantao Deng Julian Lee Sze Huey Tan Jeanie Wu Ming Hui Lee Chia Huey Ooi Sun Young Rha Wai Keong Wong Alex Boussioutas Khay Guan Yeoh Jimmy So Wei Peng Yong Akira Tsuburaya Heike Grabsch Han Chon | 2011 | Gastroenterology2011，，2： | 1 |
| 9 | A self- acting gas thrust bearing for high-speed microrotors 显示文摘 | Wong Chee Wei Zhang Xin Jacobson Stuart A | 2004 | Journal of Microelectromechanical Systems2004，13，2： | 1 |
| 10 | Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, Predict Survival and Respond Differently to Chemotherapy显示文摘 | Iain Beehuat Tan Tatiana Ivanova Kiat Hon Lim Chee Wee Ong Niantao Deng Julian Lee Sze Huey Tan Jeanie Wu Ming Hui Lee Chia Huey Ooi Sun Young Rha Wai Keong Wong Alex Boussioutas Khay Guan Yeoh Jimmy So Wei Peng Yong Akira Tsuburaya Heike Grabsch Han Chon | 2011 | Gastroenterology2011，，2： | 1 |
| 11 | Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, Predict Survival and Respond Differently to Chemotherapy显示文摘 | Iain Beehuat Tan Tatiana Ivanova Kiat Hon Lim Chee Wee Ong Niantao Deng Julian Lee Sze Huey Tan Jeanie Wu Ming Hui Lee Chia Huey Ooi Sun Young Rha Wai Keong Wong Alex Boussioutas Khay Guan Yeoh Jimmy So Wei Peng Yong Akira Tsuburaya Heike Grabsch Han Chon | 2011 | Gastroenterology2011，，2： | 1 |
| 12 | Real-time transition dynamics and stability of chipscale dispersion-managed frequency microcombs显示文摘Femtosecond mode-locked laser frequency combs have served as the cornerstone in precision spectroscopy,alloptical atomic clocks,and measurements of ultrafast dynamics.Recently frequency microcombs based on nonlinear microresonators have been examined,exhibiting remarkable precision approaching that of laser frequency combs,on a solid-state chip-scale platform and from a fundamentally different physical origin.Despite recent successes,to date,the real-time dynamical origins and high-power stabilities of such frequency microcombs have not been fully addressed.Here,we unravel the transitional dynamics of frequency microcombs from chaotic background routes to femtosecond mode-locking in real time,enabled by our ultrafast temporal magnifier metrology and improved stability of dispersion-managed dissipative solitons.Through our dispersion-managed oscillator,we further report a stability zone that is more than an order-of-magnitude larger than its prior static homogeneous counterparts,providing a novel platform for understanding ultrafast dissipative dynamics and offering a new path towards high-power frequency microcombs. | Yongnan Li Shu-Wei Huang Bowen Li Hao Liu Jinghui Yang Abhinav Kumar Vinod Ke Wang Mingbin Yu Dim-Lee Kwong Hui-Tian Wang Kenneth Kin-Yip Wong Chee Wei Wong | 2020 | Light(Science & Applications)2020，9，1： | 1 |
| 13 | Towards optimum Franson interference recurrence in mode-locked singly-filtered biphoton frequency combs显示文摘Mode-locked biphoton frequency combs exhibit multiple discrete comblike temporal correlations from the Fourier transform of its phase-coherent frequency spectrum.Both temporal correlation and Franson interferometry are valuable tools for analyzing the joint properties of biphoton frequency combs,and the latter has proven to be essential for testing the fundamental quantum nature,the time-energy entanglement distribution,and the large-alphabet quantum key distributions.However,the Franson recurrence interference visibility in biphoton frequency combs unavoidably experiences a falloff that deteriorates the quality of time-energy entanglement and channel capacity for longer cavity round trips.In this paper,we provide a new method to address this problem towards optimum Franson interference recurrence.We first observe mode-locked temporal oscillations in a5.03 GHz free-spectral range singly filtered biphoton frequency comb using only commercial detectors.Then,we observe similar falloff trend of time-energy entanglement in 15.15 GHz and 5.03 GHz free-spectral range singly filtered biphoton frequency combs,whereas,the optimum central time-bin accidental-subtracted visibility over 97%for both cavities.Here,we find that by increasing the cavity finesse F,we can enhance the detection probability in temporal correlations and towards optimum Franson interference recurrence in our singly filtered biphoton frequency combs.For the first time,via a higher cavity finesse F of 45.92 with a 15.11 GHz free-spectral range singly filtered biphoton frequency comb,we present an experimental≈3.13-fold improvement of the Franson visibility compared to the Franson visibility with a cavity finesse F of 11.14 at the sixth time bin.Near optimum Franson interference recurrence and a time-bin Schmidt number near 16 effective modes in similar free-spectral range cavity are predicted with a finesse F of 200.Our configuration is versatile and robust against changes in cavity parameters that can be designed for various quantum applications,such as high-dimensional time-energy entanglement distributions,high-dimensional quantum key distributions,and wavelength-multiplexed quantum networks. | KAI-CHI CHANG XIANG CHENG MURAT CAN SARIHAN CHEE WEI WONG | 2023 | Photonics Research2023，11，7： | 0 |
| 14 | Stimulated generation of deterministic platicon frequency microcombs显示文摘Dissipative Kerr soliton generation in chip-scale nonlinear resonators has recently observed remarkable advances,spanning from massively parallel communications, to self-referenced oscillators, and to dual-comb spectroscopy.Often working in the anomalous dispersion regime, unique driving protocols and dispersion in these nonlinear resonators have been examined to achieve the soliton and soliton-like temporal pulse shapes and coherent frequency comb generation. The normal dispersion regime provides a complementary approach to bridge the nonlinear dynamical studies, including the possibility of square pulse formation with flattop plateaus, or platicons.Here we report observations of square pulse formation in chip-scale frequency combs through stimulated pumping at one free spectral range and in silicon nitride rings with +55 fs~2∕mm normal group velocity dispersion.Tuning of the platicon frequency comb via a varied sideband modulation frequency is examined in both spectral and temporal measurements. Determined by second-harmonic autocorrelation and cross correlation, we observe bright square platicon pulse of 17 ps pulse width on a 19 GHz flat frequency comb. With auxiliary-laser-assisted thermal stabilization, we surpass the thermal bistable dragging and extend the mode-locking access to narrower 2 ps platicon pulse states, supported by nonlinear dynamical modeling and boundary limit discussions. | HAO LIU SHU-WEI HUANG WENTING WANG JINGHUI YANG MINGBIN YU DIM-LEE KWONG PIERRE COLMAN CHEE WEI WONG | 2022 | Photonics Research2022，10，8： | 0 |
| 15 | Mesenchymal stromal cell-derived small extracellular vesicles modulate macrophage polarization and enhance angio-osteogenesis to promote bone healing显示文摘Mesenchymal stem/stromal cells(MSCs)have demonstrated therapeutic efficacy for bone regeneration in animal and clinical studies.Although MSCs were initially thought to differentiate to various cell types to replace the injured/diseased tissue,it is now accepted that these cells secrete factors to promote tissue repair.1 Among these factors,small extracellular vesicles(sEVs)of size 50–200 nm,which include the exosomes,have been identified as the principal agent mediating the wide-ranging therapeutic efficacy of MSCs.2 Several studies have also reported the therapeutic effects of MSC-sEVs to enhance bone repair in animal models,as recently reviewed.3 However,the cellular processes and mechanisms mediated by MSC-sEVs in bone regeneration remain to be fully elucidated. | Shang Jiunn Chuah Chee Weng Yong Kristeen Ye Wen Teo Jacob Ren Jie Chew Yi Ann Cheow Shipin Zhang Raymond Chung Wen Wong Asher Ah Tong Lim Sai Kiang Lim Wei Seong Toh | 2022 | Genes & Diseases2022，9，4： | 0 |
| 16 | Probing 10μK stability and residual drifts in the cross-polarized dual-mode stabilization of single-crystal ultrahigh-Q optical resonators显示文摘The thermal stability of monolithic optical microresonators is essential for many mesoscopic photonic applications such as ultrastable laser oscillators,photonic microwave clocks,and precision navigation and sensing.Their fundamental performance is largely bounded by thermal instability.Sensitive thermal monitoring can be achieved by utilizing cross-polarized dual-mode beat frequency metrology,determined by the polarization-dependent thermorefractivity of a single-crystal microresonator,wherein the heterodyne radio-frequency beat pins down the optical mode volume temperature for precision stabilization.Here,we investigate the correlation between the dualmode beat frequency and the resonator temperature with time and the associated spectral noise of the dual-mode beat frequency in a single-crystal ultrahigh-Q MgF_(2) resonator to illustrate that dual-mode frequency metrology can potentially be utilized for resonator temperature stabilization reaching the fundamental thermal noise limit in a realistic system.We show a resonator long-term temperature stability of 8.53μK after stabilization and unveil various sources that hinder the stability from reaching sub-μK in the current system,an important step towards compact precision navigation,sensing,and frequency reference architectures. | Jinkang Lim Wei Liang Anatoliy A.Savchenkov Andrey B.Matsko Lute Maleki Chee Wei Wong | 2019 | Light(Science & Applications)2019，8，1： | 0 |
| 17 | Hydrodynamical self-interference of a scattered polariton quanta显示文摘Researchers have observed the free-propagation of a single microcavity polariton directly and its self-interference when scattering upon a defect.These experimental observations of quantum hydrodynamics in the single polariton limit test the wave-particle duality and aid in the development of polariton-based photonic circuits in quantum information processing. | Jiahui Huang Wei Liu Chee Wei Wong | 2020 | Light(Science & Applications)2020，9，1： | 0 |
| 18 | Measurement of sub-fm/Hz^(1/2) displacement spectral densities in ultrahigh-Q single-crystal microcavities with hertz-level lasers显示文摘Tracing a resonance frequency of a high quality factor(Q)optical cavity facilitates subpicometer displacement measurements of the optical cavity via Pound-Drever-Hall(PDH)locking scheme,tightly synchronizing a laser frequency to the optical cavity.Here we present observations of subfemtometer displacements on a ultrahigh-Q single-crystal MgF_(2)whispering-gallery-mode microcavity by frequency synchronization between a 1 Hz cavity-stabilized laser and a resonance of the MgF_(2) cavity using PDH laser-cavity locking.We characterize not only the displacement spectral density of the microcavity with a sensitivity of 1.5×10^(-16) m/Hz^(1/2) over the Fourier offset frequency ranging from 15 mHz to 100 kHz but also a 1.77 nm displacement fluctuation of the microcavity over 4500 s.Such measurement capability not only supports the analysis of integrated thermodynamical and technical cavity noise but allows for minute displacement measurements using laser-cavity locking for ultraprecise positioning,metrology,and sensing. | YOON-SOO JANG JINKANG LIM WENTING WANG SEUNG-WOO KIM ANATOLIY SAVCHENKOV ANDREY BMATSKO CHEE WEI WONG | 2022 | Photonics Research2022，10，5： | 0 |
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