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| 1 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 2 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 3 | Practice guidelines for ultrasound-guided percutaneous microwave ablation for hepatic malignancy显示文摘Primary liver cancer and liver metastases are among the most frequent malignancies worldwide,with an increasing number of new cases and deaths every year.Traditional surgery is only suitable for a limited proportion of patients and imaging-guided percutaneous thermal ablation has achieved optimistic results for management of hepatic malignancy.This synopsis outlines the first clinical practice guidelines for ultrasoundguided percutaneous microwave ablation therapy for hepatic malignancy,which was created by a joint task force of the Society of Chinese Interventional Ultrasound.The guidelines aim at standardizing the microwave ablation procedure and therapeutic efficacy assessment,as well as proposing the criteria for the treatment candidates. | Ping Liang Jie Yu Ming-De Lu Bao-Wei Dong Xiao-Ling Yu Xiao-Dong Zhou Bing Hu Ming-Xing Xie Wen Cheng Wen He Jian-Wen Jia Guo-Rong Lu | 2013 | World Journal of Gastroenterology2013，19，33： | 26 |
| 4 | The cloning of 3'-truncated preS/S gene from HBV genomic DNA and its expression in transgenic mice显示文摘INTRODUCTIONHepatitis B virus (HBV) is regarded as one of themain etiologic factors involved in the developmentof human hepatocellular carcinoma (HCC).The open reading frame (orf)of X gene of HBVencoded a transactivating factor is the evidence thatstrongly supported the notion that the X gene ofHBV DNA integrated in HCC genomic DNA couldcontribute to the carcinogenesis of liver cells byactivation of some related cellular genes | Yi Ping Hu~1 Yu Cheng Yao~1 Jian Xiu Li~1 Xin Min Wang~1 Hong Li~2 Zhong Hua Wang~1 Zhang Heng Lei~3 1 Department of Cell Biology,Second Military Medical University,Shanghai 200433,China 2 Department of Biology,Department of Basic Medicine,West-China University of Medical Sciences,Chengdu 610041,China 3 Department of Biology,North Sichuan Medical College,Nanchong 637007,China | 2000 | World Journal of Gastroenterology2000，6，5： | 18 |
| 5 | Role of Fas/FasL Pathway-mediated Alveolar Macrophages Releasing Inflammatory Cytokines in Human Silicosis显示文摘The role of Fas/Fas ligand (FasL) in mediating alveolar macrophage (AM)-derived inflammatory cytokines in 29 human lung silicosis patients and 6 controls was studied.It showed that the serum levels of IL-1β,TNF-α,IL-8,MIP-1α,MCP-1,and TGF-β1were higher in silicosis patients than in controls,and increased with the progression of silicosis except TGF-β1 and IL-8.TGF-β1,IL-8,MCP-1,MIP-1αwere efficiently down-regulated by anti-FasL antibody or caspase-8 inhibitor,indicating that Fas/FasL signaling promotes the | YAO San Qiao HE Qin Cheng YUAN Ju Xiang CHEN Jie CHEN Gang LU Yao BAI Yu Ping ZHANG Chun Min YUAN Yang XU Ying Jun | 2013 | Biomedical and Environmental Sciences2013，26，11： | 13 |
| 6 | Glucocorticoids Significantly Influence the Transcriptome of Bone Microvascular Endothelial Cells of Human Femoral Head显示文摘 | Qing-Sheng Yu Wan-Shou Guo Li-Ming Cheng Yu-Feng Lu Jian-Ying Shen Ping Li | 2015 | Chinese Medical Journal2015，，14： | 9 |
| 7 | Mitochondrial Modulation of Apoptosis Induced by Low-dose Radiation in Mouse Testicular Cells显示文摘Objective To investigate whether apoptosis induced by low-dose radiation(LDR) is regulated by mitochondrial pathways in testicular cells.Methods Male mice were exposed to whole-body LDR,and changes in mitochondrial function and in expression of apoptotic factors were analyzed in the testicular cells as follows.Total nitric-oxide synthase(T-NOS) and Na+/K+ATPase activities were biochemically assayed.Reactive oxygen species(ROS) and mitochondrial membrane potential(Δψm) were determined by flow cytometry using fluorescent probes.Levels of mRNAs encoding cytochrome c(Cyt c) and apoptosis-inducing factor(AIF) were quantified by real-time reverse-transcription PCR(RT-PCR).Expression of Cyt c,AIF,caspase-9,and caspase-3 at the proteinlevel was assessed by western blotting and immunohistochemistry.Results LDR induced an increase in T-NOS activity and ROS levels,and a decrease in Na+/K+ATPase activity and mitochondrial Δψm,in the testicular cells.The intensity of these effects increased with time after irradiation and with dose.The cells showed remarkable swelling and vacuolization of mitochondria,and displayed a time- and dose-dependent increase in the expression of Cyt c,AIF,procaspase-9,and procaspase-3.Activation of the two procaspases was confirmed by detection of the cleaved caspases.The changes in expression of the four apoptotic factors were mostly limited to spermatogonia and spermatocytes.Conclusion LDR can induce testicular cell apoptosis through mitochondrial signaling pathways. | FANG Fang GONG Ping Sheng ZHAO Hong Guang BI Yu Jing ZHAO Gang GONG Shou Liang WANG Zhi Cheng | 2013 | Biomedical and Environmental Sciences2013，26，10： | 9 |
| 8 | Association of a SLC30A8 Genetic Variant with Monotherapy of Repaglinide and Rosiglitazone Effect in Newly Diagnosed Type 2 Diabetes Patients in China显示文摘Objective To investigate a potential relationship between Solute carrier family 30 (zinc transporter) member 8 (SLC30A8) rs13266634 variant and efficacy of rosiglitazone or repaglinide in treating newly diagnosed Chinese type 2 diabetes patients.Methods A total of 209 diabetic patients without any antihyperglycemic history were recruited and treated with repaglinide or rosiglitazone randomly for 48 weeks (104 and 105 patients,respectively).Anthropometric measurements and clinical laboratory tests were carried out before and after the treatment.An non-synonymous variant rs13266634 was genotyped by matrix-assisted laser desorption ionization-time of flight mass spectroscopy.Results Ninety-one patients in repaglinide group and ninety-three patients in rosiglitazone group completed the study.Δ value of homeostasis model assessment of beta cell function (HOMA-B)and Δ value of fasting proinsulin levels were statistically significant between three genotype groups (P=0.0149 and 0.0246,respectively) after rosiglitazone treatment.However,no genotype association was observed in the repaglinide or rosiglitazone group with other parameters.Conclusion The SLC30A8 variant was associated with the efficacy of insulin sensitizer monotherapy on insulin secretion in patients with newly diagnosed type 2 diabetes mellitus in Shanghai,China. | JIANG Feng LI Qing HU Cheng ZHANG Rong WANG Cong Rong YU Wei Hui LU Jing Yi TANG Shan Shan BAO Yu Qian XIANG Kun San JIA Wei Ping | 2012 | Biomedical and Environmental Sciences2012，25，1： | 8 |
| 9 | Bartonella Species Detected in the Plateau Pikas(Ochotona curzoiae) from Qinghai Plateau in China显示文摘Bartonella 种类能感染许多哺乳动物的主人并且在人引起许多疾病,但是在那里有不是在 Ochotonidae 的 Bartonella 感染的报告。这是第一研究在 Qinghai 高原在高原一种短耳野兔检测 Bartonella,提供为对在这个区域的人的 Bartonella 感染的风险评价的基线数据。我们与 18.99% 的积极的率在 Qinghai 的 Binggou 和 Maixiu 区域从 79 只一种短耳野兔获得了 15 Bartonella 紧张。基于基因定序的 Bartonella 柠檬酸盐 synthase (gltA ) 的种系发生的分析,大多数紧张是仔细与 B 有关。taylorii (3/15 ) 和 B。grahamii (12/15 ) 。后者是在人的病原的紧张。我们的结果建议相应预防和控制策略应该在 Qinghai 省被考虑。 | RAO Hua Xiang YU Juan GUO Peng MA Yong Cheng LIU Qi Yong JIAO Ming MA Zhong Wen GE Hua WANG Chun Xiang SONG Xiu Ping SHI Yan LI Dong Mei | 2015 | Biomedical and Environmental Sciences2015，28，9： | 8 |
| 10 | Controllable optical activity with non-chiral plasmonic metasurfaces显示文摘Optical activity is the rotation of the plane of linearly polarized light along the propagation direction as the light travels through optically active materials.In existing methods,the strength of the optical activity is determined by the chirality of the materials,which is difficult to control quantitatively.Here we numerically and experimentally investigated an alternative approach to realize and control the optical activity with non-chiral plasmonic metasurfaces.Through judicious design of the structural units of the metasurfaces,the right and left circular polarization components of the linearly polarized light have different phase retardations after transmitting through the metasurfaces,leading to large optical activity.Moreover,the strength of the optical activity can be easily and accurately tuned by directly adjusting the phase difference.The proposed approach based on non-chiral plasmonic metasurfaces exhibits large optical activity with a high controllable degree of freedom,which may provide more possibilities for applications in photonics. | Ping Yu Jianxiong Li Chengchun Tang Hua Cheng Zhaocheng Liu Zhancheng Li Zhe Liu Changzhi Gu Junjie Li Shuqi Chen Jianguo Tian | 2016 | Light(Science & Applications)2016，5，1： | 8 |
| 11 | APE1 polymorphisms are associated with colorectal cancer susceptibility in Chinese Hans显示文摘AIM:To study the association between four base excision repair gene polymorphisms and colorectal cancer risk in a Chinese population.METHODS:Two hundred forty-seven colorectal cancer(CRC)patients and three hundred cancer-free controls were enrolled in this study.Four polymorphisms(OGG1Ser326Cys,APE1 Asp148Glu,-141T/G in the promoter region,and XRCC1 Arg399Gln)in components of the base excision repair pathway were determined in patient blood samples using polymerase chain reaction with confronting two-pair primers.The baseline information included age,gender,family history of cancer,and three behavioral factors[smoking status,alcohol consumption,and body mass index(BMI)].χ2tests were used to assess the Hardy-Weinberg equilibrium,the distributions of baseline characteristics,and the four gene polymorphisms between the cases and controls.Multivariate logistic regression analyses were conducted to analyze the correlations between the four polymorphisms and CRC risk,adjusted by the baseline characteristics.Likelihood ratio tests were performed to analyze the gene-behavior interactions of smoking status,alcohol consumption,and BMI on polymorphisms and CRC susceptibility.RESULTS:The APE1 148 Glu/Glu genotype was significantly associated with an increased risk of colorectal cancer(OR=2.411,95%CI:1.497-3.886,P<0.001relative to Asp/Asp genotype).There were no associations between OGG1,XRCC1,or APE1 promoter polymorphisms and CRC risk.A multivariate analysis including three behavioral factors showed that the APE1 148Glu/Glu genotype was associated with an increased risk for CRC among both smokers and non-smokers,non-drinkers and individuals with a BMI≥25 kg/m2(ORs=2.356,3.299,2.654,and 2.581,respectively).The XRCC1 399 Arg/Gln genotype was associated with a decreased risk of CRC among smokers and drinkers(OR=0.289,95%CI:0.152-0.548,P<0.001,and OR=0.327,95%CI:0.158-0.673,P<0.05,respectively).The APE1 promoter polymorphism-141 T/G genotype was associated with a reduced risk of colorectal cancer among subjects with a BMI<25 kg/m2(OR=0.214,95%CI:0.069-0.660,P<0.05 relative to T/T genotype).There were significant gene-behavior interactions between smoking status and XRCC1 Arg399Gln,as well as BMI and APE1-141T/G polymorphism(all P<0.05).CONCLUSION:APE1 Asp148Glu is associated with increased CRC risk and smoking alters the association between XRCC1 Arg399Gln and CRC risk in the Chinese Han population. | Shi-Heng Zhang Lin-Ang Wang Zheng Li Yu Peng Yan Ping Cun Nan Dai Yi Cheng He Xiao Yan-Li Xiong Dong Wang | 2014 | World Journal of Gastroenterology2014，20，26： | 8 |
| 12 | Sedimentary Evolution and Transgressions of the Western Subei Basin in Eastern China since the Late Pliocene显示文摘Sedimentary sequences in the Subei Basin are complex and have been affected by interactions between the ocean and rivers since the Late Pliocene, including the Yellow River, Huaihe River, and the Yangtze River. This sedimentary evolution, in particular the timing of Pleistocene transgressions, has long been a matter of controversy owing to the lack of precise chronological evidence. The aim of this study is to explore the evolution of the sedimentary environment throughout the past 3.00 Ma in this region on the basis of a comprehensive analysis of particle size and foraminifera and ostracods collected in the TZK9 core from the Subei Basin combined with geochronological studies of magnetostratigraphy, AMS^(14)C and optically stimulated luminescence(OSL). The results show that fluvial facies in the sedimentary environment from 3.00 to 1.01 Ma. There were fluvial facies and reflects six sea-level high stands from 1.01 to 0.25 Ma. The study area was affected by four large-scale transgressions since 0.25 Ma. The four marine sedimentary layers known as DU7(buried at 48–52 m), DU5(buried at 35–41 m), DU3(buried at 16–23 m), and DU1(buried at 2–4 m) are recorded in the MIS7(210–250 ka), MIS5, MIS3, and Holocene, respectively. The magnitude of the DU5 transgression was identical to that of the DU3 transgression, both were larger than the DU7 transgression, and the DU1 transgression was the weakest. The variation of transgression strength reflects the influence of global changes in sea level, tectonic subsidence, shell ridges, and sand dams. In the TZK9 core, we found evidence of seven sea-level high stands from the Early–Middle Pleistocene, and the first one caused by regional rapid subsidence and could be traced back to 0.83-0.84 Ma. The sea-level high stands and the age of the first one recorded above was different from other cores in eastern China, this was caused by the lack of absolute age control and the differences in paleotopography during this period. This study reconstructs sedimentary evolution, determines the transgression and its age, establishes the chronology since the Late Pliocene, and provides a scientific framework for further paleoenvironmental and tectonic studies. The results of this study highlight the important role that local tectonics and global sea level play in the sedimentary evolution and transgressions that have occurred in the western Subei Basin. | CHENG Yu LI Xiangqian SHU Junwu BAI Shibiao ZHAO Zengyu ZHANG Xiangyun GUO Gang ZHANG Ping LIN Jingxing | 2019 | Acta Geologica Sinica(English Edition)2019，93，1： | 7 |
| 13 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 14 | Molecular characters and morphological genetics of CAL gene in Chinese cabbage显示文摘BcpCAL, the homologous gene of CAL, was isolated from Chinese cabbage. Unlike bobcat of cauliflower, BcpCAL did not hold the terminating mutation in the fifth e-con. After crosses of cauliflower with Chinese cabbage, the resultant hybrids failed to form curd, which implicates the genetic complement of BcpCAL to the mutated Bob- CAL in the function of curd formation. One of CAL gene isolated from the hybrid apparently comes from the female parent (Chinese cabbage) even though there are a few of the biases substituted and deleted. The result offers the molecular and genetic evidences for the Study of biological function of CAL in morphological genetics of curd. | LI XIAO FANG RUI JUAN SHEN PING LIN LIU ZHANG CHENG TANG YU KE HE (Shanghai Institute of Plant Physiology, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032) | 2000 | Cell Research2000，10，1： | 5 |
| 15 | Out of the Pan-Himalaya:Evolutionary history of the Paeoniaceae revealed by phylogenomics显示文摘Peonies(the Paeoniaceae,Paeonia L.)are famous garden flowers,medicinal plants,and edible oil crops,but their evolutionary history largely remains unknown.To probe into their phylogenetic relationships,evolutionary history,formation of present distribution pattern,and origins of tetraploids,we sequenced 25 fragments belonging to 20 single copy nuclear genes and 14 chloroplast regions of all species in the genus to reconstruct phylogenetic relationships,date the divergence times of lineages,infer the ancestral biogeographical regions,and document the parents of tetraploids.Our results show that Paeoniaceae separated from the other members in Saxifragales in the Campanian of the late Cretaceous and diverged into two clades,woody and herbaceous clades,in the late Oligocene or early Miocene.They survived and early diverged in the Pan-Himalaya where they migrated eastwards to East Asia and further to NW America,and northwards to Middle Asia,and further to Europe.The woody lineage differentiated into two sublineages with accelerated root or floral disk evolution,while the herbaceous lineage diverged into five sublineages.Multiple glacial and interglacial cycles in Europe in the late Pliocene and early Pleistocene created opportunities for the peony species to meet and hybridize in the Mediterranean refugia,giving rise to eight allotetraploid species and four infraspecific tetraploids.Paeonia daurica Andrews,P.obovata Maxim.,and P.tenuifolia L.served as the most important parents.The phylogeny of Paeonia L.implies that a new taxonomic system with two subgenera and seven sections should be proposed. | Shi-Liang Zhou Chao Xu Jing Liu Yan Yu Ping Wu Tao Cheng De-Yuan Hong | 2021 | Journal of Systematics and Evolution2021，59，6： | 5 |
| 16 | Elevated Platelet Activating Factor Level in Ischemia-Related Arrhythmia and Its Electrophysiological Effect on Myocardium显示文摘Objective The mechanism through which platelet activating factor (PAF) induces cardiac electrical activity and arrhythmia is not well understood and previous studies have suggested a potential involvement of ion channels in its action. The present study was aimed to clarify the role of PAF in fatal arrhythmias following acute myocardia infarction (AMI) and the underlying mechanism. Methods (1) Blood PAF levels were measured among 72 AMI patients at the time of diagnosis with AMI and 48 h later, and their electrocardiogram (ECG) was recorded continuously. (2) Ischemia simulation and surface electrocardiogram were conducted in 20 pigs and their PAF levels were measured. (3) PAF perfusion and standard microelectrode recording were performed on guinea pig papillarymuscles. Results In both humans and pigs, elevated PAF levels were detected in AMI and simulated ischemia, respectively, and even higher PAF levels were found when fatal arrhythmias occurred. In guinea pig myocardium, PAF induced a shortening of action potential duration at 90% level of repolarization (APD 90 )under non-ischemic conditions and a more pronounced shortening under early simulated ischemic conditions. Conclusion AMI and ischemia are associated with increased PAF levels in humans and pigs, which are further raised when fatal arrhythmia follows. The effects of PAF on the myocardium may be mediated by multiple ion channels. | TAO Yong Kang ZHAO Shui Ping YU Pu Lin SHI Jing GU Cheng Dong SUN Hong Tao ZHANG Guo Qiang | 2013 | Biomedical and Environmental Sciences2013，26，5： | 5 |
| 17 | Two new compounds from Zingiber officinale显示文摘新周期的 diarylheptanoid, 1,5-epoxy-3-hydroxy-1-(3-methoxy-4,5-dihydroxyphenyl )-7-(4-hydroxyphenyl)-heptane (1 ) ,以及新单音的萜烯, 10-O- β - d-glucopyranosyl-hydroxy cineole (2 ) 从姜 officinale 的根茎被孤立。混合物的结构 1 和 2 被建立基于他们的光谱数据。另外,这些混合物的抗氧化剂活动也被测量。 | Yu Zhao Qiao Feng Tao Rong Ping Zhang Chang Xin Zhou Hui Dou Shu Yun Shi Ye Cheng Xiao Lian Li Sun Su Zeng Ke Xin Huang Xiao Dong Zhang Xiao Kun Li | 2007 | Chinese Chemical Letters2007，18，10： | 4 |
| 18 | Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese:a Case-control Study显示文摘Objective To investigate the association between low-density lipoprotein receptor-related protein 5(LRP5) variants(rs12363572 and rs4930588) and type 2 diabetes mellitus(T2DM) in Han Chinese. Methods A total of 1842 T2 DM cases(507 newly diagnosed cases and 1335 previously diagnosed cases) and 7777 controls were included in this case-control study. PCR-RFLP was conducted to detect the genotype of the two single nucleotide polymorphisms(SNPs). Odds ratios(ORs) and 95% confidence intervals(95% CIs) were calculated to describe the strength of the association by logistic regression. Results In the study subjects, neither rs12363572 nor rs4930588 was significantly associated with T2 DM, even after adjusting for relevant covariates. When stratified by body mass index(BMI), the two SNPs were also not associated with T2 DM. Among the 3 common haplotypes, only haplotype TT was associated with reduced risk of T2DM(OR 0.820, 95% CI 0.732-0.919). In addition, rs12363572 was associated with BMI(P<0.001) and rs4930588 was associated with triglyceride levels(P=0.043) in 507 newly diagnosed T2 DM cases but not in healthy controls. Conclusion No LRP5 variant was found to be associated with T2 DM in Han Chinese, but haplotype TT was found to be associated with T2 DM. | YOU Hai Fei ZHAO Jing Zhi ZHAI Yu Jia YIN Lei PANG Chao LUO Xin Ping ZHANG Ming WANG Jin Jin LI Lin Lin WANG Yan WANG Qian WANG Bing Yuan REN Yong Cheng HU Dong Sheng | 2015 | Biomedical and Environmental Sciences2015，28，7： | 4 |
| 19 | Adsorption of phenol from aqueous solution by a hierarchical micro-nano porous carbon material显示文摘A hierarchical micro-nano porous carbon material (MNC) was prepared using expanded graphite (EG), sucrose, and phosphoric acid as raw materials, followed by sucrose-phosphoric acid solution impregnation, solidification, carbonization and activation. Nitrogen adsorption and mercury porosimetry show that mixed nanopores and micropores coexist in MNC with a high specific surface area of 1978 m2·g-1 and a total pore volume of 0.99 cm3·g-1. In addition, the MNC is found to consist of EG and activated carbon with the latter deposited on the interior and the exterior surfaces of the EG pores. The thickness of the activated carbon layer is calculated to be about one hundred nanometers and is further confirmed by scanning electron microscope (SEM) and transmission election microscope (TEM). A maximum static phenol adsorption of 241.2 mg·g-1 was obtained by using MNC, slightly higher than that of 220.4 mg·g-1 by using commercial activated carbon (CAC). The phenol adsorption kinetics were investigated and the data fitted well to a pseudo-second-order model. Also, an intra-particle diffusion mechanism was proposed. Furthermore, it is found that the dynamic adsorption capacity of MNC is nearly three times that of CAC. The results suggest that the MNC is a more efficient adsorbent than CAC for the removal of phenol from aqueous solution. | Liu Chengbao Chen Zhigang Ni Chaoying Chen Feng Gu Cheng Cao Yu Wu Zhengying Li Ping | 2012 | Rare Metals2012，31，6： | 4 |
| 20 | Application of regional citrate anticoagulation in patients at high risk of bleeding during intermittent hemodialysis:a prospective multicenter randomized controlled trial显示文摘Objective:Safe and effective anticoagulation is essential for hemodialysis patients who are at high risk of bleeding.The purpose of this trial is to evaluate the effectiveness and safety of two-stage regional citrate anticoagulation(RCA)combined with sequential anticoagulation and standard calcium-containing dialysate in intermittent hemodialysis(IHD)treatment.Methods:Patients at high risk of bleeding who underwent IHD from September 2019 to May 2021 were prospectively enrolled in 13 blood purification centers of nephrology departments,and were randomly divided into RCA group and saline flushing group.In the RCA group,0.04 g/mL sodium citrate was infused from the start of the dialysis line during blood draining and at the venous expansion chamber.The sodium citrate was stopped after 3 h of dialysis,which was changed to sequential dialysis without anticoagulant.The hazard ratios for coagulation were according to baseline.Results:A total of 159 patients and 208 sessions were enrolled,including RCA group(80 patients,110 sessions)and saline flushing group(79 patients,98 sessions).The incidence of severe coagulation events of extracorporeal circulation in the RCA group was significantly lower than that in the saline flushing group(3.64%vs.20.41%,P<0.001).The survival time of the filter pipeline in the RCA group was significantly longer than that in the saline flushing group((238.34±9.33)min vs.(221.73±34.10)min,P<0.001).The urea clearance index(Kt/V)in the RCA group was similar to that in the saline flushing group with no statistically significant difference(1.12±0.34 vs.1.08±0.34,P=0.41).Conclusions:Compared with saline flushing,the two-stage RCA combined with a sequential anticoagulation strategy significantly reduced extracorporeal circulation clotting events and prolonged the dialysis time without serious adverse events. | Xiaoyan TANG Dezheng CHEN Ling ZHANG Ping FU Yanxia CHEN Zhou XIAO Xiangcheng XIAO Weisheng PENG Li CHENG Yanmin ZHANG Hongbo LI Kehui LI Bizhen GOU Xin WU Qian YU Lijun JIAN Zaizhi ZHU Yu WEN Cheng LIU Hen XUE Hongyu ZHANG Xin HE Bin YAN Liping ZHONG Bin HUANG Mingying MAO | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，11： | 4 |
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