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| 1 | Controlling N-doping type in carbon to boost single-atom site Cu catalyzed transfer hydrogenation of quinoline显示文摘Single-atom site(SA)catalysts on N-doped carbon(CN)materials exhibit prominent performance for their active sites being M-Nx.Due to the commonly random doping behaviors of N species in these CN,it is a tough issue to finely regulate their doping types and clarify their effect on the catalytic property of such catalysts.Herein,we report that the N-doping type in CN can be dominated as pyrrolic-N and pyridinic-N respectively through compounding with different metal oxides.It is found that the proportion of distinct doped N species in CN depends on the acidity and basicity of compounded metal oxide host.Owing to the coordination by pyrrolic-N,the SA Cu catalyst displays an enhanced activity(two-fold)for transfer hydrogenation of quinoline to access the valuable molecule tetrahydroquinoline with a good selectivity(99%)under mild conditions.The higher electron density of SA Cu species induced by the predominate pyrrolic-N coordination benefits the hydrogen transfer process and reduces the energy barrier of the hydrogenation pathway,which accounts for the improved catalytic effeciency. | Jian Zhang Caiyan Zheng Maolin Zhang Yajun Qiu Qi Xu Weng-Chon Cheong Wenxing Chen Lirong Zheng Lin Gu Zhengpeng Hu Dingsheng Wang Yadong Li | 2020 | Nano Research2020，13，11： | 29 |
| 2 | Study on air flow dynamic characteristic of mechanical ventilation of a lung simulator显示文摘As an important life support treatment, mechanical ventilation is usually adopted in clinics. With the development of the res-piratory diagnostic and treatment technologies, air flow dynamics of mechanical ventilation is usually referenced in the evaluation of pulmonary status and assessment of respiratory therapy. In order to improve the ventilation efficiency and provide a reference for pulmonary diagnostics, in this paper, a new mathematical model of mechanical ventilation system was set up. Furthermore, a prototype mechanical ventilation system for an artificial simulating lung was designed and experimentally studied. Lastly, in order to improve the ventilation efficiency and provide a reference for pulmonary diagnostics, the air flow dynamics of the mechanical ventilation system was illustrated through simulation and experimental studies. The study can be helpful to the optimization of the mechanical ventilation system. | NIU JingLong SHI Yan CAO ZhiXin CAI MaoLin CHEN Wei ZHU Jian XU WeiQing | 2017 | Science China(Technological Sciences)2017，60，2： | 8 |
| 3 | LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration显示文摘The adult mammalian heart is thought to be a terminally differentiated organ given the postmitotic nature of cardiomyocytes.Consequently,the potential for cardiac repair through cardiomyocyte proliferation is extremely limited.Low-density lipoprotein receptor-related protein 6(LRP6)is a Wnt co-receptor that is required for embryonic heart development.In this study we investigated the role of LRP6 in heart repair through regulation of cardiomyocyte proliferation.Lrp6 deficiency increased cardiomyocyte cell cycle activity in neonatal,juvenile and adult mice.Cardiomyocyte-specific deletion of Lrp6 in the mouse heart induced a robust regenerative response after myocardial infarction(MI),led to reduced MI area and improvement in left ventricular systolic function.In vivo genetic lineage tracing revealed that the newly formed cardiomyocytes in Lrp6-deficient mouse hearts after MI were mainly derived from resident cardiomyocytes.Furthermore,we found that the pro-proliferative effect of Lrp6 deficiency was mediated by the ING5/P21 signaling pathway.Gene therapy using the adeno-associated virus(AAV)9 miRNAi-Lrp6 construct promoted the repair of heart injury in mice.Lrp6 deficiency also induced the proliferation of human induced pluripotent stem cell-derived cardiomyocytes(iPSC-CMs).Our study identifies LRP6 as a critical regulator of cardiomyocyte proliferation,which may lead to the development of a novel molecular strategy to promote myocardial regeneration and repair. | Yahan Wu Liping Zhou Hongyu Liu Ran Duan Huixing Zhou Fulei Zhang Xiaoyu He Dongbo Lu Ke Xiong Maolin Xiong Jinzhu Zhuang Yi Liu Li Li Dandan Liang Yi-Han Chen | 2021 | Cell Research2021，31，4： | 5 |
| 4 | Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia显示文摘Type 2 diabetes mellitus(T2DM)and Alzheimer's disease(AD)share several common pathophysiological features.Rare variants of triggering receptor expressed on myeloid cells 2(TREM2)increase the risk of developing AD,suggesting the involvement of TREM2 and innate immunity in AD development.It is still unknown whether TREM2 is related to cognitive impairment in T2DM.Here,we investigated the effects of the hippocampal overexpression of TREM2 on cognitive in long-term high-fat diet(HFD)-fed mice.Male C57BL/6J mice were maintained on HFD for 50 weeks.TREM2 was overexpressed in the hippocampus 36 weeks after HFD feeding using adeno-associated virus vector(AAV)-mediated gene delivery.The results showed that the HFD feeding induced rapid and persistent weight gain,glucose intolerance and significant impairments in learning and memory.Compared with AAV-con,AAV-TREM2 significantly ameliorated cognitive impairment without altering body weight and glucose homeostasis in HFD mice.The overexpression of TREM2 upregulated the synaptic proteins spinophilin,PSD95 and synaptophysin,suggesting the improvement in synaptic transmission.Dendritic complexity and spine density in the CA1 region were rescued after TREM2 overexpression.Furthermore,TREM2 markedly increased the number of iba-1/Arg-1-positive microglia in the hippocampus,suppressed neuroinflammation and microglial activation.In sum,hippocampal TREM2 plays an important role in improving HFD-induced cognitive dysfunction and promoting microglial polarization towards the M2 anti-inflammatory phenotype.Our study also suggests that TREM2 might be a novel target for the intervention of obesity/diabetes-associated cognitive decline. | Min Wu Maolin Liao Rongfeng Huang Chunxiu Chen Tian Tian Hongying Wang Jiayu Li Jibin Li Yuxiang Sun Chaodong Wu Qifu Li Xiaoqiu Xiao | 2022 | Genes & Diseases2022，9，2： | 4 |
| 5 | Application of anterior decompression and reconstruction using titanium mesh with locking plates in the management of cervical spondylotic myelopathy显示文摘颈的 spondylotic myelopathy 被认为是在超过 55 的病人的最普通的针的绳索混乱。在手术后的经期,不能令人满意的神经结果经常被归因于疾病过程而非到足够的解压缩的失败,成像研究没被执行为失败决定原因。为这个目的,有 CSM 的 91 个病人临床上被检查,以及 radiologicaly 并且 electrophysiologicaly,并且在牛肉香肠的歌德大学的神经外科的神经外科, Kishinev 的医药大学,摩尔多瓦和部门的部门被操作,德国在从 1984-1996 的间隔期间。性比率是 male:female = 5.9:1。几乎所有病人被 MRI 扫描学习,常规 CT myelography 并且 electrophysiologically (SSEP 和 MEP ) 。SSEP 回答同等地与 CSM, pre- 和针的绳索的功能的手术后的状态在病人反映病理学的严厉。我们使用了操作的 5 种类型:没有熔化的前面的 discectomy 和 interbody 熔化,没有骨头 grafting 的前面的解压缩,利用 corpectomy 和 interbody 熔化的前面的解压缩, decompressive multilevel laminectomy 和部分 vertebrectomy。为在过程的不同类型以后评估外科的结果,我们使用了 Nurick 和 Crandall 规模。在 38 个病人手术后的结果:是 26 (68%)- 改善, 8 (21%)- 未改变,更坏 - 1 (3%) ,并且(8%) 3 死了。结论:1。有在有在 corpectomy 和 interbody 熔化以后的严重 CSM 的病人的好结果的流行。2。前面的 transdiscal 解压缩是在与 CSM 对待病人的选择的操作。 | Maolin He Zengming Xiao Shide Li Qianfen Chen | 2008 | Journal of Nanjing Medical University2008，22，4： | 3 |
| 6 | Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication显示文摘HepatitisBvirus(HBV)infection causes acuteand chronic liver diseases,but is not directly cytopathic.Liver injury results fromrepeated attempts of the cellular immune response system to control the viral infection.Here,we investigate the roles of cellular factors and signaling pathways involved in the regulation of HBV replication to reveal the mechanism underlying HBV infection and pathogenesis.Weshowthat collagen triple helix repeat containing 1(CTHRC1)expression is elevated in HBV-infected patients andin HBV-transfected cells through epigenetic modification and transcriptional regulation.CTHRC1 facilitates HBV replication in cultured cells and BALB/c mice by activating the PKCa/ERK/JNK/c-Jun cascade to repress the IFN/JAK/STAT pathway.HBV-activated CTHRC1 downregulates the activityof typeI interferon(IFN),theproductionof IFN-stimulatedgenes(ISGs),andthephosphorylationofsignal transducerandactivator of transcription 1/2(STAT1/2),whereas it upregulates the phosphorylation and ubiquitination of type I IFN receptors(IFNARa/b).Thus,our results showthat HBV uses a novelmechanismto hijack cellular factors and signal cascades in order to evade host antiviral immunity and maintain persistent infection.We also demonstrate that CTHRC1 has a novel role in viral infection. | Lan Bai Wei Zhang Li Tan Hongchuan Yang Maolin Ge Chengliang Zhu Rui Zhang Yanhua Cao Junbo Chen Zhen Luo Wenzhe Ho Fang Liu Kailang Wu Jianguo Wu | 2015 | Journal of Molecular Cell Biology2015，7，6： | 2 |
| 7 | Particle simulation of grid system for krypton ion thrusters显示文摘The transport processes of plasmas in grid systems of krypton(Kr) ion thrusters at different acceleration voltages were simulated with a 3 D-PIC model, and the result was compared with xenon(Xe) ion thrusters. The variation of the screen grid transparency, the accelerator grid current ratio and the divergence loss were explored. It is found that the screen grid transparency increases with the acceleration voltage and decreases with the beam current, while the accelerator grid current ratio and divergence loss decrease first and then increase with the beam current. This result is the same with Xe ion thrusters. Simulation results also show that Kr ion thrusters have more advantages than Xe ion thrusters, such as higher screen grid transparency, smaller accelerator grid current ratio, larger cut-off current threshold, and better divergence loss characteristic. These advantages mean that Kr ion thrusters have the ability of operating in a wide range of current. Through comprehensive analyses, it can be concluded that using Kr as propellant is very suitable for a multimode ion thruster design. | Maolin CHEN Anbang SUN Chong CHEN Guangqing XIA | 2018 | Chinese Journal of Aeronautics2018，31，4： | 2 |
| 8 | Total concentrations and fractions of Cd, Cr, Pb, Cu, Ni and Zn in sewage sludge from municipal and industrial wastewater treatment plants显示文摘 | WANG Chao HU Xin CHEN Maolin | 2005 | J Hazard Mater2005，119，： | 1 |
| 9 | Epoxy-POSS/silicone rubber nanocomposites with excellent thermal stability and radiation resistance显示文摘Due to the rigid Si-O-Si backbone,silicone rubber(SR)have a widespread application in extreme environment such as high temperature and high-level radiation.However,the radiation stability of SR still does not meet the practical needs in special radiation environments.Herein we prepared epoxy POSS(e POSS)/SR nanocomposites with excellent thermal stability and radiation resistance.As a physical crosslinking point in the SR,addition of small amount of ePOSS not only enhanced the mechanical properties of the matrix,but also improved its thermal stability greatly due to their good compatibility.e POSS/SR had higher radiation stability in air than SR owing to the inhibition of radiation oxidation by ePOSS,and the yield of main gaseous radiolysis products(CH_(4),H_(2),CO and CO_(2))of SR and ePOSS/SR nanocomposites was determined.By analyzing the changes of chemical structure,thermal properties and mechanical properties of the ePOSS/SR nanocomposite,combined with the characteristics of gas products afterγ-irradiation,the radiation induced crosslinking and degradation mechanism of the nanocomposites was proposed comprehensively. | Mengni Shi Yinyong Ao Lei Yu Lang Sheng Shuangxiao Li Jing Peng Hongbing Chen Wei Huang Jiuqiang Li Maolin Zhai | 2022 | Chinese Chemical Letters2022，33，7： | 1 |
| 10 | Total con- centrations and fractions of Cd, Cr, Pb, Cu, Ni and Zn in sewage sludge from municipal and industrial wastewater treatment plants显示文摘 | Wang Chao Hu Xin Chen Maolin | 2005 | Journal of Hazardous Materials2005，119，13： | 1 |
| 11 | Amphoteric ion exchange membrane synthesized by radiation-induced graft copolymerization of styrene and dimethylaminoethyl methacrylate into PVDF film for vanadium redox flow battery applications显示文摘 | Qiu Jingyi Zhang Junzhi Chen Jinhua Peng Jing Xu Ling Zhai Maolin Li Jiuqiang Wei Genshuan | | 0，，： | 1 |
| 12 | Electrochemical investigation on the interaction of benzene sulfonyl 5-fluorouracil derivatives with double-stranded DNA and G-quadruplex DNA显示文摘The interaction of double-stranded(ds) and G-quadruplex(G4) DNA with sulfonyl 5-fluorouracil derivatives(5-fluoro-1-(arylsulfonyl) pyrimidine-2,4(1H,3H)-diones) was investigated in this research,in which Au electrodes modified with ds-DNA or G4-DNAs were used as a working electrode.The investigation showed that the binding affinity with G4-DNA was significantly increased when 5-fluorouracil(5-FU) was modified with arylsulfonyl groups.The presence of strong electron-withdrawing groups on benzene sulfonyl 5-FU greatly enhanced the binding selectivity(k G4-DNA /k ds-DNA).Such results provided new insights into the potential connections between the chemical structure of drug candidates and their anticancer activities. | HU Quan ZHANG KeJun JIN HuiLe CHEN XiAn HU MaoLin WANG Shun | 2012 | Science China Chemistry2012，55，7： | 1 |
| 13 | Photodeformable polymer material:towards light-driven micropump applications显示文摘 | Chen Maolin Xing Xing Liu Zhao | 2010 | Applied Physics A:Materials Science&Processing2010，100，1： | 1 |
| 14 | A mini pig model for visualization of perforator flap by using angiography and MIMICS显示文摘 | Jin Mei ZhiXun Yin Ji Zhang Koonhei W. Lui Siwang Hu Zhou Peng Shixin Chen Maolin Tang | 2010 | Surgical and Radiologic Anatomy2010，，5： | 1 |
| 15 | Decentralized stabilization and output tracking of large-scale uncertain systems 显示文摘 | NI Maolin CHEN Ying | 1996 | Automatica1996，32，7： | 1 |
| 16 | DeceFL:a principled fully decentralized federated learning framework显示文摘Traditional machine learning relies on a centralized data pipeline for model training in various applications;however,data are inherently fragmented.Such a decentralized nature of databases presents the serious challenge for collaboration:sending all decentralized datasets to a central server raises serious privacy concerns.Although there has been a joint effort in tackling such a critical issue by proposing privacy-preserving machine learning frameworks,such as federated learning,most state-of-the-art frameworks are built still in a centralized way,in which a central client is needed for collecting and distributing model information(instead of data itself)from every other client,leading to high communication burden and high vulnerability when there exists a failure at or an attack on the central client.Here we propose a principled decentralized federated learning algorithm(DeceFL),which does not require a central client and relies only on local information transmission between clients and their neighbors,representing a fully decentralized learning framework.It has been further proven that every client reaches the global minimum with zero performance gap and achieves the same convergence rate O(1=T)(where T is the number of iterations in gradient descent)as centralized federated learning when the loss function is smooth and strongly convex.Finally,the proposed algorithm has been applied to a number of applications to illustrate its effectiveness for both convex and nonconvex loss functions,time-invariant and time-varying topologies,as well as IID and Non-IID of datasets,demonstrating its applicability to a wide range of real-world medical and industrial applications. | Ye Yuan Jun Liu Dou Jin Zuogong Yue Tao Yang Ruijuan Chen Maolin Wang Chuan Sun Lei Xu Feng Hua Yuqi Guo Xiuchuan Tang Xin He Xinlei Yi Dong Li Guanghui Wen Wenwu Yu Hai-Tao Zhang Tianyou Chai Shaochun Sui Han Ding | 2023 | National Science Open2023，2，1： | 1 |
| 17 | Asymmetric hydrogenation of aromatic ketones catalyzed by achiral monophosphine TPPTS-stabilized Ru in ionic liquids显示文摘 | Jinbo Wang Jian Feng Ruixiang Qin Haiyan Fu Maolin Yuan Hua Chen Xianjun Li | 2007 | Tetrahedron: Asymmetry2007，，14： | 1 |
| 18 | Double-strand hydrolysis of DNA by a magnesium(II) complex with diethylenetriamine显示文摘 | Pin Yang Rui Ren Maolin Guo Aixin Song Xiangli Meng Caixia Yuan Qinghua Zhou Huili Chen Zhenhai Xiong Xiaoli Gao | 2004 | JBIC Journal of Biological Inorganic Chemistry2004，，4： | 1 |
| 19 | Total concentrations and fractions of Cd, Cr, Pb, Cu, Ni and Zn in sewage sludge from municipal and industrial wastewater treatment plants显示文摘 | Wang Chao Hu Xin Chen Maolin | 2005 | Journal of Hazardous Materials2005，119，13： | 1 |
| 20 | The relationship of microstructure and property on annealing FeSiB alloy 显示文摘 | Chen Guojun Gao Maolin Wu Qiuju | 1992 | Research in Metallic Material1992，18，34： | 1 |
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