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| 1 | The Chinese Society of Clinical Oncology(CSCO):Clinical guidelines for the diagnosis and treatment of gastric cancer,2021显示文摘There exist differences in the epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selections between gastric cancer patients from the Eastern and Western countries.The Chinese Society of Clinical Oncology(CSCO)has organized a panel of senior experts specializing in all sub-specialties of gastric cancer to compile a clinical guideline for the diagnosis and treatment of gastric cancer since 2016 and renews it annually.Taking into account regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted expert consensus judgment on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes in China.The 2021 CSCO Clinical Practice Guidelines for Gastric Cancer covers the diagnosis,treatment,follow-up,and screening of gastric cancer.Based on the 2020 version of the CSCO Chinese Gastric Cancer guidelines,this updated guideline integrates the results ofmajor clinical studies from China and overseas for the past year,focused on the inclusion of research data from the Chinese population for more personalized and clinically relevant recommendations.For the comprehensive treatment of non-metastatic gastric cancer,attentions were paid to neoadjuvant treatment.The value of perioperative chemotherapy is gradually becoming clearer and its recommendation level has been updated.For the comprehensive treatment of metastatic gastric cancer,recommendations for immunotherapy were included,and immune checkpoint inhibitors fromthird-line to the first-line of treatment for different patient groups with detailed notes are provided. | Feng-Hua Wang Xiao-Tian Zhang Yuan-Fang Li Lei Tang Xiu-Juan Qu Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Hong Qiu Chang Wang Miao-Zhen Qiu Mu-Yan Cai QiWu Hao Liu Wen-Long Guan Ai-Ping Zhou Yu-Jing Zhang Tian-Shu Liu Feng Bi Xiang-Lin Yuan Sheng-Xiang Rao Yan Xin Wei-Qi Sheng Hui-Mian Xu Guo-Xin Li Jia-Fu Ji Zhi-Wei Zhou Han Liang Yan-Qiao Zhang Jing Jin Lin Shen Jin Li Rui-Hua Xu | 2021 | Cancer Communications2021，41，8： | 97 |
| 2 | New vacuum solar telescope and observations with high resolution显示文摘The New Vacuum Solar Telescope(NVST) is a one meter vacuum solar telescope that aims to observe fine structures on the Sun. The main goals of NVST are high resolution imaging and spectral observations, including measurements of the solar magnetic field. NVST is the primary ground-based facility used by the Chinese solar research community in this solar cycle. It is located by Fuxian Lake in southwest China, where the seeing is good enough to perform high resolution observations. We first introduce the general conditions at the Fuxian Solar Observatory and the primary science cases of NVST. Then, the basic structures of this telescope and instruments are described in detail. Finally, some typical high resolution data of the solar photosphere and chromosphere are also shown. | Zhong Liu Jun Xu Bo-Zhong Gu Sen Wang Jian-Qi You Long-Xiang Shen Ru-Wei Lu Zhen-Yu Jin Lin-Fei Chen Ke Lou Zhi Li Guang-Qian Liu Zhi Xu Chang-Hui Rao Qi-Qian Hu Ru-Feng Li Hao-Wen Fu Feng Wang Men-Xian Bao Ming-Chan Wu Bo-Rong Zhang | 2014 | Research in Astronomy and Astrophysics2014，14，6： | 37 |
| 3 | Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats显示文摘Objective:Our previous research showed that Naotaifang(a compound traditional Chinese herbal medicine)extract(NTE)has clinically beneficial effects on neurological improvement of patients with acute cerebral ischemia.In this study,we investigated whether NTE protected acute brain injury in rats and whether its effects on ferroptosis could be linked to the dysfunction of glutathione peroxidase 4(GPX4)and iron metabolism.Methods:We established an acute brain injury model of middle cerebral artery occlusion(MCAO)in rats,in which we could observe the accumulation of iron in neurons,as detected by Perl’s staining.Using assay kits,we measured expression levels of ferroptosis biomarkers,such as iron,glutathione(GSH),reactive oxygen species(ROS)and malonaldehyde(MDA);further the expression levels of transferrin receptor1(TFR1),divalent metal transporter 1(DMT1),solute carrier family 7 member 11(SLC7 A11)and GPX4 were determined using immunohistochemical analysis,real-time quantitative polymerase chain reaction and Western blot assays.Results:We found that treatment with NTE reduced the expression levels of TFR1 and DMT1,reduced ROS,MDA and iron accumulation and reduced neurobehavioral scores,relative to untreated MCAO rats.Treatment with NTE increased the expression levels of SLC7 A11,GPX4 and GSH,and the number of Nissl bodies in the MCAO rats.Conclusion:Taken together,our data suggest that acute cerebral ischemia induces neuronal ferroptosis and the effects of treating MCAO rats with NTE involved inhibition of ferroptosis through the TFR1/DMT1 and SCL7 A11/GPX4 pathways. | Bin Lan Jin-wen Ge Shao-wu Cheng Xi-long Zheng Jun Liao Chao He Zheng-qing Rao Guo-zuo Wang | 2020 | Journal of Integrative Medicine2020，18，4： | 37 |
| 4 | Sr-Nd isotope geochemistry of eolian dust of the arid-semiarid areas in China: Implications for loess provenance and monsoon evolution显示文摘Minerals and rocks have distinct 87Sr/86Sr and 143Nd/144Nd ratios, depending on their geological origin and ages, and these isotope ratios are less altered than elemental composition during transport in the atmosphere or after deposition as sediments, thus stable isotopes of Sr and Nd have great potential as tracers for provenance and trans- port of materials. During the hypergene process, Sr isotope ratios of sediments are controlled by their parent rocks, particle sizes and chemical weathering. In general, the higher the Sr isotope ratios of parent rocks, and/or the more the fine-grained fractions, and/or the stronger the chemical weathering, thus the higher the Sr isotope ratios of sediments. On the contrary, there are lower Sr isotope ratios of sedi- ments. Nd isotope ratios of sediments, independent of their particle sizes and chemical weathering, are only associated with parent rocks. For the prove- nance of the Chinese Loess Plateau, different re- seachers drew discordant and even contradictory conclusions by using the method of Sr-Nd isotopic tracing. From the previous Nd isotope data, it is con- sidered that the Tarim Basin, deserts in the central and west parts of Inner Mongolia and the Tibetan Plateau are the main sources of the Chinese Loess Plateau, and are also manufacturers for eolian dust of the Far East regions, together with the Chinese Loess Plateau. Sr isotope ratios of eolian dust are solely affected by wind sorting and weather- ing-pedogenesis due to its homogeneous composi- tion in the Chinese Loess Plateau. Wind sorting isrelated to the East Asian winter monsoon but weath- ering-pedogenesis is mainly associated with the East Asian summer monsoon. Studies on Sr isotopic compositions of the loess-paleosol sequence suggest that 87Sr/86Sr ratios in acid-soluble materials are an index for chemical weathering intensity of the Chi- nese Loess Plateau, indicating the East Asian sum- mer monsoon variations, whereas 87Sr/86Sr ratios in acid-insoluble materials are significantly controlled by particle sizes, and can be used as a proxy indicator reflecting the East Asian winter monsoon variations. Variations of 87Sr/86Sr ratios in acid-insoluble materi- als in the past 2.6Ma further demonstrate that the East Asian winter monsoon gradually strengthened since the beginning of the Quaternary period. This result agrees with the prior conclusion that climate gradually cooled since the onset of the Quaternary Ice Age. | RAO Wenbo YANG Jiedong CHEN Jun LI Gaojun | 2006 | Chinese Science Bulletin2006，51，12： | 21 |
| 5 | Identification and Practical Application of Silicate-dissolving Bacteria显示文摘Slime-forming bacteria were isolated from soils, rock surface and earthworm intestine, and their effects on dissolving silicate minerals and tomato growth were examined. One of the bacteria, Bacillus mucilaginosus RGBc13, had particularly strong ability to form slime and dissolve silicates. RGBc13 could also colonize and develop in both non-rhizosphere and rhizosphere soil. Total number of slime-forming bacteria increased from 2.9 × 103 cfu·g- 1and 8.4 × 103 cfu·g-1 to 9.6 × 106 cfu·g-1 and 6.0 × 107 cfu·g-1 in the non-rhizosphere and rhizosphere soils respectively. Potassium and phosphorus nutritional conditions in the rhizosphere were markedly improved through inoculation of this bacterium. Available K and P respectively increased from 25.86 and 3.63mg· kg-1 in the non-rhizosphere soil to 91.23 and 5.74mg· kg-1 in the rhizosphere soil. Tomato biomass increased by 125%, K and P uptakes were more than 150%, greater than the non- inoculation. Thus, there is a potential in applying RGBc13 for improving plant K and P nutrition. | LIN Qi-mei, RAO Zheng-hua, SUN Yan-xing, YAO Jun and XING Li-jun( Department of Soil and Water Sciences , China Agricultural University, Beijing 100094 Institute of Plant Nutrition and Resources , Beijing Academy of Agricultural and Forestry Sciences, Beijing 100081 ) | 2002 | Agricultural Sciences in China2002，1，1： | 11 |
| 6 | Characteristic gene expression profiles in the progression from normal gastric epithelial cells to moderate gastric epithelial dysplasia and to gastric cancer显示文摘 | LI Mao-lan ZHANG Jing-cheng LI Song-gang WU Wen-guang RAO Long-hua DONG Ping GU Jun LU Jian-hua ZHANG Lin DING Qi-chen WU Xiang-song MU Jia-sheng YANG Jia-hua ZHANG Wen-jie CHEN Lei LIU Ying-bin | 2012 | Chinese Medical Journal2012，，10： | 8 |
| 7 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 8 | Seed metabolomic study reveals significant metabolite variations and correlations among different soybean cultivars显示文摘Soybean[Glycine max(L.) Merr.]is one of the world's major crops,and soybean seeds are a rich and important resource for proteins and oils.While 'omics' studies,such as genomics,transcriptomics,and proteomics,have been widely applied in soybean molecular research,fewer metabolomic studies have been conducted for largescale detection of low molecular weight metabolites,especially in soybean seeds.In this study,we investigated the seed metabolomes of 29 common soybean cultivars through combined gas chromatography-mass spectrometry and ultra-performance liquid chromatography-tandem mass spectrometry.One hundred sixty-nine named metabolites were identified and subsequently used to construct a metabolic network of mature soybean seed.Among the 169 detected metabolites,104 were found to be significantly variable in their levels across tested cultivars.Metabolite markers that could be used to distinguish genetically related soybean cultivars were also identified,and metabolitemetabolite correlation analysis revealed some significant associations within the same or among different metabolite groups.Findings from this work may potentially provide the basis for further studies on both soybean seed metabolism and metabolic engineering to improve soybean seed quality and yield. | Hong Lin Jun Rao Jianxin Shi Chaoyang Hu Fang Cheng Zoe A.Wilson Dabing Zhang Sheng Quan | 2014 | Journal of Integrative Plant Biology2014，56，9： | 7 |
| 9 | Computer Vision-based Navigation and Predefined Track Following Control of a Small Robotic Airship显示文摘为小机器的飞艇,飞艇应该能够跟随一条预定义的轨道,这被要求。在这份报纸,计算机为机器的飞艇的基于视觉的航行和最佳的模糊控制策略被建议。第一,视觉航行基于环境的自然里程碑被介绍。例如,当飞艇在一个城市上正在飞时,大楼能被用作其几何性质从数字地图或一个地理信息系统(GIS ) 被知道的视觉烽火。然后,几何方法论被采用关于飞艇的取向和位置提取信息。以便在一个预定义的磁道上保留飞艇,一个模糊飞行控制系统被设计,它把那些数据用作它的输入。并且基因算法(气体) ,一个通用全球优化方法,被利用优化模糊控制器的会员功能。最后,航行和控制策略被验证。 | XIE Shao-Rong LUO Jun RAO Jin-Jun GONG Zhen-Bang | 2007 | 自动化学报2007，33，3： | 6 |
| 10 | A New Species of the Genus Rhacophorus (Anura: Rhacophoridae) from Dabie Mountains in East China显示文摘A new species of rhacophorid of the genus Rhacophorus is described from the Dabie Mountains of west Anhui,east China.The new species,Rhacophorus zhoukaiyae sp.nov.is distinguished from its congeners by a combination of the following characters: 1) the ventral surface and front-and-rear of the femur is paler yellowish and decorated with irregular grayish blotching,and without obvious spots on the dorsum of the hand and foot webbing; 2) the outer metatarsal tubercle is small; 3) outer fingers are half-webbed and outer toes two third webbed; 4) the skin on the dorsum is smooth and without compressed warts; 5) the throat,chest and belly are pure paler yellowish; 6) the dorsal part of the fingers and toes are grayish-white; 7) the iris is golden-yellow.In addition,the phylogenetic tree showed that all the individuals of R.zhoukaiyae sp.nov.clustered into one distinct clade which suggested the validity of this species.This results could also be used to the support of species delimitation.Currently,this species is known only from mid-elevation montane evergreen forest in the Dabie Mountains of west Anhui,China. | Tao PAN Yanan ZHANG Hui WANG Jun WU Xing KANG Lifu QIAN Kai LI Yu ZHANG Jinyun CHEN Dingqi RAO Jianping JIANG Baowei ZHANG | 2017 | Asian Herpetological Research2017，18，1： | 5 |
| 11 | Establishment of a human colorectal cancer cell line P6C with stem cell properties and resistance to chemotherapeutic drugs显示文摘 | Guan-hua RAO Hong-min LIU Bao-wei LI Jia-jie HAO Yan-lei YANG Ming-rong WANG Xiao-hui WANG Jun WANG Hai-jing JIN Lei DU Quan CHEN | 2013 | Acta Pharmacologica Sinica2013，34，6： | 5 |
| 12 | High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors显示文摘A new coronavirus(SARS-CoV-2)has been identified as the etiologic agent for the COVID-19 outbreak.Currently,effective treatment options remain very limited for this disease;therefore,there is an urgent need to identify new anti-COVID-19 agents.In this study,we screened over 6,000 compounds that included approved drugs,drug candidates in clinical trials,and pharmacologically active compounds to identify leads that target the SARS-CoV-2 papain-like protease(PLpro).Together with main protease(Mpro),PLpro is responsible for processing the viral replicase polyprotein into functional units.There-fore,it is an attractive target for antiviral drug develop-ment.Here we discovered four compounds,YM155,cryptotanshinone,tanshinone I and GRL0617 that inhibit SARS-CoV-2 PLpro with IC50 values ranging from 1.39 to 5.63 pmol/L.These compounds also exhibit strong antiviral activities in cell-based assays.YM155,an anti-cancer drug candidate in clinical trials,has the most potent antiviral activity with an EC50 value of 170 nmol/L.In addition,we have determined the crystal structures of this enzyme and its complex with YM155,revealing a unique binding mode.YM155 simultaneously targets three'hot'spots on PLpro,including the substrate-binding pocket,the interferon stimulating gene product 15(ISG15)binding site and zinc finger motif.Our results demonstrate the efficacy of this screening and repur-posing strategy,which has led to the discovery of new drug leads with clinical potential for COVID-19 treatments. | Yao Zhao Xiaoyu Du Yinkai Duan Xiaoyan Pan Yifang Sun Tian You Lin Han Zhenming Jin Weijuan Shang Jing Yu Hangtian Guo Qianying Liu Yan Wu Chao Peng Jun Wang Chenghao Zhu Xiuna Yang Kailin Yang Ying Lei Luke W.Guddat Wenqing Xu Gengfu Xiao Lei Sun Leike Zhang Zihe Rao Haitao Yang | 2021 | Protein & Cell2021，12，11： | 4 |
| 13 | Optical rogue wave in random fiber laser显示文摘The famous demonstration of optical rogue waves(RWs),a powerful tool to reveal the fundamental physics in different laser scenarios,opened a flourishing time for temporal statistics.Random fiber laser(RFL)has likewise attracted wide attention due to its great potential in multidisciplinary demonstrations and promising applications.However,owing to the distinctive cavity-free structure,it is a scientific challenge to achieve temporal localized RWs in RFLs,whose feedback arises from multiple scattering in disordered medium.Here,we report the exploration of RW in the highly skewed,transient intensity of an incoherently pumped RFL for the first time,to our knowledge,and unfold the involved kinetics successfully.The corresponding frequency domain measurements demonstrate that the RW event arises from a crucial sustained stimulated Brillouin scattering process with intrinsic stochastic nature.This investigation highlights a novel path to fully understanding the complex physics,such as photon propagation and localization,in disordered media. | JIANGMING XU JIAN WU JUN YE JIAXIN SONG BAICHENG YAO HANWEI ZHANG JINYONG LENG WEILI ZHANG PU ZHOU YUNJIANG RAO | 2020 | Photonics Research2020，8，1： | 4 |
| 14 | Net measure properties of Moran sets and applications显示文摘The Hausdorff and packing dimensions for a class of Moran sets are obtained. | Hui Rao Zhiying Wen Jun Wu | 1998 | Chinese Science Bulletin1998，43，5： | 3 |
| 15 | Phase Ⅱb trial of in vivo electroporation mediated dualplasmid hepatitis B virus DNA vaccine in chronic hepatitis B patients under lamivudine therapy显示文摘AIM To assess the efficacy and safety of in vivo electroporation(EP)-mediated dual-plasmid hepatitis B virus(HBV) DNA vaccine vs placebo for sequential combination therapy with lamivudine(LAM) in patients with chronic hepatitis B. METHODS Two hundred and twenty-five patients were randomized to receive either LAM + vaccine(vaccine group, n = 109) or LAM + placebo(control group, n = 116). LAM treatment lasted 72 wk. Patients received the DNA vaccine or placebo by intramuscular injection mediated by EP at weeks 12(start of treatment with vaccine or placebo, SOT), 16, 24, and 36(end of treatment with vaccine or placebo, EOT). RESULTS In the modified intent-to-treat population, morepatients had a decrease in HBV DNA > 2 log10 IU/m L in the vaccine group at week 12 after EOT compared with the control group. A trend toward a difference in the number of patients with undetectable HBV DNA at week 28 after EOT was obtained. Adverse events were similar. In the dynamic per-protocol set, which excluded adefovir(ADV) add-on cases at each time point instantly after ADV administration due to LAM antiviral failure, more patients had a decrease in HBV DNA > 2 log10 IU/mL in the vaccine group at week 12 and 28 after EOT compared with the control group. More patients with undetectable HBV DNA at week 28 after EOT in the vaccine group were also observed. Among patients with a viral load < 1000 copies/mL at week 12, more patients achieved HBeA g seroconversion in the vaccine group than among controls at week 36 after EOT, as well as less virological breakthrough and YMDD mutations. CONCLUSION The primary endpoint was not achieved using the HBV DNA vaccine. The HBV DNA vaccine could only be beneficial in subjects that have achieved initial virological response under LAM chemotherapy. | Fu-Qiang Yang Gui-Rong Rao Gui-Qiang Wang Yue-Qi Li Yao Xie Zhan-Qing Zhang Cun-Liang Deng Qing Mao Jun Li Wei Zhao Mao-Rong Wang Tao Han Shi-Jun Chen Chen Pan De-Ming Tan Jia Shang Ming-Xiang Zhang Yue-Xin Zhang Ji-Ming Yang Guang-Ming Chen | 2017 | World Journal of Gastroenterology2017，23，2： | 3 |
| 16 | Predictive value of serum uric acid on left atrial spontaneous echo contrast in non-valvular atrial fibrillation patients显示文摘ObjectivesTo 调查在浆液之间的关系尿酸( SUA )和左 atrial 在纤维性颤动( AF ) patients.MethodsWe 回顾地屏蔽了的非瓣膜的 atrial 的自发的回响对比(LA秒)在 radiofrequency 以前经历了 transesophageal echocardiography 的有 AF 的 1,476 个连续就医的病人导管脱离,在广东医院将军的左 atrial 附器闭合和电的 cardioversion 。所有病人的临床的基线特征上的数据与左 atrial 血栓从电子医药记录和病人的 analyzed.ResultsAfter 排除被收集, 1,354 个病人进入了现在的学习, 57 是 LA 秒。吝啬的女 SUA 水平(380.88 ±94.35 µ mol/L 对 323.37 ±72.19 µ mol/L, P <0.001 ) 并且男 SUA 水平(416.97 ±98.87 µ mol/L 对 367.88 ±68.50 µ mol/L, P = 0.008 ) 比在控制在有 LA 秒的病人更高显著地是两个。吝啬的左 atrial 尺寸(41.32 ±5.12 公里对 36.12 ±5.66 公里, P <0.001 ) 在有 LA 秒的病人是显著地更大的。在 multivariate 回归分析, SUA 水平是为 LA 秒的一个独立风险因素(或:1.008, P <0.001 ) 。在操作典型曲线分析的接收装置,在为在女性和男性预言 LA 秒的 SUA 的曲线下面的相应区域分别地是 0.670 和 0.657。SUA 水平在有 LA-SEC.ConclusionSUA 的非瓣膜的 AF 病人是显著地更高的水平是一个独立风险因素并且在南部的中国在非瓣膜的 AF 病人之中为 LA 秒有中等预兆的价值。 | Hong-Tao LIAO Fang-Zhou LIU Yu-Mei XUE Xian-Zhang ZHAN Xian-Hong FANG Jun HUANG Wei WEI Fang RAO Hai DENG Yang LIU Wei-Dong LIN Shu-Lin WU | 2015 | Journal of Geriatric Cardiology2015，12，6： | 3 |
| 17 | Clinical assessment and genomic landscape of a consanguineous family with three Kallmann syndrome descendants显示文摘尽管引起 Kallmann 症候群(KS ) 的一些基因被传统的连接分析和候选人基因技术识别了,症候群是在遗体糟糕理解的病人的多数的分子的病原学。在这份报纸,我们在场对与三个 KS 后代一起的一个同宗的汉中国家庭的临床的评价。从一个染色体宽的观点理解 KS 的分子的病原学,我们用 Affymetrix 染色体宽的人的 SNP 数组在这个家庭调查了结构的变化的染色体宽的侧面 6.0 站台。结果表明三个影响个人在染色体 1p21.1, 2q32.2, 8q21.13, 14q21.2 和 Xp22.31 上有普通拷贝数字变体(microdeletions ) 。而且, Xp22.31 上的拷贝数字变体位于 KAL1 的 intron,它引起 X 连接 KS。二 PCR 试金在这些区域上被执行验证用薄片获得的结果。另外,在这个区域的 genomic microdeletions 在 29 个汉中国分散的 KS 案例之一和四个另外的家庭案例之一中,然而并非用 26 汉汉语被验证分散的 normosmic 自发的 hypogonadotropic 性腺机能减退案例和 100 无关的汉汉语正常控制。我们的结果提供新奇卓见进对 KS 的分子的病原学的某些拷贝数字变体的相对贡献并且为进一步的研究产生有趣的候选人区域的一张表。 | Shilin Zhang Yanping Tang Tao Wang Jun Yang Ke Rao Lingyun Zhao Wenzhen Zhu Xianghu Meng Shaogang Wang Jihong Liu Weimin Yang Zhangqun Ye | 2011 | Asian Journal of Andrology2011，13，1： | 3 |
| 18 | BRD2 induces drug resistance through activation of the RasGRP1/Ras/ERK signaling pathway in adult T-cell lymphoblastic lymphoma显示文摘Background:Adult patients with T-cell lymphoblastic lymphoma(T-LBL)are treated with high-intensity chemotherapy regimens,but the response rate is still unsatisfactory because of frequent drug resistance.We aimed to investigate the potential mechanisms of drug resistance in adults with T-LBL.Methods:Gene expression microarray was used to identify differential mRNA expression profiles between chemotherapy-resistant and chemotherapy-sensitive adult T-LBL tissues.Real-time PCR and immunohistochemistry were performed to detect the expression of bromodomain-containing protein 2(BRD2)and c-Myc in fresh-frozen T-LBL tissues from 85 adult patients.The Ras pull-down assay was performed to monitor Ras activation.Chromatin immunoprecipitation assays were used to analyze the binding of E2F transcription factor 1(E2F1)/BRD2 to the RAS guanyl releasing protein 1(RasGRP1)promoter region.The drug resistance effect and mechanism of BRD2 were determined by both in vivo and in vitro studies.Results:A total of 86 chemotherapy resistance-related genes in adult T-LBL were identified by gene expression microarray.Among them,BRD2 was upregulated in chemotherapy-resistant adult T-LBL tissues and associated with worse progressionfree survival and overall survival of 85 adult T-LBL patients.Furthermore,BRD2 suppressed doxorubicin(Dox)-induced cell apoptosis both in vitro and in vivo.The activation of RasGRP1/Ras/ERK signaling might contribute to the Dox resistance effect of BRD2.Besides,OTX015,a bromodomain and extra-terminal(BET)inhibitor,reversed the Dox resistance effect of BRD2.Patient-derived tumor xenograft demonstrated that the sequential use of OTX015 after Dox showed superior therapeutic effects.Conclusions:Our data showed that BRD2 promotes drug resistance in adult T-LBL through the RasGRP1/Ras/ERK signaling pathway.Targeting BRD2 may be a novel strategy to improve the therapeutic efficacy and prolong survival of adults with TLBL. | Xiao-Peng Tian Jun Cai Shu-Yun Ma Yu Fang Hui-Qiang Huang Tong-Yu Lin Hui-Lan Rao Mei Li Zhong-Jun Xia Tie-Bang Kang Dan Xie Qing-Qing Cai | 2020 | Cancer Communications2020，40，6： | 3 |
| 19 | Building Information Modeling-Based Secondary Development System for 3D Modeling of Underground Pipelines显示文摘Underground pipeline networks constitute a major component of urban infrastructure,and thus,it is imperative to have an efficient mechanism to manage them.This study introduces a secondary development system to efficiently model underground pipeline networks,using the building information modeling(BIM)-based software Revit.The system comprises separate pipe point and tubulation models.Using a Revit application programming interface(API),the spatial position and attribute data of the pipe points are extracted from a pipeline database,and the corresponding tubulation data are extracted from a tubulation database.Using the Family class in Revit API,the cluster in the self-built library of pipe point is inserted into the spatial location and the attribute data is added;in the same way,all pipeline instances in the pipeline system are created.The extension and localization of the model accelerated the modeling speed.The system was then used in a real construction project.The expansion of the model database and rapid modeling made the application of BIM technology in three-dimensional visualization of underground pipeline networks more convenient.Furthermore,it has applications in pipeline engineering construction and management. | Jun Chen Rao Hu Xianfeng Guo Feng Wu | 2020 | Computer Modeling in Engineering & Sciences2020，，5： | 2 |
| 20 | Spectral matching techniques (SMTs) and automated cropland classification algorithms (ACCAs) for mapping croplands of Australia using MODIS 250-m time-series (2000–2015) data显示文摘Mapping croplands,including fallow areas,are an important measure to determine the quantity of food that is produced,where they are produced,and when they are produced(e.g.seasonality).Furthermore,croplands are known as water guzzlers by consuming anywhere between 70%and 90%of all human water use globally.Given these facts and the increase in global population to nearly 10 billion by the year 2050,the need for routine,rapid,and automated cropland mapping year-after-year and/or season-after-season is of great importance.The overarching goal of this study was to generate standard and routine cropland products,year-after-year,over very large areas through the use of two novel methods:(a)quantitative spectral matching techniques(QSMTs)applied at continental level and(b)rule-based Automated Cropland Classification Algorithm(ACCA)with the ability to hind-cast,now-cast,and future-cast.Australia was chosen for the study given its extensive croplands,rich history of agriculture,and yet nonexistent routine yearly generated cropland products using multi-temporal remote sensing.This research produced three distinct cropland products using Moderate Resolution Imaging Spectroradiometer(MODIS)250-m normalized difference vegetation index 16-day composite time-series data for 16 years:2000 through 2015.The products consisted of:(1)cropland extent/areas versus cropland fallow areas,(2)irrigated versus rainfed croplands,and(3)cropping intensities:single,double,and continuous cropping.An accurate reference cropland product(RCP)for the year 2014(RCP2014)produced using QSMT was used as a knowledge base to train and develop the ACCA algorithm that was then applied to the MODIS time-series data for the years 2000–2015.A comparison between the ACCA-derived cropland products(ACPs)for the year 2014(ACP2014)versus RCP2014 provided an overall agreement of 89.4%(kappa=0.814)with six classes:(a)producer’s accuracies varying between 72%and 90%and(b)user’s accuracies varying between 79%and 90%.ACPs for the individual years 2000–2013 and 2015(ACP2000–ACP2013,ACP2015)showed very strong similarities with several other studies.The extent and vigor of the Australian croplands versus cropland fallows were accurately captured by the ACCA algorithm for the years 2000–2015,thus highlighting the value of the study in food security analysis. | Pardhasaradhi Teluguntla Prasad S.Thenkabail Jun Xiong Murali Krishna Gumma Russell G.Congalton Adam Oliphant Justin Poehnelt Kamini Yadav Mahesh Rao Richard Massey | 2017 | International Journal of Digital Earth2017，10，9： | 2 |
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