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| 1 | An efficiently halogen-free flame-retardant long-glass-fiber-reinforced polypropylene system显示文摘 | Yun Liu Chengliang Deng Jing Zhao | | 0，，： | 1 |
| 2 | Systematic approach for targeting interplant hydrogen networks显示文摘 | DENG Chun ZHOU Yuhang CHEN Chengliang | 2015 | Energy2015，90，1： | 1 |
| 3 | The synergistic flame-retardant effect of O-MMT on the intumescent flame- retardant PP / CA / APP systems显示文摘 | Liu Yun Wang Jtmsheng Deng Chengliang | 2010 | Polymers for Advanced Technologies2010，21，11： | 1 |
| 4 | Facile template-free sonochemical fabrication of hollow ZnO spherical structures显示文摘 | Chonghai Deng Hanmei Hu Guoquan Shao Chengliang Han | 2010 | Materials Letters2010，，64： | 1 |
| 5 | An efficiently halogen-free flame-retardant long-glass-fiber-reinforced polypropylene system 显示文摘 | Yun Liu Chengliang Deng Jing Zhao | 2011 | Polymer Degradation and Stability2011，96，： | 1 |
| 6 | Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents显示文摘Programmed cell death 1(PD-1)/programmed cell death ligand 1(PD-L1)have emerged as one of the most promising immune checkpoint targets for cancer immunotherapy.Despite the inherent advantages of small-molecule inhibitors over antibodies,the discovery of small-molecule inhibitors has fallen behind that of antibody drugs.Based on docking studies between small molecule inhibitor and PD-L1 protein,changing the chemical linker of inhibitor from a flexible chain to an aromatic ring may improve its binding capacity to PD-L1 protein,which was not reported before.A series of novel phthalimide derivatives from structure-based rational design was synthesized.P39 was identified as the best inhibitor with promising activity,which not only inhibited PD-1/PD-L1 interaction(IC_(50)=8.9 nmol/L),but also enhanced killing efficacy of immune cells on cancer cells.Co-crystal data demonstrated that P39 induced the dimerization of PD-L1 proteins,thereby blocking the binding of PD-1/PD-L1.Moreover,P39 exhibited a favorable safety profile with a LD_(50)>5000 mg/kg and showed significant in vivo antitumor activity through promoting CD8^(+)T cell activation.All these data suggest that P39 acts as a promising small chemical inhibitor against the PD-1/PD-L1 axis and has the potential to improve the immunotherapy efficacy of T-cells. | Chengliang Sun Yao Cheng Xiaojia Liu Gefei Wang Wenjian Min Xiao Wang Kai Yuan Yi Hou Jiaxing Li Haolin Zhang Haojie Dong Liping Wang Chenguang Lou Yanze Sun Xinmiao Yu Hongbin Deng Yibei Xiao Peng Yang | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 0 |
| 7 | Adverse effects of triclosan on kidney in mice: Implication of lipid metabolism disorders显示文摘Triclosan(TCS)is a ubiquitous antimicrobial used in daily consumer products.Previous reports have shown that TCS could induce hepatotoxicity,endocrine disruption,disturbance on immune function and impaired thyroid function.Kidney is critical in the elimination of toxins,while the effects of TCS on kidney have not yet been well-characterized.The aim of the present study was to investigate the effects of TCS exposure on kidney function and the possible underlying mechanisms in mice.Male C57BL/6 mice were orally exposed to TCS with the doses of 10 and 100 mg/(kg•day)for 13 weeks.TCS was dissolved in dimethyl sulfoxide(DMSO)and diluted by corn oil for exposure.Corn oil containing DMSO was used as vehicle control.Serum and kidney tissues were collected for study.Biomarkers associated with kidney function,oxidative stress,inflammation and fibrosis were assessed.Our results showed that TCS could cause renal injury as was revealed by increased levels of renal function markers including serum creatinine,urea nitrogen and uric acid,as well as increased oxidative stress,pro-inflammatory cytokines and fibroticmarkers in a dose dependent manner,whichweremore significantly in 100 mg/(kg•day)group.Mass spectrometry-based analysis of metabolites relatedwith lipid metabolism demonstrated the occurrence of lipid accumulation and defective fatty acid oxidation in 100 mg/(kg•day)TCS-exposed mouse kidney.These processes might lead to lipotoxicity and energy depletion,thus resulting in kidney fibrosis and functional decline.Taken together,the present study demonstrated that TCS could induce lipid accumulation and fatty acid metabolism disturbance in mouse kidney,whichmight contribute to renal function impairment.The present study further widens our insights into the adverse effects of TCS. | Wei Huang Guodong Cao Chengliang Deng Yanyan Chen Tao Wang Da Chen Zongwei Cai | 2023 | Journal of Environmental Sciences2023，，2： | 0 |
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