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| 1 | A laser light scattering study of the interaction between human serum albumin and ampicillin sodium显示文摘The complexes formed by the interaction of human serum albumin and ampicillin sodium in aqueous solutions were investigated at 25 ± 0.1℃, ionic strength I = 0.085 mol·kg-1, pH 4.9, 5.8 and 7.4. The results of static light scattering have suggested that at pH 7.4, 5.8, 4.9, the molecular weight of the protein/drug complexes is 210,000 g·mol-1, 418,000 g·mol-1, 448,000 g·mol-1, re- spectively. The z-average root-mean-square radius of gyration and the second virial coefficients de- crease with pH decreasing. Dynamic light scattering provides information on diffusion coefficient and particle distributions of protein/drug complexes under different conditions, which suggests a broad hydrodynamic diameter range of scatters. The diffusion coefficients of the systems change with am- picillin sodium concentration and pH changing. | WANG Weiping TANG Jianghong PENG Xuhong HU Zhide CHEN Xingguo | 2006 | Science China Chemistry2006，49，4： | 3 |
| 2 | Separation and simultaneous determination of tutin,puerarin,daidzein,esculin and esculetin in medicinal preparations by non-aqueous capillary显示文摘 | Cunhong Li Anjia Chen Xiaofeng Chen Xingguo Chen Zhide Hu | | 0，，： | 1 |
| 3 | Non-aqueous capillary electrophoresis for simultaneous separation and determination of three major active components in traditional medicinal preparations显示文摘 | Cunhong Li Jiyou Zhang Anjia Chen Jianping Xie Xingguo Chen Zhide Hu | | 0，，： | 1 |
| 4 | Non-aqueous capillary electrophoresis for separation and simultaneous determination of fraxin,esculin and esculetin in Cortex fraxini and its medicinal preparations显示文摘 | Cunhong Li Anjia Chen Xiaofeng Chen Xiao Ma Xingguo Chen Zhide Hu | | 0，，： | 1 |
| 5 | Quantification of noradrenaline and dopamine in Portulace oleracea L by capillary electrophoresis with laser-induced fluorescence detection显示文摘 | Jiyou Zhang Xingguo Chen Zhide Hu | 2002 | Analytica Chimica Acta2002，471，： | 1 |
| 6 | Binding study of diprophylline with lysozyme by spectroscopic methods显示文摘 | Weiping Wang Wenao Min Jianrong Chen Xiaohua Wu Zhide Hu | 2010 | Journal of Luminescence2010，，4： | 1 |
| 7 | Application of artificial neural network for determination of proteins with CPA - pl by Raleigh light scattering teachnique显示文摘 | DONG Lijun CHEN Xingguo HU Zhide | 2006 | Journal of Luminescence2006，124，1： | 1 |
| 8 | Interaction of isofraxidin with human serum albumin显示文摘 | Jiaqin Liu Jianniao Tian Xuan Tian Zhide Hu Xingguo Chen | 2003 | Bioorganic & Medicinal Chemistry2003，，2： | 1 |
| 9 | Study on the relation- ship between intake of trace elements and breast cancer mortality with chemometric methods 显示文摘 | Honglin Zhai Xingguo Chen Zhide Hu | 2003 | Computational Biology and Chemistry2003，27，6： | 1 |
| 10 | Binding of wogonin to human serum albumin: a common binding site of wogonin in subdomain IIA显示文摘 | Jianniao Tian Jiaqin Liu Jianping Xie Xiaojun Yao Zhide Hu Xinguo Chen | 2004 | Journal of Photochemistry & Photobiology, B: Biology2004，，1： | 1 |
| 11 | Determination of Micro Amounts of Palladium(Ⅱ) by Extraction Method without Usual Organic Solvents显示文摘 | Chen Xingguo Li Guanbin Hu Zhide | 1996 | Microchimica Acta1996，122，： | 1 |
| 12 | 显示文摘 | ZHANG Jiyou HU Zhide CHEN Xingguo | 2005 | Talanta2005，65，4： | 1 |
| 13 | High-performance liquid chromatographic method for simultaneous determination of honokiol and magnolol in rat plasma 显示文摘 | Wu Xinan Chen Xingguo Hu Zhide | 2003 | Talanta2003，59，1： | 1 |
| 14 | Determination of micro amounts of palladium(Ⅱ) by extraction method without usual organic solvents显示文摘 | Guanbin Li Zhide Hu | 1996 | Microchimica Acta1996，，122： | 1 |
| 15 | Interaction of magnolol with bovine serum albumin: a fluorescence-quenching study显示文摘 | Jiaqin Liu Jian-niao Tian Jiyou Zhang Zhide Hu Xingguo Chen | 2003 | Analytical and Bioanalytical Chemistry2003，，6： | 1 |
| 16 | Pd@Ir-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy显示文摘Lactic acid(LA)plays a major role in the occurrence,development,and spread of cancer.Enlightened by its high accumulation in tumor site,a novel lactate oxidase(LOD)conjugated two-dimensional Pd@Ir nanoplatform(Pd@Ir-LOD,PIL)was fabricated to combine cascade reaction with photothermal for tumor therapy.In detail,the overexpressed LA in tumor microenvironment(TME)was a key factor to activate the PIL-based cascade reaction:(1)Plenty of H_(2)O_(2)could be generated from LA by the catalysis of LOD with O_(2);(2)potent·OH was produced from H_(2)O_(2)due to the peroxidase(POD)-like activity of PIL;(3)meantime,PIL’s catalase(CAT)-like activity could decompose part H_(2)O_(2)into O_(2)to achieve the purpose of LA cyclic oxidization.Moreover,the reduced glutathione(GSH)scavenging capability of PIL might protect the produced reactive oxygen species(ROS)from being cleared to further improve the cascade therapeutic effect.More importantly,PIL had excellent photothermal conversion efficiency(37.35%)and manifested a surprising temperature rising effect in tumor.Taken together,the decreasing LA concentration,accumulation of high-toxic ROS,the depletion of GSH together with the higher intra-tumoral temperature potently enhanced in vivo antitumor therapy.Therefore,a promising therapeutic tactic based on PIL integrating endogenous LA consumption,chemodynamic therapy(CDT),and photothermal therapy(PTT)has been put forward. | Zichen Ye Yun Li Jingchao Li Xinyan Hu Jinyang Zheng Gongxin Zhang Sijin Xiang Tianbao Zhu Zhide Guo Xiaolan Chen | 2024 | Nano Research2024，17，1： | 0 |
| 17 | Insurance ratemaking method for risk of construction diversion project显示文摘Based on analyzing risk factors of diversion project,synthetic risk rate and engineering insurance period,the frequency and distribution law of loss are researched on the grounds that foundation pit is submerged after diversion project ceases to be effective.And then,the standpoint that these total loss is subject to non-homogeneous compound Poisson processes is put forward.Furthermore,the collective risk model of the total loss about engineering insurance is established on the basis of construction diversion project risk.Ultimately,insurance ratemaking method for construction engineering risk and its mathematical expression are presented,which provides theoretical method for the insurance ratemaking of hydropower engineering to some extent. | Chen Zhiding Hu Zhigen | 2012 | Engineering Sciences2012，10，2： | 0 |
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