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| 1 | FEM Analysis of Spring-backs in Age Forming of Aluminum Alloy Plates显示文摘The age forming technology, characterized by huge spring-backs, has been developed to manufacture large integral wing-skin panel parts, which necessitates devising a method of predicting spring-backs. A 7B04-T7451 aluminum alloy creep test in tension is accomplished at 155 °C, and the creep curves are obtained. The material constants of the mechanism-based creep constitutive equations are determined through experiments. The age forming process and the spring-backs of 7B04 aluminum alloy plates are analyzed using the commercial finite element software ABAQUS. The effects of plate thickness and forming time on spring-backs are researched. The spring-backs decrease with the increase of plate thickness and forming time. The test results verify the reliability of the finite element method (FEM) analysis. | Huang Lin Wan Min Chi Cailou Ji Xiusheng | 2007 | Chinese Journal of Aeronautics2007，20，6： | 23 |
| 2 | Short-term Prognosis of Fragmented QRS Complex in Patients with Non-ST Elevated Acute Myocardial Infarction显示文摘 | Min Li Xiao Wang Shu-Hua Mi Zhe Chi Qing Chen Xin Zhao Shao-Ping Nie | 2016 | Chinese Medical Journal2016，，5： | 14 |
| 3 | Downregulation of STEAP4, a highly-expressed TNF-α-inducible gene in adipose tissue, is associated with obesity in humans显示文摘 | Chunsmei ZHANG Xia CHI Bin WANG Min ZHANG Yu-hui NI Rong-hua CHEN Xiao-nan LI Xi-rong GUO | 2008 | Acta Pharmacologica Sinica2008，29，5： | 11 |
| 4 | Ampullary neuroendocrine tumor diagnosed by endoscopic papillectomy in previously confirmed ampullary adenoma显示文摘Ampullary adenoma is a common indication for endoscopic papillectomy. Ampullary neuroendocrine tumor(NET) is a rare disease for which complete surgical resection is the treatment of choice. However, because of the morbidity and mortality associated with surgical resection, endoscopic papillectomy is increasingly used in selected cases of low grade, with no metastasis and no invasion of the pancreatic or bile duct. Also, confirmed and complete endoscopic resection of ampullary NET accompanied by adenoma has not been reported to date. We report herein a rare case of an ampullary NET accompanied with adenoma, which was successfully and completely resected via endoscopic papillectomy. Prior to papillectomy, this case was diagnosed as an ampullary adenoma. | Seoung Ho Lee Tae Hoon Lee Si-Hyong Jang Chi Young Choi Won Myung Lee Ji Hey Min Hyun Deuk Cho Sang-Heum Park | 2016 | World Journal of Gastroenterology2016，22，13： | 6 |
| 5 | mrle, a conotoxin from Conus marmoreus with a novel disulfide pattern显示文摘 | Yanfang Wang Xiaoxia Shao Min Li Sumin Wang Chengwu Chi Chunguang Wang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，5： | 5 |
| 6 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 7 | Spontaneous Ureteropelvic Junction Rupture Caused by a Small Distal Ureteral Calculus显示文摘To the Editor: Spontaneous ureteral rupture is rare, and urolithiasis is the most common cause.[1,2] The underlying mechanism may be the pressure around the ureteral wall due to stone impaction or a tear during the stone passage.Smaller distal stones exert higher intraureteral pressures than do larger proximal stones because of the greater length of obstructed ureter and the smaller diameter of the distal ureter. | Chi Heon Jeon Jun Ho Kang Jin Hong Min Jung Soo Park | 2015 | Chinese Medical Journal2015，，22： | 5 |
| 8 | Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice显示文摘 | Jizheng Chen Yang Zhao Chao Zhang Hairong Chen Jin Feng Xiumei Chi Yu Pan Jun Du Min Guo Huang Cao Honghe Chen Zilong Wang Rongjuan Pei Qian Wang Lei Pan Junqi Niu Xinwen Chen Hong Tang | 2014 | Cell Research2014，24，9： | 5 |
| 9 | The structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis显示文摘Dear Editor,Ferroptosis is an iron-dependent,non-apoptotic form of regulated cell death characterized by an accumulation of lipid.derived reactive oxygen species(ROS).The small-molecule compo und erastin in duces ferroptosis via in hibiti ng the cystineglutamate antiporter system x_(c).which consists of two subunits,namely the light chain xCT and the heavy chain 4F2hc(encoded by the SLC7A11 and SLC3A2 genes,respectively).^(1-4) | Renhong Yan Enjun Xie Yaning Li Jin Li Yuanyuan Zhang Ximin Chi Xueping Hu Lei xu Tingjun Hou Brent R.Stockwell Junxia Min Qiang Zhou Fudi Wang | 2022 | Cell Research2022，32，7： | 4 |
| 10 | Pollution levels and characteristics of phthalate esters in indoor air in hospitals显示文摘The concentrations of phthalate esters(PAEs) in Chinese hospitals were investigated by simultaneously determining concentrations of gas- and particle-phase PAEs. PAEs were detected in two third-class first-grade hospitals, two second-class first-grade hospitals, and a community health service center. Hospital drugstores had the highest concentration(24.19 μg/m3), which was 1.54 times that of newly decorated houses. The second highest concentration was found in the transfusion rooms, averaging 21.89 μg/m3; this was followed by the concentrations of PAEs in the nurse's workstations, the wards, and the doctor's offices, with mean concentrations of 20.66, 20.0, and 16.92 μg/m3, respectively. The lowest concentrations were found in the hallways(16.30 μg/m3). Of the six different kinds of PAEs found, major pollutants included diethyl phthalates, dibutyl phthalates, butylbenzyl phthalates and di(2-ethylhexyl) phthalates, comprising more than 80% of all PAEs present.Meanwhile, a comparison between different wards showed that PAE concentrations in the maternity wards were 1.63 times higher than in the main wards. Based on known health hazards, our results suggest that the PAEs seriously influence the health of the pregnant women and babies; therefore, it is of great importance to take the phthalate concentrations in hospitals into consideration. In addition, hospital indoor air was more seriously contaminated than the air of newly decorated houses. | Xueqing Wang Min Song Min Guo Chenchen Chi Feifei Mo Xueyou Shen | 2015 | Journal of Environmental Sciences2015，27，11： | 4 |
| 11 | Pollution levels and characteristics of phthalate esters in indoor air of offices显示文摘The pollution status and characteristics of PAEs(phthalate esters) were investigated in indoor air of offices, and PAEs of both gas-phase and particulate-phase were detected in all the samples. The concentration(sum of the gas phase and the particulate phase) was4748.24 ng/m3, ranging between 3070.09 and 6700.14 ng/m3. Diethyl phthalate, dibutyl phthalate, and di(2-ethylhexyl) phthalate were the most abundant compounds, together accounting for 70% of the ∑ 6PAEs. Dividing the particulate-phase PAEs into four size ranges(< 2.5, 2.5–5, 5–10, > 10 μm), the result indicated that PAEs in PM2.5were the most abundant,with the proportion of 72.64%. In addition, the PAE concentration in PM2.5correlated significantly with the total particulate-phase PAEs(R2= 0.85). Thus, the amount of PAEs in PM2.5can be estimated from the total amount of particulate-phase PAEs using this proportion. In a comparison between the offices and a newly decorated study room, it was found that pollution characteristics were similar between these two places. Thus, it is implied that the PAE concentration decreased by 50% 2 yr after decorating. | Min Song Chenchen Chi Min Guo Xueqing Wang Lingxiao Cheng Xueyou Shen | 2015 | Journal of Environmental Sciences2015，27，2： | 3 |
| 12 | Activatingα7nAChR ameliorates abdominal aortic aneurysm through inhibiting pyroptosis mediated by NLRP3 inflammasome显示文摘Abdominal aortic aneurysm(AAA)is defined as a dilated aorta in diameter at least 1.5 times of a normal aorta.Our previous studies found that activatingα7 nicotinic acetylcholine receptor(α7nAChR)had a protective effect on vascular injury.This work was to investigate whether activatingα7nAChR could influence AAA formation and explore its mechanisms.AAA models were established by angiotensin II(Ang II)infusion in ApoE^(-/-)mice or in wild type andα7nAChR^(-/-)mice.In vitro mouse aortic smooth muscle(MOVAS)cells were treated with tumor necrosis factor-α(TNF-α).PNU-282987 was chosen to activateα7nAChR.We found that cell pyroptosis effector GSDMD and NLRP3 inflammasome were activated in abdominal aorta,and inflammatory cytokines in serum were elevated in AAA models of ApoE^(-/-)mice.Activatingα7nAChR reduced maximal aortic diameters,preserved elastin integrity and decreased inflammatory responses in ApoE^(-/-)mice with Ang II infusion.Whileα7nAChR^(-/-)mice led to aggravated aortic injury and increased inflammatory cytokines with Ang II infusion when compared with wild type.Moreover,activatingα7nAChR inhibited NLRP3/caspase-1/GSDMD pathway in AAA model of ApoE^(-/-)mice,whileα7nAChR deficiency promoted this pathway.In vitro,N-acetylcysteine(NAC)inhibited NLRP3 inflammasome activation and NLRP3 knockdown reduced GSDMD expression,in MOVAS cells treated with TNF-α.Furthermore,activatingα7nAChR inhibited oxidative stress,reduced NLRP3/GSDMD expression,and decreased cell pyroptosis in MOVAS cells with TNF-α.In conclusion,our study found that activatingα7nAChR retarded AAA through inhibiting pyroptosis mediated by NLRP3 inflammasome.These suggested thatα7nAChR would be a potential pharmacological target for AAA. | Hui Fu Qi-rui Shen Yi Zhao Min Ni Can-can Zhou Ji-kuai Chen Chen Chi Dong-jie Li Guang Liang Fu-ming Shen | 2022 | Acta Pharmacologica Sinica2022，43，10： | 3 |
| 13 | Investigation of cell mechanics using single-beam acoustic tweezers as a versatile tool for the diagnosis and treatment of highly invasive breast cancer cell lines: an in vitro study显示文摘Advancements in diagnostic systems for metastatic cancer over the last few decades have played a significant role in providing patients with effective treatment by evaluating the characteristics of cancer cells.Despite the progress made in cancer prognosis,we still rely on the visual analysis of tissues or cells from histopathologists,where the subjectivity of traditional manual interpretation persists.This paper presents the development of a dual diagnosis and treatment tool using an in vitro acoustic tweezers platform with a 50MHz ultrasonic transducer for label-free trapping and bursting of human breast cancer cells.For cancer cell detection and classification,the mechanical properties of a single cancer cell were quantified by single-beam acoustic tweezers(SBAT),a noncontact assessment tool using a focused acoustic beam.Cell-mimicking phantoms and agarose hydrogel spheres(AHSs)served to standardize the biomechanical characteristics of the cells.Based on the analytical comparison of deformability levels between the cells and the AHSs,the mechanical properties of the cells could be indirectly measured by interpolating the Young’s moduli of the AHSs.As a result,the calculated Young’s moduli,i.e.,1.527kPa for MDA-MB-231(highly invasive breast cancer cells),2.650kPa for MCF-7(weakly invasive breast cancer cells),and 2.772 kPa for SKBR-3(weakly invasive breast cancer cells),indicate that highly invasive cancer cells exhibited a lower Young’s moduli than weakly invasive cells,which indicates a higher deformability of highly invasive cancer cells,leading to a higher metastasis rate.Single-cell treatment may also be carried out by bursting a highly invasive cell with high-intensity,focused ultrasound. | Hae Gyun Lim Hsiao-Chuan Liu Chi Woo Yoon Hayong Jung Min Gon Kim Changhan Yoon Hyung Ham Kim KKirk Shung | 2020 | Microsystems & Nanoengineering2020，6，1： | 3 |
| 14 | Ten‐Day Quadruple Therapy Comprising Proton‐Pump Inhibitor, Bismuth, Tetracycline, and Levofloxacin Achieves a High Eradication Rate for H elicobacter pylori Infection after Failure of Sequential Therapy显示文摘 | Ping‐I Hsu Wen‐Chi Chen Feng‐Woei Tsay Chih‐An Shih Sung‐Shuo Kao Huay‐Min Wang Hsien‐Chung Yu Kwok‐Hung Lai Hui‐Hwa Tseng Nan‐Jing Peng Angela Chen Chao‐Hung Kuo Deng‐Chyang Wu | 2014 | Helicobacter2014，，1： | 3 |
| 15 | Biocompatible custom ceria nanoparticles against reactive oxygen species resolve acute inflammatory reaction after intracerebral hemorrhage显示文摘Intracerebral 出血(ICH ) 是有高死亡率,当前为没有有效治疗的击的一种破坏子类型。强烈煽动性的反应引起的 perihematomal 浮肿自己比 hematoma 更有害并且能导致神经病学的恶化和死亡。Ceria nanoparticles (CeNPs ) 是有势力有为生物医学的应用的潜力的免费激进的 scavengers。当氧化应力在 post-ICH 发炎起一个主要作用,我们假设了那 CeNPs 可能免于 ICH。测试这个假设,核心 CeNPs 用一个修改反向的 micelle 方法被综合并且用 phospholipid 聚乙烯乙二醇(木钉) 盖住完成 biocompatibility。我们调查了是否我们的定做的 biocompatible CeNPs 对 ICH 有保护的效果。CeNPs 在 vitro 减少了氧化应力,导致 hemin 的 cytotoxicity,和发炎。在一个啮齿类动物 ICH 模型,静脉内地管理了 CeNPs,建议他们能通过损坏血大脑障碍扩散是主要在出血性的半球散布了。而且, CeNPs 在出血性的损害和煽动性的蛋白质表示附近稀释了 microglia/macrophage 招募。最后, CeNP 处理作为与控制相比在 68.4% 减少了大脑浮肿。这些结果与 ICH 为病人作为一个新奇治疗学的代理人揭示 CeNPs 的大潜力。 | Dong-Wan Kang Chi Kyung Kim Han-Gil Jeong Min Soh Taeho Kim In-Young Choi SeuI-Ki Ki Do Yeon Kim Wookjin Yang Taeghwan Hyeon Seung-Hoon Lee | 2017 | Nano Research2017，10，8： | 3 |
| 16 | Efficacy of texture analysis of pre-operative magnetic resonance imaging in predicting microvascular invasion in hepatocellular carcinoma显示文摘BACKGROUND Presence of microvascular invasion(MVI)indicates poorer prognosis postcurative resection of hepatocellular carcinoma(HCC),with an increased chance of tumour recurrence.By present standards,MVI can only be diagnosed postoperatively on histopathology.Texture analysis potentially allows identification of patients who are considered‘high risk’through analysis of pre-operative magnetic resonance imaging(MRI)studies.This will allow for better patient selection,improved individualised therapy(such as extended surgical margins or adjuvant therapy)and pre-operative prognostication.AIM This study aims to evaluate the accuracy of texture analysis on pre-operative MRI in predicting MVI in HCC.METHODS Retrospective review of patients with new cases of HCC who underwent hepatectomy between 2007 and 2015 was performed.Exclusion criteria:No preoperative MRI,significant movement artefacts,loss-to-follow-up,ruptured HCCs,previous hepatectomy and adjuvant therapy.Fifty patients were divided into MVI(n=15)and non-MVI(n=35)groups based on tumour histology.Selected images of the tumour on post-contrast-enhanced T1-weighted MRI were analysed.Both qualitative(performed by radiologists)and quantitative data(performed by software)were obtained.Radiomics texture parameters were extracted based on the largest cross-sectional area of each tumor and analysed using MaZda software.Five separate methods were performed.Methods 1,2 and 3 exclusively made use of features derived from arterial,portovenous and equilibrium phases respectively.Methods 4 and 5 made use of the comparatively significant features to attain optimal performance.RESULTS Method 5 achieved the highest accuracy of 87.8%with sensitivity of 73%and specificity of 94%.CONCLUSION Texture analysis of tumours on pre-operative MRI can predict presence of MVI in HCC with accuracies of up to 87.8%and can potentially impact clinical management. | Jordan Zheng Ting Sim Terrence Chi Hong Hui Tong Kuan Chuah Hsien Min Low Cher Heng Tan Vishal GShelat | 2022 | World Journal of Clinical Oncology2022，13，11： | 3 |
| 17 | Semi-enclosed experimental system for coal spontaneous combustion for determining regional distribution of high-temperature zone of coal fire显示文摘Temperature variation and gas generation at diferent depths and positions in the coal combustion process were studied to determine the propagation and evolution of high temperature regions in the process of coal spontaneous combustion.This study selected coal samples from Mengcun,Shaanxi Province,People’s Republic of China,and developed a semi-enclosed experimental system(furnace)for simulating coal combustion.The thermal mass loss of coal samples under various heating rates(5,10,and 15℃/min)was analyzed through thermogravimetric analysis,and the dynamic characteristics of the coal samples were analyzed;the reliability of the semi-enclosed experimental system was verifed through the equal proportional method of fuzzy response.The results reveal that the high-temperature zone is distributed nonlinearly from the middle to the front end of the furnace,and the temperatures of points in this zone decreased gradually as the layer depth increased.The apparent activation energy of the coal samples during combustion frst increased and then decreased as the conversion degree increased.Furthermore,the proportion of mass loss and the mass loss rate in the coal samples observed in the thermogravimetric experiment is consistent with that observed in the frst and second stages of the experiment conducted using the semi-enclosed system.The research fndings can provide a theoretical basis for the prevention and control of hightemperature zones in coal combustion. | Jingyu Zhao Hanqi Ming Tao Guo Yuxuan Zhang Jun Deng Jiajia Song Qiang Zeng Chi‑Min Shu | 2022 | International Journal of Coal Science & Technology2022，9，5： | 3 |
| 18 | Is High Serum Uric Acid a Risk Marker or a Target for Treatment? Examination of its Independent Effect in a Large Cohort With Low Cardiovascular Risk显示文摘 | Chi Pang Wen Ting-Yuan David Cheng Hui Ting Chan Min Kuang Tsai Wen-Shen Isabella Chung Shan Pou Tsai Mark L. Wahlqvist Yi Chen Yang Shiuan Be Wu Po Huang Chiang Sung Feng Wen | 2010 | American Journal of Kidney Diseases2010，，2： | 2 |
| 19 | Tectonically-controlled Evolution of the Late Cenozoic Nihewan Basin, North China Craton: Constraints from Stratigraphy, Mineralogy, and Geochemistry显示文摘The Late Cenozoic basins in the Weihe–Shanxi Graben, North China Craton are delineated by northeast-striking faults. The faults have, since a long time, been related to the progressive uplift and northeastward expansion of the Tibetan Plateau. To show the relation between the basins and faults, two Pliocene–Pleistocene stratigraphic sections(Chengqiang and Hongyanangou) in the southern part of the Nihewan Basin at the northernmost parts of the graben are studied herein. Based on the sedimentary sequences and facies, the sections are divided into three evolutionary stages, such as alluvial fan-eolian red clay, fan delta, and fluvial, with boundaries at ~2.8 and ~1.8 Ma. Paleocurrent indicators, the composition of coarse clastics, heavy minerals, and the geochemistry of moderate–fine clastics are used to establish the temporal and spatial variations in the source areas. Based on features from the middlenorthern basin, we infer that the Nihewan Basin comprises an old NE–SW elongate geotectogene and a young NW–SE elongate subgeotectogene. The main geotectogene in the mid-north is a half-graben bounded by northeast-striking and northwest-dipping normal faults(e.g., Liulengshan Fault). This group of faults was mainly affected by the Pliocene(before ~2.8–2.6 Ma) NW–SE extension and controlled the deposition of sediments. In contrast, the subgeotectogene in the south was affected by northwest-striking normal faults(e.g., Huliuhe Fault) that were controlled by the subsequent weak NE–SW extension in the Pleistocene. The remarkable change in the sedimentary facies and provenance since ~1.8 Ma is possibly a signal of either weak or strong NE–SW extension. This result implies that the main tectonic transition ages of ~2.8–2.6 Ma and ~1.8 Ma in the Weihe–Shanxi Graben are affected by the Tibetan Plateau in Pliocene–Pleistocene. | LIU Jin CHEN Xingqiang CHI Zhenqing WANG Yong MIN Longrui LI Tingdong | 2018 | Acta Geologica Sinica(English Edition)2018，92，2： | 2 |
| 20 | Clustering of Non-communicable Diseases Risk Factors in Healthy Adults Aged 35 Years and Older in Shenzhen,China显示文摘We assessed the prevalence of non‐ communicable diseases(NCDs) risk factors with a focus on their clustering among healthy adults in Shenzhen, China. Data from the 2011 China Health and Nutrition Survey, comprising a regionally representative sample of 806 healthy adults aged 35 years or older, were obtained to determine the prevalence of five risk factors for NCDs. The prevalence of current smoking, central obesity, impaired fasting glucose, borderline hypertension, and borderline high total cholesterol was 19.97%, 28.29%, 4.47%, 10.55%, and 36.10%, respectively. A total 63.77% of participants had at least one risk factor. Upon examination of risk factor clustering, we observed that 7.57% of participants had at least three risk factors. Using this threshold as a cutoff, clustering of risk factors was associated with sex [odds ratio(OR) = 3.336, 95% confidence interval(CI): 1.782 to 6.246], physical activity(OR = 1.913, 95% CI: 1.009 to 3.628), and BMI(OR = 7.376, 95% CI: 3.812 to 14.270). The prevalence of risk factors for NCDs is fairly high among healthy adults in Shenzhen, with a clustering tendency. | NI Wen Qing XU Jian LIU Min LIU Xiao Li YANG Li Chen ZHUO Zhi Peng YUAN Xue Li SONG Jin Ping CHI Hong Shan BAI Ya Min | 2017 | Biomedical and Environmental Sciences2017，30，9： | 2 |
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