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| 1 | Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft显示文摘Polyphyllin 我(PPI ) ,从巴黎 polyphyllin 的根茎提取的小分子的单体,在以前的学习显示出强壮的 anticancer 效果。人的肺腺癌 A549 房间,人的肺有鳞的房间癌 SK-MES-1 房间,和人的肺大房间癌 H460 房间与 PPI 有教养然后对待。房间增长和 apoptosis 被 3- 测量[4,5-dimethylthiazol-2-yl ]-2,5-diphenyltetrazolium 溴化物试金,流动 cytometry,西方的污点分析,和 DNA 梯子。Athymic 裸体老鼠适用肿瘤与 PPI 被注射,并且肿瘤生长被记录。我们的结果证明 PPI 显著地禁止了房间衬里的三非小的房间肺癌症(NSCLC ) 的增长,与为 A549, H460,和 SK-MES-1 的 1.24, 2.40,和 2.33 g/ml 的禁止的集中(IC50 ) 房间分别地。在为 24 h 与 PPI 的 2.5 g/ml 被对待以后, A549 房间的 apoptotic 率是 39.68% ,它比控制的显著地高。肿瘤生长显著地与在裸体老鼠与 cisplatin (DDP ) 或 PBS 对待的组相比在对待 PPI 的组被禁止。在在 vitro 并且在 vivo 的 NSCLC 房间的 PPI 展览 antitumor 能力,它可能与 apoptosis 有关由 PPI 导致了。 | Minjian Kong Junqiang Fan Aiqiang Dong Haifeng Cheng Rongzhen Xu | 2010 | Acta Biochimica et Biophysica Sinica2010，42，11： | 15 |
| 2 | Regional gas drainage techniques in Chinese coal mines显示文摘China's rapid economic development has increased the demand for coal.These results in Chinese coal mines being extended to deeper levels.The eastern Chinese,more economical developed,regions have a long history of coal mining and many coal mines have now started deep mining at a depth from 800 to 1500 m.This increase in mining depth,geostresses,pressures,and gas content of the coal seam complicates geologic construction conditions.Lower permeability and softer coal contribute to increasing numbers of coal and gas outburst,and gas explosion,disasters.A search on effective methods of preventing gas disasters has been provided funds from the Chinese government since 1998.The National Engineering Research Center of Coal Gas Control and the Huainan and Huaibei Mining Group have conducted theoretical and experimental research on a regional gas extraction technology.The results included two important findings.First,grouped coal seams allow adoption of a method where a first,key protective layer is mined to protect upper and lower coal seams by increasing permeability from 400 to 3000 times.Desorption of gas and gas extraction in the protected coal seam of up to 60%,or more,may be achieved in this way.Second,a single seam may be protected by using a dense network of extraction boreholes consisting of cross and along-bed holes.Combined with this is increased use of water that increases extraction of coal seam gas by up to 50%.Engineering practice showed that regional gas drainage technology eliminates regional coal and gas outburst and also enables mining under low gas conditions.These research results have been adopted into the national safety codes of production technology.This paper systematically introduces the principles of the technology,the engineering methods and techniques,and the parameters of regional gas drainage.Engineering applications are discussed. | Wang Haifeng Cheng Yuanping Wang Lei | 2012 | International Journal of Mining Science and Technology2012，22，6： | 13 |
| 3 | Genome Characteristics and Evolution of Pseudorabies Virus Strains in Eastern China from 2017 to 2019显示文摘Since late 2011,outbreaks of pseudorabies virus(PRV)have occurred in southern China causing major economic losses to the pig industry.We previously reported that variant PRV forms and recombination in China could be the source of continued epidemics.Here,we analyzed samples from intensive pig farms in eastern China between 2017 and 2019,and sequenced the main glycoproteins(gB,gC,gD,and gE)to study the evolution characteristics of PRV.Based on the gC gene,we found that PRV variants belong to clade 2 and detected a founder effect during by the PRV epidemic.In addition,we detected inter-and intra-clade recombination;in particular,inter-clade recombination in the gB genes of strains FJ-ZXF and FJ-W2,which were recombinant with clade 1 strains.We also found specific amino-acid changes and positively selected sites,possibly associated with functional changes.This analysis of the emergence of PRV in China illustrates the need for continuous monitoring and the development of vaccines against specific variants of PRV. | Xiaofeng Zhai Wen Zhao Kemang Li Cheng Zhang Congcong Wang Shuo Su Jiyong Zhou Jing Lei Gang Xing Haifeng Sun Zhiyu Shi Jinyan Gu | 2019 | Virologica Sinica2019，34，6： | 12 |
| 4 | Oxidation Behavior of C/C-SiC Gradient Matrix Composites显示文摘Oxidation behavior of C/C-SiC gradient matrix composites and C/C composites were compared in stationary air. The results show that oxidation threshold of C-SiC materials increases with the amount of SiC particles in the codeposition matrix. Oxidation rate of C/C-SiC gradient matrix composites is significantly lower than that of C/C material. The micro-oxidation process was observed by SEM. | Jingyi DENG, Wenchuan LIU, Haifeng DU, Huiming CHENG and Yiyi LI Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China | 2001 | Journal of Materials Science & Technology2001，17，5： | 6 |
| 5 | Similarity model tests of movement and deformation of coal-rock mass below stopes显示文摘For a study of the movement and deformation of coal-rock mass and low protected seams below a stope,as well as for fracture developments and rules of evolution of permeability,we designed a plane strain model test stand to carry out model tests of similar materials in order to improve the effect of gas drainage from low protected seams and to measure the movement and deformation of coal-rock mass using a method of non-contact close-range photogrammetry.Our results show that 1) using paraffin melting to take the place of coal seam mining can satisfy the mining conditions of a protective seam;2) coal-rock mass under goafs has an upward movement after the protective seam has been mined,causing floor heaving;3) low protected seams become swollen and deformed,providing a good pressure-relief effect and causing the coal-rock mass under both sides of coal pillars to become deformed by compression and 4) the evolution of permeability of low protected seams follows the way of initial values→a slight decrease→a great increase→stability→final decrease.Simultaneously,the coefficient of air permeability increased at a decreasing rate with an increase in interlayer spacing. | WANG, Haifeng CHENG, Yuanping YUAN, Liang WANG, Liang | 2010 | Mining Science and Technology2010，20，2： | 6 |
| 6 | Anlotinib as third- or further-line therapy for short-term relapsed small-cell lung cancer: subgroup analysis of a randomized phase 2 study (ALTER1202)显示文摘Patients with small-cell lung cancer (SCLC) relapse within months after completing previous therapies. This study aimed to investigate the efficacy and safety of anlotinib as third- or further-line therapy in patients with short-term relapsed SCLC from ALTER1202. Patients with short-term relapsed SCLC (disease progression within 3 months after completing ≥ two lines of chemotherapy) in the anlotinib (n = 67) and placebo (n = 34) groups were analyzed. The primary endpoint was progression-free survival (PFS). The secondary endpoints included overall survival, objective response rate (ORR), disease control rate, and safety. Anlotinib significantly improved median PFS/OS (4.0 vs. 0.7 months, P < 0.0001)/(7.3 vs. 4.4 months, P = 0.006) compared with placebo. The ORR was 4.5%/2.9% in the anlotinib/placebo group (P = 1.000). The DCR in the anlotinib group was higher than that in the placebo group (73.1% vs. 11.8%, P < 0.001). The most common adverse events (AEs) were hypertension (38.8%), loss of appetite (28.4%), and fatigue (22.4%) in the anlotinib group and gamma-glutamyl transpeptidase elevation (20.6%) in the placebo group. No grade 5 AEs occurred. For patients with short-term relapsed SCLC, third- or further-line anlotinib treatment was associated with improved survival benefit. Further studies are warranted in this regard. | Jianhua Shi Ying Cheng Qiming Wang Kai Li Lin Wu Baohui Han Gongyan Chen Jianxing He Jie Wang Haifeng Qin Xiaoling Li | 2022 | Frontiers of Medicine2022，16，5： | 5 |
| 7 | Prediction method for risks of coal and gas outbursts based on spatial chaos theory using gas desorption index of drill cuttings显示文摘Based on the evolution of geological dynamics and spatial chaos theory, we proposed the advanced prediction an advanced prediction method of a gas desorption index of drill cuttings to predict coal and gas outbursts. We investigated and verified the prediction method by a spatial series data of a gas desorption index of drill cuttings obtained from the II3112 coal roadway at the Shitai Mine. Our experimental results show that the spatial distribution of the gas desorption index of drill cuttings has some chaotic characteristics, which implies that the risk of coal and gas outbursts can be predicted by spatial chaos theory. We also found that a proper amount of sample data needs to be chosen in order to ensure the accuracy and practical maneuverability of prediction. The relative prediction error is small when the prediction pace is chosen carefully. In our experiments, it turned out that the optimum number of sample points is 80 and the optimum prediction pace 30. The corresponding advanced prediction pace basically meets the requirements of engineering applications. | Li Dingqi Cheng Yuanping Wang Lei Wang Haifeng Wang Liang Zhou Hongxing | 2011 | Mining Science and Technology2011，21，3： | 5 |
| 8 | Cryo-self-assembled silk fibroin sponge as a biodegradable platform for enzyme-responsive delivery of exosomes显示文摘Although advances in protein assembly preparation have provided a new platform for drug delivery during tissue engineering,achieving long-term controlled exosome delivery remains a significant challenge.Diffusion-dominated exosome release using protein hydrogels results in burst release of exosomes.Here,a fibroin-based cryo-sponge was developed to provide controlled exosome release.Fibroin chains can self-assemble into silk I structures under ice-cold conditions when annealed above the glass transition temperature.Exosome release is enzyme-responsive,with rates primarily determined by enzymatic degradation of the scaffolds.In vivo experiments have demonstrated that exosomes remain in undigested sponge material for two months,superior to their retention in fibrin glue,a commonly used biomaterial in clinical practice.Fibroin cryo-sponges were implanted subcutaneously in nude mice.The exosome-containing sponge group exhibited better neovascularization and tissue ingrowth effects,demonstrating the efficacy of this exosome-encapsulating strategy by realizing sustained release and maintaining exosome bioactivity.These silk fibroin cryo-sponges containing exosomes provide a new platform for future studies of exosome therapy. | Muyang Sun Qi Li Huilei Yu Jin Cheng Nier Wu Weili Shi Fengyuan Zhao Zhenxing Shao Qingyang Meng Haifeng Chen Xiaoqing Hu Yingfang Ao | 2022 | Bioactive Materials2022，7，2： | 4 |
| 9 | Knockdown of insulin-like growth factor 1 receptor enhances chemosensitivity to cisplatin in human lung adenocarcinoma A549 cells显示文摘RNA 调停干扰的像胰岛素的生长的效果响应在在 vivo 并且在 vitro 的肺癌症房间线 A549 的 cisplatin (DDP ) 的因素 1 受体(IGF1R ) 基因 silencing 用表示短发卡 RNA (shRNA ) 到 IGF1R 的二个原生质标志被调查。A549 房间是有表示每 shRNA 的原生质标志的 transfected 然后与 DDP 对待。半量的反向的 transcription-PCR 和蛋白质印迹分析被用来检测 IGF1R 的表示。在 athymic 裸体人老鼠的 MTT 试金,流动 cytometry 和肿瘤生长试金被用来估计 chemosensitivity 到 DDP 后面的 IGF1R 击倒。我们的数据证明有 shRNA 的 A549 房间的转染在蛋白质水平在 mRNA 水平并且在 89.8% 在 78.9% 导致了 IGF1R 的特定的 silencing。IGF1R 的下面规定显著地提高了房间敏感到 DDP,减少在在 24 h, 48 h 和 72 h 的 A549 房间的 DDP 的 IC50,并且在 G (0 )/G (1 ) 保留了 77.5% A549 房间阶段。而且,在有 DDP 处理的联合的 IGF1R 的调停 shRNA 的 silencing 在超过 60% 在尺寸和重量提高了肿瘤生长的抑制并且增加了 apoptosis 超过 75% 什么时候与在 vivo 的控制相比。由 shRNA 的 IGF1R 基因表达的抑制在 vitro 并且在 vivo 提高 A549 房间的 chemosensitivity 到 DDP,显示象为在治疗肺癌症的基因治疗的一个方法的 RNA 干扰的治疗学的潜力。 | Aiqiang Dong Minjian Kong Zhiyuan Ma Jianfang Qian Haifeng Cheng Xiaohong Xu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 4 |
| 10 | 北斗导航系统卫星激光测距综述显示文摘Satellite laser ranging(SLR)is an unambiguous measurement technique and generates high accuracy satellite orbit data.All satellites in the BeiDou navigation satellite system(BDS)carried laser retro-reflector arrays(LRAs),so they can be tracked by ground SLR stations in order to provide the accurate observation data.The Shanghai astronomical observatory(SHAO)designed the LRAs,and also developed the dedicated SLR systems using a 1 m-aperture telescope and a transportable cabin-based SLR system with a telescopes of 60 cm aperture.These enable BDS satellite ranging during daytime and nighttime with centimeter-level precision,allowing highly accurate estimations of satellite orbits.Moreover,some of the BDS satellites are also equipped with laser time transfer(LTT)payloads,which were developed by the SHAO and China Academy of Space Technology(CAST),providing a highly accurate time comparison between the satellites and ground clocks.This paper describes the dedicated SLR system and the design of the LRAs for BDS satellites,as well as global SLR measurements.The SLR tracking data is used for evaluating the orbit accuracy of BDS satellites and broadcast ephemeris,with an accuracy of less than 1 m.The LTT measurements to BDS satellites for a single shot have a precision of approximately 300 picoseconds,with a time stability of 20 picoseconds in 500 s. | ZHANG Haifeng LONG Mingliang YANG Huafeng MENG Wendong CHENG Zhi’en DENG Huarong ZHANG Zhongping ZHANG A’li | 2020 | Aerospace China2020，21，4： | 4 |
| 11 | Effects of Exogenous 5-Aminolevulinic Acid and 24-Epibrassinolide on Cd Accumulation in Rice from Cd-Contaminated Soil显示文摘High grain-Cd-accumulating rice variety Yongyou 9 was planted in Cd-contaminated farmland in Taizhou City, Zhejiang Province, China to study the effects of 5-aminolevulinic acid(ALA) and24-epibrassinolide(EBR) on Cd accumulation in brown rice. Results showed that the exogenous ALA and EBR had no significant effects on agronomic traits, soil pH and total Cd content in soil, but had some effects on the available Cd content in soil, and significantly influenced the Cd accumulation in the different parts of rice. Results also showed that 100 mg/L exogenous ALA significantly reduced the Cd accumulation in brown rice to blow the food safety standard(0.2 mg/kg), and also significantly reduced the Cd contents in the roots and culm of rice. However, 200 mg/L exogenous ALA treatment increased the Cd content in brown rice remarkably. In addition, 0.15 mg/L EBR treatment increased Cd accumulation in roots, culm, leaves and brown rice notably, whereas 0.30 mg/L exogenous EBR treatment reduced the Cd accumulation in brown rice properly, but it was not significant. Therefore,proper concentration of ALA can effectively reduce the Cd accumulation in brown rice, which can be used as an effective technical method for the safe production of rice in Cd polluted farmland. | WANG Feijuan ZHANG Yiting GUO Qinxin TAN Haifeng HAN Jiahui LIN Haoran WEI Hewen XU Guangwei ZHU Cheng | 2018 | Rice science2018，25，6： | 3 |
| 12 | Dynamic Tensile Property of Zr-based Metallic Glass/Porous W Phase Composite显示文摘The dynamic tensile deformation and fracture behavior of the Zr-based metallic glass/porous W phase composite were investigated at room temperature by means of the Split Hopkinson Tension Bar (SHTB).It was found that the composite exhibited no appreciable macroscopic plastic deformation prior to catastrophic fracture and the fracture surface was perpendicular to the axial direction.Substantive micro cracks were observed along the interface between W grains or the interface between the metallic glass phase and the W phase.Scanning electron microscopy (SEM) observations revealed that vein-like patterns,dimple-like patterns and substantive ridge-like structures were the typical fracture morphologies on the fracture surface for the metallic glass phase and the morphology of the W phase is a mixture of intergranular and transgranular fracture.Based on those results referred above,the dynamic tensile deformation and fracture mechanism of the Zr-based metallic glass/porous W phase composite were discussed in detail. | Yunfei Xue Lu Wang Huanwu Cheng Fuchi Wang Haifeng Zhang Aiming Wang | 2010 | Journal of Materials Science & Technology2010，26，10： | 2 |
| 13 | Mg AmorphousZr_(0.9)Ti_(0.1)(Ni_(0.57)Mn_(0.28)V_(0.1)Co_(0.05))_(2.1)Composite for Hydrogen Storage显示文摘The reactive mechanical alloying (RMA) method was used to produce Mg-40 wt pct amorphous Zr0.9Ti0.1(Ni0.57-Mn0.25V0.1Co0.05)2.1 composite in this study, and the absorption/desorption property of the composite was improved remarkably. The composite possessed excellent kinetic properties even at moderate temperature (393 K) without activation. Owing to the formation of the embrittle MgH2, the reactive mechanical milling process reduced the particle size of Mg and made the composite phase being highly efficiently distributed, which determined the excellent hydriding properties of the composite. | Haiyan LENG, Demin CHEN, Manqi LU, Haifeng ZHANG, Huiming CHENG and Ke YANGInstitute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China | 2003 | Journal of Materials Science & Technology2003，19，2： | 2 |
| 14 | Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-[beta]-like signaling pathway显示文摘 | Ding Lihua Wang Zhaoyun Yan Jinghua Yang Xiao Liu Aijun Qiu Weiyi Zhu Jianhua Han Juqiang Zhang Hao Lin Jing Cheng Long Qin Xi Niu Chang Yuan Bin Wang Xiaohui Zhu Cui Zhou Yan Li Jiezhi Song Haifeng Huang Cuifen Ye Qinong | 2009 | Journal of Clinical Investigation2009，，2： | 1 |
| 15 | 显示文摘 | Yang Yueping Xu Xinhua Cheng Haifeng | 2004 | Journal of Zhejiang University (SCIENCE)2004，5，4： | 1 |
| 16 | Programmable metallization cells based on amorphous La 0.79 Sr 0.21 MnO 3 thin films for memory applications显示文摘 | Dongqing Liu Nannan Wang Guang Wang Zhengzheng Shao Xuan Zhu Chaoyang Zhang Haifeng Cheng | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 17 | Effect of carbonization time on the structure and electromagnetic parameters of porous-hollow carbon fibres 显示文摘 | Wei Xie Cheng Haifeng Chu Zengyong | 2009 | Ceramics International2009，35，7： | 1 |
| 18 | SnS_2 nanosheets arrays sandwiched by N-doped carbon and TiO_2 for high-performance Na-ion storage显示文摘In this paper, SnS_2 nanosheets arrays sandwiched by porous N-doped carbon and TiO_2(TiO_2@SnS_2@N-C) on flexible carbon cloth are prepared and tested as a free-standing anode for high-performance sodium ion batteries. The as-obtained TiO_2@SnS_2@N-C composite delivers a remarkable capacity performance(840 mA h g^(-1) at a current density of 200 mA g^(-1)), excellent rate capability and long-cycling life stability(293 mA h g^(-1) at 1 A g^(-1) after 600 cycles). The excellent electrochemical performance can be attributed to the synergistic effect of each component of the unique hybrid structure, in which the SnS_2 nanosheets with open framworks offer high capacity, while the porous N-doped carbon nanoplates arrays on flexible carbon cloth are able to improve the conductivity and the TiO_2 passivation layer can keep the structure integrity of SnS_2 nanosheets. | Weina Ren Haifeng Zhang Cao Guan Chuanwei Cheng | 2018 | Green Energy & Environment2018，3，1： | 1 |
| 19 | Vasorelaxant effect of osthole on isolated thoracic aortic rings in rats显示文摘OBJECTIVE: To investigate the effect of osthole on isolated thoracic aortic rings, and to determine the potential mechanism of action.METHODS: Thoracic aortas were isolated from Wistar rats, and were suspended in tissue organ chambers for vascular tension measurement. The effect of cumulative osthole(10-9, 10-8, 10-7, 10-6, and 10-5 mol/L) on endothelium-intact and endothelium-denuded thoracic aortic rings pre-contracted with phenylephrine(PE, 10-6 mol/L) or KCl(6 × 10-2 mol/L) was recorded. Histomorphological changes of thoracic aorta were analyzed by hematoxylin-eosin. The effects of different osthole concentrations on endothelium-intact aortic rings, which were pre-inhibited with the non-selective nitric oxide synthase inhibitor L-Arg(NO2)-OMe·HCl(3 × 10-4 mol/L), endothelium-derived nitric oxide synthase inhibitor Nω-nitro-L-arginine(3 × 10-4 mol/L), guanylate cyclase inhibitor 1 H-[1,2,4] oxadiazolo [4,3-α]quinoxaline-1-one(10-5 mol/L), cyclooxygenase inhibitor indometacin(10-5 mol/L), and the Ca2+-activated potassium channel inhibitor tetraethylammonium nitrate(10-5 mol/L), and then contracted with PE, were examined. Aortic rings incubated with osthole(10-5 mol/L), phentolamine(10-5 mol/L), or verapamil(10-5 mol/L) in Ca2+-free Krebs-Henseleit solution(KHS) were stimulated with PE or KCl.RESULTS: There was a dose-dependent increase in vasorelaxation of isolated thoracic aortic rings(both with and without endothelium) with increasing osthole concentration. Hematoxylin-eosin staining showed that osthole significantly improved thoracic aorta ring morphology. Compared with the control group, there were also significant differences after incubation with L-Arg(NO2)-OMe ω-nitro-L-arginine, and 1 H-[1,2,4] oxadiazo·lo HCl,N [4,3-α] quinoxaline-1-one(P < 0.05 for all). The relaxation rate of the rings in the osthole group incubated with indometacin and tetraethylammonium nitrate were similar to controls. In Ca2+-free KHS, the PE-induced contraction was similar between the osthole(4.37% ± 0.41%) and control(4.21% ± 1.33%)groups. However, after cumulative CaCl2(0.5, 1, 1.5,2, 2.5, and 3 mmol/L), the Ca2+-induced contraction was significantly inhibited in the osthole and phentolamine groups compared with controls(P < 0.05).After cumulative CaCl2 was added to Ca2+-free KHS(high K+ concentration), the contraction rate was significantly higher than both of the control and the osthole groups(P < 0.05). The contraction rate in the osthole group was higher than the verapamil group(P < 0.05).CONCLUSION: Osthole has a vasorelaxant effect on isolated rat thoracic aortic rings, via inhibition of both receptor-operated and voltage-dependent Ca2+channels in arterial smooth muscle, leading to decreased Ca2+ influx, and via inhibition of nitric oxide release on arterial endothelial cells. | Huang Ying Kong Liting Wang Yanping Sun Mingjie Cui Haifeng Zhai Huaqiang LüCheng Fan Danping | 2019 | Journal of Traditional Chinese Medicine2019，39，4： | 1 |
| 20 | Does sleeve lobectomy concomitant with or without pulmonary artery reconstruction (double sleeve) have favorable results for non-small cell lung cancer compared with pneumonectomy? A meta-analysis显示文摘 | Zhiyuan Ma Aiqiang Dong Junqiang Fan Haifeng Cheng | 2007 | European Journal of Cardio-Thoracic Surgery2007，，1： | 1 |
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