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| 1 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 2 | Human adipose tissue-and umbilical cord-derived stem cells: which is a better alternative to treat spinal cord injury?显示文摘Multiple types of stem cells have been proposed for the treatment of spinal cord injury,but their comparative information remains elusive.In this study,a rat model of T10 contusion spinal cord injury was established by the impactor method.Human umbilical cord-derived mesenchymal stem cells(UCMSCs)or human adipose tissue-derived mesenchymal stem cells(ADMSCs)(2.5μL/injection site,1×10^5 cells/μL)was injected on rostral and caudal of the injury segment on the ninth day after injury.Rats injected with mesenchymal stem cell culture medium were used as controls.Our results show that although transplanted UCMSCs and ADMSCs failed to differentiate into neurons or glial cells in vivo,both significantly improved motor and sensory function.After spinal cord injury,UCMSCs and ADMSCs similarly promoted spinal neuron survival and axonal regeneration,decreased glial scar and lesion cavity formation,and reduced numbers of active macrophages.BioPlex analysis of spinal samples showed a specific increase of interleukin-10 and decrease of tumor necrosis factorαin the ADMSC group,as well as a downregulation of macrophage inflammatory protein 3αin both UCMSC and ADMSC groups at 3 days after cell transplantation.Upregulation of interleukin-10 and interleukin-13 was observed in both UCMSC and ADMSC groups at 7 days after cell transplantation.Isobaric tagging for relative and absolute quantitation proteomics analyses showed that UCMSCs and ADMSCs induced changes of multiple genes related to axonal regeneration,neurotrophy,and cell apoptosis in common and specific manners.In conclusion,UCMSC and ADMSC transplants yielded quite similar contributions to motor and sensory recovery after spinal cord injury via anti-inflammation and improved axonal growth.However,there were some differences in cytokine and gene expression induced by these two types of transplanted cells.Animal experiments were approved by the Laboratory Animal Ethics Committee at Jinan University(approval No.20180228026)on February 28,2018,and the application of human stem cells was approved by the Medical Ethics Committee of Medical College of Jinan University of China(approval No.2016041303)on April 13,2016. | Ai-Mei Liu Bo-Li Chen Ling-Tai Yu Tao Liu Ling-Ling Shi Pan-Pan Yu Yi-Bo Qu Kwok-Fai So Li-Bing Zhou | 2020 | Neural Regeneration Research2020，15，12： | 6 |
| 3 | Insulin-like growth factor 1 partially rescues early developmental defects caused by SHANK2 knockdown in human neurons显示文摘SHANK2 is a scaffold protein that serves as a protein anchor at the postsynaptic density in neurons.Genetic variants of SHANK2 are strongly associated with synaptic dysfunction and the pathophysiology of autism spectrum disorder.Recent studies indicate that early neuronal developmental defects play a role in the pathogenesis of autism spectrum disorder,and that insulin-like growth factor 1 has a positive effect on neurite development.To investigate the effects of SHANK2 knockdown on early neuronal development,we generated a sparse culture system using human induced pluripotent stem cells,which then differentiated into neural progenitor cells after 3–14 days in culture,and which were dissociated into single neurons.Neurons in the experimental group were infected with shSHANK2 lentivirus carrying a red fluorescent protein reporter(shSHANK2 group).Control neurons were infected with scrambled sh Control lentivirus carrying a red fluorescent protein reporter(sh Control group).Neuronal somata and neurites were reconstructed based on the lentiviral red fluorescent protein signal.Developmental dendritic and motility changes in VGLUT1^+glutamatergic neurons and TH+dopaminergic neurons were then evaluated in both groups.Compared with sh Control VGLUT1^+neurons,the dendritic length and arborizations of shSHANK2 VGLUT1^+neurons were shorter and fewer,while cell soma speed was higher.Furthermore,dendritic length and arborization were significantly increased after insulin-like growth factor 1 treatment of shSHANK2 neurons,while cell soma speed remained unaffected.These results suggest that insulin-like growth factor 1 can rescue morphological defects,but not the change in neuronal motility.Collectively,our findings demonstrate that SHANK2 deficiency perturbs early neuronal development,and that IGF1 can partially rescue the neuronal defects caused by SHANK2 knockdown.All experimental procedures and protocols were approved by the Laboratory Animal Ethics Committee of Jinan University,China(approval No.20170228010)on February 28,2017. | Shu-Ting Chen Wan-Jing Lai Wei-Jia Zhang Qing-Pei Chen Li-Bing Zhou Kwok-Fai So Ling-Ling Shi | 2020 | Neural Regeneration Research2020，15，12： | 3 |
| 4 | Surgical intervention combined with weight-bearing walking training improves neurological recoveries in 320 patients with clinically complete spinal cord injury:a prospective self-controlled study显示文摘Although a large number of trials in the SCI field have been conducted,few proven gains have been realized for patients.In the present study,we determined the efficacy of a novel combination treatment involving surgical intervention and long-term weight-bearing walking training in spinal cord injury(SCI)subjects clinically diagnosed as complete or American Spinal Injury Association Impairment Scale(AIS)Class A(AIS-A).A total of 320 clinically complete SCI subjects(271 male and 49 female),aged 16–60 years,received early(≤7 days,n=201)or delayed(8–30 days,n=119)surgical interventions to reduce intraspinal or intramedullary pressure.Fifteen days post-surgery,all subjects received a weight-bearing walking training with the“Kunming Locomotion Training Program(KLTP)”for a duration of 6 months.The neurological deficit and recovery were assessed using the AIS scale and a 10-point Kunming Locomotor Scale(KLS).We found that surgical intervention significantly improved AIS scores measured at 15 days post-surgery as compared to the pre-surgery baseline scores.Significant improvement of AIS scores was detected at 3 and 6 months and the KLS further showed significant improvements between all pair-wise comparisons of time points of 15 days,3 or 6 months indicating continued improvement in walking scores during the 6-month period.In conclusion,combining surgical intervention within 1 month post-injury and weight-bearing locomotor training promoted continued and statistically significant neurological recoveries in subjects with clinically complete SCI,which generally shows little clinical recovery within the first year after injury and most are permanently disabled.This study was approved by the Science and Research Committee of Kunming General Hospital of PLA and Kunming Tongren Hospital,China and registered at ClinicalTrials.gov(Identifier:NCT04034108)on July 26,2019. | Yansheng Liu Jia-Xin Xie Fang Niu Zhexi Xu Pengju Tan Caihong Shen Hongkun Gao Song Liu Zhengwen Ma Kwok-Fai So Wutian Wu Chen Chen Sujuan Gao Xiao-Ming Xu Hui Zhu | 2021 | Neural Regeneration Research2021，16，5： | 3 |
| 5 | In vivo neuronal and astrocytic activation in somatosensory cortex by acupuncture stimuli显示文摘Acupuncture is a medical treatment that has been widely pra cticed in China for over 3000 years,yet the neural mechanisms of acupuncture are not fully understood.We hypothesized that neurons and astrocytes act independently and synergistically under acupuncture stimulation.To investigate this,we used two-photon in vivo calcium reco rding to observe the effects of acupuncture stimulation at ST36(Zusanli)in mice.Acupuncture stimulation in peripheral acupoints potentiated calcium signals of pyramidal neurons and astrocytes in the somatosensory cortex and resulted in late-onset calcium transients in astrocytes.Chemogenetic inhibition of neurons augmented the astrocytic activity.These findings suggest that acupuncture activates neuronal and astrocytic activity in the somatosensory co rtex and provide evidence for the involvement of both neurons and astrocytes in acupuncture treatment. | Xiao-Yue Chang Kai Chen Tong Cheng Pui To Lai Li Zhang Kwok-Fai So Edward S.Yang | 2022 | Neural Regeneration Research2022，17，11： | 2 |
| 6 | Lutein delays photoreceptor degeneration in a mouse model of retinitis pigmentosa显示文摘Retinitis pigmentosa is a retinal disease characterized by photoreceptor degeneration.There is currently no effective treatment for retinitis pigmentosa.Although a mixture of lutein and other antioxidant agents has shown promising effects in protecting the retina from degeneration,the role of lutein alone remains unclear.In this study,we administered intragastric lutein to Pde6brd10 model mice,which display degeneration of retinal photoreceptors,on postnatal days 17(P17)to P25,when rod apoptosis reaches peak.Lutein at the optimal protective dose of 200 mg/kg promoted the survival of photoreceptors compared with vehicle control.Lutein increased rhodopsin expression in rod cells and opsin expression in cone cells,in line with an increased survival rate of photoreceptors.Functionally,lutein improved visual behavior,visual acuity,and retinal electroretinogram responses in Pde6brd10 mice.Mechanistically,lutein reduced the expression of glial fibrillary acidic protein in Müller glial cells.The results of this study confirm the ability of lutein to postpone photoreceptor degeneration by reducing reactive gliosis of Müller cells in the retina and exerting anti-inflammatory effects.This study was approved by the Laboratory Animal Ethics Committee of Jinan University(approval No.LACUC-20181217-02)on December 17,2018. | Hui-Jun Zhang Xiao-Bin Liu Xiong-Min Chen Qi-Hang Kong Yu-Sang Liu Kwok-Fai So Jian-Su Chen Ying Xu Xue-Song Mi Shi-Bo Tang | 2022 | Neural Regeneration Research2022，17，7： | 2 |
| 7 | All roads lead to Rome-a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease显示文摘Age-related neurodegenerative disorders such as Alzheimer’s disease(AD)have become a critical public health issue due to the significantly extended human lifespan,leading to considerable economic and social burdens.Traditional therapies for AD such as medicine and surgery remain ineffective,impractical,and expensive.Many studies have shown that a variety of bioactive substances released by physical exercise(called“exerkines”)help to maintain and improve the normal functions of the brain in terms of cognition,emotion,and psychomotor coordination.Increasing evidence suggests that exerkines may exert beneficial effects in AD as well.This review summarizes the neuroprotective effects of exerkines in AD,focusing on the underlying molecular mechanism and the dynamic expression of exerkines after physical exercise.The findings described in this review will help direct research into novel targets for the treatment of AD and develop customized exercise therapy for individuals of different ages,genders,and health conditions. | Yi-Yao Liang Li-Dan Zhang Xi Luo Li-Li Wu Zhao-Wei Chen Guang-Hao Wei Kai-Qing Zhang Ze-An Du Ren-Zhi Li Kwok-Fai So Ang Li | 2022 | Neural Regeneration Research2022，17，6： | 2 |
| 8 | Treadmill Exercise Relieves Chronic Restraint Stress-induced Cognitive Impairments in Mice Via Activating Protein Phosphatase 2A显示文摘Dear Editor,Aerobic exercise is well known to improve cognitive functions including hippocampus-dependent spatial memory[1]and object recognition[2].Regarding the molecular mechanisms,the indispensable role of brain-derived neurotrophic factor(BDNF)in governing exercise-induced neural plasticity has been demonstrated for the improvement of learning and memory[3].Our recent study further demonstrated the activation of mechanistic target of rapamycin pathways downstream of BDNF to drive synaptic protein synthesis upon persistent exercise[4],but leaving the effect of exercise on the post-translational modification of proteins largely unknown. | Wenjing Zhang Haining Ou Borui Zhang Meifeng Zheng Lan Yan Yang Chen Kwok-Fai So Li Zhang | 2021 | Neuroscience Bulletin2021，37，10： | 2 |
| 9 | An eight-year study of epidemiologic features of enterovims 71 infection in Taiwan显示文摘 | Chen SO Chang HL Yan TB | 2007 | Am J Trop Med Hyg2007，77，1： | 1 |
| 10 | Xinjiang Medical U- niversity clinical medicine professional training scheme implementa- tion effect and analysis of influencing factors of显示文摘 | Tang Jinhua Chen Yu Zhang Huixia and so on | 2011 | Chinese Journal of medical education research journal2011，10，7： | 1 |
| 11 | Soft tissue profile changes of reverse headgear treatment in Chinese boys with complete unilateral cleft lip and palate显示文摘 | Chen K So LL | 1997 | The Angle Orthodontist1997，67，1： | 1 |
| 12 | An Improved DV-Hop Localization Algorithm with Reduced Node location Error for Wireless Sensor Networks显示文摘 | Hongyang CHEN Kaoru SEZAKI PingDENG and Hing Cheung SO | 2008 | Communacations and Computer Sciences2008，91，8： | 1 |
| 13 | Use of serum prolactin in diagnosing epileptic seizures: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology 显示文摘 | Chen D K So Y T Fisher R S | 2005 | Neurology2005，65，5： | 1 |
| 14 | Discovery of (2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity显示文摘 | Chu XJ DePinto W Bartkovitz D So SS Vu BT Packman K Lukacs C Ding Q Jiang N Wang K Goelzer P Yin X Smith MA Higgins BX Chen Y Xiang Q Moliterni J Kaplan G Graves B Lovey A Fotouhi N | 2006 | J Med Chem2006，49，22： | 1 |
| 15 | Visual re- sponse properties of Y cells in the detached feline retina显示文摘 | Nan Y Xiao C Chen B Ellis-Behnke RG So KF Pu M | 2010 | In- vest Ophthalmol Vis Sci2010，51，2： | 1 |
| 16 | The Prophylactic Effect of Tropisetron on Epidural Morphine-Related Nausea and Vomiting: A Comparison of Dexamethasone with Saline显示文摘 | Jhi-Joung Wang Jann-Inn Tzeng Shung-Tai Ho Jen-Yin Chen Chin-Chen Chu Edmund C. So | 2002 | Anesthesia & Analgesia2002，，3： | 1 |
| 17 | Role for p27(Kip1)in Vascular Smooth Muscle Cell Migration显示文摘 | SUN J MARX SO CHEN HJ | 2001 | Circulation2001，103，24： | 1 |
| 18 | One-pot solvothermal synthesis of Pd/Fe 3 O 4 nanocomposite and its magnetically recyclable and efficient catalysis for Suzuki reactions显示文摘 | Shaozhong Li Wei Zhang Man-Ho So Chi-Ming Che Runming Wang Rong Chen | 2012 | Journal of Molecular Catalysis A Chemical2012，，： | 1 |
| 19 | Gene expression patterns in human liver cancers显示文摘 | Chen X Cheung S T So S | 2002 | Mol Biol Cell2002，13，6： | 1 |
| 20 | Gene expression pattems in human liver cancers 显示文摘 | Chen X Cheung S T So S | 2002 | Mol Biol Cell2002，13，6： | 1 |
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