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| 1 | Differential hepatic features presenting in Wilson disease-associated cirrhosis and hepatitis B-associated cirrhosis显示文摘BACKGROUND Cirrhosis is a chronic late stage liver disease associated with hepatitis viruses,alcoholism, and metabolic disorders, such as Wilson disease(WD). There are no clear markers or clinical features that define cirrhosis originating from these disparate origins. We hypothesized that cirrhosis is not one disease and cirrhosis of different etiology may have differential clinical hepatic features.AIM To delineate the liver features between WD-associated cirrhosis and hepatitis Bassociated cirrhosis in the Chinese population.METHODS In this observational study, we reviewed the medical data of consecutive inpatients who had WD-associated cirrhosis or hepatitis B-associated cirrhosis from January 2010 to August 2018, and excluded patients who had carcinoma,severe heart or pulmonary diseases, or other liver diseases. According to the etiology of cirrhosis, patients were divided into two groups: WD-associated cirrhosis group(60 patients) and hepatitis B-associated cirrhosis group(56 patients). The liver fibrosis degree, liver function indices, and portal hypertension features of these patients were compared between the two groups.RESULTS No inter-group differences were observed in the diagnostic liver fibrosis markers,however, clinical features clearly defined the origin of cirrhosis. WD-associated cirrhosis patients(16-29 years) had lower levels of alanine transaminase,aspartate transaminase, and bilirubin, lower prothrombin time, lower incidence of hepatic encephalopathy, and lower portal vein diameter(P < 0.05), compared to cirrhosis resulting from hepatitis B in older patients(45-62 years). Importantly,they had decreased risks of progression from Child-Pugh grade A to B(odds ratio = 0.046, 95% confidence interval: 0.006-0.387, P = 0.005) and of ascites(odds ratio = 0.08, 95% confidence interval: 0.01-0.48, P = 0.005). Conversely, WDassociated cirrhosis patients had a higher risk of splenomegaly(odds ratio = 4.15,95% confidence interval: 1.38-12.45, P = 0.011).CONCLUSION WD-associated cirrhosis presents a higher risk of splenomegaly associated with leukopenia and thrombocytopenia, although revealing milder liver dysfunction and portal hypertension symptoms, which recommends WD patients to be monitored for associated complications. | Hao-Jie Zhong Huan-Huan Sun Lan-Feng Xue Eileen M McGowan Yu Chen | 2019 | World Journal of Gastroenterology2019，25，3： | 19 |
| 2 | 儿童NTRK重排间叶源性肿瘤临床病理学观察显示文摘目的:探讨儿童NTRK重排间叶源性肿瘤临床和病理学特征,以提高对该类疾病的认识。方法:收集上海交通大学医学院附属上海儿童医学中心及新加坡KK Women′s and Children′s Hospital从2017年1月至2019年9月5例手术切除标本,采用EnVision法检测免疫组织化学表型,荧光原位杂交(FISH)检测相关基因并对NTRK基因重排进行克隆性分析。结果:该组5例患儿,3例男性,2例女性。年龄从3个月到13岁,部位包括软组织(膝、胸腔、腹壁)和肾,肿瘤大小为4.5~12.5 cm。组织学检查主要呈梭形细胞肿瘤,浸润性生长,可伴有炎性细胞。免疫表型上,肿瘤细胞阳性表达Pan-TRK,分子检测均存在NTRK基因重排,包括DCTN1-NTRK1的发现。除2例目前接受靶向药物治疗,其余均为无疾病进展病例,随访时间9~29个月。结论:NTRK重排间叶源性肿瘤,其肿瘤发生部位广泛,组织学图像多变。免疫组织化学Pan-TRK可以帮助诊断,NTRK基因检测确认其存在重排是诊断的金标准,对不能完整切除或有复发、转移病例建议靶向药物治疗。 | 殷敏智 马靖 何巧 沈萍 陈洁枫 金晓婷 张忠德 Chik Hong Kuick Chen Huiyi Eileen Hui Qi Ng Sze Jet Aw Kenneth Tou En Chang | 2020 | 中华病理学杂志2020，49，7： | 6 |
| 3 | Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis显示文摘 | Kurt Degenhardt Robin Mathew Brian Beaudoin Kevin Bray Diana Anderson Guanghua Chen Chandreyee Mukherjee Yufang Shi Céline Gélinas Yongjun Fan Deirdre A. Nelson Shengkan Jin Eileen White | 2006 | Cancer Cell2006，，1： | 2 |
| 4 | Effects of distribution-based parameter aggregation on a spatially distributed agricultural nonpoint source pollution model显示文摘 | Eileen Chen D.Scott Mackay | 2004 | Journal of Hydrology2004，，1： | 2 |
| 5 | Autophagy Opposes p53-Mediated Tumor Barrier to Facilitate Tumorigenesis in a Model of PALB2-Associated Hereditary Breast Cancer显示文摘 | Yanying Huo Hong Cai Irina Teplova Christian Bowman-Colin Guanghua Chen Sandy Price Nicola Barnard Shridar Ganesan Vassiliki Karantza Eileen White Bing Xia | 2013 | Cancer Discovery2013，，8： | 2 |
| 6 | Durable easy-cleaning and antibacterial cotton fabrics using fluorine-free silane coupling agents and CuO nanoparticles显示文摘Multifunctional fabrics of high durability through a scalable and eco-friendly technique remains a great challenge hindering their commercialization.In this work,we report a facile synthesis technique for the fabrication of superhydrophobic antibacterial fabrics by employing fluorine-free silane coupling agents as cross-linkers for enhanced durability.Three silane cross-linkers,Aminoethylaminopropyltrimethoxysilane(AEAPTMS),Aminopropyltriethoxysilane(APTES),and Methacryloyloxypropyltrimethoxysilane(MPTMS),have been investigated.During the fabrication,a low surface energy polymer,polydimethylsiloxane(PDMS)was first deposited on cotton fabrics.Subsequently,antibacterial copper oxide(CuO)nanoparticles were anchored on the PDMS coated fabrics using the silane cross-linkers.The as-prepared fabrics displayed high superhydrophobicity and antibacterial performance with water contact angle(WCA)>153,water shedding angle(WSA)<5,and up to 99%antibacterial efficiency.Additionally,the as-prepared fabrics displayed high durability against abrasion,ultrasonic washing,and soaking in harsh chemical environments.The air permeability and flexibility of the fabric was not compromised after the coating.The above-reported technique is simple,cost-effective and holds tremendous potential for large-scale production of energy-saving clothing and healthcare products. | Neha Agrawal Pearlie Sijia Low Jasmine Si Jia Tan Eileen Wen Mei Fong Yuekun Lai Zhong Chen | 2020 | Nano Materials Science2020，2，3： | 2 |
| 7 | Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression显示文摘 | Zhengzhao Liu Peng Chen Hong Gao Yu Gu Jiao Yang Hong Peng Xingxing Xu Haifeng Wang Meiqiang Yang Xiaoying Liu Libin Fan Shiyao Chen Jian Zhou Yihong Sun Kangchen Ruan Shuqun Cheng Masaaki Komatsu Eileen White Lin Li Hongbin Ji Daniel Finley Ronggui Hu | 2014 | Cancer Cell2014，，： | 1 |
| 8 | Autophagy Suppresses Tumorigenesis through Elimination of p62显示文摘 | Robin Mathew Cristina M. Karp Brian Beaudoin Nhan Vuong Guanghua Chen Hsin-Yi Chen Kevin Bray Anupama Reddy Gyan Bhanot Celine Gelinas Robert S. DiPaola Vassiliki Karantza-Wadsworth Eileen White | 2009 | Cell2009，，6： | 1 |
| 9 | Expression of human FUS protein in Drosophila leads to progressive neurodegeneration显示文摘Mutations in the Fused in sarcoma/Translated in liposarcoma gene(FUS/TLS,FUS)have been identified among patients with amyotrophic lateral sclerosis(ALS).FUS protein aggregation is a major pathological hallmark of FUS proteinopathy,a group of neurodegenerative diseases characterized by FUS-immunoreactive inclusion bodies.We prepared transgenic Drosophila expressing either the wild type(Wt)or ALS-mutant human FUS protein(hFUS)using the UAS-Gal4 system.When expressing Wt,R524S or P525L mutant FUS in photoreceptors,mushroom bodies(MBs)or motor neurons(MNs),transgenic flies show age-dependent progressive neural damages,including axonal loss in MB neurons,morphological changes and functional impairment in MNs.The transgenic flies expressing the hFUS gene recapitulate key features of FUS proteinopathy,representing the first stable animal model for this group of devastating diseases. | Yanbo Chen Mengxue Yang Jianwen Deng Xiaoping Chen Ye Ye Li Zhu Jianghong Liu Haihong Ye Yan Shen Yan Li Elizabeth J.Rao Kazuo Fushimi Xiaohong Zhou Eileen H.Bigio Marsel Mesulam Qi Xu Jane Y.Wu | 2011 | Protein & Cell2011，2，6： | 1 |
| 10 | Effects of distribution- based parameter aggregation on a spatially distributed agricultural nonpoint source pollution model显示文摘 | Chen Eileen Mackay D Scott | 2004 | Journal of Hydrology2004，，295： | 1 |
| 11 | A phase II study of cixutumumab (IMC-A12, NSC742460) in advanced hepatocellular carcinoma显示文摘 | Ghassan K. Abou-Alfa Marinela Capanu Eileen M. O’Reilly Jennifer Ma Joanne F. Chou Bolorsukh Gansukh Jinru Shia Marcia Kalin Seth Katz Leslie Abad Diane L. Reidy-Lagunes David P. Kelsen Helen X. Chen Leonard B. Saltz | 2014 | Journal of Hepatology2014，，2： | 1 |
| 12 | Volume-outcome relationships in cardiovascular operations: New York state, 1990-1995显示文摘 | Josephine A. Sollano Annetine C. Gelijns Alan J. Moskowitz Daniel F. Heitjan Suzanne Cullinane Ted Saha Jonathan M. Chen Patrick J. Roohan Keith Reemtsma Eileen P. Shields | 1999 | The Journal of Thoracic and Cardiovascular Surgery1999，，： | 1 |
| 13 | Effects of distribution-based parameter aggregation on a spatially distributed agricultural nonpoint source pollution model显示文摘 | Eileen Chen Scott Mackay D | 2004 | Journal of Hydrology2004，295，： | 1 |
| 14 | How Does Brand-related User-generated Content Differ across YouTube, Facebook, and Twitter?显示文摘 | Andrew N. Smith Eileen Fischer Chen Yongjian | 2012 | Journal of Interactive Marketing2012，，2： | 1 |
| 15 | Effects of distribution- based parameter aggregation on a spatially distributed agricultural non-point source pollution model 显示文摘 | CHEN Eileen MACKAY D Scott | 2004 | Journal of hydrology2004，295，1234： | 1 |
| 16 | Functional Theoretical Perspectives on the 'Modernization' of the Chinese Language显示文摘 | | 1988 | Journal of Chinese Linguistics1988，16，1： | 1 |
| 17 | Evaluation of Genetic Variation Contributing to Differences in Gene Expression between Populations显示文摘 | Wei Zhang Shiwei Duan Emily O. Kistner Wasim K. Bleibel R. Stephanie Huang Tyson A. Clark Tina X. Chen Anthony C. Schweitzer John E. Blume Nancy J. Cox M. Eileen Dolan | 2008 | The American Journal of Human Genetics2008，，3： | 1 |
| 18 | Genetic Architecture of Transcript-Level Variation in Humans显示文摘 | Shiwei Duan R. Stephanie Huang Wei Zhang Wasim K. Bleibel Cheryl A. Roe Tyson A. Clark Tina X. Chen Anthony C. Schweitzer John E. Blume Nancy J. Cox M. Eileen Dolan | 2008 | The American Journal of Human Genetics2008，，5： | 1 |
| 19 | Identification of Genetic Variants Contributing to Cisplatin-Induced Cytotoxicity by Use of a Genomewide Approach显示文摘 | R. Stephanie Huang Shiwei Duan Sunita J. Shukla Emily O. Kistner Tyson A. Clark Tina X. Chen Anthony C. Schweitzer John E. Blume M. Eileen Dolan | 2007 | The American Journal of Human Genetics2007，，3： | 1 |
| 20 | Cancer immunotherapy with envelopedself-amplifying mRNA CARG-2020 thatmodulates IL-12,IL-17 and PD-L1 pathways toprevent tumor recurrence显示文摘Targeting multiple immune mechanisms may overcome therapy resistance and further improve cancer immunotherapy for humans.Here,we describe the application of virus-like vesicles(VLV)for delivery of three immunomodulators alone and in combination,as a promising approach for cancer immunotherapy.VLV vectors were designed to deliver single chain interleukin(IL)-12,shorthairpin RNA(shRNA)targeting programmed death ligand 1(PD-L1),and a dominant-negative form of IL-17 receptor A(dn-IL17RA)as a single payload or as a combination payload.Intralesional delivery of the VLV vector expressing IL-12 alone,as well as the trivalent vector(designated CARG-2020)eradicated large established tumors.However,only CARG-2020 prevented tumor recurrence and provided long-term survival benefit to the tumor-bearing mice,indicating a benefit of the combined immunomodulation.The abscopal effects of CARG-2020 on the non-injected contralateral tumors,as well as protection from the tumor cell re-challenge,suggest immune-mediated mechanism of protection and establishment of immunological memory.Mechanistically,CARG-2020 potently activates Th1 immune mechanisms and inhibits expression of genes related to T cell exhaustion and cancer-promoting inflammation.The ability of CARG-2020 to prevent tumor recurrence and to provide survival benefit makes it a promising candidate for its development for human cancer immunotherapy. | Ju Chen Bhaskara Reddy Madina Elham Ahmadi Timur Olegovich Yarovinsky Marie Marthe Krady Eileen Victoria Meehan Isabella China Wang Xiaoyang Ye Elise Pitmon Xian-Yong Ma Bijan Almassian Valerian Nakaar Kepeng Wang | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
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