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| 1 | A review for the breeding of orchids: Current achievements and prospects显示文摘Orchids are horticultural plants with significant ornamental and economic value.Increasing market circulation and rising trade in orchids is forcing breeders to develop varieties with unique characteristics,including flower color,morphology,and resistance using a range of approaches,including traditional and molecular breeding.Advances in high-throughput technologies have generated extensive data sets with greater sequencing depths and broader coverage,providing the potential for discovering new genes/pathways that give rise to key traits.Several attempts have been made to use emerging molecular and omics methods to accelerate the breeding process in certain of the commercially valuable orchids.This review consolidates current approaches and achievements in orchid breeding and discusses their future applications for improving the resistance,ornamental,and other valuable characteristics of these plants. | Chengru Li Na Dong Yamei Zhao Shasha Wu Zhongjian Liu Junwen Zhai | 2021 | Horticultural Plant Journal2021，7，5： | 5 |
| 2 | A/E大肠杆菌疫苗动物模型的建立显示文摘致病性和出血性大肠杆菌 (代表株 EPEC E2 34 8和 EHEC O15 7)是婴幼儿腹泻、出血性结肠炎和尿路感染综合征 (尿毒症 )的主要病原菌 ,它们同属于粘附脱落 (Attaching/ Effacing,A/ E)大肠杆菌群 ,具有许多共同的毒力基因 ,定位于致病岛 L EE(the locus of enterocyte effacement)上。本试验主要就 A/ E大肠杆菌致病岛 L EE的 2个主要调节基因 lux和 ler基因对细菌致病性和免疫原性的影响进行了研究。所使用的始发菌株为兔致病性大肠杆菌 RDEC- 1,根据同源重组的原理 ,利用自杀性载体 p CVD44 2技术 ,敲除了位于染色体上的 lux和 ler基因 ,构建了 lux和 ler基因缺失突变株 ,研究了这 2个基因对细菌生长、毒力因子表达的调控作用以及基因缺失突变株的致病性和免疫保护作用。家兔实验研究表明 ,lux基因缺失突变株仍然残存着部分致病作用 ,不足以成为理想的致弱疫苗 ;而 ler基因缺失突变株安全性好 ,具有良好的免疫保护作用 ,是理想的家兔致弱疫苗候选株。这些研究资料为人 A/ E大肠杆菌疫苗 ,尤其是 EHEC O15 7疫苗的研制指明了方向 ,并提供了技术路线。 | 冯书章 Edgar C Boedeker Chengru Zhu Timothy Thate James Kaper 朱平 邓定华 | 2002 | 中国兽医学报2002，22，6： | 3 |
| 3 | 大肠杆菌REPEC O103 ler基因缺失突变株的构建与免疫显示文摘目的 研究大肠杆菌致病岛LEE基因群中调节基因ler对细菌致病性和免疫原性的影响 ,评价基因缺失突变疫苗株的免疫效果 ,为人致病性和出血性大肠杆菌基因缺失突变疫苗的研制提供技术路线。方法 利用兔致病性大肠杆菌REPECO1 0 3为始发菌株 ,根据同源重组的原理 ,运用自杀性载体 pCVD442技术 ,敲除位于细菌染色体上的ler基因 ,构建ler基因缺失突变株 ,通过动物实验 ,检测基因缺失突变株的致病性和免疫保护作用。结果 构建了REPECO1 0 3ler基因缺失突变株 ,并证实ler基因细菌致病岛的正调控作用和对细菌生长的负调控作用。家兔实验研究表明 ,ler基因缺失突变株无致病性 ,但保留着良好的免疫原性。结论 首次揭示了ler调节基因与细菌致病性和免疫原性的关系 ,构建的REPECO1 0 3ler基因缺失突变株安全性好 ,具有良好的免疫保护作用 ,是理想的家兔的致弱疫苗候选株。 | 冯书章 Edgar C.Boedeker Chengru Zhu Timothy Thate James Kaper | 2003 | 中国人兽共患病杂志2003，19，2： | 3 |
| 4 | Immediate or delayed repair of pelvic fracture urethral disruption defects in young boys: twenty years of comparative experience显示文摘 | Qu Yanchao Zhang Weiping Sun Ning Huang Chengru Tian Jun Li Minglei, Song Hongcheng Li Ning | 2014 | Chinese Medical Journal2014，，19： | 2 |
| 5 | Evaluating the organizational performance of Taiwanese hospitals using the fuzzy analytic hierarchy process显示文摘 | Wu Chengru Chang Chewei Lin Hunglung | 2006 | Jour-nal of American Academy of Business2006，，： | 1 |
| 6 | Alternative codon usage of PRRS virus ORF5 gene increases eukaryotic expression of GPS glycoprotein and improves immune response in challenged pigs显示文摘 | Kheyar A Jabrane A Chengru Z | 2005 | Vaccine2005，23，： | 1 |
| 7 | Integrating fuzzy theory and hierarchy concepts to evaluate soft-ware quality 显示文摘 | CHANG Chewei WU Chengru LIN Hunglung | 2008 | Software Quality Journal2008，16，2： | 1 |
| 8 | Nano-crystalline diamond films synthesized at low temperature and low pressure by hot filament chemical vapor deposition显示文摘 | Tianliang Hao Heng Zhang Chengru Shi Gaorong Han | 2006 | Surface & Coatings Technology2006，，3： | 1 |
| 9 | Evaluating the organizational performance of Taiwanese hospitals using the fuzzy analytic hierarchy process 显示文摘 | Wu Chengru Chang Chewei Lin Hunglung | 2006 | Journal of American Academy of Business2006，9，2： | 1 |
| 10 | Constrained data clustering by depth control and progressive constraint relaxation显示文摘 | Lin Chengru Chen Mingsyan | 2007 | The VLDB Journal2007，16，2： | 1 |
| 11 | Dual Clustering : Integrating Data Clustering over Optimization and Constraint Domains显示文摘 | Lin Chengru Liu Kenhao Chen Ming-syan | 2005 | IEEE Transactions on Knowledge and Data En- gineering2005，17，5： | 1 |
| 12 | Study on enhancement of diamond nucleation on fused silica substrate by ultrasonic pretreatment显示文摘 | Hao Tianliang Shi Chengru | 2004 | Diamond and Related Materials2004，13，： | 1 |
| 13 | A new thermosensitive polymer as nonadhesive liquid embolism material 显示文摘 | Chengru Zhao Qin Wang Jianwen Meng | 2005 | Current Applied Physics2005，5，： | 1 |
| 14 | Towards a vaccine for attaching/effacing Escherichia coli : a LEE encoded regulator ( ler ) mutant of rabbit enteropathogenic Escherichia coli is attenuated, immunogenic, and protects rabbits from lethal challenge with the wild-type virulent strain显示文摘 | Chengru Zhu Shuzhang Feng Timothy E. Thate James B. Kaper Edgar C. Boedeker | 2005 | Vaccine2005，，18： | 1 |
| 15 | Protection against Hemorrhagic Colitis in an Animal Model by Oral Immunization with Isogeneic Rabbit Enteropathogenic Escherichia coli Attenuated by Truncating Intimin显示文摘 | Tonia S Agin Chengru Zhu | 2005 | Infect Immun2005，73，： | 1 |
| 16 | Sliding window filtering: an efficient method for incremental mining on a time-variant database 显示文摘 | LEE Changhung LIN Chengru CHEN Mingsyan | 2005 | Information Systems2005，30，3： | 1 |
| 17 | The genome sequence of star fruit(Averrhoa carambola)显示文摘Oxalidaceae is one of the most important plant families in horticulture,and its key commercially relevant genus,Averrhoa,has diverse growth habits and fruit types.Here,we describe the assembly of a high-quality chromosomescale genome sequence for Averrhoa carambola(star fruit).Ks distribution analysis showed that A.carambola underwent a whole-genome triplication event,i.e.,the gamma event shared by most eudicots.Comparisons between A.carambola and other angiosperms also permitted the generation of Oxalidaceae gene annotations.We identified unique gene families and analyzed gene family expansion and contraction.This analysis revealed significant changes in MADS-box gene family content,which might be related to the cauliflory of A.carambola.In addition,we identified and analyzed a total of 204 nucleotide-binding site,leucine-rich repeat receptor(NLR)genes and 58 WRKY genes in the genome,which may be related to the defense response.Our results provide insights into the origin,evolution and diversification of star fruit. | Shasha Wu Wei Sun Zhichao Xu Junwen Zhai Xiaoping Li Chengru Li Diyang Zhang Xiaoqian Wu Liming Shen Junhao Chen Hui Ren Xiaoyu Dai Zhongwu Dai Yamei Zhao Lei Chen Mengxia Cao Xinyu Xie Xuedie Liu Donghui Peng Jianwen Dong Yu-Yun Hsiao Shi-lin Chen Wen-Chieh Tsai Siren Lan Zhong-Jian Liu | 2020 | Horticulture Research2020，7，1： | 1 |
| 18 | Study on Enhancement of Diamond Nucleation on Fused Silica Substrate by Ultrasonic Pretreatment 显示文摘 | Tianliang Hao Chengru Shi | 2004 | Diamond Relat Mater2004，，13： | 1 |
| 19 | Dual clustering :integrating data clustering over optimization and constraintdomains显示文摘 | Lin Chengru Liu Kenhao Chen Ming-syan | 2005 | IEEE Transactions on Knowledge and Data Engi-neering2005，，： | 1 |
| 20 | A Rarely Encountered Case: A Patient with Primary Pituitary Tuberculosis and Stroke显示文摘Dear Editor,Infections are a common cause of stroke,and tuberculosis is one of the most dangerous causes of central nervous system(CNS)diseases[1].For example,cerebral infarction is a relatively common and serious CNS disease associated with tuberculosis[2].Patients with | Min Chen Chengru Song Hongbo Liu | 2018 | Neuroscience Bulletin2018，34，3： | 0 |
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