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| 1 | Lignin Interaction with Cellulase during Enzymatic Hydrolysis显示文摘The conversion of lignocellulosic biomass into biofuels or biochemicals typically involves a pretreatment process followed by the enzyme-catalyzed hydrolysis of cellulose and hemicellulose components to fermentable sugars.Many factors can contribute to the recalcitrance of biomass,e.g.,the lignin content and structure,crystallinity of cellulose,degree of fiber polymerization,and hemicellulose content,among others.However,nonproductive binding between cellulase and lignin is the factor with the greatest impact on enzymatic hydrolysis.To reduce the nonproductive adsorption of enzymes on lignin and improve the efficiency of enzymatic hydrolysis,this review comprehensively summarized the progress that has been made in understanding the interactions between lignin and enzymes.Firstly,the effects of pretreatment techniques on lignin content and enzymatic hydrolysis were reviewed.The effects of lignin content and functional groups on enzymatic hydrolysis were then summarized.Methods for the preparation and characterization of lignin films were assessed.Finally,the methods applied to characterize the interactions between lignin and cellulase were reviewed,and methods for decreasing the nonproductive binding of enzymes to lignin were discussed.This review provides an overview of the current understanding of how lignin hinders the enzymatic hydrolysis of lignocellulosic biomass,and provides a theoretical basis for the development of more economical and effective methods and additives to reduce the interaction of lignin and enzymes to improve the efficiency of enzymatic hydrolysis. | Mingfu Li Qingtong Zhang Changzhou Chen Shuangfei Wang Douyong Min | 2019 | Paper And Biomaterials2019，4，4： | 12 |
| 2 | Serum semaphorin 4C as a diagnostic biomarker in breast cancer:A multicenter retrospective study显示文摘Background:To date,there is no approved blood-based biomarker for breast cancer detection.Herein,we aimed to assess semaphorin 4C(SEMA4C),a pivotal protein involved in breast cancer progression,as a serum diagnostic biomarker.Methods:We included 6,213 consecutive inpatients from Tongji Hospital,Qilu Hospital,and Hubei Cancer Hospital.Training cohort and two validation cohorts were introduced for diagnostic exploration and validation.A pan-cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid tumors.Breast cancer patients who underwent mass excision prior to modified radical mastectomy were also analyzed.We hypothesized that increased pretreatment serum SEMA4C levels,measured using optimized in-house enzymelinked immunosorbent assay kits,could detect breast cancer.The endpoints were diagnostic performance,including area under the receiver operating characteristic curve(AUC),sensitivity,and specificity.Post-surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM classification.There was no restriction on disease stage for eligibilities.Results:We included 2667 inpatients with breast lesions,2378 patients with other solid tumors,and 1168 healthy participants.Specifically,118 patients with breast cancer were diagnosed with stage 0(5.71%),620 with stage I(30.00%),966 with stage II(46.73%),217 with stage III(10.50%),and 8 with stage IV(0.39%).Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls(P<0.001).Elevated serum SEMA4C levels had AUC of 0.920(95%confidence interval[CI]:0.900–0.941)and 0.932(95%CI:0.911–0.953)for breast cancer detection in the two validation cohorts.The AUCs for detecting early-stage breast cancer(n=366)and ductal carcinoma in situ(n=85)were 0.931(95%CI:0.916–0.946)and 0.879(95%CI:0.832–0.925),respectively.Serum SEMA4C levels significantly decreased after surgery,and the reduction was more striking after modified radical mastectomy,compared with mass excision(P<0.001).The positive rate of enhanced serum SEMA4C levels was 84.77%for breast cancer and below 20.75%for the other 14 solid tumors.Conclusions:Serum SEMA4C demonstrated promising potential as a candidate biomarker for breast cancer diagnosis.However,validation in prospective settings and by other study groups is warranted. | Ya Wang Long Qiao Jie Yang Xiong Li Yaqi Duan Jiahao Liu Shaoqi Chen Huayi Li Dan Liu Tian Fang Jingjing Ma Xiaoting Li Fei Ye Junxiang Wan Juncheng Wei Qin Xu Ensong Guo Ping Jin Mingfu Wu Lin Zhang Yun Xia Yaqun Wu Jun Shao Yaojun Feng Qing Zhang Zongyuan Yang Gang Chen Qinghua Zhang Xingrui Li Shixuan Wang Junbo Hu Xiaoyun Wang Mona P.Tan Kazuaki Takabe Beihua Kong Qifeng Yang Ding Ma Qinglei Gao | 2021 | Cancer Communications2021，41，12： | 3 |
| 3 | Effects of Tightening Torque on Dynamic Characteristics of Low Pressure Rotors Connected by a Spline Coupling显示文摘A rotor dynamic model is built up for investigating the effects of tightening torque on dynamic characteristics of low pressure rotors connected by a spline coupling.The experimental rotor system is established using a fluted disk and a speed sensor which is applied in an actual aero engine for speed measurement.Through simulating calculation and experiments,the effects of tightening torque on the dynamic characteristics of the rotor system connected by a spline coupling including critical speeds,vibration modes and unbalance responses are analyzed.The results show that when increasing the tightening torque,the first two critical speeds and the amplitudes of unbalance response gradually increase in varying degrees while the vibration modes are essentially unchanged.In addition,changing axial and circumferential positions of the mass unbalance can lead to various amplitudes of unbalance response and even the rates of change. | Chen Xi Liao Mingfu Li Quankun | 2017 | Transactions of Nanjing University of Aeronautics and Astronautics2017，34，5： | 2 |
| 4 | Activities of hydrocolloids as inhibitors of acrylamide formation in model systems and fried potato strips显示文摘 | Xiaohui Zeng Ka-Wing Cheng Yegang Du Ricky Kong Clive Lo Ivan K. Chu Feng Chen Mingfu Wang | 2010 | Food Chemistry2010，，2： | 1 |
| 5 | Similar distribution of simple sequence repeats in diverse completed Human lmmunodeficiency Virus Type 1 genomes显示文摘 | Ming Chen Zhongyang Tan Jianhui Jiang Mingfu Li Hongjun Chen and Ruqin Yu | 2009 | Federation of European Biochemical Societies2009，583，： | 1 |
| 6 | Characterization of the cDNA encoding a BPI/LBP homologue in venom gland of the hundred-pace snake Deinagkistrodon acutus显示文摘Bactericidal/permeability-increasing protein(BPI)and LPS-binding protein(LBP)play an important role in host defence.Current evidence shows that BPI/LBP may be widely existed in different cells and tissue types of animals.A full-length cDNA clone encoding a BPI/LBP homologue(dBPI),1757 bp in size,was characterized in venom gland of the hundred-pace snake Deinagkistrodon acutus.Its deduced amino acid sequence of 417 residues had 13.8%-21.5% identity to BPI like 1(BPIL1)and BPI like 3(BPIL3)of other animals.Conserved cysteine residues which are involved in disulfide bond formation between the final strand of the N-terminal beta sheet and the long alpha helix of BPI are identified as Cys146-Cys183 of dBPI.Phylogenetic tree analysis showed that the BPI/LBP homologues formed five large clusters and dBPI was in a large cluster including BPIL1 and BPIL3.dBPI mRNA shows a tissue specific expression in venom gland.This is the first study to identify the cDNA encoding BPI/LBP homologues from reptiles. | Jianrao HU Mingfu CAO Jiong CHEN | 2009 | Current Zoology2009，55，5： | 1 |
| 7 | Wetting Transition in Cylindrical Alumina Nanopores with Polymer Melts显示文摘 | Mingfu Zhang Priyanka Dobriyal Jiun -Tai Chen | 2006 | Nano letters2006，6，6： | 1 |
| 8 | Wetting transition in cylindrical alumina nar opores with polymer melts显示文摘 | Zhang Mingfu Dobriyal P Chen Jiun-Tai | 2006 | Nano Letters2006，6，5： | 1 |
| 9 | HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19显示文摘Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)is a major pathological feature of Coronavirus Disease 2019(COVID-19)and a crucial determinant in COVID-19 prognosis.Understanding the mechanism underlying the SARS-CoV-2-induced cytokine storm is critical for COVID-19 control.Here,we identify that SARS-CoV-2 ORF3a and host hypoxia-inducible factor-1α(HIF-1α)play key roles in the virus infection and pro-inflammatory responses. | Mingfu Tian Weiyong Liu Xiang Li Peiyi Zhao Muhammad Adnan Shereen Chengliang Zhu Shanyu Huang Siyu Liu Xiao Yu Miaomiao Yue Pan Pan Wenbiao Wang Yongkui Li Xulin Chen Kailang Wu Zhen Luo Qiwei Zhang Jianguo Wu | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 10 | Antidiabetic activity of mung bean extracts in diabetic KK-Ay mice显示文摘 | YAO Yang CHEN Feng WANG Mingfu | 2008 | Journal of Agricultural and Food Chemistiy2008，56，19： | 1 |
| 11 | A Study of an Electronic Nose for Detection of Lung Cancer Based on a Virtual SAW Gas Sensors Array and Imaging Recognition Method显示文摘 | Chen Xing Cao Mingfu Li Yi Hu Weijun Wang Ping | 2005 | Meas Sci Technol2005，，16： | 1 |
| 12 | Inhibitory activities of dietary phenolic compounds on heterocyclic amine formation in both chemical model system and beef patties显示文摘 | CHENG K W CHEN Feng WANG Mingfu | 2007 | Molecular Nutrition and Food Research2007，51，8： | 1 |
| 13 | On the yield functions in Lagrangian stress space of elastic-plastic materials with internal constraints显示文摘在现在的纸,在第二 Piola Kirchhoff 的有弹性的范围强调空间能在通过 Lagrangian 压力空间的起源的一架亢奋的飞机被选择,这被显示出并且对在塑料配置歧管的限制的正常垂直,如果有有一些状况的简单内部限制的有弹性的塑料材料的确定的压力反应正确地被选择,不那样它是一般来说由 Il yushin 的家在亢奋的表面和正常流动统治要求将有不确定的部分。因为它的不确定,确定的压力反应的选择是可能的。因此因为有弹性的范围的几何中心一般来说在有弹性的范围内,收益功能应该是躺在亢奋的飞机的第二个 Piola Kirchhoff 压力的功能以便它是简单的更多和背压力。最后,一些例子被担心。 | Mingfu Fu Liangsen Chen | 2007 | Acta Mechanica Sinica2007，23，3： | 1 |
| 14 | Inhibition of acrylamide formation by vitamins in model reactions and fried potato strips显示文摘 | Xiaohui Zeng Ka-Wing Cheng Yue Jiang Zhi-Xiu Lin Jian-Jun Shi Shi-Yi Ou Feng Chen Mingfu Wang | 2009 | Food Chemistry2009，，1： | 1 |
| 15 | Inhibitory effects of microalgal extracts on the formation of advanced glycation endproducts (AGEs)显示文摘 | SUN Zheng WANG Mingfu CHEN Feng | 2010 | Food Chemistry2010，120，： | 1 |
| 16 | Antidiabetic activity ofmung bean extracts in diabetic KK-Ay mice显示文摘 | YAO Yang CHEN Feng WANG Mingfu | 2008 | Journal of Agriculturaland Food Chemistry2008，56，19： | 1 |
| 17 | 2,2-Diphenyl-1- picrylhydra-zyl radical-scavenging active components from Polygonum multiflorum Thunb显示文摘 | CHEN Yong WANG Mingfu ROSEN R T | 1999 | Journal of Agricultural and Food Chemistry1999，4，7： | 1 |
| 18 | Inhibitory activities of dietary phenolic compounds on heterocyclic amine formation in both chemical model system and beef patties显示文摘 | Cheng Ka-Wing Chen Feng Wang Mingfu | | 0，，： | 1 |
| 19 | Similar distribution of simple sequence repeats in diverse completed Human Immunodeficiency Virus Type 1 genomes显示文摘 | Ming Chen Zhongyang Tan Jianhui Jiang Mingfu Li Hongjun Chen Guoli Shen Ruqin Yu | 2009 | FEBS Letters2009，，17： | 1 |
| 20 | Wetting transition in cylindrical alumina nanopores with polymer melts显示文摘 | Zhang Mingfu Dobriyal P Chen Jiun-Tai | 2006 | Nano letters2006，6，6： | 1 |
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