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| 1 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 2 | Hyperhomocysteinemia induces cardiac injury by up-regulation of p53-dependent Noxa and Bax expression through the p53 DNA methylation in ApoE-/- mice显示文摘Hyperhomocysteinemia (HHcy ) 是为心血管的疾病的一个风险因素并且与心失败有强壮的关联。然而,心脏的织物上的 HHcy 的效果仍然保持不太好理解。阐明在导致 HHcy 的心脏的损害的 p53 依赖的 apoptosis 的角色,我们用高蛋氨酸饮食喂了 ApoE/ 老鼠建立 HHcy 模型。浆液 Hcy,心脏的酶,和类脂化合物被测量。Noxa, DNMT1, caspases-3/9,和 p53 的蛋白质层次被连接酶的 immunosorbent 试金决定。Bcl-2 和 Bax 蛋白质被染色的 immunohistochemistry 检测。S-adenosyl 蛋氨酸和 S-adenosyl homocysteine 集中被高效的液体层析决定。p53 和 DNMT1 的 mRNA 层次被即时聚合酶链反应(PCR ) 分析, p53 的 methylation 层次被嵌套的 methylation-specific-PCR 分析。我们的数据证明浆液 Hcy 和类脂化合物的集中与 N 控制组相比在 Meth 组被增加,它显示模型成功地被建立。p53 和 Noxa 的表示层次在 Meth 组被增加,当 p53 的 methylation 地位是 hypomethylation 时。caspase-3/9 的活动与 N 控制组相比在 Meth 组被增加。另外,染色的 immunohistochemistry 证明 Bax 的表示显著地与 N 控制组相比在 Meth 和 Meth-F 组被增加。在摘要, HHcy 由 p53 依赖的 pro-apoptotic 的起来规定导致心脏的损害联系了基因 Noxa 和 Bax,当 p53 DNA hypomethylation 是在 HHcy 导致的病理学的过程的关键分子的机制时。 | ShengchaoMa Huiping Zhang Weiwei Sun HuiHui Gong YanhuaWang Changjian Ma Ju Wang Chengjian Cao Xiaoling Yang Jue Tian Yideng Jiang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，5： | 12 |
| 3 | In vitro and in vivo biodegradation and biocompatibility of an MMT/BSA composite coating upon magnesium alloy AZ31显示文摘The performance of biodegradable magnesium alloy requires special attention to rapid degradation and poor biocompatibility, which can cause the implant to fail. Here, a sodium montmorillonite(MMT)/bovine serum albumin(BSA) composite coating was prepared upon magnesium alloy AZ31 via hydrothermal synthesis, followed by dip coating. We evaluated the surface characterization and corrosion behavior in vitro, and the biocompatibility in vitro and in vivo. Biodegradation progress of the MMT-BSA coated Mg pieces was examined through hydrogen evolution, immersion tests, and electrochemical measurements in Hank’s solution. In vitro biocompatibility studies were evaluated via hemolysis tests, dynamic cruor time tests, platelet adhesion, MTT testing and live-dead stain of osteoblast cells(MC3 T3-E1). It was found that the MMT-BSA coating had good corrosion resistance and a marked improvement in biocompatibility in comparison to bare Mg alloy AZ31. in vivo studies were carried out in rat model and the degradation was characterized by computed tomography scans. Results revealed that the MMT-BSA coated Mg alloy AZ31 implants maintained their structural integrity and slight degradation after 120 d of post-implantation. A100% survival rate for the rats was observed with no obvious toxic damages on the organs and tissues.Additionally, we proposed a sound coating formation mechanism. Considering the good corrosion protection and biocompatibility, the MMT-BSA coated Mg alloy AZ31 is a promising candidate material for biomedical implants. | Jian Wang Lanyue Cui Yande Ren Yuhong Zou Jinlong Ma Chengjian Wang Zhongyin Zheng Xiaobo Chen Rongchang Zeng Yufeng Zheng | 2020 | Journal of Materials Science & Technology2020，47，12： | 7 |
| 4 | Simultaneous elution of polycyclic aromatic hydrocarbons and heavy metals from contaminated soil by two amino acids derived from β-cyclodextrins显示文摘Two highly water-soluble amino acids,which derived from β-CDs,i.e.,glutamic acid-β-cyclodextrin (GluCD) and ethylene-diamineβ-cyclodextrin (EDCD),were synthesized and were examined for their effect on solubilization of anthracene (ANT),complexation of cadmium (Cd2+),and elution removal of ANT and Cd2+ in soil.The results showed that GluCD and EDCD were powerful complexant for ANT and Cd2+.In the presence of 10 g/L GluCD and EDCD,the solubilization of ANT increased by 47.04 and 23.85 times compared to the control,respectively.GluCD resulted in approximately 90% complexation of Cd2+ while 70% complexation was observed for EDCD.Simultaneously,GluCD and EDCD could greatly enhance the elution removal of ANT and Cd 2+ from soil.GluCD resulted in the highest elution efficiency of ANT and Cd2+.With the addition of 10 g/L GluCD,53.5% of ANT and 85.6% of Cd2+ were eluted,respectively.The ANT had a negligible effect on the Cd2+ removal due to different complexing sites of ANT and Cd2+,while Cd2+ enhanced the ANT removal under the addition of GluCD because Cd2+ neutralized the-COOH group of GluCD.Adversely,the removal of ANT was decreased with Cd2+ under the addition of EDCD,this was due to the fact that Cd2+ enhanced the polarity of EDCD molecule and inhibited the complexation between ANT and EDCD.The study suggested that GluCD could be preferred and be successfully applied to remediation of heavy metals or organic compounds in contaminated soil. | Chengjian Yang Qingru Zeng Yunzhong Wang Bohan Liao Jian Sun Hui Shi Xingdou Chen | 2010 | Journal of Environmental Sciences2010，22，12： | 7 |
| 5 | A Study of the Characteristics of Microorganisms for Effective Degradation of Marine Oil Spills显示文摘Four microorganism strains were isolated from coastal petroleum-polluted soil and sand samples of Bohai Sea oilfield; they were found to degrade marine oil spills effectively. The experimental results show that the degradation efficiency of crude oil with these four strains (XT-4, SZ-1-25, B-4-9, BS-3-12) is 95.97%, 96.01%, 97.99% and 98.99%, respectively, in their optimum conditions. The characteristics of bacterial biodegradation are investigated. The simulation biotreatment of oil-contaminated beach sand, with an initial oil content of 5,664mg/kg-dry-sand, shows that the residual oil content is 2,700 mg/kg-dry-sand and 2,679 mg/kg-dry-sand after 170 days’ treatment with two bacteria (B-4-9, BS-3-12), respectively. | Zhang Zhongzhi Wei Xiaofang Zong Chang Yu Hongwen Li Chengjian He Ruibing | 2006 | Petroleum Science2006，3，1： | 6 |
| 6 | Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis显示文摘 | Lin He Xinhua Liu Jianguo Yang Wanjin Li Shumeng Liu Xujun Liu Ziran Yang Jie Ren Yue Wang Lin Shan Chengjian Guan Fei Pei Liandi Lei Yu Zhang Xia Yi Xiaohan Yang Jing Liang Rong Liu Luyang Sun Yongfeng Shang | 2018 | Cell Research2018，28，9： | 5 |
| 7 | Backward Euler-Maruyama method applied to nonlinear hybrid stochastic differential equations with time-variable delay显示文摘In this paper, we consider strong convergence and almost sure exponential stability of the backward Euler-Maruyama method for nonlinear hybrid stochastic differential equations with time-variable delay. Under the local Lipschitz condition and polynomial growth condition, it is proved that the backward Euler-Maruyama method is strongly convergent. Additionally, the moment estimates and almost sure exponential stability for the analytical solution are proved. Also, under the appropriate condition, we show that the numerical solutions for the backward Euler-Maruyama methods are almost surely exponentially stable. A numerical experiment is given to illustrate the computational effectiveness and the theoretical results of the method. | Chengjian Zhang Ying Xie | 2019 | Science China Mathematics2019，62，3： | 5 |
| 8 | ALMOST SURE AND MOMENT EXPONENTIAL STABILITY OF PREDICTOR-CORRECTOR METHODS FOR STOCHASTIC DIFFERENTIAL EQUATIONS显示文摘这份报纸几乎肯定处理并且预言者修正者方法的一个班的指数的稳定性用于它的随机的微分方程的时刻 ? 类型。为这类方法的稳定性标准被导出。方法被显示几乎肯定维持并且时刻为在适当条件下面的所有足够地小的 timesteps 的指数的稳定性。一个数字实验进一步证明这些理论结果。 | Yuanling NIU Chengjian ZHANG | 2012 | Journal of Systems Science & Complexity2012，25，4： | 4 |
| 9 | SUPERCONVERGENCE OF A DISCONTINUOUS GALERKIN METHOD FOR FIRST-ORDER LINEAR DELAY DIFFERENTIAL EQUATIONS显示文摘 | Dongfang Li Chengjian Zhang | 2011 | Journal of Computational Mathematics2011，29，5： | 4 |
| 10 | A review of enantioselective dual transition metal/photoredox catalysis显示文摘Transition metal catalysis is one of the most important tools to construct carbon-carbon and carbon-heteroatom bonds in modern organic synthesis. Visible-light photoredox catalysis has recently drawn considerable attention of the scientific community owing to its unique activation modes and significance for the green synthesis. The merger of photoredox catalysis with transition metal catalysts, termed metallaphotoredox catalysis, has become a popular strategy for expanding the synthetic utility of visiblelight photocatalysis. This strategy has led to the discovery of novel asymmetric transformations, which are unfeasible or not easily accessible by a single catalytic system. This contemporary area of organic chemistry holds promise for the development of economical and environmentally friendly methods for the asymmetric synthesis of chiral compounds. In this review, the advances in the enantioselective metallaphotoredox catalysis(EMPC) are summarized. | Hong-Hao Zhang Hui Chen Chengjian Zhu Shouyun Yu | 2020 | Science China Chemistry2020，63，5： | 3 |
| 11 | Neutron halo state of ^(13)C显示文摘Angular distributions for the 12C(d, p)13C transfer reactions have been measured at Ed = 11.8 MeV, and compared with those of the DWBA calculations. By means of this comparison, density distributions of the last neutron in the ground state and the first 1/2+ state of 13C are extracted. The properties of these states in 13C have also been studied in the framework of the nonlinear relativistic mean-field theory with NL-SH parameters. It is found that the first l/2+ state in 13C is a neutron halo state shown by both the experimental and theoretical density distributions of the last neutron. | LIU Zuhua, LIN Chengjian, LI Zhichang, ZHANG Huanqiao, CHEN Baoqiu, MA Zhongyu, WU Yuewei, LIU Jiancheng & LI ShuyuanChina Institute of Atomic Energy, Beijing 102413, China | 2001 | Chinese Science Bulletin2001，46，1： | 3 |
| 12 | STRONG PREDICTOR-CORRECTOR APPROXIMATION FOR STOCHASTIC DELAY DIFFERENTIAL EQUATIONS显示文摘 | Yuanling Niu Chengjian Zhang Kevin Burrage | 2015 | Journal of Computational Mathematics2015，33，6： | 3 |
| 13 | Biodegradation of N,N-dimethylacetamide by Rhodococcus sp.strain B83 isolated from the rhizosphere of pagoda tree显示文摘The biodegradation characteristic and potential metabolic pathway for removal of environmental N,N-dimethylacetamide(DMAC) by Rhodococcus sp. strain B83 was studied.Rhodococcus sp. strain B83 was isolated from the rhizosphere of a pagoda tree and proved capable of utilizing DMAC as sole source of carbon and nitrogen. Batch culture studies showed that strain B83 could tolerate up to 25 g/L DMAC and showed distinct growth on possible catabolic intermediates except for acetate. The nitrogen balance analysis revealed that approximately 71% of the initial nitrogen was converted to organic nitrogen. DMAC degradation has led to accumulation of acetate and organic nitrogen, meanwhile traces of nitrate and ammonia was build-up but without nitrite. The growth of strain B83 could be inhibited by adding exogenous acetate. By means of the assay of enzymatic degradation of DMAC, several catabolic intermediates at different intervals were observed and identified.Based on the results obtained from culture solution and enzymatic degradation assay, a detailed pathway is proposed for DMAC biodegradation. | Xingdu Chen Chengjian Yang Weiwei Wang Bizhou Ge Jun Zhang Yucan Liu Yaping Nan | 2017 | Journal of Environmental Sciences2017，29，3： | 3 |
| 14 | SOLIDIFICATION MICROSTRUCTURE OF Ni-BASE SUPERALLOY POWDER显示文摘The solidification microstructure and phase composition of Ni-base superalloy FGH95 pow-der with different mesh size have been investigated.The structure transition was found fromdendrite in major into cellular structure as the powder size reduces and the cooling rate in-creases.The predominant phase was identified as MC-type carbide,with differentmorphologies,which may be related to their composition and the condition ofsolidification.Minor phases,such as boride,Laves and primary γ’ are also present as ac-companiments of the carbide. | HU Benfu LI Huiying WU Chengjian ZHANG Shouhua University of Science and Technology Beijing,Beijing,China Associate Professor,Dept.of Material Science and Engineering,University of Science and technology Beijing,Beijing 100083,China. | 1991 | Acta Metallurgica Sinica(English Letters)1991，4，2： | 2 |
| 15 | In situ FTIR investigation on phase transformations in BN nanoparticles显示文摘Fourier transformation infrared spectrum (FTIR) was employed to investigate phase transformation of nanoparticle BN, containing eBN, rBN, wBN and cBN, in which eBN and rBN are the main components. We found that part of eBN was converted into rBN at 200―350℃. At and above 400℃, eBN transformed into wBN, and some of wBN were converted into cBN simultaneously. This conclusion is supported by the results from high- resolution transmission electron microscopic (HRTEM) and Raman spectroscopic measurements. In this work, the converting processes be- tween different BN phases were continuously monitored by in situ FTIR spectroscopy. The results will be helpful for synthesis of cBN at moderate conditions. | YU Lili GAO Bin CHEN Zhi SUN Chuantao CUI Deliang WANG Chengjian WANG Qilong JIANG Minhua | 2005 | Chinese Science Bulletin2005，50，24： | 2 |
| 16 | Constructing Judgement Matrix Using Ratio Scale by Analytic Hierarchy Process显示文摘 | LIU BAOLU MAXIAOHONG YU CHENGJIAN | 2005 | Journal of Computational and Information System2005，1，2： | 1 |
| 17 | The asymptotic stability of theoretical and numerical solutions for systems of neutral multidelay-differential equations显示文摘 | Chengjian Zhang Shuzi Zhou | 1998 | Science in China Series A: Mathematics1998，，11： | 1 |
| 18 | An Analysis of Stability of Milstein Method for Stochastic Differential Equations with Delay显示文摘 | WANG Zhiyong ZHANG Chengjian | 2006 | Computers and Mathematics with Applications2006，51，： | 1 |
| 19 | Ag-Pd alloy decorated ZnIn_(2)S_(4) microspheres with optimal Schottky barrier height for boosting visible-light-driven hydrogen evolution显示文摘Rapid charge carrier recombination rate and insufficient light harvesting capacity are two dominat-ing drawbacks encountered in zinc indium sulfide(ZnIn_(2)S_(4))for photocatalytic applications.Herein,a chemical reduction method was performed to combine bimetallic Ag-Pd alloy nanoparticles(NPs)with spherical-like ZnIn_(2)S_(4)(ZIS).By optimizing Ag:Pd molar ratio and overall loading amount,the optimal Ag_(0.25)Pd_(0.75)-ZIS sample exhibited a maximum H_(2)evolution rate(125.4μmol/h)under visible light,which was higher than that of ZIS,Ag-ZIS and Pd-ZIS.The loading of Ag NPs contribution to PHE reaction by its plasmonic effect was negligible compared to that of Pd loading(Schottky effect).The apparent quan-tum yield(AQY)values over Ag_(0.25)Pd_(0.75)-ZIS sample could reach up to 18.3%at 400 nm and 15.8%at 420 nm.The enhanced activity for photocatalytic hydrogen evolution(PHE)over Ag_(0.25)Pd_(0.75)-ZIS sample was mainly due to the bimetallic synergistic effect that presented as follows.Firstly,the plasmon hy-bridization by loading Ag-Pd bimetallic alloy can significantly increase light harvesting capacity of ZIS.Secondly,the optimal Schottky barrier height formed between Ag-Pd alloy and ZIS interface was benefi-cial for prolonging electron-hole pair lifetimes,promoting charge carrier separation and thus facilitating PHE efficiency.Density functional theory(DFT)analysis indicated that the adsorption energy of H∗over Pd_(0.75)Ag_(0.25)alloy was very close to zero and thus theoretically possessed the highest activity for H_(2)evo-lution,which is in line with experimental results.Combined theoretical calculation with experimental results,a reasonable photocatalytic mechanism was proposed and verified. | Chao Liu Yulong Zhang Jiaxin Wu Hailu Dai Chengjian Ma Qinfang Zhang Zhigang Zou | 2022 | Journal of Materials Science & Technology2022，，19： | 1 |
| 20 | Revisiting the elastic solution for an inner-pressured functionally graded thick-walled tube within a uniform magnetic field显示文摘In this paper, the mechanical responses of a thick-walled functionally graded hollow cylinder subject to a uniform magnetic field and inner-pressurized loads are studied. Rather than directly assume the material constants as some specific function forms displayed in pre-studies, we firstly give the volume fractions of different constituents of the functionally graded material(FGM) cylinder and then determine the expressions of the material constants. With the use of the Voigt method, the corresponding analytical solutions of displacements in the radial direction, the strain and stress components, and the perturbation magnetic field vector are derived. In the numerical part, the effects of the volume fraction on the displacement, strain and stress components, and the magnetic perturbation field vector are investigated. Moreover, by some appropriate choices of the material constants, we find that the obtained results in this paper can reduce to some special cases given in the previous studies. | Libiao XIN Yanbin LI Dongmei PAN Guansuo DUI Chengjian JU | 2018 | Applied Mathematics and Mechanics(English Edition)2018，39，10： | 1 |
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