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| 1 | Thermodynamic conditions of framework grain dissolution of clastic rocks and its application in Kela 2 gas field显示文摘Feldspar and clastic debris are the most important constituent framework grains of sedimentary clastic rocks and their chemical dissolution plays an essential role in the formation and evolution of the secondary pore in the reservoir rocks. On the basis of thermodynamic phase equilibrium, this study investigates the chemical equilibrium relationships between fluid and various plagioclase and K-feldspar in diagenesis of the sediments, particularly, the impact of temperature and fluid compositions (pH, activity of K+, Na+, Ca2+ and so on) on precipitation and dissolution equilibria of feldspars. Feldspar is extremely easily dissolved in the acid pore water with a low salinity when temperature decreases. The dissolution of anorthite end-member of plagioclase is related to the Ca content of the mineral and the fluid, higher Ca either in the mineral or in the fluid, easier dissolution of the feldspar. Moreover, the dissolution of albite end-member of plagioclase is related to Na of both the mineral and fluid, lower Na out of both the mineral and fluid, easier dissolution of the mineral. Similarly, lower-K fluid is more powerful to dissolve K-feldspar than the higher. The anorthite component of plagioclase is most easily dissolved in ground water-rock system, the albite is the secondary, and K-feldspar is the most stable. Selective dissolution of plagioclase occurs in diagenesis because of the plagioclase solid solution that is mainly composed of albite and anorthite end-members, Ca-rich part of which is preferentially dissolved by the pore water, in contrast to the Na-rich parts. Based on investigation of reservoir quality, secondary pore, dissolution structures of feldspar, clay minerals and ground water chemistry of the Kela 2 gas field of Kuqa Depression in the Tarim basin of Western China, we discovered that the secondary pore is very well developed in the highest quality section of the reservoir, and the plagioclase of which was obviously selectively dissolved, in contrast to the overgrowth of K-feldspar. Chemistry of the ground water out of the highest quality section of the reservoir is consistent with the complete dissolution field of anorthite, partial dissolution field of albite component of plagioclase, and the precipitation of K-feldspar on the temperature-logK phase equilibrium diagram drawn from this study. The thermodynamic modeling calculation gave us an insight into formation of the secondary pore within the reservoir, and the dissolution of plagioclase an important cause of the secondary pore. It is assumed that the solvent to dissolve the plagioclase frame grains originated from the origin-enriched compacted fluid acids out of the mudstone buried beneath the top of geopressured zones in the Kuqa Depression. | LAI Xingyun, YU Bingsong, CHEN Junyuan, CHEN Xiaolin, LIU Jianqing, MEI Mingxiang, JING Weiguang & CHENG Suhua School of Earth Sciences and Mineral Resources, China University of Geosciences, Beijing 100083, China Key Laboratory of Lithospheric Tectonics, Deep-level Process and Exploration of Ministry of Education, Beijing 100083, China | 2005 | Science China Earth Sciences2005，48，1： | 9 |
| 2 | Effects of grain size on phase transition behavior of nanocrystalline shape memory alloys显示文摘We report recent advances in the experimental and theoretical study of grain size(GS)effects on the thermal and mechanical properties of nanostructured NiTi polycrystalline shape memory alloy(SMA).It is shown that when GS<60 nm,the superelastic stress-strain hysteresis loop area(H)of the polycrystal decreases rapidly with GS and tends to vanish as GS approaches 10 nanometers.At the same time,the temperature dependence of the transition stress also decreases with GS and eventually approaches zero,leading to a wide superelastic temperature window and breakdown of the Clausius-Claperyon relationship.Rate dependence of the stress-strain responses is significantly reduced and the cyclic stability of the material is improved by the nanocrystallization.It is proposed that the emergence of such significant changes in the behavior of the material with GS reduction originate from the large increase in the area-to-volume ratios of the nanometer-thick interfaces(grain boundary and Austenite-Martensite(A-M)interface)in the polycrystal.In particular,with GS reduction,interfacial energy terms will gradually become dominant over the bulk energy of the crystallite,eventually bring fundamental changes in the phase transition responses of the material.Modelling strategy leading to the establishment of quantitative relationships among GS,grain boundary,A-M interfaces and the macroscopic responses of the material are outlined. | SUN QingPing ASLAN Ahadi LI MingPeng CHEN MingXiang | 2014 | Science China(Technological Sciences)2014，57，4： | 9 |
| 3 | Liraglutide alleviates cardiac fibrosis through inhibiting P4hα-1 expression in STZ-induced diabetic cardiomyopathy显示文摘Diabetic cardiomyopathy is an important contributor to morbidity and mortality of diabetic patients by causing heart failure.Interstitial and perivascular fibrosis plays a crucial role in diabetic cardiomyopathy.However,there is a lack of effective specific treatments available for diabetic cardiomyopathy.In the present study,we aim to explore the effects of Liraglutide,a GLP-1 analogue,on diabetic cardiomyopathy in STZ-induced diabetic rats fed with high-fat diet.A total of 60 male Wistar rats were randomly assigned to three groups,i.e.normal group,model group,and Liraglutide group,with 20 rats in each group.Serum levels of TC,TG,LDL-C,NEFA,and hydroxyproline were measured using commercial kits.Cardiac function was evaluated by QRS waves,LVEDd,LVESd,and LVEF.Myocardial fibrosis was measured by immunohistochemistry.Our results demonstrated that chronic administration of Liraglutide decreased the level of blood glucose and significantly alleviated lipid metabolic disturbance compared with the model group.Furthermore,Liraglutide was found to improve the damaged cardiac function.In line with this,we also found that the alleviation of cardiac dysfunction was associated with the decreased fibrosis in diabetic myocardial tissues,which was reflected by the decreased expressions of P4hα-1,COL-1,COL-3,MMP-1,and MMP-9.Our results thus suggest that Liraglutide might have a myocardial protective effect by inhibiting P4hα-1-mediated myocardial fibrosis. | Tong Zhao Huiqiang Chen Fei Xu Juan Wang Yusheng Liu Xiaowei Xing Linlin Guo Mingxiang Zhang Qinghua Lu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 9 |
| 4 | 3-year Treatment of Tenofovir Alafenamide vs.Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China显示文摘Background and Aims:Tenofovir alafenamide(TAF)has similar efficacy to tenofovir disoproxil fumarate(TDF)but with improved renal and bone safety in chronic hepatitis B patients studied outside of China.We report 3-year results from two phase 3 studies with TAF in China(Clinicaltrials.gov:NCT02836249 and NCT02836236).Methods:Chinese hepatitis B e antigen(HBeAg)-positive and-negative chronic hepatitis B patients with viremia and elevated alanine aminotransferase were randomized 2:1 to TAF or TDF treatment groups and treated in a double-blind fashion for 144 weeks(3 years).Efficacy responses were assessed by individual study while safety was assessed by a pooled analysis.Results:Of the 334 patients(180 HBeAg-positive and 154 HBeAg-negative)randomized and treated,baseline characteristics were similar between groups.The overall mean age was 38 years and 73%were male.The mean HBV DNA was 6.4 log10 IU/mL.The median alanine aminotransferase was 88 U/L,and 37%had a history of antiviral use.At week 144,the proportion with HBV DNA<29 IU/mL was similar among the two groups,with TAF at 83%vs.TDF at 79%,and TAF at 93%vs.TDF at 92%for the HBeAg-positive and-negative patients,respectively.In each study,higher proportions of TAF than TDF patients showed normalized alanine aminotransferase(via the American Association for the Study of Liver Diseases and the China criteria)and showed loss of HBsAg;meanwhile,the HBeAg seroconversion rates were similar.Treatment was well-tolerated among the TAF patients,who showed a smaller median decline in creatinine clearance(−0.4 vs.−3.2 mL/min;p=0.014)and less percentage change in bone mineral density vs.TDF at hip(−0.95%vs.−1.93%)and spine(+0.35%vs.−1.40%).Conclusions:In chronic hepatitis B patients from China,TAF treatment provided efficacy similar to TDF but with better renal and bone safety at 3 years. | Jinlin Hou Qin Ning Zhongping Duan You Chen Qing Xie Fu-Sheng Wang Lunli Zhang Shanming Wu Hong Tang Jun Li Feng Lin Yongfeng Yang Guozhong Gong John FFlaherty Anuj Gaggar Shuyuan Mo Cong Cheng Gregory Camus Chengwei Chen Yan Huang Jidong Jia Mingxiang Zhang GS-US-320-0110 and GS-US-320-0108 China Investigators | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 7 |
| 5 | From Basin Black Shales to Platform Carbonate Rocks:A Study on Sequence Stratigraphy for the Lower Cambrian of the Upper-Yangtze Region in South China显示文摘在 Upper-Yangtze 区域,特别在贵州省和它的邻近的区域,更低寒武纪很好被开发并且由从盆外形的黑页岩的继任是显著的焦化站台外形的岩石。从 Sinian 发生在拐弯到的站台的淹死的事件寒武纪导致了一套黑页岩,即 Niutitang 形成,它完成底部部分更低寒武纪。与沉积环境变浅,一套碳酸盐摇,即 Qingxudong 形成,在最高的部分被形成更低寒武纪。因此,更低在学习区域寒武纪使能进一步的一个秒顺序序列起来细分进五个第三顺序的序列,并且形成违反回归的定期周期的继任。为在秒顺序顺序的第三顺序的序列有一个定期垂直的叠模式。从底部到顶,继任“ CS (压缩的节)+HST (高看台的系统道) ”第三顺序的序列被变成继任“ TST (transgressive 系统道)+CS+HST' 。相应地,淹死类型顺序边界被变成暴露类型那条。因此,秒顺序和第三顺序的序列有类似的沉积外形的体系结构。有这些时间的变化的伴随物,更低与包含五个第三顺序的序列的 1000 m 的厚度寒武纪被变成不能与加深沉积环境向东南识别第三顺序的序列的压缩继任。根据第三顺序的序列的基本特征,即整齐 o 在空间和沉积环境的变化的同步性的沉积外形的继任及时,在在不同 paleogeographical 背景的主要的记载的节的第三顺序的序列的详细部门成为基础建立能在 stratigraphic 记录表明改变外形的表面的二种类型和 diachronism 的二种类型的 sequence-stratigraphic 框架。这个 sequence-stratigraphic 框架从盆外形的黑页岩形成的压缩继任的库显示出碳酸盐平台的成长进程。从 Sinian 在拐弯源于快速的违反到寒武纪生态的空间变得开,它形成了为“寒武纪的生物爆炸”设定的 paleogeographical 的先前的条件。最终,在 depositional 事件之间的基因关系和生物差异的事件是很复杂的并且在那里仍然是以后需要推进研究的大量问题。 | MEI Mingxiang MA Yongsheng ZHANG Hai MENG Xiaoqing CHEN Yonghong | 2007 | Acta Geologica Sinica(English Edition)2007，81，5： | 6 |
| 6 | Characteristics and Protection Approaches of Human Settlement in Ancient Villages of Jiangxi: A Case Study of Ancient Dongyuan Zengs' Village显示文摘Ancient village as a precious historical and cultural heritage of China is hailed as the 'eco-museum' of classical folk cultures and 'living fossil' of rural history culture. This paper elaborated human settlement characteristics of ancient Dongyuan Zengs' Village, Jinxi County from the perspectives of village environment, history evolution, village layout and village building, and explored the substantial content of village human settlement protection, and proposed specifi c approaches of protecting the human settlement, such as ancient village layout, history and culture, and provided references for protecting human settlement of the ancient villages. | CHENG Mingxiang CHEN Xiaogang HUANG Yuxi | 2015 | Journal of Landscape Research2015，7，3： | 4 |
| 7 | Materials Experiment on Tiangong-2 Space Laboratory显示文摘During the China's Tiangong-2(TG-2) flight mission, the experiments of 18 kinds of material samples were conducted in space by using a Multiple Materials Processing Furnace(MMPF) mounted in the orbital module of the TG-2 space laboratory. After the experiments of 12 kinds of samples of the first and second batches were completed successfully, astronauts packed and brought them back to the ground by ShenzhouII spacecraft. By studying processing and formation on semiconductor and optoelectronics materials, metal alloys and metastable materials, functional single-crystal, micro-and nano-composite materials encapsulated in sample ampoules both in space and on Earth, we expect to explore some physical and chemical processes and mechanism of the materials formation that are normally obscured and therefore are difficult to study quantitatively on the ground due to the gravity-induced convection, to obtain the processing and synthesis technology for preparing high quality materials, and lead to the improvement and development of materials processing techniques on Earth, and also develop the experiment device and comprehensive ability for materials experiment in microgravity environment. This report briefly introduces the main points of each research work and preliminary comparative analysis results of 12 samples carried out by scientists undertaking research task. | LI Xiangyang LU Ye MENG Xiangjian WANG Jianlu WANG Reng CHEN Lidong HUA Zile LI Xiaoya SHI Jianlin LIU Jinfeng XU Guisheng WEI Bingbo XIE Wenjun YIN Zhigang ZHANG Xingwang JIANG Hongxiang LI Hong LUO Xinghong ZHANG Haifeng ZHAO Jiuzhou WANG Binbin PAN Mingxiang | 2018 | 空间科学学报2018，38，5： | 4 |
| 8 | Study on localized induction heating for wafer level packaging显示文摘Micro-electro-mechanical systems(MEMS)are being developed as a new multi-disciplinary technology,which will undoubtedly have a revolutionary impact on the future of human life.However,with the development of MEMS technology,the packaging has become the main technical obstacle to the commercialization of MEMS.An approach to MEMS packaging by high-frequency electromagnetic induction heating at wafer level is presented in terms of numerical simulation and experimental study.The structure of inductor is firstly designed and optimized.Then the heating situation of PCB board is verified.The results indicate that the heat impact on the chip during the packaging process can be effectively reduced by local induction heating packaging,therefore the thermal stress on the chip is considerably lowered.This method can effectively improve the reliability of the MEMS devices. | XI YanYan 1,LUO XiaoBing 1,2,LIU WenMing 2,CHEN MingXiang 2 &LIU Sheng 2 1School of Energy and Power Engineering,Huazhong University of Science and Technology,Wuhan 430074,China 2MoEMS Division,Wuhan National Laboratory for Optoelectronics,Huazhong University of Science and Technology,Wuhan 430074,China | 2010 | Science China(Technological Sciences)2010，53，3： | 2 |
| 9 | Unique sandwich design of high-efficiency heat-conducting phosphor-in-glass film for high-quality laser-driven white lighting显示文摘Multi-color phosphor-in-glass(PiG)film has been considered as a promising color converter in high-quality laser lighting owing to its outstanding merits of phosphor versatility,tunable luminescence,and simple preparation.However,the opto-thermal properties of PiG film are severely affected by the photon reabsorption and backward scattering of phosphor structure and the heat conduction of substrate.Herein,a unique sandwich design of phosphor structure was introduced in the multi-color PiG film for high-quality laser lighting.By elaborately synthesizing the borosilicate glass with low glass transition temperature(T_(g)),similar expansion coefficient,and high refractive index(RI),the sandwiched PiGs were prepared by sintering(~600℃)broadband green and red phosphor glass films on the double sides of sapphire.The green and red PiG films were tightly coated on the sapphire with no delamination and maintained higher luminescence intensity than raw phosphors at high temperatures.By simultaneously coupling photon reabsorption and backward scattering,the sandwiched green PiG film-sapphire-red PiG film(G-S-R PiG)yields a high-quality white light with a high luminous efficacy of 163 lm/W and an excellent color rendering index(CRI)of 85.4 under a laser power of 2.4 W,which are the best comprehensive results yet reported.Benefiting from the ingenious sandwich design with heat-conducting sapphire and thin PiG films,the G-S-R PiG displays low working temperatures(<200℃)under high-power laser excitation.This work reveals the role of sandwiched phosphor structure in photon loss and heat dissipation,which provides a new strategy to design PiG films for high-quality laser lighting. | Yang PENG Zikang YU Jiuzhou ZHAO Qing WANG Jiaxin LIU Bo SUN Yun MOU Mingxiang CHEN | 2022 | Journal of Advanced Ceramics2022，11，12： | 2 |
| 10 | TXV Technology:The cornerstone of 3D system-in-packaging显示文摘System-in-packaging(Si P) can realize the integration and miniaturization of electronic devices and it is significant to continue Moore’s law.Through-X-via(TXV) technology is the cornerstone of 3 D-SiP,which enables the vertical stacking and electrical interconnection of electronic devices.TXV originated from through-hole(TH) in PCB substrates and evolved in different substrate materials,such as silicon,glass,ceramic,and polymer.This work provides a comprehensive review of four distinguishing TXV technologies(through silicon via(TSV),through glass via(TGV),through ceramic via(TCV),and through mold via(TMV)),including the fabrication mechanisms,processes,and applications.Every TXV technology has unique characteristics and owns particular processes and functions.The process methods,key technologies,application fields,and advantages and disadvantages of each TXV technology were discussed.The cutting-edge through-hole process and development direction were reviewed. | ZHAO HeRan CHEN MingXiang PENG Yang WANG Qing KANG Min CAO LiHua | 2022 | Science China(Technological Sciences)2022，65，9： | 1 |
| 11 | Preparation of a YAG : Ce Phosphor Glass by Screen-printing Technolo-gy and Its Application in LED Packaging显示文摘 | Yang Liang Chen Mingxiang Lv Zhicheng | 2013 | Optics Letters2013，38，13： | 1 |
| 12 | Research on Performances of Dry-ground Fine Cement for Grouting显示文摘 | Huang Zhichu Chen Mingxiang | 2002 | J Wuhan Uni of Tec(Material Science Edition)2002，17，3： | 1 |
| 13 | Sedimentary Facies Architectures of Third-Order Sequences from Early to Middle Triassic in Nanpanjiang Basin显示文摘There are complex and regular changes on sedimentary facies from the Early to the Middle Triassic in the Nanpanjiang basin. After the obvious drowned event of carbonate platforms in the transitional period between Permian and Triassic, carbonate platforms have evolved into the ramp type from the rimmed shelf type. The differentiation of sedimentary facies becomes clearer in space, which are marked by the changes from an attached platform to a turbidity basin and several isolated platforms in the basin. The striking characteristics are the development of oolitic banks on isolated platforms in Nanning and Jingxi and the reef and bank limestones in the margin of the attached platform in the Early Triassic. Despite the difference of the time span and the architecture of facies succession of third order sedimentary sequences, the process of the third order relative sea level changes reflected by the sedimentary facies succession of the third order sequences is generally synchronous. Therefore, six third order sequences could be discerned in the strata from the Early to the Middle Triassic in the Nanpanjiang basin. Using two types of facies changing surfaces and two types of diachronisms in stratigraphic records as the key elements, the sedimentary facies architectures of the third order sequences that represent sequence stratigraphic frameworks from the Early to the Middle Triassic in the Nanpanjiang basin could be constructed. | Mei Mingxiang Ma Yongsheng Deng Jun Gao Jinhan Chen Huijun Meng Qingfen Li Donghai Faculty of Earth Sciences and Resources, China University of Geosciences, Beijing 100083 | 2003 | Journal of China University of Geosciences2003，14，2： | 1 |
| 14 | Selective Induction Heating for Sensor Packaging显示文摘 | Chen Mingxiang Yi Xinjian Yuan Liulin | 2005 | Proceedings of 2005 ICEPT2005，，： | 1 |
| 15 | Research on Low-temperature Anodic Bonding Using Induction Heating显示文摘 | CHEN MINGXIANG YUAN LIULIN LIU SHENG | 2007 | Sensors and Actuators A2007，，133： | 1 |
| 16 | New‐onset diabetes after liver transplantation and its impact on complications and patient survival;肝移植后的新发糖尿病及其对并发症和预后的影响显示文摘 | Chaoyang Lv Yao Zhang Xianying Chen Xiaowu Huang Mengjuan Xue Qiman Sun Ting Wang Jing Liang Shunmei He Jian Gao Jian Zhou Mingxiang Yu Jia Fan Xin Gao | 2015 | Journal of Diabetes2015，，6： | 1 |
| 17 | Integrative Analysis of Genome,3D Genome,and Transcriptome Alterations of Clinical Lung Cancer Samples显示文摘Genomic studies of cancer cell alterations,such as mutations,copy number variations(CNVs),and translocations,greatly promote our understanding of the genesis and development of cancers.However,the 3D genome architecture of cancers remains less studied due to the complexity of cancer genomes and technical difficulties.To explore the 3D genome structure in clinical lung cancer,we performed Hi-C experiments using paired normal and tumor cells harvested from patients with lung cancer,combining with RNA sequenceing analysis.We demonstrated the feasibility of studying 3D genome of clinical lung cancer samples with a small number of cells(1×10^(4)),compared the genome architecture between clinical samples and cell lines of lung cancer,and identified conserved and changed spatial chromatin structures between normal and cancer samples.We also showed that Hi-C data can be used to infer CNVs and point mutations in cancer.By integrating those different types of cancer alterations,we showed significant associations between CNVs,3D genome,and gene expression.We propose that 3D genome mediates the effects of cancer genomic alterations on gene expression through altering regulatory chromatin structures.Our study highlights the importance of analyzing 3D genomes of clinical cancer samples in addition to cancer cell lines and provides an integrative genomic analysis pipeline for future larger-scale studies in lung cancer and other cancers. | Tingting Li Ruifeng Li Xuan Dong Lin Shi Miao Lin Ting Peng Pengze Wu Yuting Liu Xiaoting Li Xuheng He Xu Han Bin Kang Yinan Wang Zhiheng Liu Qing Chen Yue Shen Mingxiang Feng Xiangdong Wang Duojiao Wu Jian Wang Cheng Li | 2021 | Genomics, Proteomics & Bioinformatics2021，19，5： | 1 |
| 18 | Re- liability of anodically bonded silicon-glass packages 显示文摘 | Chen Mingxiang Yi Xinjian Gan Zhiyin | 2005 | Sensors and Actuators A: Physical2005，120，1： | 1 |
| 19 | Dynamical Simulation of Cornea Deformation in Laser Surgery显示文摘A dynamical simulation method is presented to model the cornea deformation in surgery of laser thermokeratoplasty. The virtual cornea is constructed as a mass-spring system. The corneal surface tension is simulated by damping spring stretch between mass points on the cornea model. The aqueous humor in the eyeball is modeled as ideal gas, and the intraocular pressure is simulated by gas pressure. The coagulation force is exerted on each photocoagulation spot to demonstrate its collapse caused by the condensation of corneal soft tissue irradiated by laser. An extra viscous drag force is added to each mass point to weaken the mass point oscillation. The use of the effective time-corrected Verlet integral method brings about flowing and stable dynamic simulation procedures. The simulation results show that, comparing to the undeformed model, the curvature of the region between the optical center and photocoagulation spot increases obviously. Moreover, the shape of the deformed virtual cornea is much similar to that of the real cornea after surgery. | GAO Mingxiang CHEN Dingfang YANG Yanfang | 2011 | Wuhan University Journal of Natural Sciences2011，16，4： | 0 |
| 20 | An anisotropic micromechamcal model for calculation of effective elastic moduli of Ni-based single crystal superalloys显示文摘An anisotropic micromechanical model based on Mori-Tanaka method is developed to calculate the effective elastic moduli | LI ShuangYu WU WenPing LI YunLi CHEN MingXiang | 2017 | Science China(Technological Sciences)2017，60，3： | 0 |
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