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| 1 | Direct conversion of astrocytes into neuronal cells by drug cocktail显示文摘 | Lin Cheng Longfei Gao Wuqiang Guan Jianxin Mao Wenxiang Hu Binlong- Qiu Jian Zhao Yongchun Yu Gang Pei | 2015 | Cell Research2015，25，11： | 14 |
| 2 | Menthol-modified casein nanoparticles loading 10-hydroxycamptothecin for glioma targeting therapy显示文摘Chemotherapy outcomes for the treatment of glioma remains unsatisfactory due to the inefficient drug transport across the blood–brain barrier(BBB) and insufficient drug accumulation in the tumor region. Although many approaches, including various nanosystems, have been developed to promote the distribution of chemotherapeutics in the brain tumor, the delivery efficiency and the possible damage to the normal brain function still greatly restrict the clinical application of the nanocarriers.Therefore, it is urgent and necessary to discover more safe and effective BBB penetration and gliomatargeting strategies. In the present study, menthol, one of the strongest BBB penetration enhancers screened from traditional Chinese medicine, was conjugated to casein, a natural food protein with brain targeting capability. Then the conjugate self-assembled into the nanoparticles to load anti-cancer drugs.The nanoparticles were characterized to have appropriate size, spheroid shape and high loading drug capacity. Tumor spheroid penetration experiments demonstrated that penetration ability of mentholmodified casein nanoparticles(M-CA-NP) into the tumor were much deeper than that of unmodified nanoparticles. In vivo imaging further verified that M-CA-NPs exhibited higher brain tumor distribution than unmodified nanoparticles. The median survival time of glioma-bearing mice treated with HCPT-MCA-NPs was significantly prolonged than those treated with free HCPT or HCPT-CA-NPs. HE staining ofthe organs indicated the safety of the nanoparticles. Therefore, the study combined the advantages of traditional Chinese medicine strategy with modern delivery technology for brain targeting, and provide a safe and effective approach for glioma therapy. | Caifang Gao Jianming Liang Ying Zhu Chengli Ling Zhekang Cheng Ruixiang Li Jing Qin Weigen Lu Jianxin Wang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 12 |
| 3 | An Efficient and Stable Ionic Liquid System for Synthesis of Ethylene Glycol via Hydrolysis of Ethylene Carbonate显示文摘An ionic liquid system of [Bmim]X/[Bmim]OH(X Cl,BF4,and PF6,) was developed for the hydroly-sis of ethylene carbonate to ethylene glycol. The important parameters,such as the variety of ionic liquids,molar ratio of [Bmim]X to [Bmim]OH,amount of ionic liquid,molar ratio of water to ethylene carbonate,reaction tem-perature,pressure and reaction time,were investigated systematically. Excellent yield(>93%) and high selectivity(99.5%) of ethylene glycol were achieved. Under the optimum reaction conditions,the ionic liquid system could be reused at least five times and the selectivity of ethylene glycol remained higher than 99.5%. | MENG Zhenying SUN Jian WANG Jinquan ZHANG Jianxin FU Zengzeng CHENG Weiguo ZHANG Xiangping | 2010 | Chinese Journal of Chemical Engineering2010，18，6： | 8 |
| 4 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 5 | Seed metabolomic study reveals significant metabolite variations and correlations among different soybean cultivars显示文摘Soybean[Glycine max(L.) Merr.]is one of the world's major crops,and soybean seeds are a rich and important resource for proteins and oils.While 'omics' studies,such as genomics,transcriptomics,and proteomics,have been widely applied in soybean molecular research,fewer metabolomic studies have been conducted for largescale detection of low molecular weight metabolites,especially in soybean seeds.In this study,we investigated the seed metabolomes of 29 common soybean cultivars through combined gas chromatography-mass spectrometry and ultra-performance liquid chromatography-tandem mass spectrometry.One hundred sixty-nine named metabolites were identified and subsequently used to construct a metabolic network of mature soybean seed.Among the 169 detected metabolites,104 were found to be significantly variable in their levels across tested cultivars.Metabolite markers that could be used to distinguish genetically related soybean cultivars were also identified,and metabolitemetabolite correlation analysis revealed some significant associations within the same or among different metabolite groups.Findings from this work may potentially provide the basis for further studies on both soybean seed metabolism and metabolic engineering to improve soybean seed quality and yield. | Hong Lin Jun Rao Jianxin Shi Chaoyang Hu Fang Cheng Zoe A.Wilson Dabing Zhang Sheng Quan | 2014 | Journal of Integrative Plant Biology2014，56，9： | 7 |
| 6 | Characteristics in the Distribution of Chronic Benzene Poisoning Associated Industries-6 PLADs, China, 2005−2019显示文摘Summary What is already known on this topic?Starting in the early 1950s,the main industries in China associated with chronic benzene poisoning(CBP)included painting,pharmaceuticals,and shoemaking.However,because of rapid socioeconomic development,the distribution of industries associated with CBP likely changed. | Jin Zhou Lei Han Jianxin Zhao Xiurong Cheng Fenxia Hou Qiang Jia Juan Zhang Peiyu Xu Jing Liu Zihuan Wang Baoli Zhu Caihong Xing | 2020 | China CDC weekly2020，2，47： | 4 |
| 7 | High-performance all-solid-state polymer electrolyte with fast conductivity pathway formed by hierarchical structure polyamide 6 nanofiber for lithium metal battery显示文摘The utilization of all-solid-state electrolytes is considered to be an effective way to enhance the safety performance of lithium metal batteries.However,the low ionic conductivity and poor interface compatibility greatly restrict the development of all-solid-state battery.In this study,a composite electrolyte combining the electrospun polyamide 6(PA6)nanofiber membrane with hierarchical structure and the polyethylene oxide(PEO)polymer is investigated.The introduction of PA6 nanofiber membrane can effectively reduce the crystallinity of the polymer,so that the ionic conductivity of the electrolyte can be enhanced.Moreover,it is found that the presence of finely branched fibers in the hierarchical structure PA6 membrane allows the polar functional groups(C=O and N-H bonds)to be fully exposed,which provides sufficient functional sites for lithium ion transport and helps to regulate the uniform deposition of lithium metal.Moreover,the hierarchical structure can enhance the mechanical strength(9.2 MPa)of the electrolyte,thereby effectively improving the safety and cycle stability of the battery.The prepared Li/Li symmetric battery can be stably cycled for 1500 h under 0.3 mA cm^(-2) and 60℃.This study demonstrates that the prepared electrolyte has excellent application prospects in the next generation all-solid-state lithium metal batteries. | Lu Gao Jianxin Li Jingge Ju Bowen Cheng Weimin Kang Nanping Deng | 2021 | Journal of Energy Chemistry2021，30，3： | 4 |
| 8 | Proteomics provides individualized options of precision medicine for patients with gastric cancer显示文摘While precision medicine driven by genome sequencing has revolutionized cancer care,such as lung cancer,its impact on gastric cancer(GC)has been minimal.GC patients are routinely treated with chemotherapy,but only a fraction of them receive the clinical benefit.There is an urgent need to develop biomarkers or algorithms to select chemo-sensitive patients or apply targeted therapy.Here,we carried out retrospective analyses of 1,020 formalin-fixed,paraffin-embedded GC surgical resection samples from 5 hospitals and developed a mass spectrometry-based workflow for proteomic subtyping of GC.We identified two proteomic subtypes:the chemo-sensitive group(CSG)and the chemo-insensitive group(CIG)in the discovery set.The 5-year overall survival of CSG was significantly improved in patients who had received adjuvant chemotherapy after surgery compared with those who received surgery only(64.2%vs.49.6%;Cox P-value=0.002),whereas no such improvement was observed in CIG(50.0%vs.58.6%;Cox P-value=0.495).We validated these results in an independent validation set.Further,differential proteome analysis uncovered 9 FDA-approved drugs that may be applicable for targeted therapy of GC.A prospective study is warranted to test these findings for future GC patient care. | Wenwen Huang Dongdong Zhan Yazhuo Li Nairen Zheng Xin Wei Bin Bai Kecheng Zhang Mingwei Liu Xuefei Zhao Xiaotian Ni Xia Xia Jinwen Shi Cheng Zhang Zhihao Lu Jiafu Ji Juan Wang Shiqi Wang Gang Ji Jipeng Li Yongzhan Nie Wenquan Liang Xiaosong Wu Jianxin Cui Yongsheng Meng Feilin Cao Tieliu Shi Weimin Zhu Yi Wang Lin Chen Qingchuan Zhao Hongwei Wang Lin Shen Jun Qin | 2021 | Science China(Life Sciences)2021，64，8： | 3 |
| 9 | 0.35%THz pulse conversion efficiency achieved by Ti:sapphire femtosecond laser filamentation in argon at 1 kHz repetition rate显示文摘In this study,an optical setup for generating terahertz(THz)pulses through a two-color femtosecond laser filament was carefully designed to achieve a precise overlap of two-color laser pulses in space and time.β-barium borate(BBO),α-BBO,and a dual-wavelength plate were used to compensate the phase delay of the two-color lasers.Tilting ofα-BBO could further realize the precise spatial overlap of the two beams by counteracting the walk-off effect.The maximum out-put THz pulse energy reached 21μJ in argon gas when using a commercial Ti:sapphire laser with a pulse energy of 6 mJ at a 1 kHz repetition rate.The corresponding conversion efficiency exceeded 0.35%. | Zhiqiang Yu Nan Zhang Jianxin Wang Zijie Dai Cheng Gong Lie Lin Lanjun Guo Weiwei Liu | 2022 | Opto-Electronic Advances2022，5，9： | 2 |
| 10 | A Quasi-Optimal Probabilistic Fault Localization Algorithm in Communication Networks显示文摘 | LIAO Jianxin ZHANG Cheng LI Tonghong ZHU Xiaomin | 2011 | Chinese Journal of Electronics2011，20，1： | 2 |
| 11 | Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration显示文摘The circadian clock participates in maintaining homeostasis in peripheral tissues,including intervertebral discs(IVDs).Abnormal mechanical loading is a known risk factor for intervertebral disc degeneration(IDD).Based on the rhythmic daily loading pattern of rest and activity,we hypothesized that abnormal mechanical loading could dampen the IVD clock,contributing to IDD.Here,we investigated the effects of abnormal loading on the IVD clock and aimed to inhibit compression-induced IDD by targeting the core clock molecule brain and muscle Arnt-like protein-1(BMAL1).In this study,we showed that BMAL1 KO mice exhibit radiographic features similar to those of human IDD and that BMAL1 expression was negatively correlated with IDD severity by systematic analysis based on 149 human IVD samples.The intrinsic circadian clock in the IVD was dampened by excessive loading,and BMAL1 overexpression by lentivirus attenuated compression-induced IDD.Inhibition of the RhoA/ROCK pathway by Y-27632 or melatonin attenuated the compression-induced decrease in BMAL1 expression.Finally,the two drugs partially restored BMAL1 expression and alleviated IDD in a diurnal compression model.Our results first show that excessive loading dampens the circadian clock of nucleus pulposus tissues via the RhoA/ROCK pathway,the inhibition of which potentially protects against compression-induced IDD by preserving BMAL1 expression.These findings underline the importance of the circadian clock for IVD homeostasis and provide a potentially effective therapeutic strategy for IDD. | Dong Wang Pandi Peng Michal Dudek Xueyu Hu Xiaolong Xu Qiliang Shang Di Wang Haoruo Jia Han Wang Bo Gao Chao Zheng Jianxin Mao Chu Gao Xin He Pengzhen Cheng Huanbo Wang Jianmin Zheng Judith A.Hoyland Qing-Jun Meng Zhuojing Luo Liu Yang | 2022 | Bone Research2022，10，2： | 2 |
| 12 | WEEE flow and mitigating measures in China显示文摘 | YANG JIANXIN LU BIN XU CHENG | 2008 | Waste Management2008，28，9： | 1 |
| 13 | WEEE flow and mitigating measures in China显示文摘 | Yang Jianxin Lu Bin Xu Cheng | 2008 | Waste Management2008，28，9： | 1 |
| 14 | High-accuracy target tracking for multistatic passive radar based on a deep feedforward neural network显示文摘In radar systems,target tracking errors are mainly from motion models and nonlinear measurements.When we evaluate a tracking algorithm,its tracking accuracy is the main criterion.To improve the tracking accuracy,in this paper we formulate the tracking problem into a regression model from measurements to target states.A tracking algorithm based on a modified deep feedforward neural network(MDFNN)is then proposed.In MDFNN,a filter layer is introduced to describe the temporal sequence relationship of the input measurement sequence,and the optimal measurement sequence size is analyzed.Simulations and field experimental data of the passive radar show that the accuracy of the proposed algorithm is better than those of extended Kalman filter(EKF),unscented Kalman filter(UKF),and recurrent neural network(RNN)based tracking methods under the considered scenarios. | Baoxiong XU Jianxin YI Feng CHENG Ziping GONG Xianrong WAN | 2023 | Frontiers of Information Technology & Electronic Engineering2023，24，8： | 1 |
| 15 | A model of heat and moisture transfer through parallel pore Textiles显示文摘 | XU Dinghua CHENG Jianxin ZHOU Xiaohong | 2010 | Proceedings of Textile Bioengineering and Informatics Symposium2010，，5： | 1 |
| 16 | Optimized CeO_(2) Nanowires with Rich Surface Oxygen Vacancies Enable Fast Li-Ion Conduction in Composite Polymer Electrolytes显示文摘Low-cost and flexible solid polymer electrolytes are promising in all-solid-state Li-metal batteries with high energy density and safety.However,both the low room-temperature ionic conductivities and the small Li^(+)transference number of these electrolytes significantly increase the internal resistance and overpotential of the battery.Here,we introduce Gd-doped CeO_(2) nanowires with large surface area and rich surface oxygen vacancies to the polymer electrolyte to increase the interaction between Gd-doped CeO_(2) nanowires and polymer electrolytes,which promotes the Li-salt dissociation and increases the concentration of mobile Li ions in the composite polymer electrolytes.The optimized composite polymer electrolyte has a high Li-ion conductivity of 5×10^(-4)4 S cm^(-1) at 30℃ and a large Li+transference number of 0.47.Moreover,the composite polymer electrolytes have excellent compatibility with the metallic lithium anode and high-voltage LiNi_(0.8)Mn _(0.1)Co_(0.1)O_(2)(NMC)cathode,providing the stable cycling of all-solid-state batteries at high current densities. | Lu Gao Nan Wu Nanping Deng Zhenchao Li Jianxin Li Yong Che Bowen Cheng Weimin Kang Ruiping Liu Yutao Li | 2023 | Energy & Environmental Materials2023，6，1： | 1 |
| 17 | An inverse problem of thickness design for single layer textile material under low temperature 显示文摘 | XU Dinghua CHENG Jianxin ZHOU Xiaohong | 2010 | Journal of Math-for-Industry2010，2，4： | 1 |
| 18 | A novel method of controlled grafting modification of ehitosan via RAFT polymerization using chitosan-RAFT agent 显示文摘 | Daoben Hua Jing Tang Jianxin Cheng | 2008 | Carbohydrate Polymers2008，73，： | 1 |
| 19 | FPC: A New Approach to Firewall Policies Compression显示文摘Firewalls are crucial elements that enhance network security by examining the field values of every packet and deciding whether to accept or discard a packet according to the firewall policies. With the development of networks, the number of rules in firewalls has rapidly increased, consequently degrading network performance.In addition, because most real-life firewalls have been plagued with policy conflicts, malicious traffics can be allowed or legitimate traffics can be blocked. Moreover, because of the complexity of the firewall policies, it is very important to reduce the number of rules in a firewall while keeping the rule semantics unchanged and the target firewall rules conflict-free. In this study, we make three major contributions. First, we present a new approach in which a geometric model, multidimensional rectilinear polygon, is constructed for the firewall rules compression problem.Second, we propose a new scheme, Firewall Policies Compression(FPC), to compress the multidimensional firewall rules based on this geometric model. Third, we conducted extensive experiments to evaluate the performance of the proposed method. The experimental results demonstrate that the FPC method outperforms the existing approaches, in terms of compression ratio and efficiency while maintaining conflict-free firewall rules. | Yuzhu Cheng Weiping Wang Jianxin Wang Haodong Wang | 2019 | Tsinghua Science and Technology2019，24，1： | 1 |
| 20 | The effect of homogenization temperature on the corrosion resistance of extruded 7050 Al-alloy bars显示文摘 | Wenrong Hou Weibin Ji Zhihao Zhang Jianxin Xie Xiaole Cheng | 2014 | Journal of Materials Processing Tech2014，，3： | 1 |
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