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| 1 | Tandem organic solar cells with efficiency over 19% via the careful subcell design and optimization显示文摘The series-connected tandem device strategy is an effective approach to promote the efficiency of organic solar cells(OSCs) with broadened absorption range and alleviated thermalization and transmission loss.In this article,two nonfullerene acceptors,FB rThCl and BTP-4Se,with complementary absorptions covering the range from 300 to 1,000 nm were designed and synthesized for the front and rear cell,respectively.The front cell based on D18:FBr-ThCl exhibited a Voc of 1.053 V with high external quantum efficiency(EQE) response values ranging from 300 to 740 nm.The rear cell with a ternary active layer PM6:BTP-4 Se:F-2F was optimized and afforded the Voc of 0.840 V and Jsc of 26.88 mA cm^(-2).Subsequently,the tandem device was constructed with a fully solution-processed interconnected layer of ZnO/PEDOT:PS S/PMA,and demonstrated a power conversion efficiency(PCE) of 19.55% with a Voc of 1.880 V,a Jsc of 13.25 mA cm^(-2) and an FF of 78.47%. | Lingxian Meng Huazhe Liang Guangkun Song Mingpeng Li Yuzhong Huang Changzun Jiang Kai Zhang Fei Huang Zhaoyang Yao Chenxi Li Xiangjian Wan Yongsheng Chen | 2023 | Science China Chemistry2023，66，3： | 1 |
| 2 | RNA m^(6)A meets transposable elements and chromatin显示文摘A^(6)-methyladenosine(m^(6)A)is the most abundant internal chemical mark in eukaryotic messenger RNAs(mRNAs),regulating various processes in the life cycle of mRNA including splicing,nuclear export,degradation and translation(reviewed in(Shi et al.,2019)). | Chenxi He Fei Lan | 2021 | Protein & Cell2021，12，12： | 1 |
| 3 | Low on-resistance 1.2 kV 4H-SiC power MOSFET with Ron, sp of 3.4 mΩ·cm^2显示文摘A 4H-SiC power MOSFET with specific on-resistance of 3.4 mΩ·cm^2 and breakdown voltage exceeding 1.5 kV is designed and fabricated.Numerical simulations are carried out to optimize the electric field strength in gate oxide and at the surface of the semiconductor material in the edge termination region.Additional n-type implantation in JFET region is implemented to reduce the specific on-resistance.The typical leakage current is less than 1μA at VDS=1.4 kV.Drain–source current reaches 50 A at VDS=0.75 V and VGS=20 V corresponding to an on-resistance of 15 mΩ.The typical gate threshold voltage is 2.6 V. | Qiang Liu Qian Wang Hao Liu Chenxi Fei Shiyan Li Runhua Huang Song Bai | 2020 | Journal of Semiconductors2020，41，6： | 1 |
| 4 | Pivotal roles of tumor-draining lymph nodes in the abscopal effects from combined immunotherapy and radiotherapy显示文摘Background:Currently,due to synergy enhancement of anti-tumor effects and potent stimulation of abscopal effects,combination therapy with irradiation and programmed cell death protein 1/programmed death-ligand 1(PD-1/PD-L1)immune checkpoint inhibition(immuno-radiotherapy,iRT)has revolutionized the therapeutic guidelines.It has been demonstrated that tumor-draining lymph nodes(TDLN)are essential for effective antitumor immunity induced by radiotherapy,immunotherapy,or iRT.Given that the function of TDLN in iRT remains unclear,this study aimed to investigate the function and mechanism of TDLN in iRT-induced abscopal effects.Methods:The function of TDLN was evaluated using unilateral or bilateral MC38 and B16F10 subcutaneous tumor models with or without indicated TDLN.The flow cytometry,multiple immunofluorescence analysis,and NanoString analysis were utilized to detect the composition and function of the immune cells in the primary and abscopal tumor microenvironment.Additionally,we tempted to interrogate the possible mechanisms via RNA-sequencing of tumor-infiltrating lymphocytes and TDLN.Results:TDLN deficiency impaired the control of tumor growth by monotherapy.Bilateral TDLN removal rather than unilateral TDLN removal substantially curtailed iRT-stimulated anti-tumor and abscopal effects.Furthermore,in the absence of TDLN,the infiltration of CD45+and CD8+T cells was substantially reduced in both primary and abscopal tumors,and the anti-tumor function of CD8+T cells was attenuated as well.Additionally,the polarization of tumor-associated macrophages in primary and abscopal tumors were found to be dependent on intact bilateral TDLN.RNA-sequencing data indicated that impaired infiltration and anti-tumor effects of immune cells partially attributed to the altered secretion of components from the tumor microenvironment.Conclusions:TDLN play a critical role in iRT by promoting the infiltration of CD8+T cells and maintaining the M1/M2 macrophage ratio. | Zhaoyun Liu Zhiyong Yu Dawei Chen Vivek Verma Chenxi Yuan Minglei Wang Fei Wang Qing Fan Xingwu Wang Yang Li Yuequn Ma Meng Wu Jinming Yu | 2022 | Cancer Communications2022，42，10： | 1 |
| 5 | Adipose-derived stem cells in stroke treatment: translational possibility and mechanism显示文摘Stroke has become one of the secondary worldwide mortal diseases that burdens the family and the society both emotionally and economically.The announcement of China's Ministry of Health in 2008 showed that stroke had been the first cause of death in urban and rural residents.1,2 Traditional therapies such as thrombolysis,anti-platelets,and rehabilitation showed limited effects.Replacement therapy with stem cells promises to be a good solution due to its possible thorough therapy for the damaged brain area,reconstruction of neuronal circuitry,and probable long-term efficacy. | Zhou Fei Gao Shan'e Sun Chenxi Cao Limei Ren Haiyan Li Qiang Wang Guangming Dong Chuanming Zhu Liang Yang Danjing Wang Xianli Xu Jun Chen Xu | 2014 | Chinese Medical Journal2014，，20： | 1 |
| 6 | Small diameter polyurethane vascular graft reinforced by elastic weft-knitted tubular fabric of polyester/spandex显示文摘 | Xu Weilin Zhou Fei Ouyang Chenxi | 2007 | Fibers and Polymers2007，8，6： | 1 |
| 7 | Mechanical properties of small diameter polyurethane vascular grafts reinforced by weft knitted tubular fabric显示文摘 | Xu Weilin Zhou Fei Ouyang Chenxi | 2010 | Journal of Biomedical Materials Research2010，92，1： | 1 |
| 8 | Small diameter Polyurethane vascular graft reinforced by elastic weft-knitted tubular fabric of polyester/spandex显示文摘 | Weilin Xu Fei Zhou Chenxi Ouyang Weigang Cui Mu Yao Xungai Wang | 2008 | Fibers and Polymers2008，，1： | 1 |
| 9 | Si-induced insertion of Li into SiC to form Li-rich SiC twin crystal显示文摘The energy density of Li-ion batteries is closely related to the capacity and average voltage of cathode materials.Unfortunately,current cathode materials either have low capacity or voltage,which limits the development of high-energy-density Li-ion batteries.This has given challenge to many attempts to develop new cathode materials with high capacity and voltage.In this study,we find that Li easily inserts into the(111)plane of SiC in the presence of Si,and a well-organized Li-rich SiC twin crystal is formed.Ultraviolet-visible diffuse reflectance spectra and electrochemical test results suggest that this Li-rich SiC twin crystal possesses the band gap energy of 3.5 eV and charging capacity of 1979 mAh/g at the current density of 200 mA/g,making it a promising candidate for the cathode material in high-capacity Li-ion batteries.X-ray photoelectron spectroscopy and high-resolution transmission electron microscopy results reveal that Si-induced Li insertion contributes to the changes in the surface species and structure of pristine SiC.These findings suggest that the Li-rich SiC twin crystal raises new possibilities for the development of high-capacity cathode materials and merits further investigation to expand its application scope. | Di Zhang Chenxi Zhang Feng Lu Hairong Jiang Fei Wei | 2023 | Particuology2023，，3： | 0 |
| 10 | Activation of Pancreatic Acinar FXR Protects against Pancreatitis via Osginl-Mediated Restoration of Efficient Autophagy显示文摘Pancreatitis is the leading cause of hospitalization in gastroenterology,and no medications are available for treating this disease in current clinical practice.FxR plays an anti-inflammatory role in diverse inflammatory diseases,while its function in pancreatitis remains unknown.In this study,we initially observed a marked increase of nuclear FXR in pancreatic tissues of human patients ithpancratis eleting theFXRinpancreati acinar cels FXRicnara/a)ledto moreseverepancreatitis in mousemodels of caerulein-induced acute and chronic pancreatitis,while the FXR agonist GW4064 significantly attenuated pancreatitis in caerulein or arginine-induced acute pancreatitis and caerulein-induced chronic pancreatitis.FXR deletion impaired the viability and stress responses of pancreatic exocrine organoids(PEOs)in vitro.Utilizing RNA-seq and ChIP-seq of PEOs,we identified Osginl as a direct target of FxR in the exocrine pancreas,which was also increasingly expressed in human pancreatitis tissues compared to normal pancreatic tissues.Pancreatic knockdown of Osgin1 by AAV-pan abolished the therapeutic effects of FXR activation on pancreatitis,whereas pancreatic overexpression of Osginl effectively alleviated caerulein-induced pancreatitis.Mechanistically,we found that the FXR-OSGINl axis stimulated autophagic flux in the pancreatic tissues and cell lines,which was considered as the intrinsic mechanisms through which FXR-OSGINI protecting against pancreatitis.Our results highlight the protective role of the FXR-OSGIN1 axis in pancreatitis and provided a new target for the treatment of this disease. | Yufan Zheng Wenrui Sun Zhengyang Wang Jiaying Liu Cong Shan Chenxi He Borui Li Xiao Hu Wenjia Zhu Liyan Liu Fei Lan Changtao Jiang Chao Zhao Xiaobo Li Ning Sun | 2023 | Research2023，，1： | 0 |
| 11 | Architectural Design and Additive Manufacturing of Mechanical Metamaterials:A Review显示文摘Mechanical metamaterials can be defined as a class of architected materials that exhibit unprecedented mechanical properties derived from designed artificial architectures rather than their constituent materials.While macroscale and simple layouts can be realized by conventional top-down manufacturing approaches,many of the sophisticated designs at various length scales remain elusive,due to the lack of adequate manufacturing methods.Recent progress in additive manufacturing(AM)has led to the realization of a myriad of novel metamaterial concepts.AM methods capable of fabricating microscale architectures with high resolution,arbitrary complexity,and high feature fidelity have enabled the rapid development of architected meta materials and drastically reduced the design-computation and experimental-validation cycle.This paper first provides a detailed review of various topologies based on the desired mechanical properties,including stiff,strong,and auxetic(negative Poisson’s ratio)metamaterials,followed by a discussion of the AM technologies capable of fabricating these metamaterials.Finally,we discuss current challenges and recommend future directions for AM and mechanical metamaterials. | Chenxi Lu Mengting Hsieh Zhifeng Huang Chi Zhang Yaojun Lin Qiang Shen Fei Chen Lianmeng Zhang | 2022 | Engineering2022，，10： | 0 |
| 12 | Controlled growth of crossed ultralong carbon nanotubes by gas flow显示文摘Carbon nanotubes(CNTs)work as the promising components of miniature electromechanical systems due to their ecellent performances from individual to bundle scales.But it's challenging to achieve precise patterning at nanoscale resolution with controlled position and orientation.Here,we demonstrate a fluidic strategy to interlace one-dimensional(1D)ultralong CNTs into the crossed pattern in a one-step in-situ process.Semi-circular substrates of different diameters were placed in front of the growth substrate to change the path and momentum of gas flow.Such flow perturbation caused by substrates could be markedly reflected within a micro-channel reactor,which led to formation of crossed utralong CNTs at definite positions.Furthermore,precise control over the crossing angle as well as the diameter distribution of CNTs was achieved by varying the CNT length and diameter of semi-circular substrates.Our strategy has offered a feasible route for production of crossed ultralong CNTs and will contribute to multidimensional fluidic assembly of flexible nanomaterals. | Zhenxing Zhu Yunxiang Bai Nan Wei Jun Gao Silei Sun Chenxi Zhang Fei Wei | 2020 | Nano Research2020，13，7： | 0 |
| 13 | The effect of aerobic dancing on physical fitness and cognitive function in older adults during the COVID-19 pandemic-a natural experiment显示文摘During the Coronavirus disease(COVID-19),the physical activity of older adults is at a lower level.The study aimed to examine the effectiveness of aerobic dancing on physical fitness and cognitive function in older adults.We conducted a randomized controlled trial with 34 older adults who were assigned into an aerobic dancing group and a control group.Three dance sessions weekly for 60min were scheduled for the aerobic dancing group for a total of 12 weeks.Physical fitness,blood pressure,lipids,glucose,cognitive function were assessed before and after the intervention.Baseline adjusted Analysis of Covariance(ANCOVA)was used to determine whether outcome variables varied between groups at pre-test and post-test.Effect size(Cohen's d)was calculated to determine the differences between groups from baseline to post-test.After 12 weeks,we found that the aerobic dancing group showed significant improvement in memory(portrait memory:F=10.45,p=0.003,d=1.18).The Limit of Stability(LOS)parameters in the aerobic dancing group displayed a significant increase after the intervention(right angle:F=5.90,p=0.022,d=0.60;right-anterior angle:F=4.23,p=0.049,d=0.12).Some beneficial effects were found on flexibility,grip strength,balance and subjective well-being(sit and reach:F=0.25,p=0.62,d=−0.40;grip strength:F=3.38,p=0.08,d=0.89;one-legged standing with eyes closed:F=1.26,p=0.27,d=0.50)in the aerobic dancing group.Aerobic dancing training was effective in improving memory and balance ability in older adults during the COVID-19 pandemic in China.In the future,aerobic dancing is a promising tool to encourage physical activity in older adults. | Lin Wang Fei Guo Chenxi Zhao Minmin Zhao Chenglei Zhao Jiawei Guo Longhai Zhang Ling Zhang Zheng'ao Li Wenfei Zhu | 2023 | Sports Medicine and Health Science2023，5，3： | 0 |
| 14 | Ferroelectricity of hafnium oxide-based materials:Current status and future prospects from physical mechanisms to device applications显示文摘The finding of the robust ferroelectricity in HfO_(2)-based thin films is fantastic from the view point of both the fundamentals and the applications.In this review article,the current research status of the future prospects for the ferroelectric HfO_(2)-based thin films and devices are presented from fundamentals to applications.The related issues are discussed,which include:1)The ferroelectric characteristics observed in HfO_(2)-based films and devices associated with the factors of dopant,strain,interface,thickness,defect,fabrication condition,and more;2)physical understanding on the observed ferroelectric behaviors by the density functional theory(DFT)-based theory calculations;3)the characterizations of microscopic and macroscopic features by transmission electron microscopes-based and electrical properties-based techniques;4)modeling and simulations,5)the performance optimizations,and 6)the applications of some ferroelectric-based devices such as ferroelectric random access memory,ferroelectric-based field effect transistors,and the ferroelectric tunnel junction for the novel information processing systems. | Wanwang Yang Chenxi Yu Haolin Li Mengqi Fan Xujin Song Haili Ma Zheng Zhou Pengying Chang Peng Huang Fei Liu Xiaoyan Liu Jinfeng Kang | 2023 | Journal of Semiconductors2023，44，5： | 0 |
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