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| 1 | Re-Os isotopes and PGE geochemistry of black shales and intercalated Ni-Mo polymetallic sulfide bed from the Lower Cambrian Niutitang Formation, South China显示文摘The Lower Cambrian Niutitang Formation consists of a thick black shale sequence with a regionally distributed conformable Ni Mo polymetallic sulfide horizon and a chert bed at its basal strata on theYangtze Platform, South China. In this paper, we discuss all available data on Re Os isotopes and Platinum Group Element (PGE) distribution pattern of the Ni Mo polymetallic sulfide ore and its host rocks (black shales, cherts, and phosphorites) from Guizhou and Hunan provinces. Our results show that the black shales and the Ni Mo sulfide ore have a high initial 187 Os/ 188 Os ratio of 0.78~0.86, indicating that the Early Cambrian ocean across the Yangtze Platform had a highly radiogenic Os value. This ratio is slightly lower than but still similar to present day seawater, possibly as a result of high continental weathering at that time. The Ni Mo sulfide ore yields a Re Os isochron of 537±10 Ma (MSWD=11.9), possibly representing the depositional age of the Niutitang Formation. The chondrite normalized PGE pattern, Pt anomaly (Pt/Pt *), Pt/Pd, Ir/Pd, Au/Ir and Re/Mo ratios of the Ni Mo sulfide ore and its host rocks from South China indicate a varying source contribution of the PGE and other metals for different rocks. It is suggested that the cherts and Ni Mo sulfide ore may have a significant proportion of PGE and probably other metals deriving from submarine hydrothermal fluids with a mantle signature. | JIANG Shaoyong*, YANG Jinghong, LING Hongfei, FENG Hongzhen, CHEN Yongquan and CHEN Jianhua(State Key Laboratory for Mineral Deposits Research, Department of Earth Sciences, Nanjing University, Nanjing 210093, China) | 2003 | Progress in Natural Science:Materials International2003，13，10： | 78 |
| 2 | Pb-Pb isotope dating of black shales from the Lower Cambrian Niutitang Formation, Guizhou Province, South China显示文摘The Lower Cambrian black shales of the Niutitang Formation and their lateral equivalents occur widely on the Yangtze Platform, South China. In this study, we examine two sections of the Niutitang Formation in Guizhou Province. We employ a stepwise acid leaching technique to obtain Pb isotope compositions of the black shales. At the Zhongnan section, the black shales display large Pb isotope variations, with 206 Pb/ 204 Pb of 20.5396~33.5709, and 207 Pb/ 204 Pb of 15.8407~16.5782. In contrast, Pb isotope data show a relatively limited range in 206 Pb/ 204 Pb (18.2797~18.5972) and 207 Pb/ 204 Pb (15.6813~15.7159) at the Zhijin section. Data for all acid leached black shale samples from the two sections yield a Pb Pb isochron age of 531±24 Ma. This age may represent the sedimentary age of the black shales. The initial Pb isotope composition of the black shales falls near the upper crust evolution curve in a Zartman Pb Pb evolution diagram. Hence, it is likely that the Pb in the black shales may have been derived from an upper continental crustal source. | CHEN Yongquan, JIANG Shaoyong*, LING Hongfei, FENG Hongzhen, YANG Jinghong and CHEN Jianhua (State Key Laboratory for Mineral Deposits Research, Department of Earth Sciences, Nanjing University, Nanjing 210093, China) | 2003 | Progress in Natural Science:Materials International2003，13，10： | 19 |
| 3 | Superplastic behaviour and microstructure evolution of a fine-grained TA15 titanium alloy显示文摘The fine-grained microstructure of TA15 titanium alloy was prepared through two-step forging technology combined with high and low temperatures, and a transnormal superplastic elongation of more than 2000% was obtained. The superplastic behaviour and microstructure evolution were systematically researched at different temperatures and strain rates through superplastic tensile test. The results indicate that the fine-grained TA15 alloy exhibits superplasticity at temperatures of 760-980°C and initial strain rates from 1.1 × 10-2 to 5.5 × 10-5 s-1. The optimal superplastic conditions are 940°C and 3.3 × 10-4 s-1, in which the average elongation is 2526% and the maximum elongation is 2743%. During superplastic deformation, dynamic recovery and recrystallization occur obviously, and the corporate effect of strain hardening and recrystallization softening decides the superplastic ability directly. | ZHAO Zhanglong GUO Hongzhen CHEN Li YAO Zekun | 2009 | Rare Metals2009，28，5： | 6 |
| 4 | Immunotherapy of Epstein-Barr Virus Associated Malignancies Using Mycobacterial HSP70 and LMP2A356-364 Epitope Fusion Protein显示文摘Epstein-Barr virus infection is strongly associated with a number of malignancies.The EBV latent membrane protein 2A has been implicated as one of the most attractive candidates for immunotherapy of related malignancies.In previous studies,the T cell epitopes of LMP2A have been identified systematically.However,the epitope-based vaccine generally meets inefficient immunogenicity when used in vivo directly,which could be overcome by combination with appropriate adjuvants.Heat shock protein is a natural chaperon,which is able to activate the classical major histocompatibility complex class I antigen-processing pathway(cross-presentation).In this study,a minigene encoding LMP2A356-364(FLYALALLL)was genetically fused to the carboxy-terminal of mycobacterial heat shock protein 70.The epitope fusion protein was expressed and purified,and the cross-presentation of LMP2A_(356-364) by monocyte-derived dendritic cells pulsed with the epitope fusion protein was evaluated.Results showed that the epitope fusion protein-pulsed mDCs were much more efficient than the single peptide-pulsed mDCs on CTL activation.Immunization of HLA-A2.1 transgenic mice with MtHsp70-LMP2A_(356-364) generated peptide specific CTL more effectively than a single peptide plus incomplete Freund's adjuvant(IFA).Growth of LMP2A expressing B16 melanoma tumor cells was suppressed in the vaccinated groups.Our results suggested that MtHsp70-LMP2A_(356-364) fusion protein was more effective than the CD8^(+)T cell epitope alone on anti-tumor immunity.As a result,the MtHsp70-LMP2A_(356-364) fusion protein is considered to be a promising candidate vaccine for EBV related malignancies. | Genyan Liu Kun Yao Bing Wang Yun Chen Feng Zhou Yidi Guo Jian Xu Hongzhen Shi | 2009 | Cellular & Molecular Immunology2009，6，6： | 6 |
| 5 | Adaptive changes of gastro-entero-pancreatic system endocrine cells in the black-spotted pond frog Rana nigromaculata after fasting显示文摘Changes in distribution density,morphology and secretory content of endocrine cells in the gastro-entero-pancreatic system of black-spotted frogs Rana nigromaculata before and after fasting were investigated using immunohistochemistry and antisera to six gut hormones.Six types of endocrine cells were detected in the digestive tract of Rana nigromaculata,including 5-hydroxytryptamine(5-HT),gastrin(GAS),somatostatin(SOM),glucagon(GLU),pancreatic polypeptide(PP)and vasoactive intestinal polypeptide(VIP)cells.After fasting,the density of 5-HT cells in the esophagus,cardia and fundus,GAS cells in the fundus and pylorus,PP cells in the fundus decreased significantly(P<0.01),while SOM cells in the cardia,GLU cells in the rectum increased significantly(P<0.01).The cytoplasmic processes of 5-HT cells became shorter or not detectable.The secretory content of GAS cells reduced in the cardia.The positive immunostaining reaction in the perinuclear region of SOM cells in the cardia,fundus and pylorus became weaker,while the staining intensity in the periphery of these cells became stronger.VIP cells were not detectable in the whole digestive tract after fasting.Five types of endocrine cells were found in the pancreas of Rana nigromaculata,including 5-HT,GAS,SOM,GLU and PP cells.After fasting,the density of 5-HT cells decreased slightly(P>0.05),while SOM,GAS,GLU and PP cells increased significantly(P<0.01).Furthermore,the secretory content of GLU cells increased significantly.Considering their functionalities,our results indicate that the changes of GEP endocrine cells in Rana nigromaculata responded adaptively to starvation-induced stress. | Hongzhen PAN Honghong CHEN Lianjiu ZHU Yang LI Changchun LI Shengzhou ZHANG | 2009 | Current Zoology2009，55，4： | 4 |
| 6 | Proximal development,systematic taxonomy,and dispersal pattern of the Early-Middle Ordovician graptolite Acrograptus from South China显示文摘Based on the well-preserved specimens from the Nanba section in Yiyang,Hunan Province,the definition of the graptolite genus Acrograptus is revised here.The revised Acrograptus is a dichograptid form with stipes subhorizontal to deeply declined,sicula long and slender;th1 1 budding from the top of the metasicula,proximal development of isograptid type with th1 2 as the dicalycal theca;asymmetric proximal end resulting from the divergence of th1 1 and th1 2 from the sicula at different levels;slender crossing canals composed of extremely slender prothecae of th1 1 and th1 2.According to the revised definition,Acrograptus is assigned to the subfamily Sigmagraptinae of the family Dichograptidae,including six species,i.e.,A.affinis (Nicholson),A.filiformis (Tullberg),A.gracilis (Trnquist),A.nicholsoni (Lapworth),A.pusillus (Tullberg),and A.saukros (Ni).During the Early-Middle Ordovician,these six species were widely distributed in South China,especially in the Upper Yangtze Region as well as the central and eastern Jiangnan Region.This study further indicates that Acrograptus first appeared in a deep-water setting on the Jiangnan Slope in South China during early Floian (Tetragraptus approximatus Biozone),and subsequently expanded into the shallow-water region on the Yangtze Platform due to a remarkable dispersion event in middle Floian (Pendeograptus fruticosus Biozone).It is here indicated that the dispersal of Acrograptus may be directly controlled by the large-scale transgression event occurring in middle Floian. | LI LiXia FENG HongZhen WANG WenHui CHEN WenJian | 2012 | Science China Earth Sciences2012，55，7： | 4 |
| 7 | Process-scheme-driven automatic construction of NC machining cell for aircraft structural parts显示文摘In order to enhance the NC programming effciency and quality of aircraft structural parts(ASPs),an intelligent NC programming pattern driven by process schemes is presented.In this pattern,the NC machining cell is the minimal organizational structure in the technological process,consisting of an operation machining volume cell,and the type and parameters of the machining operation.After the machining cell construction,the fnal NC program can be easily obtained in a CAD/CAM system by instantiating the machining operation for each machining cell.Accordingly,how to automatically establish the machining cells is a key issue in intelligent NC programming.On the basis of the NC machining craft of ASP,the paper aims to make an in-depth research on this issue.Firstly,some new terms about the residual volume and the machinable volume are defned,and then,the technological process is modeled with a process scheme.Secondly,the approach to building the machining cells is introduced,in which real-time complement machining is mainly considered to avoid interference and overcutting.Thirdly,the implementing algorithm is designed and applied to the Intelligent NC Programming System of ASP.Finally,the developed algorithm is validated through two case studies. | Chen Shulin Zheng Guolei Zhou Min Du Baorui Chu Hongzhen | 2013 | Chinese Journal of Aeronautics2013，26，5： | 4 |
| 8 | Highly stable lithium anode enabled by self-assembled monolayer of dihexadecanoalkyl phosphate显示文摘Li has been considered as the ultimate anode material for high energy density secondary Li batteries.However,its practical application has been limited due to its low Coulombic efficiency(CE)and the formation of lithium dendrites.Recently,we have developed a microspherical Li-carbon nanotube(Li-CNT)composite material passivated with octadecylphosphonic acid(OPA)self-assembled monolayer(SAM)exhibiting suppressed lithium dendrite formation and improved environmental/electrochemical stability.In this work,we demonstrated the significantly enhanced passivation effects of a SAM using dihexadecanoalkyl phosphate(DHP),a molecule that is comprised of double hydrophobic alkyl chains and forms a denser SAM on surfaces with large curvature.As a result,the DHP SAM delivers superior environmental and electrochemical stability to the OPA passivated Li-CNT material.In specific,the DHP passivated Li-CNT composite(DHP-Li-CNT)delivers a high CE of 99.25%under a 33.3%depth of discharge(DOD)at 1 C,when it is paired with a LiFePO4 cathode.The evolution of the SAM during cycling and the effects of DOD and current density on the CE of the DHP-Li-CNT anode have also been investigated.The improved SAM passivation constitutes an important step in achieving the goal of practically applicable Li anodes. | Lei Zheng Feng Guo Tuo Kang Jin Yang Ya Liu Wei Gu Yanfei Zhao Hongzhen Lin Yanbin Shen Wei Lu Liwei Chen | 2020 | Nano Research2020，13，5： | 1 |
| 9 | Dynamic analysis and test study of ultrasonic compound micro-fine electrical-machining sys- tem 显示文摘 | Zhu Yongwei Shao Jian Chen Hongzhen | 2013 | Journal of Chemical and Pharmaceutical Research2013，5，： | 1 |
| 10 | Detection and Prevention of Environmental Hormone显示文摘The sorts and detection methods of environmental hormone were analyzed firstly,and then the effects of environmental hormone on organisms and humanity were discussed. Finally the control measures of environmental hormone pollution,such as reducing the use of goods and pesticide and the study of new substitutes and degradation technology are advanced. | Qili Chen Ling Pan Yanhong Xv Xuan Fu Hongzhen Sun Hongyan Li Pingping Liu | 2013 | Meteorological and Environmental Research2013，4，12： | 1 |
| 11 | A carbon nanotube- based high-sensitivity electrochemical immunosensor for rapid andportable detection of clenbuterol显示文摘 | LIU Gang CHEN Haode PENG Hongzhen | 2011 | Biosensors and Bioelectronics2011，28，1： | 1 |
| 12 | Long-range gene regulation network of the MGMT enhancer modulates glioma cell sensitivity to temozolomide显示文摘Approximately 80%of primary tumors in the central nervous system are malignant glioma,and>50%of those are diagnosed as glioblastoma(GBM),the most aggressive glioma.Despite treatment advances,GBM prognosis is unsatisfying,and the median survival time of patients is only 14-17 months. | Bohan Chen Anshun He Jinfang Bi Shupeng Sun Yiping Ma Wenbin Wang Dianhao Guo Jun Chen Yuyang Qian Tengfei Shi Guohui Nie Zhongfang Zhao Jiandang Shi Hongzhen Yang Lei Zhang Wange Lu | 2021 | Journal of Genetics and Genomics2021，48，10： | 1 |
| 13 | Event-Triggered-Backstepping-Based Parallel Approaching Guidance Method for Maneuvering Target Interception显示文摘In order to achieve a straight ballistic trajectory of missile and reduce the update frequency of the missile normal acceleration for the interception of maneuvering target,a backstepping-based parallel approaching guidance method is designed with nonlinear disturbance observer(NDO)technique and event-triggered(ET)mechanism in this paper.In order to suppress the adverse e®ect of target maneuver,the NDO is designed to estimate the target maneuvering acceleration.Then,the NDO-based backstepping method is used to obtain the normal acceleration of missile and realize the parallel approaching guidance.In order to reduce the update frequency of missile normal acceleration,the ET mechanism is employed in the parallel approaching guidance method.If the missile trajectory is relatively straight,the normal acceleration of missile remains unchanged.On the contrary,if the missile trajectory is not straight,the normal acceleration of missile is updated to make the missile trajectory straight.In this way,the ET-based parallel approaching guidance can be obtained.Furthermore,a determined method for the initial missile°ight-path angle is proposed to keep the normal acceleration of missile at zero in the initial stage of interception.Besides,Lyapunov stability analysis method is used to prove that all signals in the closed-loop guidance system are uniformly ultimately bounded.Finally,simulation results show the e®ectiveness of the proposed guidance method. | Yaohua Shen Mou Chen Zixuan Zheng Hongzhen Guo | 2022 | Guidance, Navigation and Control2022，2，1： | 1 |
| 14 | A carbon nanotube-based high-sensitivity electrochemical im- munosensor for rapid and portable detection of clenbuterol显示文摘 | Gang Liu Haode Chen Hongzhen Peng | 2011 | Biosensors and bioelectronics2011，28，： | 1 |
| 15 | Preparation of Water Soluble Poly (aniline) and its Gas - sensitivity 显示文摘 | Ma Xingfa Wang Mang Chen Hongzhen | 2005 | Green Chemistry2005，7，7： | 1 |
| 16 | Hierarchically nanostructured Ni O-Co3O4 with rich interface defects for the electro-oxidation of 5-hydroxymethylfurfural显示文摘Ni-based electrocatalysts with strong redox abilities are active for the electrochemical oxidation of 5-hydroxymethylfurfural(HMF). Interface engineering is an efficient way to modulate the electronic structure, tune the intermediate adsorption, and expose more active sites. Herein, we increased the concentration of interfacial sites with rich defects in a 3D hierarchical nanostructured NiO-Co3O4 electrocatalyst and investigated its catalytic performance for HMF electro-oxidation. The interface effect created abundant cation vacancies, modulated the electronic properties of Co and Ni atoms, and raised the oxidation state of Ni species. The NiO-Co3O4 catalysts show superb HMF oxidation activities with a low onset potential of 1.28 VRHE.Meanwhile, in-situ surface-selective vibrational spectroscopy of sum-frequency generation was performed to study the reaction pathway during the oxidation process on the electrocatalysts. The current study offers an efficient way to create cation vacancies and proves the decisive role of cation vacancies in catalyzing the HMF electro-oxidation. | Yuxuan Lu Chung-Li Dong Yu-Cheng Huang Yuqin Zou Yanbo Liu Yingying Li Nana Zhang Wei Chen Ling Zhou Hongzhen Lin Shuangyin Wang | 2020 | Science China Chemistry2020，63，7： | 1 |
| 17 | OsAMT1.1 Expression by Nitrate-Inducible Promoter of OsNAR2.1 Increases Nitrogen Use Efficiency and Rice Yield显示文摘Nitrate(NO_(3)^(-))and ammonium(NH_(4)^(+))are two main inorganic nitrogen(N)sources during crop growth.Here,we enhanced the expression of OsAMT1.1,which encodes a NH_(4)^(+)transporter,using the NO_(3)^(-)-inducible promoter of OsNAR2.1 and an ubiquitin promoter in transgenic rice plants.Under field condition of 120 kg/hm2 N,agronomic N use efficiency,N recovery efficiency and N transport efficiency,and grain yield of the pOsNAR2.1:OsAMT1.1 transgenic lines were increased compared with those of the wild type(WT)and the pUbi:OsAMT1.1 transgenic plants.Under 2.0 mmol/L NO_(3)^(-)+0.5 mmol/L NH_(4)^(+)and 0.5 mmol/L NO_(3)^(-)+2.0 mmol/L NH_(4)^(+)conditions of hydroponic culture,compared with the WT,both biomass and total N content were increased in the pOsNAR2.1:OsAMT1.1 transgenic lines.However,biomass was significantly reduced in pUbi:OsAMT1.1 transgenic plants under 0.5 mmol/L NO_(3)^(-)+2.0 mmol/L NH_(4)^(+)condition.The lines expressing pOsNAR2.1:OsAMT1.1 exhibited increased OsAMT1.1 expression and 15NH_(4)^(+)influx in roots under both 2.0 mmol/L NO_(3)^(-)+0.5 mmol/L NH_(4)^(+)and 0.5 mmol/L NO_(3)^(-)+2.0 mmol/L NH_(4)^(+)conditions.Our study showed that expression of OsAMT1.1 can be promoted when driven by the OsNAR2.1 promoter,especially under high-level nitrate condition,leading to enhancement of NH_(4)^(+)uptake,N use efficiency and grain yield. | JIANG Hongzhen WANG Yamei LAI Liuru LIU Xintong MIAO Changjian LIU Ruifang LI Xiaoyun TAN Jinfang GAO Zhenyu CHEN Jingguang | 2023 | Rice science2023，30，3： | 0 |
| 18 | Neoadjuvent androgen deprivation for seminal vesicle reduction:The optimal portion of seminal vesicle included in the high-dose CTV in localized prostate cancer radiotherapy显示文摘Objective:To clarify the length and volume reduction of seminal vesicles(SVs)after neo-adjuvant hormonal therapy(NHT),in order to help contour the optimal SV included into high-dose clinical target volume(CTV)for radiotherapy in intermediate-and high-risk patients.Methods:MR images both before and after NHT(5.3±2.2 months)were collected from thirty-one patients with cT2-4N0M0 prostate cancer.SV volume was measured in axial T1WI,while SV length was obtained in a reconstructed oblique coronary plane through its long axial from a 3D sequence.Results:SVs showed evident reduction both in length and volume(length:median 12.1%,range 4.0%–28.0%;volume:median 39.9%,range 9.4%–66.2%).For SVs with and without MR detected involvement,length shortening were(16.7±4.8)%and(11.1±4.4)%(P<0.001);for involved SVs and lesions,volume reduction were(41.0±16.0)%and(66.3±14.4)%,respectively(P<0.001),both indicating a more sensitive response to NHT of the involved portion than normal SV.Conclusions:Both volume and length of the SV will be reduced after receiving NHT.Besides,the invaded segments shrink more than normal SV tissue,indicating that SV portion included within the CTV can be reduced. | Xin Qi Xianshu Gao Xiaomei Li Shangbin Qin Xiaoying Li Mingwei Ma Yun Bai Jiayan Chen Xueying Ren Hongzhen Li | 2023 | Radiation Medicine and Protection2023，4，1： | 0 |
| 19 | Inverse design and accurate optimization of layered structured seeding mechanism for sugarcane planters显示文摘Existing sugarcane planters are difficult to have ideal seeding trajectory and motion attitude at the same time, and the speed is difficult to meet the requirements at the critical stage, resulting in poor stability, which ultimately makes it impossible to ensure that the sugarcane seeding is carried out in accordance with the agronomic requirements to ensure that the cane buds are oriented toward the wall of the seeding trench. Aiming at the second-order non-circular planetary gear system pendulum seeding mechanism of the planter, the paper innovatively adopts the combination of inverse design and multi-objective layered accurate optimization to solve the problems of attitude, speed and trajectory that do not meet the requirements of fixed-attitude seeding that still exists in the process of sugarcane seeding. The second-order non-circular planetary gear system is simplified into a three-rod two-degree-of-freedom mechanism, and the radius of the pitch curve of each non-circular gear is solved inversely by actively preplanning the static trajectory of the cane seed motion and analyzing the law of motion of the rod assembly. Determining the range of cane seed attitude angles in different motion phases as the first layer optimization objective, and fine-tuning the position of static trajectory key type value points to achieve the first layer optimization. Based on the non-circular gear pitch curve obtained from optimization, the interpolation points are marked on each non-circular gear pitch curve of the second-order non-circular planetary gear system, and based on the parameter optimization method of human-computer interaction, the radius values corresponding to the interpolation points of the non-circular gear pitch curve are fine-tuned to optimize the pitch curves, so as to satisfy the speed requirements of the cane species in each stage, and at the same time to make the convexity of non-circular gears in line with the principle of gear mesh, so as to complete the second layer of accurate optimization. The results of simulation verification show that the motion trajectory attitude of the virtual prototype is basically consistent with the theoretical model, which verifies the feasibility of the mechanism design. This study provides a new optimized design method for the cane seeding mechanism of sugarcane planters to achieve directional seeding. | Jiaodi Liu Qingli Chen Hongzhen Xu Yong Hua Xiaoman Wu | 2023 | International Journal of Agricultural and Biological Engineering2023，16，6： | 0 |
| 20 | Preparation of the selenome-thionine derivative of tab-toxin resistance protein显示文摘In order to obtain phase information for the X-ray diffraction of tabtoxin resistance protein (TTR) crystal using the MAD phasing method, a selenomethionine (Se-Met) derivative of TTR was overexpressed in E. coli strain M15, with pQE-30 plasmid, through IPTG induction in M9 medium containing Se-Met. The product was purified to an estimated homogeneity of greater than 95% according to SDS-PAGE, by a Ni-NTA metal affinity followed by a Mono Q anion exchange column chromatography. The successful substitution of Se-Met for methionine (Met) was confirmed by MALDI-TOF and ESI-Quadrupole Mass Spectrometry analysis. The derivative crystal was obtained using similar conditions as those for the native. | HE Hongzhen SHAO Yu CHEN Yuhang LIU Bingbing CAO Zhenbo JIANG Fan LIU Yiwei TANG Hong LIU Jinyuan ZHAO Nanming RAO Zihe | 2001 | Chinese Science Bulletin2001，46，15： | 0 |
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