|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A Control Strategy for Grid-connected Inverters With LCL Filters显示文摘把LCL滤波器作为电压源型并网逆变器与电网的接口已受到广泛关注。与单电感L滤波器相比,利用电感值较小的LCL滤波器对入网电流的高次谐波具有显著的衰减效果,特别是在低开关频率的大功率并网逆变系统应用中更具明显优势,但是仅采用直接入网电流控制时,LCL滤波器接口的并网逆变器系统存在稳定性问题。该文采用电网侧电感电流和逆变侧电感电流双闭环控制策略对并网电流进行直接控制,电网侧电感电流作为外环更容易抑制并网电流的谐波因素,且可以直接控制入网电流的单位功率因数,采用逆变器侧电感电流作为内环可以增加系统阻尼,从而可抑制系统振荡,增加系统稳定性。对该方案进行系统建模,并深入分析了滤波器参数、控制器参数及系统稳定性之间的精确量化关系。仿真和实验结果表明,该控制策略既可有效抑制入网电流谐振和实现进网电流的高功率因数运行,同时又具有良好的稳态和动态性能。 | HU Xuefeng WEI Zheng CHEN Yihan GONG Chunying ZHANG Jiayan | 2012 | 中国电机工程学报2012，32，27： | 37 |
| 2 | Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine显示文摘With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies.Despite numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases.It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies.There has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two decades.Among all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.In fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral vectors.This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative medicine.Current challenges and future directions regarding the use of adenoviral vectors are also discussed.It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine. | Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He | 2017 | Genes & Diseases2017，4，2： | 19 |
| 3 | Radiofrequency ablation combined with transcatheter arterial chemoembolization therapy versus surgical resection for Barcelona-Clinic Liver Cancer(BCLC) A hepatocellular carcinoma: a meta-analysis显示文摘Purpose: The objective of our study was to compare the effectiveness of the combination of transcatheter arterial chemoembolization(TACE) and radiofrequency ablation(RFA) with that of surgical resection(SR) in Barcelona-Clinic Liver Cancer(BCLC) A hepatocellular carcinoma. Materials and Methods: PubMed, Medline, Embase, and Cochrane Library were searched for comparisons of the two therapies from January 2006 to December 2017. Overall survival rate(OS), recurrence-free survival rate(RFS), complications, and the average length of hospital stay were compared and analyzed. Review Manager v. 5.2 from the Cochrane Collaboration was used for statistical analyses. Results: Seven case-control studies and one randomized controlled trial were identified, of which 717 were treated with a combination of TACE and RFA and 785 were treated with SR. Meta-analysis data revealed that TACE plus RFA had significantly better effectiveness on 1.0-y OS(OR = 0.50, p =.009). The major complications(ORcomplications = 1.88, p =.02) after the combined therapy were significantly lower than those after SR. There were three studies that reported the average length of hospital stay. The hospital stay for the SR group vs the combined therapy group was 19.8 ± 8.4 d vs 7.4 ± 2.2 d, respectively(p <.0001); 18.7 ± 4.9 d vs 11.5 ± 6.9 d, respectively(p <.0001); and 16.6 ± 6.7 d vs 8.5 ± 4.1 d, respectively(p <.0001). There was no significant difference in 3.0-or 5.0-y OS and 1.0-, 3.0-, or 5.0-y RFS. Conclusion: The combination of TACE and RFA has advantages in improving 1.0-y OS, reducing complications, and shortening the length of hospital stay over that of SR in the treatment of patients with BCLC A HCC. | Weidong Wang Sinan Hou Zelong Zhong JiaYan Ni Xiongying Jiang Dong Chen Yaoting Chen Jianghong Luo Hongliang Sun Linfeng Xu | 2018 | Journal of Interventional Medicine2018，1，1： | 9 |
| 4 | Spinel MnCo2O4 nanoparticles cross-linked with two-dimensional porous carbon nanosheets as a high-efficiency oxygen reduction electrocatalyst显示文摘为氧减小反应(ORR ) 的催化剂在燃料房间起一个重要作用。有到基于磅的催化剂的可比较的 ORR 活动的其他的非宝贵的金属催化剂为燃料房间的发展是高度合乎需要的。在这个工作,我们第一次报导尖晶石 MnCo 2 O 4/C ORR 催化剂由一致 MnCo 2 O 4 nanoparticles cross-linked 与二维( 2D )多孔的碳 nanosheets (缩短的同样多孔的 MnCo 2 O 4/C nanosheets ),在哪个葡萄糖作为模板被用作碳来源和 NaCl 。获得的多孔的 MnCo 2 在场的 O 4/C nanosheets 互连的多孔的体系结构和一个大表面区域的联合性质(175.3 m 2( | Gengtao Fu Zhenyuan Liu Jingfei Zhang Jiayan Wu Lin Xu Dongmei Sun Jubing Zhang Yawen Tang Pei Chen | 2016 | Nano Research2016，9，7： | 7 |
| 5 | Characterization of atomic defects on the photoluminescence in two-dimensional materials using transmission electron microscope显示文摘Two-dimensional material(2D)that possesses atomic thin geometry and remarkable properties is a star material for the fundamental researches and advanced applications.Defects in 2D materials are critical and fundamental to understand the chemical,physical,and optical properties.Photoluminescence arises in 2D materials owing to various physical phenomena including activator/dopant-induced luminescence and defect-related emissions,and so forth.With the advanced transmission electron microscopy(TEM)technologies,such as aberration correction and low voltage technologies,the morphology,chemical compositions and electronic structures of defects in 2D material could be directly characterized at the atomic scale.In this review,we introduce the applications of state-of-the-art TEM technologies on the studies of the role of atomic defects in the photoluminescence characteristics in 2D material.The challenges in spatial and time resolution are also discussed.It is proved that TEM is a powerful tool to pinpoint the relationship between the defects and the photoluminescence characteristics. | Jiayan Zhang Ye Yu Peng Wang Chen Luo Xing Wu Ziqi Sun Jianlu Wang Wei Da Hu Guozhen Shen | 2019 | InfoMat2019，1，1： | 6 |
| 6 | Dendritic platinum-copper bimetallic nanoassemblies with tunable composition and structure: Arginine-driven self-assembly and enhanced electrocatalytic activity显示文摘 | Gengtao Fu Huimin Liu Nika You Jiayan Wu Dongmei Sun Lin Xu Yawen Tang Yu Chen | 2016 | Nano Research2016，9，3： | 6 |
| 7 | Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes(imPODs)显示文摘Glomerular podocytes are highly specialized epithelial cells and play an essential role in establishing the selective permeability of the glomerular filtration barrier of kidney.Maintaining the viability and structural integrity of podocytes is critical to the clinical management of glomerular diseases,which requires a thorough understanding of podocyte cell biology.As mature podocytes lose proliferative capacity,a conditionally SV40 mutant tsA58-immortalized mouse podocyte line(designated as tsPC)was established from the Immortomouse over 20 years ago.However,the utility of the tsPC cells is hampered by the practical inconvenience of culturing these cells.In this study,we establish a user-friendly and reversibly-immortalized mouse podocyte line(designated as imPOD),on the basis of the tsPC cells by stably expressing the wildtype SV40 T-antigen,which is flanked with FRT sites.We show the imPOD cells exhibit long-term high proliferative activity,which can be effectively reversed by FLP recombinase.The imPOD cells express most podocyte-related markers,including WT-1,Nephrin,Tubulin and Vinculin,but not differentiation marker Synaptopodin.The imPOD cells do not form tumor-like masses in vivo.We further demonstrate that TGFb1 induces a podocyte injury-like response in the FLP-reverted imPOD cells by suppressing the expression of slit diaphragm-associated proteins P-Cadherin and ZO-1 and upregulating the expression of mesenchymal markers,a-SMA,Vimentin and Nestin,as well as fibrogenic factors CTGF and Col1a1.Collectively,our results strongly demonstrate that the newly engineered im-POD cells should be a valuable tool to study podocyte biology both under normal and under pathological conditions. | Xinyi Yu Liqun Chen Ke Wu Shujuan Yan Ruyi Zhang Chen Zhao Zongyue Zeng Yi Shu Shifeng Huang Jiayan Lei Xiaojuan Ji Chengfu Yuan Linghuan Zhang Yixiao Feng Wei Liu Bo Huang Bo Zhang Wenping Luo Xi Wang Bo Liu Rex C.Haydon Hue H.Luu Tong-Chuan He Hua Gan | 2018 | Genes & Diseases2018，5，2： | 5 |
| 8 | Tolerance of Physocypria kraepelini (Crustacean, Ostracoda) to water-borne ammonia, phosphate and pH value显示文摘This study evaluated the median lethal concentration (LC50) and safe concentration of water-borne ammonia, phosphate and pH value on Physocypria kraepelini, a freshwater Ostracoda with a static renewal test system. The results indicated that the LC50 values of ammonia for P. kraepelini were 1026.71, 859.98, 771.79 and 583.82 mg/L at 24, 48, 72 and 96 h exposure, respectively, and the safe concentration range of ammonia for the long-term survival of P. kraepelini was less than 58.38 mg/L. The safe range of pH value for the survival of P. kraepelini was from 6.59 to 7.61. P. kraepelini has a high tolerance to ammonia, phosphate and pH value which are the main environmental factors in the serious eutrophication water. | YU Na, CHEN Shimei, LI Erchao, CHEN Jiayan, CHEN Liqiao School of Life Science, East China Normal University, Shanghai 200062, China | 2009 | Journal of Environmental Sciences2009，21，11： | 4 |
| 9 | Arginine-mediated synthesis of cube-like platinum nanoassemblies as efficient electrocatalysts显示文摘可控制高贵金属 nanocrystals 自己组装具有为高度活跃的 electrocatalysts 的发展的宽广兴趣。这里,我们与多孔的洞和不平的表面为像立方体的磅 nanoassemblies (Pt-CNAs ) 的产量很高的合成报导一条有效调停精氨酸的热水的途径基于零维的磅 nanocrystals 自己组装。在这进程,精氨酸充当在邻近的 nanocrystals 之间的 reductant,结构指导代理人,和连接器。有趣地, Pt-CNAs 展览单个水晶的结构与主导 { 100 } 方面由 X 光检查衍射证实了。把研究基于 electrocatalytic,同样综合的 Pt-CNAs 展览在甲醇氧化反应改进了 electrocatalytic 活动以及好稳定性和公司忍耐。Pt-CNAs 好表演被归因于他们的唯一的形态学和表面结构。我们相信这里构画出的合成策略能被递讲道理地设计的其它为在高效燃料房间的使用的一金属或二金属的 nanoassemblies。 | Gengtao Fu Qian Zhang Jiayan Wu Dongmei Sun Lin Xu Yawen Tang Yu Chen | 2015 | Nano Research2015，8，12： | 4 |
| 10 | CRISPR-Cas9-based genome-wide screening identified novel targets for treating sorafenib-resistant hepatocellular carcinoma:a cross-talk between FGF21 and the NRF2 pathway显示文摘The treatment of hepatocellular carcinoma(HCC)has been dominated by multikinase inhibitors for more than a decade.However,drug resistance can severely restrict the efficacy of these drugs.Using CRISPR/CAS9 genome library screening,we evaluated Kelch-like ECH-associated protein 1(KEAP1)as a key regulator of sorafenib’s susceptibility in HCC.We also investigated whether KEAP1’s knockdown can stabilize nuclear factor(erythroid-derived 2)-like 2(NRF2)protein levels that led to sorafenib’s resistance,including an NRF2 inhibitor that can synergize with sorafenib to abolish HCC’s growth in vitro and in vivo.Furthermore,we clarified that fibroblast growth factor 21(FGF21)is an important downstream regulator of NRF2 in HCC.Intriguingly,we observed that FGF21 bound to NRF2 through the C-terminus of FGF21,thereby stabilizing NRF2 by reducing its ubiquitination and generating a positive feedback loop in sorafenib-resistant HCC.These findings,therefore,propose that targeting FGF21 is a promising strategy to combat HCC sorafenib’s resistance. | Jiang Chen Shi Jiang Huijiang Shao Bixia Li Tong Ji Daniel Staiculescu Jiayan He Jie Zhao Liuxin Cai Xiao Liang Junjie Xu Xiujun Cai | 2022 | Science China(Life Sciences)2022，65，10： | 4 |
| 11 | The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs显示文摘While the human genome is pervasively transcribed,<2%of the human genome is transcribed into protein-coding mRNAs,leaving most of the transcripts as noncoding RNAs,such as microRNAs and long-noncoding RNAs(lncRNAs),which are critical components of epigenetic regulation.lncRNAs are emerging as critical regulators of gene expression and genomic stability.However,it remains largely unknown about how lncRNAs are regulated.Here,we develop a highly sensitive and dynamic reporter that allows us to identify and/or monitor negative modulators of lncRNA transcript levels in a high throughput fashion.Specifically,we engineer a fluorescent fusion protein by fusing three copies of the PEST destruction domain of mouse ornithine decarboxylase(MODC)to the C-terminal end of the codon-optimized bilirubin-inducible fluorescent protein,designated as dBiFP,and show that the dBiFP protein is highly destabilized,compared with the commonly-used eGFP protein.We further demonstrate that the dBiFP signal is effectively down-regulated when the dBiFP and mouse lncRNA H19 chimeric transcript is silenced by mouse H19-specific siRNAs.Therefore,our results strongly suggest that the dBiFP fusion protein may serve as a sensitive and dynamic transcript reporter to monitor the inhibition of lncRNAs by microRNAs,synthetic regulatory RNA molecules,RNA binding proteins,and/or small molecule inhibitors so that novel and efficacious inhibitors targeting the epigenetic circuit can be discovered to treat human diseases such as cancer and other chronic disorders. | Zongyue Zeng Bo Huang Shifeng Huang Ruyi Zhang Shujuan Yan Xinyi Yu Yi Shu Chen Zhao Jiayan Lei Wenwen Zhang Chao Yang Ke Wu Ying Wu Liping An Xiaojuan Ji Cheng Gong Chengfu Yuan Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Rex C.Haydon Hue H.Luu Lan Zhou Russell R.Reid Tong-Chuan He Xingye Wu | 2018 | Genes & Diseases2018，5，1： | 4 |
| 12 | Vascular endothelial growth factor induces multidrug resistance-associated protein 1 overexpression through phosphatidylinositol-3-kinase/protein kinase B signaling pathway and transcription factor specificity protein 1 in BGC823 cell line显示文摘Multidrug 抵抗(MDR ) 是化疗失败和癌复发的最重要的原因之一。但是 rolesof 在 MDR 遗体的联系 MDR 的蛋白质 MRP1 糟糕理解。脉管的 endothelial 生长因素(VEGF ) , themost 之一活跃、特定的脉管的生长因素,在增长,区别,和 metastasisof 癌症起一个重要作用。在 MRP1 的表示上探索 VEGF 的效果,我们使用了 recombinant 人 VEGF 刺激 K562 andBGC-823 房间线。量的即时聚合酶链反应和西方的污点分析证明在 mRNA 和蛋白质层次的 expressionof MRP1 被增加。3-(4,5-Dimethylthiazol-2-yl )-2,5-diphenyl tetrazolium 溴化物 resultsalso 证明 VEGF 显著地提高了与 adriamycin 对待的房间的 IC 50 。探索内在的规章的机制,我们构造了 MRP1 倡导者和 theluciferase 记者基因 recombinant 向量。,酶记者基因试金证明 MRP1 倡导者的活动被 VEGF 刺激显著地增加 LY294002, phosphatidylinositol-3-kinase (PI3K ) 的一个禁止者表明小径的 /proteinkinase B (Akt ) ,减少了这效果。抄写因素特性蛋白质 1 (SP1 ) 有约束力的地点 mutationpartially 由 VEGF 堵住了 MRP1 倡导者活动的起来规定。在摘要,我们的结果表明了 MRP1 的那 VEGF enhancedthe 表情,并且表明小径和 SP1 的 PI3K/Akt 可以涉及这调整。 | Juan Li Xiaojun Wu Jinling Gong Jing Yang Jiayan Leng Qiaoyun Chen Wenlin Xu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，8： | 2 |
| 13 | Combining mannose receptor mediated nanovaccines and gene regulated PD-L1 blockade for boosting cancer immunotherapy显示文摘Tumor nanovaccines have potential applications in the prevention and treatment of malignant tumors.However,it remains a longstanding challenge in exploiting efficient nanocarriers for inducing potent specifically cellular immune responses.Toward this objective,we herein explore an intensive tumor immunotherapeutic strategy by combining mannosylated nanovaccines and gene regulated PD-L1 blockade for immune stimulation and killing activity.Here,we fabricate a mannose modified PLL-RT(Man-PLL-RT)mediated nanovaccines with dendritic cells(DCs)targeting capacity.Man-PLL-RT is capable of co-encapsulating with antigen(ovalbumin,OVA)and adjuvant(unmethylated cytosine-phosphate-guanine,CpG)by electrostatic interaction.This positively charged Man-PLL-RT/OVA/CpG nanovaccines can facilitate the endocytosis,maturation and cross presentation in DCs.However,the nanovaccines arouse limited inhibition of tumor growth,which is mainly due to the immunosuppressed microenvironment of tumors.Combining tumor nanovaccines with gene regulated PD-L1 blockade leads to an obvious tumor remission in B16F10 melanoma bearing mice.The collaborative strategy provides essential insights to boost the benefits of tumor vaccines by regulating the checkpoint blockade with gene therapy. | Jie Chen Huapan Fang Yingying Hu Jiayan Wu Sijia Zhang Yuanji Feng Lin Lin Huayu Tian Xuesi Chen | 2022 | Bioactive Materials2022，7，1： | 2 |
| 14 | Supply-Demand Analysis of Urban Emergency Shelters Based on Spatiotemporal Population Estimation显示文摘Supply–demand analysis is an important part of the planning of urban emergency shelters.Using Pudong New Area,Shanghai,China as an example,this study estimated daytime and nighttime population of the study area based on fine-scale land use data,census data,statistical yearbook information,and Tencent user-density big data.An exponential function-based,probability density estimation method was used to analyze the spatial supply of and demand for shelters under an earthquake scenario.The results show that even if all potential available shelters are considered,they still cannot satisfy the demand of the existing population for evacuation and sheltering,especially in the northern region of Pudong,under both the daytime and the nighttime scenarios.The proposed method can reveal the spatiotemporal imbalance between shelter supply and demand.We also conducted a preliminary location selection analysis of shelters based on the supply–demand analysis results.The location selection results demonstrate the advantage of the proposed method.It can be applied to identify the areas where the supply of shelters is seriously inadequate,and provide effective decision support for the planning of urban emergency shelters. | Xiaodong Zhang Jia Yu Yun Chen Jiahong Wen Jiayan Chen Zhan'e Yin | 2020 | International Journal of Disaster Risk Science2020，11，4： | 2 |
| 15 | Evaluating the bioavailability of heavy metals in natural-zeoliteamended aquatic sediments using thin-film diffusive gradients显示文摘The effectiveness of natural zeolite amendment of sediments as a restorative material was studied,as was the feasibility of utilizing thin-film gradient diffusion(DGT)as a proxy for the accumulation of heavy metals in Venerupis philippinaram.The results showed that addition of natural zeolite to sediment,significantly decreased the equilibrium partitioning of Cu,Pb,Cd,Cr and As between the sediment pore water and natural zeolite over 24 h by 67%,81%,72%,62%and 71%,respectively.Furthermore,the accumulation of Cu,Pb,Cd,Cr and As in V.philippinaram in the zeolite-amended sediments decreased by 44%,37%,54%,30%and 59%,respectively after 28 days and the absorption rates also declined.The amount of heavy metals enriched into the DGT film and V.philippinaram over 28 days showed a significant correlation(P<0.001)and indicated that DGT has the potential as a proxy to predict the bioaccumulation of heavy metals in benthic organisms in sediments amended by natural zeolite.Further studies focused on the modification of natural zeolite and the predictive ability of DGT in different sediments/organism scenarios are warranted. | Juanying Li Chen Zhang Jianwei Lin Jie Yin Jiayan Xu Yiqin Chen | 2018 | Aquaculture and Fisheries2018，3，3： | 2 |
| 16 | High‑Performance Flexible Microneedle Array as a Low‑Impedance Surface Biopotential Dry Electrode for Wearable Electrophysiological Recording and Polysomnography显示文摘Microneedle array(MNA)electrodes are an effective solution to achieve high-quality surface biopotential recording without the coordination of conductive gel and are thus very suitable for long-term wearable applications.Existing schemes are limited by flexibility,biosafety,and manufacturing costs,which create large barriers for wider applications.Here,we present a novel flexible MNA electrode that can simultaneously achieve flexibility of the substrate to fit a curved body surface,robustness of microneedles to penetrate the skin without fracture,and a simplified process to allow mass production.The compatibility with wearable wireless systems and the short preparation time of the electrodes significantly improves the comfort and convenience of electrophysiological recording.The normalized electrode–skin contact impedance reaches 0.98 kΩcm^(2)at 1 kHz and 1.50 kΩcm^(2)at 10 Hz,a record low value compared to previous reports and approximately 1/250 of the standard electrodes.The morphology,biosafety,and electrical/mechanical properties are fully characterized,and wearable recordings with a high signal-to-noise ratio and low motion artifacts are realized.The first reported clinical study of microneedle electrodes for surface electrophysiological monitoring was conducted in tens of healthy and sleep-disordered subjects with 44 nights of recording(over 8 h per night),providing substantial evidence that the electrodes can be leveraged to substitute for clinical standard electrodes. | Junshi Li Yundong Ma Dong Huang Zhongyan Wang Zhitong Zhang Yingjie Ren Mengyue Hong Yufeng Chen Tingyu Li Xiaoyi Shi Lu Cao Jiayan Zhang Bingli Jiao Junhua Liu Hongqiang Sun Zhihong Li | 2022 | Nano-Micro Letters2022，14，8： | 1 |
| 17 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
| 18 | Understanding Communities in China and Europe: Similarities, Differences and Consequences for Socially Integrative Cities显示文摘One large challenge we face in achieving integrative and sustainable cities in China and Europe is to understand what is making people 'stick together' and care for their local communities.Only when we understand local communities better will it be possible to make improvements.In this paper we start by reviewing the way in which communities and community building have been understood in Europe and China respectively.The paper then goes on to assess the similarities and differences between China and Europe with respect to the role of communities and provides an overview of potential barriers and opportunities for achieving socially integrative cities through local community building and public engagement. | Chen Yulin Thea Marie Valler Liu Jiayan Liu Jian Marius Korsnes | 2019 | China City Planning Review2019，28，2： | 1 |
| 19 | PCDD/F, PAH and heavy metals in the sewage sludge from six wastewater treatment plants in Beijing, China显示文摘 | Jiayan Dai Muqi Xu Jiping Chen | 2007 | Chemosphere2007，66，： | 1 |
| 20 | Faster RCNN Target Detection Algorithm Integrating CBAM and FPN显示文摘Small targets and occluded targets will inevitably appear in the image during the shooting process due to the influence of angle,distance,complex scene,illumination intensity,and other factors.These targets have few effective pixels,few features,and no apparent features,which makes extracting their efficient features difficult and easily leads to false detection,missed detection,and repeated detection,affecting the performance of target detection models.An improved faster region convolutional neural network(RCNN)algorithm(CF-RCNN)integrating convolutional block attention module(CBAM)and feature pyramid networks(FPN)is proposed to improve the detection and recognition accuracy of small-size objects,occluded or truncated objects in complex scenes.Firstly,the CBAM mechanism is integrated into the feature extraction network to improve the detection ability of occluded or truncated objects.Secondly,the FPN-featured pyramid structure is introduced to obtain high-resolution and vital semantic data to enhance the detection effect of small-size objects.The experimental results show that the mean average precision of target detection of the improved algorithm on PASCAL VOC2012 is improved to 76.1%,which is 13.8 percentage points higher than that of the commonly used Faster RCNN and other algorithms.Furthermore,it is better than the commonly used small sample target detection algorithm. | Wenshun Sheng Xiongfeng Yu Jiayan Lin Xin Chen | 2023 | Computer Systems Science & Engineering2023，47，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员