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| 1 | Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species显示文摘 | Chen-chun ZHONG Feng CHEN Jun-ling YANG Wei-wei JIA Li LI Chen CHENG Fei-fei DU Su-ping ZHANG Chengying XIE Na-ting ZHANG Olajide E OLALEYE Feng-qing WANG Fang XU Li-guang LOU Dong-ying CHEN Wei NIU Chuan LI | 2018 | Acta Pharmacologica Sinica2018，39，6： | 24 |
| 2 | Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis显示文摘 | Xu Xiaojie Fan Zhongyi Kang Lei Han Juqiang Jiang Chengying Zheng Xiaofei Zhu Ziman Jiao Huabo Lin Jing Jiang Kai Ding Lihua Zhang Hao Cheng Long Fu Hanjiang Song Yi Jiang Ying Liu Jiahong Wang Rongfu Du Nan Ye Qinong | 2013 | Journal of Clinical Investigation2013，，2： | 7 |
| 3 | Isolation and characterization of ferrous-and sulfur-oxidizing bacteria from Tengchong solfataric region,China显示文摘Microbial oxidation and reduction of iron and sulfur are important parts of biogeochemical cycles in acidic environments such as geothermal solfataric regions.Species of Acidithiobacillus and Leptospirillum are the common ferrous-iron and sulfur oxidizers from such environments.This study focused on the Tengchong sofataric region,located in Yunnan Province,Southwest China.Based on cultivation,9 strains that grow on ferrous-iron and sulfuric compounds were obtained.Analysis of 16S rRNA genes of the 9 strains indicated that they were affliated to Acidithiobacillus,Alicyclobacillus,Sulfobacillus,Leptospirillum and Acidiphilium.Physiological and phylogenetic studies indicated that two strains(TC-34 and TC-71) might represent two novel members of Alicyclobacillus.Strain TC-34 and TC-71 showed 94.8%-97.1%16S rRNA gene identities to other species of Alicyclobacillus.Different from the previously described Alicyclobacillus species,strains TC-34 and TC-71 were mesophilic and their cellular fatty acids do not containω-cyclic fatty acids.Strain TC-71 was obligately dependent on ferrous-iron for growth.It was concluded that the ferrous-iron oxidizers were diversified and Alicyclobacillus species were proposed to take part in biochemical geocycling of iron in the Tengchong solfataric region. | JIANG Chengying LIU Ying LIU Yanyang GUO Xu LIU Shuang-Jiang | 2009 | Journal of Environmental Sciences2009，21，9： | 5 |
| 4 | Proteomic and molecular investigations revealed that Acidithiobacillus caldus adopts multiple strategies for adaptation to NaCl stress显示文摘Acidithiobacillus caldus plays an important role in commercial bioleaching.To understand how NaCl stress adaptation occurs in A.caldus,we grew A.caldus strain SM-1 in media containing high NaCl concentrations.SM-1 grew at concentrations of up to 1.0-mol L^(-1)NaCl,but growth was severely inhibited at higher concentrations.Proteomic analysis showed that SM-1 used multiple strategies to respond to NaCl stress.In addition to several heatshock proteins,enzymes involved in proline biosynthesis increased under NaCl stress.In addition,two DNA-binding proteins and a third protein of unknown function(Atc_(1291)),which was subsequently identified as a putative single-stranded DNA-binding protein,were up-regulated in the presence of NaCl stress.These DNA-binding proteins might play a role in response to osmotic stress.Atc_(1291)was cloned and expressed in Escherichia coli.Surprisingly,we found that E.coli BL21/pET28a-atc_(1291)grew to higher cell densities than E.coli BL21/pET28a,regardless of NaCI stress.Homologs to Atc_(1291)were identified in several groups of Proleohacleria.The role of Atc_(1291)in enhancing cell growth needs further investigation. | Xu Guo Chengying Jiang Yuanming Luo Mingjiang Zhang Ansgar Poetsch Shuangjiang Liu | 2014 | Chinese Science Bulletin2014，59，3： | 2 |
| 5 | Interaction of the cutting tools and the ceramic-reinforced metal matrix composites during micro machining: A review 显示文摘 | Jian Liu Juan Li Chengying Xu | 2014 | CIRP Journal of Manufacturing Science and Technology2014，7，： | 1 |
| 6 | Control of Cutting Force for Creep-Feed Grinding Processes Using a Multi-Level Fuzzy Controller 显示文摘 | XU Chengying SHIN Yung C | 2007 | Journal of Dynamic Systems Measurement and Control2007，129，4： | 1 |
| 7 | SAR observation and modeltracking ofan oilspilleventin coastal waters显示文摘 | CHENGY C LI X F XU Q | 2011 | Marine Pollution Bulle- tin2011，，62： | 1 |
| 8 | Interaction of the cutting tools and the ceramic-reinforced metal matrix composites during micro-machining: A review显示文摘 | Jian Liu Juan Li Chengying Xu | 2014 | CIRP Journal of Manufacturing Science and Technology2014，，： | 1 |
| 9 | Molecular characterization and phylogenetic analysis of new Newcastle disease virus isolates from the mainland of China显示文摘 | Hualei Liu Zhiliang Wang Yangong Wu Yang Wu Chengying Sun Dongxia Zheng Tiangang Xu Jinming Li | 2008 | Research in Veterinary Science2008，，3： | 1 |
| 10 | Molecular epidemiological analysis of Newcastle disease virus isolated in China in 2005显示文摘 | Hualei Liu Zhiliang Wang Yangong Wu Dongxia Zheng Chengying Sun Daorong Bi Yuanyuan Zuo Tiangang Xu | 2006 | Journal of Virological Methods2006，，1： | 1 |
| 11 | A self-tuning fuzzy controller for a class of multi-input multi-output nonlinear systems显示文摘 | Chengying Xu Yung C. Shin | 2010 | Engineering Applications of Artificial Intelligence2010，，2： | 1 |
| 12 | A self-tuning fuzzy con- troller for a class of multi-input multi-output nonlinear systems显示文摘 | Xu Chengying Yung C Shin | 2011 | Engineering Applications of Artificial In- telligence2011，，24： | 1 |
| 13 | Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis显示文摘 | Xu Xiaojie Fan Zhongyi Kang Lei Han Juqiang Jiang Chengying Zheng Xiaofei Zhu Ziman Jiao Huabo Lin Jing Jiang Kai Ding Lihua Zhang Hao Cheng Long Fu Hanjiang Song Yi Jiang Ying Liu Jiahong Wang Rongfu Du Nan Ye Qinong | 2013 | Journal of Clinical Investigation2013，，2： | 1 |
| 14 | Daily administration times of Canhuang tablet based on a pharmacodynamic/pharmacokinetic model in jaundiced rats显示文摘OBJECTIVE: To study the daily administration times of Canhuang tablet(CHT) for treating jaundice in rats based on a pharmacodynamic/ pharmacokinetic model.METHODS: Rats were modeled by 4% 1-Naphthylisothiocyanate(75 mg/kg, p.o.). After 48 h, CHT was given(p.o.) at 0.75 g/kg once a day, 0.375 g/kg twice a day, and 0.25 g/kg three times a day. Blood was collected from the orbital sinus at different intervals. Levels of liver enzymes and bilirubin were detected using these blood samples. Bile was collected and determined after the first administration of CHT. High-performance liquid chromatography was used to determine the concentration of berberine in bile simultaneously. Time-effect and time-dose curves were then obtained.RESULTS: Compared with rats taking CHT twiceand three times a day, the total amount of bile within 10 h of rats taking CHT once a day were 1.32-and 1.47-fold higher, respectively. There was good consistency between the pharmacokinetics of berberine and the pharmacodynamics of the effect on liver enzymes and bilirubin in vivo. The pharmacokinetic analyses showed that rats administered CHT once daily maintained a higher concentration of berberine in bile for a longer period than rats administered CHT two- and three-times daily.CONCLUSION: In jaundiced rats, taking CHT once a day is better than taking CHT twice or three times a day. These data may provide a reference for the clinical application of CHT. | Bai Jinxia Han Jin Chen Hongge Shen Baode Xu He Dai Ling Shen Chengying Yuan Hailong | 2015 | Journal of Traditional Chinese Medicine2015，35，1： | 1 |
| 15 | EFFECTS OF SEEDING DENSITY AND BASIC MANURE ON THE GROWTH OF DRY NURSERY SEEDLINGS IN LATE DOUBLE CROPPING RICE IN SOUTH CHINA显示文摘During the period of dry nursery seedling raising of late double cropping indica rice in South China, both chemical fertilizer and farmyard manure did not show obvious effect on the growth of shoot and root in young seedlings at 4-leaf stage (18-day-old seedling), but had significant effects on root growth in old seedlings with 6-7 leaves (27-day-old seedling) at suitable seeding densities (65-125g m-2). There were satistically significant differences (at 0.01 or 0.05 levels)between treatments in root number and rooting ability of root-pruned seedlings. | Zhang Xu Kong Qingni Huang Nongrong Lin Daoxuan Liu Yanzhuo(Rice Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640)Cai Hanxiong Liang Quan Liang Youqiang Liang Chengying(Cereal and Oil Crop Production Section, Agricultural Department of Guangdong Province, Guangzhou 510500) | 1996 | 热带亚热带植物学报1996，4，S1： | 0 |
| 16 | Identification of a Low-spin Isomer in ^(176)Ir显示文摘Theβ+/EC decay of doubly odd 176Ir has been studied via the 146Nd(35Cl,5nγ) heavy ion fusion evaporation reaction at the Sector-Focusing Cyclotron (SFC) accelerator in the Institute of Modern Physics (IMP), Lanzhou. A 210 MeV 35C1 beam from the cyclotron entered a helium-filed target chamber, | Wang Hualei, Zhang Yuhu, Zhou Xiaohong, Guo Yingxiang, Lei Xiangguo, Xu Shuwei Xie Yuanxiang,Liu Minliang, Zheng Yong, Xing Yebing, Xie Chengying, Song Litao Lou Peng, Yu Haiping, Guo Wentao,Ding Huajie and Niu Yanning | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 17 | Structural insights into plant phytochrome A as a highly sensitized photoreceptor显示文摘Dear Editor,Phytochromes(phys),first discovered in plants,are red and far-red photoreceptors that are also widely found in bacteria and fungi later.1,2 Plant phys utilize the linear tetrapyrrole chromophore called photochromobilin(PΦB).Phys reversibly toggle between the red light-absorbing Pr and the far-red light-absorbing Pfr conformers by photoconversion,with absorption peaks at~667 nm and~730 nm,respectively.The Pfr conformer can be converted to Pr in darkness,a process called dark reversion or thermoreversion. | Yuxuan Zhang Xiaoli Lin Chengying Ma Jun Zhao Xiaojin Shang Zhengdong Wang Bin Xu Ning Gao Xing Wang Deng Jizong Wang | 2023 | Cell Research2023，33，10： | 0 |
| 18 | Targeting the ferroptosis crosstalk:novel alternative strategies for the treatment of major depressive disorder显示文摘Depression is a major contributor to poor global health and disability,with a recently increasing incidence.Although drug therapy is commonly used to treat depression,conventional antidepressant drugs have several disadvantages,including slow onset,low response rates and severe adverse effects.Therefore,developing effective therapies for depression remains challenging.Although various aetiological theories of depression exist,the underlying mechanisms of depression are complex,and further research is crucial.Moreover,oxidative stress(OS)-induced lipid peroxidation has been demonstrated to trigger ferroptosis.Both OS and ferroptosis are pivotal mechanisms implicated in the pathogenesis of neurological disorders,and investigation of the mediators involved in these processes has emerged as a prominent and active research direction.One previous study revealed that regulatory proteins involved in ferroptosis are implicated in the pathogenesis of depression,and antidepressant drugs could reverse depressive symptoms by inhibiting ferroptosis in vivo,suggesting an important role of ferroptosis in the pathogenesis of depression.Hence,our current comprehensive review offers an up-to-date perspective on the intricate mechanisms involved,specifically concerning ferroptosis and OS in the context of depression,along with promising prospects for using molecular mediators to target ferroptosis.We delineate the key targets of molecular mediators involved in OS and ferroptosis implicated in depression,most notably reactive oxygen species and iron overload.Considering the pivotal role of OS-induced ferroptosis in the pathogenesis of neurological disorders,delving deeper into the underlying subsequent mechanisms will contribute significantly to the identification of novel therapeutic targets for depression. | Luyao Wang Rongyang Xu Chengying Huang Guozhong Yi Zhiyong Li Huayang Zhang Rongxu Ye Songtao Qi Guanglong Huang Shanqiang Qu | 2023 | General Psychiatry2023，36，5： | 0 |
| 19 | The antiferroptotic role of TRIM7:Molecular mechanism and synergistic effect with temozolomide显示文摘Ferroptosis is a distinct form of regulated cell death characterized by the accumulation of lipid peroxides and iron-dependent membrane damage that is a significant contributor to drug resistance in glioblastoma(GBM).Dysregulated iron metabolism is a hallmark of cancer,making ferroptosis a unique potential target for anticancer therapy.Ferritinophagy,the selective autophagy of ferritin,plays an essential role in cellular iron homeostasis and may impact the vulnerability of cells to ferroptosis.Nuclear receptor coactivator 4(NCOA4)protein is a selective cargo receptor that plays a crucial role in ferritinophagy by targeting and delivering the ferritin iron storage protein to the lysosome for degradation,releasing iron[1].However,the underlying molecular mechanism that causes reduced NCOA4 expression in glioma is not fully understood. | Luyao Wang Rongyang Xu Chengying Huang Shanqiang Qu | 2023 | Cancer Innovation2023，2，4： | 0 |
| 20 | Thermally Conductive Study of Polyethylene/Al2O3 Composite Networks Cross-linked by Electron Beam Irradiation显示文摘The surface-modifled Al2O3 particles were introduced into polyethylene(PE)to enhance the thermal conductivity,and PE/Al2O3 cross-linked networks with improved thermal and mechanical properties were prepared through electron beam(EB)irradiation technology.The incorporation of reactive irradiation sensitizer was useful in fabricating a high degree of cross-linking(DC)PE networks under a low irradiation dose.In the PE sample containing 2%sensitizer,DC ca.67.1%could be obtained under 60 kGy(1 kGy=1000 J/kg).EB-irradiation greatly improved thetensile stress of PE-based samples,and the tensile stresses of the samples with 0.2—5%TMPTA(trimethylolpr pane triacrvlate)under 60 kGy were 24.61—27.77 MPa.All the EB-irradiated samples had higher Vicat softening temperatures than the samples without irradiation.After treatment at 120 kGy,the Vicat softening temperatures of PE-Al2O3-44/TMPTA-2 increased from 127℃to 130.4℃.SEM images revealed that PE-Al2O3-5O samples with increased amount of Al2O3 particles showed a conduction'pathway,'and thennal conductivity reached 0.67 W/(m·K).Thus,high-performance pipes were extruded,which could satisfy the static hydraulic blasting test and exhibit improved thennal conduction capability. | SHI Chengying YANG Jiayu LIU Yang WANG Yanmiao XU Wenge XU Yiquan HU Wei LIU Baijun | 2020 | Chemical Research in Chinese Universities2020，36，5： | 0 |
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